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Journal Article
Blood, ISSN 0006-4971, 03/2003, Volume 101, Issue 5, pp. 1692 - 1697
We investigated the clinical activity of the farnesyl transferase inhibitor R115777 in 22 patients with chronic myelogenous leukemia (CML) in chronic,... 
IN-VITRO | THERAPY | ANGIOGENESIS | RAS SIGNALING PATHWAY | MECHANISMS | HEMATOLOGY | CANCER | ASTROCYTOMA-CELLS | ENDOTHELIAL GROWTH-FACTOR | FARNESYLTRANSFERASE INHIBITORS | PROTEIN PRENYLATION | Nausea - chemically induced | Vascular Endothelial Growth Factors | Humans | Lymphokines - blood | Middle Aged | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Alkyl and Aryl Transferases - antagonists & inhibitors | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Fatigue - chemically induced | Antineoplastic Agents - administration & dosage | Enzyme Inhibitors - administration & dosage | Primary Myelofibrosis - blood | Quinolones - therapeutic use | Multiple Myeloma - blood | Enzyme Inhibitors - adverse effects | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - blood | Leukemia, Myeloid, Chronic-Phase - drug therapy | Enzyme Inhibitors - pharmacology | Fibroblast Growth Factor 2 - blood | Enzyme Inhibitors - therapeutic use | Farnesyltranstransferase | Tumor Necrosis Factor-alpha - analysis | Endothelial Growth Factors - blood | Quinolones - administration & dosage | Blast Crisis - blood | Vascular Endothelial Growth Factor A | Blast Crisis - drug therapy | Salvage Therapy | Quinolones - pharmacology | Intercellular Signaling Peptides and Proteins - blood | Multiple Myeloma - drug therapy | Quinolones - adverse effects | Antineoplastic Agents - adverse effects | Adult | Female | Antineoplastic Agents - pharmacology | Leukemia, Myeloid, Accelerated Phase - blood | Drug Eruptions - etiology | Primary Myelofibrosis - drug therapy | Leukemia, Myeloid, Accelerated Phase - drug therapy | Drug Administration Schedule | Leukemia, Myeloid, Chronic-Phase - blood | Treatment Outcome | Hepatocyte Growth Factor - blood | Interferon-alpha - blood | Neoplasm Proteins - blood | Aged
Journal Article
The EMBO Journal, ISSN 0261-4189, 07/2002, Volume 21, Issue 13, pp. 3245 - 3254
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 11/2012, Volume 199, Issue 5, pp. 723 - 734
Lysosomal storage diseases (LSDs) are a family of disorders that result from inherited gene mutations that perturb lysosomal homeostasis. LSDs mainly stem from... 
LATE ENDOSOMES | CHAPERONE-MEDIATED AUTOPHAGY | CHOLESTEROL ACCUMULATION | CALCIUM HOMEOSTASIS | MOUSE MODEL | MITOCHONDRIAL ABERRATIONS | DISEASE | GENE-THERAPY | SALVAGE PATHWAY | ENZYME REPLACEMENT THERAPY | CELL BIOLOGY | Gene mutations | Lysosomes | Physiological aspects | Cytogenetics | Homeostasis | Genetic aspects | Research | Health aspects | Reviews
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2018, Volume 115, Issue 32, p. E7458
The authors give different opinion on the reported role of Poldip2 and ACSM1 in a mammalian lipoic acid salvage pathway controlling HIF-1 activation. Prior... 
Enzymes | Lipoic acid | Yeast | Scavenging | Activation | Mammals | Proteins | Eukaryotes | Mitochondria | Salvage | Acids | Mutation | Electron transport | Metabolic disorders
Journal Article
Cancer, ISSN 0008-543X, 02/2019, Volume 125, Issue 3, pp. 398 - 405
Background The objective of this study was to assess the correlation between mismatch repair (MMR) status, disease recurrence patterns, and recurrence‐free... 
recurrence | endometrial cancer | adjuvant treatment | mismatch repair (MMR) deficiency | high‐intermediate–risk | high-intermediate–risk | SALVAGE | MICROSATELLITE INSTABILITY | CLINICOPATHOLOGICAL SIGNIFICANCE | OPEN-LABEL | PELVIC RADIATION-THERAPY | high-intermediate-risk | EXTERNAL-BEAM RADIOTHERAPY | IMPACT | ONCOLOGY | DOSE-RATE BRACHYTHERAPY | CARCINOMA | ISOLATED VAGINAL RECURRENCES | Immunohistochemistry | Prognosis | Endometrial Neoplasms - mortality | Humans | Endometrial Neoplasms - metabolism | Neoplastic Syndromes, Hereditary - metabolism | Carcinoma, Endometrioid - diagnosis | Brain Neoplasms - metabolism | Colorectal Neoplasms - diagnosis | Carcinoma, Endometrioid - metabolism | Neoplastic Syndromes, Hereditary - mortality | DNA Repair Enzymes - metabolism | Biomarkers, Tumor - metabolism | Female | Retrospective Studies | Brain Neoplasms - mortality | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - mortality | Neoplasm Recurrence, Local - metabolism | Biomarkers, Tumor - analysis | Brain Neoplasms - diagnosis | Risk Factors | Neoplastic Syndromes, Hereditary - diagnosis | Neoplasm Recurrence, Local - diagnosis | Endometrial Neoplasms - diagnosis | DNA Repair Enzymes - analysis | Carcinoma, Endometrioid - mortality | Survival Analysis | Endometrial Neoplasms - pathology | Aged | Carcinoma, Endometrioid - pathology | Endometrial cancer | MLH1 protein | MSH2 protein | Health risks | Vagina | Homology | Regression analysis | Patients | Survival | Proteins | MSH6 protein | Survival analysis | Correlation analysis | Mismatch repair | Risk assessment | Biomarkers | Hazard assessment | Repair | Endometrium | Cancer
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2018, Volume 13, Issue 12, p. e0208947
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0165777
Background Accumulating evidence suggests a cardioprotective role of pacing postconditioning (PPC) maneuvers in animal models and more recently in humans. The... 
ISCHEMIA-REPERFUSION INJURY | HEART | PERCUTANEOUS CORONARY INTERVENTION | CHYMASE | MYOCARDIAL-INFARCTION | MULTIDISCIPLINARY SCIENCES | SIZE | MECHANISMS | TYPE-1 RECEPTOR | STRESS | II FORMATION | Heart - physiopathology | Receptors, Angiotensin - metabolism | Angiotensin II - pharmacology | Tetrazoles - pharmacology | Captopril - pharmacology | Rats, Wistar | Angiotensin Receptor Antagonists - pharmacology | Rats | Male | Peptide Fragments - pharmacology | Renin-Angiotensin System - physiology | Hemodynamics - physiology | Cardiac Pacing, Artificial - methods | Myocardial Reperfusion Injury - physiopathology | Myocardial Reperfusion Injury - metabolism | Animals | Biphenyl Compounds - pharmacology | Myocardium - metabolism | Heart - drug effects | Renin-Angiotensin System - drug effects | Angiotensin I - pharmacology | Angiotensin-Converting Enzyme Inhibitors - pharmacology | Hemodynamics - drug effects | Myocardial Reperfusion Injury - drug therapy | Physiological aspects | Creatine | Captopril | Creatine kinase | Angiotensin | Angiotensin converting enzyme | Heart | Animal models | Heart attacks | Cardiovascular disease | AKT protein | Activation | Kinases | Maneuvers | Reperfusion | Salvage | Renin | Ischemia | Peptidyl-dipeptidase A | Rodents | Angiotensin AT1 receptors | Physiology | Angiotensin II | Heart diseases | Injuries | Hypertension | Enzymes | Health risks | Extracellular signal-regulated kinase | Lactate dehydrogenase | L-Lactate dehydrogenase | Chymase | Medicine | Studies | Signaling | Coronary vessels | Lactic acid | Hemodynamics | Veins & arteries
Journal Article
European Journal of Inorganic Chemistry, ISSN 1434-1948, 04/2019, Volume 2019, Issue 16, pp. 2164 - 2167
Bioinspired oxidative cleavage of aliphatic C–C bonds of the acireductone model substrate 2‐hydroxy‐3‐oxo‐1,3‐diphenylprop‐1‐en‐1‐olate, bound to two... 
Aliphatic C–C cleavage | Enzymes | Nickel | Oxidation | Acireductone dioxygenase | Enzyme mimics | ACETYL-COA SYNTHASE | ENOLATE COMPLEX | CRYSTAL-STRUCTURE | ACTIVE-SITES | X-RAY-STRUCTURE | Aliphatic C-C cleavage | METHIONINE SALVAGE PATHWAY | CHEMISTRY, INORGANIC & NUCLEAR | CARBON-MONOXIDE | HYDROGENASE | CONTAINING SUPEROXIDE-DISMUTASE | Analysis | Cleavage | Biomimetics | Aliphatic compounds | Substrates
Journal Article