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1. Full Text Algicidal activity of Salvia miltiorrhiza Bung on Microcystis aeruginosa—Towards identification of algicidal substance and determination of inhibition mechanism
by Zhang, Chao and Yi, Yang-Lei and Hao, Kai and Liu, Guang-Lu and Wang, Gao-Xue
Chemosphere, ISSN 0045-6535, 10/2013, Volume 93, Issue 6, pp. 997 - 1004
The present study was to isolate and identify a potent algicidal compound from extract of and study the potential inhibition mechanism on . Column... 
Oxidative stress | Neo-przewaquinone A | Photosynthesis-related genes | Salvia miltiorrhiza Bung | Algicidal | Cell morphology | GROWTH-INHIBITION | ALLELOCHEMICALS | LIPID-PEROXIDATION | COMPOUND | MYRIOPHYLLUM-SPICATUM | HARMFUL ALGAL BLOOM | RESPONSES | ENVIRONMENTAL SCIENCES | OFFICINALIS L | VULGARIS | EXPRESSION | Salvia miltiorrhiza - chemistry | Photosynthesis - drug effects | Quinones - toxicity | Heterocyclic Compounds, 4 or More Rings - toxicity | Biological Products - toxicity | Disinfectants - toxicity | Microcystis - drug effects | Eutrophication
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2. Full Text SmLEA2, a gene for late embryogenesis abundant protein isolated from Salvia miltiorrhiza, confers tolerance to drought and salt stress in Escherichia coli and S. miltiorrhiza
by Wang, Huaiqin and Wu, Yucui and Yang, Xinbing and Guo, Xiaorong and Cao, Xiaoyan
Protoplasma, ISSN 0033-183X, 3/2017, Volume 254, Issue 2, pp. 685 - 696
Abiotic stresses, such as drought and high salinity, are major factors that limit plant growth and productivity. Late embryogenesis abundant (LEA) proteins are... 
Life Sciences | Salvia miltiorrhiza | Abiotic stress | Zoology | Escherichia coli | LEA | Plant Sciences | Cell Biology | ARABIDOPSIS-THALIANA | DESICCATION TOLERANCE | LEA PROTEINS | PLANT SCIENCES | CELL BIOLOGY | OVEREXPRESSION | ORYZA-SATIVA | TANSHINONE BIOSYNTHESIS | ACCLIMATION | REGULATORY NETWORKS | PLANTS | EXPRESSION | Potassium - metabolism | Genes, Plant | Sodium Chloride - pharmacology | Escherichia coli - drug effects | Adaptation, Physiological - drug effects | Phylogeny | Sodium - metabolism | Adaptation, Physiological - genetics | Droughts | Salvia miltiorrhiza - drug effects | Plants, Genetically Modified | Plant Proteins - metabolism | Stress, Physiological - drug effects | Escherichia coli - physiology | Salvia miltiorrhiza - physiology | Plant Proteins - isolation & purification | Plant Transpiration - drug effects | Microbial Viability - drug effects | Stress, Physiological - genetics | Electrophoresis, Polyacrylamide Gel | Salinity | Plant Proteins - genetics | Gene Expression Regulation, Plant - drug effects | Phenotype | Salvia miltiorrhiza - genetics | Proteins | Embryonic development | Genetically modified plants | Cladistic analysis | Analysis | Superoxide | Genetic engineering
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3. Full Text The Anticancer Properties of Salvia Miltiorrhiza Bunge (Danshen): A Systematic Review
by Chen, Xiuping and Guo, Jiajie and Bao, Jiaolin and Lu, Jinjian and Wang, Yitao
Medicinal Research Reviews, ISSN 0198-6325, 07/2014, Volume 34, Issue 4, pp. 768 - 794
Salvia miltiorrhiza Bunge (Danshen in Chinese) is a classical Huoxue Huayu (a traditional Chinese medical term means promoting blood circulation and removing... 
derivatives | tanshinones | cancer | Salvia miltiorrhiza Bunge | phenolic acids | Derivatives | Tanshinones | Phenolic acids | Cancer | GROWTH-INHIBITION | CHEMISTRY, MEDICINAL | CELLS IN-VITRO | DIHYDROTANSHINONE-I | ACID-B | PROSTATE-CANCER CELLS | TANSHINONE-II-A | LEUKEMIA-CELLS | PHARMACOLOGY & PHARMACY | TNF-ALPHA | NEO-TANSHINLACTONE | APOPTOSIS INDUCTION | Hydrophobic and Hydrophilic Interactions | Salvia miltiorrhiza - chemistry | Antineoplastic Agents - pharmacology | Animals | Antineoplastic Agents - chemistry | Humans | Care and treatment | Analysis
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4. Full Text Combining metabolomics and transcriptomics to characterize tanshinone biosynthesis in Salvia miltiorrhiza
by Gao, Wei and Sun, Hai-Xi and Xiao, Hongbin and Cui, Guanghong and Hillwig, Matthew L and Jackson, Alana and Wang, Xiao and Shen, Ye and Zhao, Nan and Zhang, Liangxiao and Wang, Xiu-Jie and Peters, Reuben J and Huang, Luqi
BMC Genomics, ISSN 1471-2164, 01/2014, Volume 15, Issue 1, pp. 73 - 73
Background: Plant natural products have been co-opted for millennia by humans for various uses such as flavor, fragrances, and medicines. These compounds often... 
PATHWAYS | ACTIVATION | METABOLISM | ISOPRENOID BIOSYNTHESIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENHANCEMENT | GENETICS & HEREDITY | HAIRY-ROOT CULTURE | GENE-EXPRESSION | YEAST ELICITOR | MASS-SPECTROMETRY | RICE | Metabolomics | Plant Roots - metabolism | Cells, Cultured | Transcriptome | Cytochrome P-450 Enzyme System - metabolism | Diterpenes, Abietane - biosynthesis | Plant Roots - cytology | Transcription Factors - genetics | RNA, Messenger - metabolism | Transcription Factors - metabolism | Plant Proteins - genetics | Metabolic Networks and Pathways - genetics | Salvia miltiorrhiza - metabolism | Cytochrome P-450 Enzyme System - genetics | Salvia miltiorrhiza - genetics | High-Throughput Nucleotide Sequencing | Plant Proteins - metabolism | Principal Component Analysis | Plant genetics | Genetic research | Biosynthesis | Genetic aspects | Research | Genetic transcription | Sage | Medicinal plants | Medicine, Herbal | DNA binding proteins | Medicine, Botanic | Enzymes | Chinese medicine | Heart attacks | Metabolites | Natural products | Genomics | Principal components analysis | Kinases | Angina pectoris | Plastids | Chromatography | Cytochrome P450
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5. Full Text Compound Astragalus and Salvia miltiorrhiza extract inhibits cell proliferation, invasion and collagen synthesis in keloid fibroblasts by mediating transforming growth factor‐β / Smad pathway
by He, S and Yang, Y and Liu, X and Huang, W and Zhang, X and Yang, S and Zhang, X
British Journal of Dermatology, ISSN 0007-0963, 03/2012, Volume 166, Issue 3, pp. 564 - 574
Summary Background  The transforming growth factor (TGF)‐β/Smad pathway plays a key role in keloid development. We have previously demonstrated that compound... 
FIBROSIS | ACCOUNT | TGF-BETA | GENE-EXPRESSION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | PROTEIN-KINASE PATHWAYS | MECHANISMS | MODULATION | HYPERTROPHIC SCAR FIBROBLASTS | SMAD7 | DERMATOLOGY | Phosphorylation | Keloid - metabolism | Keloid - pathology | Humans | Middle Aged | Smad2 Protein - metabolism | Drugs, Chinese Herbal - pharmacology | Male | Dose-Response Relationship, Drug | Young Adult | Salvia miltiorrhiza | Animals | Signal Transduction - drug effects | Cattle | Fibroblasts - drug effects | Adult | Female | Serum | Cell Proliferation - drug effects | Collagen - biosynthesis | Transforming Growth Factor beta - metabolism | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism
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6. Full Text Magnetic molecularly imprinted polymers based on silica modified by deep eutectic solvents for the rapid simultaneous magnetic‐based solid‐phase extraction of Salvia miltiorrhiza bunge, Glycine max (Linn.) Merr and green tea
by Li, Guizhen and Wang, Xiaoqin and Row, Kyung Ho
ELECTROPHORESIS, ISSN 0173-0835, 04/2018, Volume 39, Issue 8, pp. 1111 - 1118
Novel magnetic molecularly imprinted polymers (MMIPs) with multiple‐template based on silica were modified by four types of deep eutectic solvents (DESs) for... 
Magnetic molecularly imprinted polymers | Extraction | Deep eutectic solvents | Magnetic solid‐phase extraction | Magnetic solid-phase extraction | CHEMISTRY, ANALYTICAL | RECOGNITION | BIOCHEMICAL RESEARCH METHODS | CATECHINS | NANOPARTICLES | ISOFLAVONES | DAIDZEIN | URINE | IONIC LIQUIDS | WATER | Salvia miltiorrhiza - chemistry | Silicon Dioxide - chemistry | Solid Phase Extraction - methods | Plant Extracts - isolation & purification | Polymers - chemistry | Solid Phase Extraction - standards | Spectrum Analysis | Molecular Imprinting - methods | Tea - chemistry | Catechin | Polymer industry | Silica | Green tea | Isoflavones | Solvents | Scanning electron microscopy | Fourier transformation | Salvia miltiorrhiza | Imprinted polymers | Field emission microscopy | Silicon dioxide
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7. Full Text Full‐length transcriptome sequences and splice variants obtained by a combination of sequencing platforms applied to different root tissues of Salvia miltiorrhiza and tanshinone biosynthesis
by Xu, Zhichao and Peters, Reuben J and Weirather, Jason and Luo, Hongmei and Liao, Baosheng and Zhang, Xin and Zhu, Yingjie and Ji, Aijia and Zhang, Bing and Hu, Songnian and Au, Kin Fai and Song, Jingyuan and Chen, Shilin
The Plant Journal, ISSN 0960-7412, 06/2015, Volume 82, Issue 6, pp. 951 - 961
Summary Danshen, Salvia miltiorrhiza Bunge, is one of the most widely used herbs in traditional Chinese medicine, wherein its rhizome/roots are particularly... 
single‐molecule real‐time sequencing | tanshinone biosynthesis | Salvia miltiorrhiza | alternative splicing | next‐generation sequencing | single-molecule real-time sequencing | next-generation sequencing | LANDSCAPE | TRADITIONAL MEDICINE | VIEW | DISCOVERY | PLANT SCIENCES | EVOLUTION | TOPHAT | RNA-SEQ | COMPLEXITY | BIOLOGY | SUPERFAMILY | Plant Roots - metabolism | Alternative Splicing | Diterpenes, Abietane - metabolism | Transcriptome | Plant Roots - genetics | Gene Expression Profiling - methods | Diterpenes, Abietane - biosynthesis | Plant Proteins - genetics | Salvia miltiorrhiza - metabolism | Gene Expression Regulation, Plant | Salvia miltiorrhiza - genetics | Plant Proteins - metabolism | High-Throughput Nucleotide Sequencing - methods | Sequence Analysis, DNA - methods | Genomics | Herbal medicine | Chinese medicine | Biosynthesis | Botany
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8. Full Text Aureonitols A and B, Two New C13‐Polyketides from Chaetomium globosum, an Endophytic Fungus in Salvia miltiorrhiza
by Yang, Sheng‐Xiang and Zhao, Wen‐Ting and Chen, Heng‐Ye and Zhang, Lei and Liu, Ting‐Kai and Chen, He‐Ping and Yang, Jian and Yang, Xiao‐Long
Chemistry & Biodiversity, ISSN 1612-1872, 09/2019, Volume 16, Issue 9, p. n/a
Two new C13‐polyketides, aureonitols A and B (1 and 2), along with five known compounds (3–7), were isolated from the solid fermentation culture of the plant... 
Salvia miltiorrhiza | Chaetomium globosum | polyketides | antimicrobial activities | Fungi | Drug resistance in microorganisms | Ketoconazole | Analysis | Information management | Fermentation | Ciprofloxacin | Data analysis | Polyketides | Minimum inhibitory concentration | Endophytes
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9. Full Text Efficacy of Salvia miltiorrhiza injection combined with steroids in the treatment of oral submucous fibrosis A meta-analysis of randomized controlled trials
by Xie, H and Guo, JC and Tan, BY and Wu, H
MEDICINE, ISSN 0025-7974, 07/2019, Volume 98, Issue 27, p. e16339
Background: This study was performed to systematically review the efficacy of Salvia miltiorrhiza injection combined with steroids in the treatment of oral... 
PATHOGENESIS | oral submucous fibrosis | MEDICINE, GENERAL & INTERNAL | INHIBITION | meta-analysis | QUID | steroids | MICE | salvia miltiorrhiza | DRUG-TREATMENT | Injections | Oral Submucous Fibrosis - drug therapy | Salvia miltiorrhiza | Steroids - therapeutic use | Drugs, Chinese Herbal - therapeutic use | Humans | Medicine, Experimental | Medical research | Usage | Care and treatment | Steroids (Drugs) | Fibrosis
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10. Full Text In Salvia miltiorrhiza , phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors
by Zhou, Yongqiang and Li, Weize and Xu, Lei and Chen, Lvyi
Environmental Toxicology and Pharmacology, ISSN 1382-6689, 2011, Volume 31, Issue 3, pp. 443 - 452
Abstract Radix Salvia miltiorrhiza (RSM), a traditional Chinese medicinal herb, has been alleged to possess therapeutic effects against senile dementia, also... 
Emergency | Acetylcholinesterase | Radix Salvia miltiorrhiza | Amyloid β | PROTEIN | INDUCED APOPTOSIS | ALZHEIMERS-DISEASE | ANTIOXIDANT ACTIVITIES | RAT CORONARY-ARTERY | BUNGE | ENVIRONMENTAL SCIENCES | Amyloid beta | CALCIUM-CHANNELS | LIVER-INJURY | PHARMACOLOGY & PHARMACY | TOXICOLOGY | CHINESE MEDICINAL PREPARATIONS | EXTRACT | L-Lactate Dehydrogenase - metabolism | Neuroprotective Agents | Apoptosis - drug effects | Calcium - metabolism | Plant Extracts - pharmacology | Polyphenols - pharmacology | Benzofurans - pharmacology | Male | PC12 Cells | Tetrazolium Salts | Hydroxybenzoates - pharmacology | Hydroxybenzoates - chemistry | Thiazoles | Phosphatidylinositols - metabolism | Cell Survival - drug effects | Polyphenols - isolation & purification | Cholinesterase Inhibitors | Amyloid beta-Peptides - toxicity | Diterpenes, Abietane - chemistry | Rats | Antioxidants - pharmacology | Rats, Sprague-Dawley | Amyloid beta-Peptides - antagonists & inhibitors | Diterpenes, Abietane - pharmacology | Salvia miltiorrhiza - chemistry | Animals | Herbs | Brain | Enzymes | Ethanol | Neurodegenerative diseases | Toxicity | Herbal medicines | phenolic compounds | Cytotoxicity | beta -Amyloid | L-Lactate dehydrogenase | tanshinones | phenolic acids | Dementia disorders | Polyphenols | Amyloid | Alzheimer's disease | Apoptosis
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11. Full Text A comparative study of Danhong injection and Salvia miltiorrhiza injection in the treatment of cerebral infarction A systematic review and meta-analysis
by Wang, KH and Zhang, D and Wu, JR and Liu, S and Zhang, XM and Zhang, B
MEDICINE, ISSN 0025-7974, 06/2017, Volume 96, Issue 22, p. e7079
Background: To evaluate systematically the clinical effectiveness and safety of Danhong injection (DI) and Salvia miltiorrhiza injection (SMI) in the treatment... 
meta-analysis | MEDICINE, GENERAL & INTERNAL | Salvia miltiorrhiza injection | systematic review | cerebral infarction | Danhong injection | Cerebral Infarction - drug therapy | Injections | Phytotherapy - adverse effects | Salvia miltiorrhiza - adverse effects | Humans | Drugs, Chinese Herbal - administration & dosage | Drugs, Chinese Herbal - adverse effects | Medicine, Chinese Traditional - adverse effects | Randomized Controlled Trials as Topic | Treatment outcome | Cerebral ischemia | Care and treatment | Usage | Safety and security measures | Analysis
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12. Full Text Separation and analysis of phenolic acids from Salvia miltiorrhiza and its related preparations by off-line two-dimensional hydrophilic interaction chromatography×reversed-phase liquid chromatography coupled with ion trap time-of-flight mass spectrometry
by Sun, Wanyang and Sun, Henry and Tong, Ling and Miao, Jingzhuo and Huang, Jingyi and Li, Yunfei and Li, Dongxiang and Xiao, Hongting and Bi, Kaishun
Journal of Chromatography A, ISSN 0021-9673, 01/2016, Volume 1431, pp. 79 - 88
(SM) is one of the most widely used Traditional Chinese Medicine. Active constituents of SM mainly contain hydrophilic phenolic acids (PAs) and lipophilic... 
Salvia miltiorrhiza | Hydrophilic interaction chromatography (HILIC) | Time-of-flight mass spectrometry (TOF-MS) | Phenolic acids | Two-dimensional liquid chromatography (2D-LC) | Reversed-phase liquid chromatography (RP-LC) | Constituents | Separation | PAS | Liquid chromatography | Samarium | Filters (fluid) | Chromatography
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13. Full Text The Complete Chloroplast Genome Sequence of the Medicinal Plant Salvia miltiorrhiza
by Qian, Jun and Song, Jingyuan and Gao, Huanhuan and Zhu, Yingjie and Xu, Jiang and Pang, Xiaohui and Yao, Hui and Sun, Chao and Li, Xian'en and Li, Chuyuan and Liu, Juyan and Xu, Haibin and Chen, Shilin
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, p. e57607
Salvia miltiorrhiza is an important medicinal plant with great economic and medicinal value. The complete chloroplast (cp) genome sequence of Salvia... 
POPULATION-GENETICS | PLASTID GENOMES | EVOLUTION | TRANSFER-RNAS | PHYLOGENETIC-RELATIONSHIPS | DNA | MULTIDISCIPLINARY SCIENCES | GENES | ANGIOSPERMS | INVERTED REPEAT | COMPLETE NUCLEOTIDE-SEQUENCE | Lamiaceae - genetics | Reproducibility of Results | Introns - genetics | Genome, Chloroplast - genetics | Anticodon - genetics | Molecular Sequence Data | Exons - genetics | Chromosome Mapping | Phylogeny | Open Reading Frames - genetics | Microsatellite Repeats - genetics | Genetic Variation | Genes, Plant - genetics | Plants, Medicinal - genetics | Base Sequence | Salvia miltiorrhiza - genetics | Codon - genetics | Medicinal plants | Genes | Genomics | Genomes | Cladistic analysis | Codon | Analysis | Medicine, Botanic | Genetically modified organisms | Genetic aspects | Medicine, Herbal | Genetic engineering | Biotechnology | Gene order | Divergence | Nucleotide sequence | Laboratories | Regional analysis | Population genetics | Gene sequencing | Herbal medicine | Studies | Engineering | Salvia miltiorrhiza | Conserved sequence | Chloroplasts | Phylogenetics | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid
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