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Free Radical Biology and Medicine, ISSN 0891-5849, 12/2016, Volume 101, pp. 401 - 412
Acetaminophen (APAP) overdose accounts for the majority of acute liver failure cases, and oxidative stress plays a key role in its toxic effects. Esculentoside... 
OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | OXIDANT STRESS | NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | ENDOCRINOLOGY & METABOLISM | INJURY | AMPK | MICE | ARACHIDONIC-ACID | HEPATOTOXICITY | AMP-Activated Protein Kinases - metabolism | Heme Oxygenase-1 - metabolism | Phosphorylation | Oxidative Stress | Humans | Oleanolic Acid - analogs & derivatives | Analgesics, Non-Narcotic - pharmacology | Glycogen Synthase Kinase 3 beta - genetics | Oleanolic Acid - pharmacology | JNK Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | Heme Oxygenase-1 - genetics | Acetaminophen - pharmacology | Gene Deletion | Superoxides - metabolism | Female | NF-E2-Related Factor 2 - genetics | Membrane Proteins - metabolism | JNK Mitogen-Activated Protein Kinases - genetics | Proto-Oncogene Proteins c-akt - metabolism | bcl-2-Associated X Protein - genetics | Apoptosis Inducing Factor - metabolism | Signal Transduction | Membrane Proteins - genetics | Acetaminophen - antagonists & inhibitors | Gene Expression Regulation | bcl-2-Associated X Protein - metabolism | NF-E2-Related Factor 2 - deficiency | Glycogen Synthase Kinase 3 beta - metabolism | Apoptosis Inducing Factor - genetics | Hep G2 Cells | Hydrogen Peroxide - metabolism | Animals | CRISPR-Cas Systems | Mice | Mice, Inbred BALB C | AMP-Activated Protein Kinases - genetics | Saponins - pharmacology
Journal Article
Medicine, ISSN 0025-7974, 09/2018, Volume 97, Issue 38, p. e12424
Rationale: Familial hydatidiform mole is extremely rare while familial gestational trophoblastic neoplasia (GTN) has never been reported. Inspired by 2... 
susceptibility | MANAGEMENT | KHDC3L | liver | PLACENTA | ABCB5 | RISK | drug transporter | familial | MEDICINE, GENERAL & INTERNAL | RECURRENT HYDATIDIFORM MOLES | NLRP7 MUTATIONS | gestational trophoblastic neoplasia | DISEASE | MOLAR PREGNANCIES | EPIDEMIOLOGY | Chorionic Gonadotropin, beta Subunit, Human - analysis | Drug-Related Side Effects and Adverse Reactions - complications | Humans | Triterpenes - therapeutic use | Asian Continental Ancestry Group - genetics | Antibiotics, Antineoplastic - adverse effects | Tomography, X-Ray Computed - methods | Lung Neoplasms - pathology | Young Adult | Dactinomycin - therapeutic use | Liver - drug effects | Lung Neoplasms - secondary | Dactinomycin - adverse effects | Female | Saponins - therapeutic use | Chemical and Drug Induced Liver Injury - blood | Treatment Outcome | Dactinomycin - administration & dosage | Chemical and Drug Induced Liver Injury - genetics | Pregnancy | Proteins - genetics | Administration, Intravenous | Antibiotics, Antineoplastic - therapeutic use | Adaptor Proteins, Signal Transducing - genetics | Chemical and Drug Induced Liver Injury - drug therapy | Lung Neoplasms - diagnostic imaging | Gestational Trophoblastic Disease - pathology | Hypolipidemic Agents - therapeutic use | Mutation | Neoplasm Staging | Gestational Trophoblastic Disease - drug therapy | Phosphatidylcholines - therapeutic use | Women | Chemotherapy | Usage | Analysis | Dosage and administration | Dactinomycin | Drug therapy | Health aspects | Trophoblastic tumors | Cancer
Journal Article
Chemosphere, ISSN 0045-6535, 08/2018, Volume 204, pp. 243 - 250
Saponin-rich plant extracts contain bioactive natural compounds and have many applications, e.g. as biopesticides and biosurfactants. The composition of... 
Saponins | Aquatic toxicity | Biopesticides | Natural compounds | Environmental monitoring | Biological products | Index Medicus
Journal Article
Regulatory Toxicology and Pharmacology, ISSN 0273-2300, 07/2015, Volume 72, Issue 2, pp. 323 - 334
Journal Article
Chemical Research in Toxicology, ISSN 0893-228X, 06/2019, Volume 32, Issue 6, pp. 1014 - 1026
Saponins are a type of compounds bearing a hydrophobic steroid/triterpenoid moiety and hydrophilic carbohydrate branches. The majority of the saponins... 
CHEMISTRY, MEDICINAL | CHOLESTEROL | DIGITONIN | MEMBRANES | CLASSIFICATION | NATURAL COMPOUND | CHEMISTRY, MULTIDISCIPLINARY | TRITERPENOID SAPONINS | OSW-1 | BEARING | TOXICOLOGY | CYTOTOXICITY | CELL
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 10/2017, Volume 24, Issue 34, pp. 3681 - 3697
Background: Natural medicine monomers (NMMs) isolated from plants have been recognized for their roles in treating different human diseases including cancers.... 
Cell cycle arrest | Natural medicine monomer | Signaling pathway | Cancer therapy | Anti-cancer activity | Apoptosis | HEPATOCELLULAR-CARCINOMA CELLS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | signaling pathway | apoptosis | CELL-CYCLE ARREST | cell cycle arrest | MITOCHONDRIAL-DEPENDENT APOPTOSIS | OLEANOLIC ACID | cancer therapy | GREEN TEA | CHLOROGENIC ACID | ALBUMIN-BOUND PACLITAXEL | TRADITIONAL CHINESE MEDICINE | PHARMACOLOGY & PHARMACY | natural medicine monomer | GANODERMA-LUCIDUM POLYSACCHARIDES | NF-KAPPA-B | Apoptosis - drug effects | Humans | Terpenes - toxicity | Flavonoids - therapeutic use | Saponins - chemistry | Terpenes - chemistry | Quinones - toxicity | Hydroxybenzoates - chemistry | Saponins - therapeutic use | Hydroxybenzoates - therapeutic use | Plants - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Biological Products - therapeutic use | Alkaloids - toxicity | Quinones - chemistry | Quinones - therapeutic use | Antineoplastic Agents, Phytogenic - chemistry | Saponins - toxicity | Neoplasms - drug therapy | Antineoplastic Agents, Phytogenic - toxicity | Flavonoids - toxicity | Plants - metabolism | Terpenes - therapeutic use | Alkaloids - therapeutic use | Hydroxybenzoates - toxicity | Flavonoids - chemistry | Alkaloids - chemistry | Medicinal plants | Cell proliferation | Drugs | Camptothecin | Toxicity | Radiation therapy | Drug development | Cancer therapies | Monomers | Metastases | Anticancer properties | Medicine | Signaling | Chemotherapy | Molecular modelling | Cell death | Paclitaxel | Cancer
Journal Article
Chemistry & Biodiversity, ISSN 1612-1872, 11/2018, Volume 15, Issue 11, pp. e1800282 - n/a
Journal Article
Journal Article
Environmental Pollution, ISSN 0269-7491, 05/2018, Volume 236, pp. 416 - 424
Saponin-rich extracts from and have been registered by US EPA as active ingredients in biopesticides, and extract from tea seed powder, has been proposed for... 
Saponins | Species sensitivity distribution | Biopesticides | Aquatic toxicity | ENVIRONMENTAL SCIENCES | POMACEA-CANALICULATA | DIVERSITY | Quinoa | Biological products | Pests | Biological control | Biocides | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2018, Volume 115, Issue 23, pp. E5419 - E5428
Journal Article