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Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7391, pp. 570 - 575
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2012, Volume 21, Issue 3, pp. 418 - 429
Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates... 
INTERSTITIAL FLUID PRESSURE | SOLID TUMORS | ONCOLOGY | COMPARING STANDARD PANCREATICODUODENECTOMY | HUMAN OSTEOSARCOMA XENOGRAFTS | RANDOMIZED-TRIAL | HEAD ADENOCARCINOMA | TUMOR VASCULATURE | EXTENDED LYMPHADENECTOMY | CANCER | BLOOD-PRESSURE | CELL BIOLOGY | Adenocarcinoma - pathology | Cell Adhesion Molecules - administration & dosage | Stromal Cells - pathology | Pancreatic Neoplasms - blood supply | Deoxycytidine - pharmacology | Hyaluronic Acid - physiology | Polyethylene Glycols - therapeutic use | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Pancreatic Neoplasms - drug therapy | Deoxycytidine - therapeutic use | Stromal Cells - drug effects | Hyaluronoglucosaminidase - administration & dosage | Drug Evaluation, Preclinical | Hyaluronoglucosaminidase - therapeutic use | Tumor Microenvironment - drug effects | Animals, Genetically Modified | Deoxycytidine - administration & dosage | Pancreatic Neoplasms - pathology | Microvessels - drug effects | Adenocarcinoma - drug therapy | Carcinoma, Pancreatic Ductal - pathology | Extracellular Fluid - drug effects | Polyethylene Glycols - administration & dosage | Adenocarcinoma - blood supply | Hyaluronoglucosaminidase - pharmacology | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Hyaluronic Acid - metabolism | Mice | Carcinoma, Pancreatic Ductal - blood supply | Cell Adhesion Molecules - therapeutic use | Deoxycytidine - analogs & derivatives | Enzymes | Medical colleges | Care and treatment | Glycosaminoglycans | Oncology, Experimental | Research | Chemotherapy | Universities and colleges | Drug therapy | Hyaluronic acid | Public health | Tumors | Cancer | Index Medicus
Journal Article
Journal of Vascular Surgery, ISSN 0741-5214, 2015, Volume 61, Issue 6, pp. 156S - 156S
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 2015, Volume 72, Issue 5, pp. AB120 - AB120
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 02/2013, Volume 23, Issue 2, pp. 249 - 262
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 08/2015, Volume 373, Issue 8, pp. 726 - 736
Journal Article
Immunity, ISSN 1074-7613, 02/2017, Volume 46, Issue 2, pp. 197 - 204
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2016, Volume 67, pp. 130 - 140
Abstract Objectives Dose-finding trials are fundamental to develop novel drugs for children and adolescents with advanced cancer. It is crucial to maximise... 
Hematology, Oncology and Palliative Medicine | Innovative Therapies for Children with Cancer | Dose-finding trial | Prognostic factor | Phase I trial | Children | Adolescents | Survival | ONCOLOGY TRIALS | SCORE | VALIDATION | I CLINICAL-TRIALS | CONTEXT | PEDIATRIC PHASE-I | CENTER EXPERIENCE | ONCOLOGY | Osteosarcoma - drug therapy | Multivariate Analysis | Prognosis | Neuroectodermal Tumors, Primitive - drug therapy | Humans | Child, Preschool | Infant | Male | Neuroblastoma - mortality | Sarcoma, Ewing - mortality | Medulloblastoma - mortality | Ependymoma - drug therapy | Employment | Ependymoma - mortality | Sarcoma - mortality | Female | Rhabdomyosarcoma - drug therapy | Retrospective Studies | Child | Rhabdomyosarcoma - mortality | Schools | Osteosarcoma - mortality | Glioma - mortality | Neuroectodermal Tumors, Primitive - mortality | Europe | Proportional Hazards Models | Neoplasms - mortality | Therapies, Investigational | Survival Rate | Sarcoma - drug therapy | Neoplasms - drug therapy | Sarcoma, Ewing - drug therapy | Neuroblastoma - drug therapy | Adolescent | Medulloblastoma - drug therapy | Central Nervous System Neoplasms - drug therapy | Central Nervous System Neoplasms - mortality | Clinical Trials, Phase I as Topic | Glioma - drug therapy | Care and treatment | Patient outcomes | Children's hospitals | Oncology, Experimental | Clinical trials | Research | Health aspects | Cancer | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 01/2017, Volume 36, Issue 1, pp. 1 - 12
Journal Article
British Journal of Cancer, ISSN 0007-0920, 06/2017, Volume 117, Issue 1, pp. 33 - 40
Background: Pembrolizumab (P) is an anti-PD-1 antibody that blocks the interaction between programmed cell death protein 1 (PD-1) on T-cells and PD-L1 and... 
clinical trial | pembrolizumab | advanced/metastatic solid tumours | phase I | chemotherapy | immunotherapy | CRITERIA | EFFICACY | CELL LUNG-CANCER | ONCOLOGY | ADVANCED MELANOMA | COHORT | NIVOLUMAB | IPILIMUMAB | Lung Neoplasms - drug therapy | Nausea - chemically induced | Humans | Middle Aged | Male | Fatigue - chemically induced | Vinblastine - administration & dosage | Diarrhea - chemically induced | Small Cell Lung Carcinoma - drug therapy | Pancreatic Neoplasms - drug therapy | Antibodies, Monoclonal, Humanized - administration & dosage | Vinblastine - analogs & derivatives | Doxorubicin - analogs & derivatives | Adult | Camptothecin - administration & dosage | Female | Paclitaxel - administration & dosage | Ovarian Neoplasms - drug therapy | Camptothecin - analogs & derivatives | Doxorubicin - administration & dosage | Drug Eruptions - etiology | Deoxycytidine - administration & dosage | Albumins - administration & dosage | Treatment Outcome | Sarcoma - drug therapy | Adenocarcinoma - drug therapy | Breast Neoplasms - drug therapy | Polyethylene Glycols - administration & dosage | Neoplasms - drug therapy | Taxoids - administration & dosage | Vomiting - chemically induced | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Deoxycytidine - analogs & derivatives | Gemcitabine | PD-1 protein | Toxicity | Exanthema | Diarrhea | Fatigue | Nausea | Lymphocytes T | Patients | Doxorubicin | Metastases | Irinotecan | Chemotherapy | Vomiting | Cell death | Immunotherapy | PD-L1 protein | Paclitaxel | Safety | Vinorelbine | Tumors | Cancer | Apoptosis | Index Medicus | metastatic solid tumours | advanced | Clinical Study
Journal Article