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1. Full Text Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma
by Byun, Minji and Abhyankar, Avinash and Lelarge, Virginie and Plancoulaine, Sabine and Palanduz, Ayse and Telhan, Leyla and Boisson, Bertrand and Picard, Capucine and Dewell, Scott and Zhao, Connie and Jouanguy, Emmanuelle and Feske, Stefan and Abel, Laurent and Casanova, Jean-Laurent
Journal of Experimental Medicine, ISSN 0022-1007, 10/2010, Volume 207, Issue 11, pp. 2307 - 2312
Classic Kaposi sarcoma (KS) is exceedingly rare in children from the Mediterranean Basin, despite the high prevalence of human herpesvirus-8 (HHV-8) infection... 
PATHOGENESIS | MEDICINE, RESEARCH & EXPERIMENTAL | HERPESVIRUS | DNA-SEQUENCES | KSHV | MUTATION | ORAI1 | INFECTION | IMMUNOLOGY | Stromal Interaction Molecule 1 | Genome-Wide Association Study | RNA Splice Sites - genetics | Calcium - metabolism | Membrane Proteins - genetics | Humans | Genetic Diseases, Inborn - genetics | Genetic Diseases, Inborn - immunology | Neoplasm Proteins - immunology | Calcium - immunology | Child, Preschool | Herpesvirus 8, Human | Male | Membrane Proteins - immunology | Sarcoma, Kaposi - virology | Homozygote | Turkey | Female | Sarcoma, Kaposi - immunology | Mutation | Neoplasm Proteins - genetics | Sarcoma, Kaposi - genetics | Brief Definitive Report
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2. Full Text Inherited human OX40 deficiency underlying classic kaposi sarcoma of childhood
by Byun, Minji and Ma Cindy S, C.S and Akçay, Arzu and Pedergnana, Vincent and Palendira, Umaimainthan and Myoung, Jinjong and Avery, Danielle T and Liu, Yifang and Abhyankar, Avinash and Lorenzo, Lazaro and Schmidt, Monika and Lim, Hye Kyung and Cassar, Olivier and Migaud, Melanie and Rozenberg, Flore and Canpolat, Nur and Aydogan, Gönül and Fleckenstein, Bernhard and Bustamante, Jacinta and Picard, Capucine and Gessain, Antoine and Jouanguy, Emmanuelle and Cesarman, Ethel and Olivier, Martin and Gros, Philippe and Abel, Laurent and Croft, Michael and Tangye, Stuart G and Casanova, Jean-Laurent
Journal of Experimental Medicine, ISSN 0022-1007, 2013, Volume 210, Issue 9, pp. 1743 - 1759
Kaposi sarcoma (KS), a human herpes virus 8 (HHV-8; also called KSHV)-induced endothelial tumor, develops only in a small fraction of individuals infected with... 
MEDICINE, RESEARCH & EXPERIMENTAL | HERPESVIRUS | B-CELL | OX40/GP34 SYSTEM | KALA-AZAR | VASCULAR ENDOTHELIAL-CELLS | IMMUNOLOGY | LEISHMANIA-DONOVANI | EPIDEMIOLOGY | PRIMARY HUMAN-HERPESVIRUS-8 INFECTION | CD8 T-CELLS | CHILDREN | Receptors, OX40 - genetics | Sarcoma, Kaposi - blood | Humans | Molecular Sequence Data | Cysteine - genetics | Young Adult | Receptors, OX40 - metabolism | Base Sequence | HEK293 Cells | Inheritance Patterns - genetics | Adult | Female | Cell Membrane - metabolism | Sarcoma, Kaposi - immunology | Child | Immunologic Memory - immunology | Amino Acid Sequence | Antibody Formation - immunology | Receptors, OX40 - deficiency | Mutant Proteins - metabolism | Mutation - genetics | Sarcoma, Kaposi - pathology | Receptors, OX40 - chemistry | Homozygote | T-Lymphocyte Subsets - metabolism | Intracellular Space - metabolism | Mutant Proteins - chemistry | Age of Onset | Lymphocyte Count | Amino Acid Substitution - genetics | Sarcoma, Kaposi - genetics | Life Sciences | Genetics | Human genetics | Cancer
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3. Full Text Kaposi sarcoma-associated herpesvirus: Immunobiology, oncogenesis, and therapy
by Dittmer, Dirk P and Damania, Blossom
Journal of Clinical Investigation, ISSN 0021-9738, 09/2016, Volume 126, Issue 9, pp. 3165 - 3175
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8, is the etiologic agent underlying Kaposi sarcoma, primary effusion lymphoma,... 
MEDICINE, RESEARCH & EXPERIMENTAL | TO-MESENCHYMAL TRANSITION | AIDS MALIGNANCY CONSORTIUM | PROTEIN-COUPLED RECEPTOR | LYTIC SWITCH PROTEIN | INTERFERON-REGULATORY FACTOR-1 | INFLAMMATORY CYTOKINE SYNDROME | PRIMARY EFFUSION LYMPHOMA | STAGE-STRATIFIED APPROACH | MULTICENTRIC CASTLEMANS-DISEASE | EPSTEIN-BARR-VIRUS | Signal Transduction | Genomics | Humans | Herpesvirus 8, Human | MicroRNAs - metabolism | Inflammation | Immunity, Innate | Carcinogenesis | DNA-Binding Proteins - metabolism | Animals | Cell Transformation, Neoplastic | Sarcoma, Kaposi - immunology | Sarcoma, Kaposi - therapy | Toll-Like Receptors - metabolism | Sarcoma, Kaposi - genetics | Complications and side effects | Care and treatment | Kaposi's sarcoma | Analysis | Research | HIV infection | Risk factors | Disease | Cytokines | Viruses | Infections | Vaccines | Gene expression | Cancer therapies | Proteins | Chemotherapy | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Lymphomas | Sensors | Deoxyribonucleic acid--DNA | Immune system | Cancer
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4. Full Text Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway
by Liu, G and Yu, F.-X and Kim, Y.C and Meng, Z and Naipauer, J and Looney, D.J and Liu, X and Gutkind, J.S and Mesri, E.A and Guan, K.-L
Oncogene, ISSN 0950-9232, 07/2015, Volume 34, Issue 27, pp. 3536 - 3546
Kaposi sarcoma-associated herpesvirus (KSHV) is an oncogenic virus and the culprit behind the human disease Kaposi sarcoma (KS), an AIDS-defining malignancy.... 
YES-ASSOCIATED PROTEIN | GROWTH-CONTROL | ORGAN SIZE CONTROL | BIOCHEMISTRY & MOLECULAR BIOLOGY | PRIMARY EFFUSION LYMPHOMA | SCF-BETA-TRCP | CELL-PROLIFERATION | TEAD/TEF FAMILY | CELL BIOLOGY | ONCOLOGY | PROTEIN-COUPLED RECEPTOR | GENETICS & HEREDITY | GENE-EXPRESSION | YAP PATHWAY | Sarcoma, Kaposi - metabolism | Humans | Cells, Cultured | Gene Expression Regulation, Neoplastic | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Transcription Factors - genetics | Sarcoma, Kaposi - pathology | Transcription Factors - metabolism | Animals | Mice, Nude | HEK293 Cells | Cell Transformation, Viral - genetics | Mice | Nuclear Proteins - genetics | Sarcoma, Kaposi - genetics | Herpesvirus 8, Human - physiology | Protein-Serine-Threonine Kinases - metabolism | Development and progression | Genetic aspects | Cellular signal transduction | Health aspects | Kaposi's sarcoma | Proteins | Tumorigenesis | Neurons | Herpes viruses | Kaposi sarcoma | YAP | TAZ | KSHV | Hippo | vGPCR
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5. Full Text Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA
by Tagawa, T and Gao, SJ and Koparde, VN and Gonzalez, M and Spouge, JL and Serquina, AP and Lurain, K and Ramaswami, R and Uldrick, TS and Yarchoan, R and Ziegelbauer, JM
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 12/2018, Volume 115, Issue 50, pp. 12805 - 12810
Noncoding RNAs have substantial effects in host-virus interactions. Circular RNAs (circRNAs) are novel single-stranded noncoding RNAs which can decoy other... 
circRNA-Seq | AFRICA | noncoding RNA | VIRUS | KSHV | circular RNA | herpesvirus | MULTIDISCIPLINARY SCIENCES | EXPRESSION | Human Umbilical Vein Endothelial Cells | Cell Line | Humans | Gene Expression Profiling - methods | Herpesvirus 8, Human - genetics | Lymphoma, Primary Effusion - virology | Gene Expression Regulation, Viral - genetics | Sarcoma, Kaposi - virology | Open Reading Frames - genetics | RNA - genetics | RNA, Viral - genetics | Castleman Disease - genetics | Genes, Viral - genetics | HEK293 Cells | B-Lymphocytes - virology | MicroRNAs - genetics | Castleman Disease - virology | Endothelial Cells - virology | Lymphoma, Primary Effusion - genetics | Sarcoma, Kaposi - genetics | RNA sequencing | Human herpesvirus 8 | Genetic aspects | Methods
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6. Full Text Whole-genome sequencing of Kaposi's sarcoma-associated herpesvirus from Zambian Kaposi's sarcoma biopsy specimens reveals unique viral diversity
by Olp, Landon N and Jeanniard, Adrien and Marimo, Clemence and West, John T and Wood, Charles
Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 24, pp. 12299 - 12308
Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent for Kaposi's sarcoma (KS). Both KSHV and KS are endemic in sub-Saharan Africa where... 
VARIABILITY | DNA-SEQUENCES | PROTEIN | HUMAN-HERPESVIRUS-8 | VIROLOGY | ALIGNMENT | GLYCOPROTEIN K8.1 | PERFORMANCE | AIDS | ALGORITHMS | EPSTEIN-BARR-VIRUS | Genome, Viral | Humans | Middle Aged | Genotype | Herpesvirus 8, Human - genetics | Male | Zambia | Phylogeny | Sarcoma, Kaposi - pathology | Polymorphism, Genetic | Herpesvirus 8, Human - isolation & purification | Biopsy | Adolescent | Adult | Female | Sarcoma, Kaposi - genetics
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7. Full Text Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma
by Croci, Diego O and Salatino, Mariana and Rubinstein, Natalia and Cerliani, Juan P and Cavallin, Lucas E and Leung, Howard J and Ouyang, Jing and Ilarregui, Juan M and Toscano, Marta A and Domaica, Carolina I and Croci, María C and Shipp, Margaret A and Mesri, Enrique A and Albini, Adriana and Rabinovich, Gabriel A
Journal of Experimental Medicine, ISSN 0022-1007, 10/2012, Volume 209, Issue 11, pp. 1985 - 2000
Kaposi's sarcoma (KS), a multifocal vascular neoplasm linked to human herpesvirus-8 (HHV-8/KS-associated herpesvirus [KSHV]) infection, is the most common... 
MEDICINE, RESEARCH & EXPERIMENTAL | T-CELL APOPTOSIS | TUMOR-IMMUNE PRIVILEGE | PARACRINE NEOPLASIA | CANCER CELLS | PROTEIN-COUPLED RECEPTOR | KSHV | ENDOTHELIAL-CELLS | GENE-EXPRESSION | HERPESVIRUS VGPCR | INDUCTION | IMMUNOLOGY | Galectin 1 - immunology | Sarcoma, Kaposi - metabolism | Humans | Gene Expression Regulation, Neoplastic | Galectin 1 - genetics | Galectin 1 - metabolism | Immunoblotting | Sarcoma, Kaposi - drug therapy | Cell Hypoxia | RNA Interference | Protein Binding - drug effects | HEK293 Cells | Neovascularization, Pathologic - prevention & control | Herpesvirus 8, Human - physiology | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Antibodies, Neutralizing - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Polysaccharides - metabolism | Host-Pathogen Interactions | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Hypoxia | Neovascularization, Pathologic - genetics | Mice | Neovascularization, Pathologic - metabolism | Sarcoma, Kaposi - genetics
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8. Full Text Identification of cellular genes targeted by KSHV-encoded microRNAs
by Samols, Mark A and Skalsky, Rebecca L and Maldonado, Ann M and Riva, Alberto and Lopez, M. Cecilia and Baker, Henry V and Renne, Rolf
PLoS Pathogens, ISSN 1553-7366, 2007, Volume 3, Issue 5, pp. 0611 - 0618
MicroRNAs (miRNAs) are 19 to 23 nucleotide-long RNAs that post-transcriptionally regulate gene expression. Human cells express several hundred miRNAs which... 
GROWTH-FACTOR-BETA | DNA-SEQUENCES | KAPOSIS-SARCOMA | MESSENGER-RNA | NUCLEAR ANTIGEN | SARCOMA-ASSOCIATED HERPESVIRUS | THROMBOSPONDIN-1 | MICROBIOLOGY | CYTOKINE | ANIMAL MICRORNAS | EXPRESSION | PARASITOLOGY | Thrombospondin 1 - antagonists & inhibitors | Humans | Molecular Sequence Data | MicroRNAs - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kidney - metabolism | RNA, Viral - genetics | Thrombospondin 1 - genetics | Genes, Viral | Transforming Growth Factor beta - antagonists & inhibitors | RNA, Viral - metabolism | RNA, Messenger - genetics | Cells, Cultured | Herpesvirus 8, Human - genetics | Sarcoma, Kaposi - virology | Reverse Transcriptase Polymerase Chain Reaction | RNA, Viral - chemistry | Transforming Growth Factor beta - genetics | Gene Expression Regulation, Viral | MicroRNAs - genetics | Thrombospondin 1 - metabolism | MicroRNAs - chemistry | Sarcoma, Kaposi - genetics | Transforming Growth Factor beta - metabolism | Human herpesvirus 8 | Genetic aspects | Research | RNA | Gene expression | Kaposi's sarcoma | KSHV | microRNA targets | Virology | Biomedical research | Target recognition | Pathogenesis | Genomes | Cell adhesion & migration | Signal transduction | Cell cycle | Regulation | Lymphomas | Kaposis sarcoma | Binding sites | Cancer | Apoptosis
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9. Full Text Genotypic distribution of HHV-8 in AIDS individuals without and with Kaposi sarcoma: Is genotype B associated with better prognosis of AIDS-KS?
by Tozetto-Mendoza, Tania Regina and Ibrahim, Karim Yaqub and Tateno, Adriana Fumie and De Oliveira, Cristiane Mendes and Sumita, Laura Massami and Sanchez, Maria Carmem Arroyo and Luna, Expedito José and Pierrotti, Ligia Camara and Drexler, Jan Felix and Braz-Silva, Paulo Henrique and Pannuti, Claudio Sérgio and Romano, Camila Malta
Medicine (United States), ISSN 0025-7974, 2016, Volume 95, Issue 48, p. e5291
AIDS-associated Kaposi's sarcoma (AIDS-KS) caused by human herpes virus 8 (HHV-8) is the most severe and resistant form of KS tumor. Our aim was to verify... 
ORF K1 | Genotype | HHV-8 | AIDS-KS | Saliva | SAO-PAULO | SUBTYPES | K1 PROTEIN | HUMAN-HERPESVIRUS-8 INFECTION | MULTIPLE SEQUENCE ALIGNMENT | genotype | saliva | LOW VIRAL LOAD | MEDICINE, GENERAL & INTERNAL | HERPESVIRUS TYPE 8 | GENETIC-VARIABILITY | BRAZILIAN AMAZON | MOLECULAR EPIDEMIOLOGY | Prognosis | Cross-Sectional Studies | Humans | Open Reading Frames | Viral Proteins - genetics | DNA, Viral - analysis | Male | Sarcoma, Kaposi - virology | Phylogeny | Acquired Immunodeficiency Syndrome - genetics | Genetic Variation | Saliva - virology | AIDS-Related Opportunistic Infections - virology | AIDS-Related Opportunistic Infections - genetics | Genes, Viral | Brazil | Female | Real-Time Polymerase Chain Reaction | Sarcoma, Kaposi - genetics | Complications and side effects | Human herpesvirus 8 | Kaposi's sarcoma | AIDS (Disease) | Research | Diagnosis | Risk factors
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10. Full Text Molecular and Cellular Mechanisms of KSHV Oncogenesis of Kaposi's Sarcoma Associated with HIV/AIDS
by Cavallin, Lucas E and Goldschmidt-Clermont, Pascal and Mesri, Enrique A
PLoS Pathogens, ISSN 1553-7366, 2014, Volume 10, Issue 7, p. e1004154
  Evidence pointing to the existence of a circulating KS progenitor, which is increased in AIDS-KS [11], includes: (a) KS spindle cells in renal-transplant... 
HERPESVIRUS | AIDS MALIGNANCY CONSORTIUM | ANGIOGENESIS | MICROBIOLOGY | ANTIRETROVIRAL THERAPY | MODEL | IDENTIFICATION | PATHOGENESIS | VIROLOGY | PROTEIN-COUPLED RECEPTOR | ENDOTHELIAL-CELLS | TUMORIGENESIS | PARASITOLOGY | Acquired Immunodeficiency Syndrome - metabolism | Herpesvirus 8, Human - metabolism | Sarcoma, Kaposi - metabolism | Humans | Acquired Immunodeficiency Syndrome - pathology | Cell Transformation, Viral - genetics | Herpesvirus 8, Human - genetics | Sarcoma, Kaposi - genetics | Acquired Immunodeficiency Syndrome - genetics | Acquired Immunodeficiency Syndrome - virology | Sarcoma, Kaposi - pathology | Antiviral agents | Sarcoma | Kaposi's sarcoma | Distribution | AIDS (Disease) | Genetic aspects | Drug therapy | Health aspects | Cell growth | Acquired immune deficiency syndrome | HIV | Cytokines | Cyclin-dependent kinases | Cell cycle | AIDS | Infections | Human immunodeficiency virus | Grants | Gene expression | Kaposis sarcoma
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11. Full Text Cancer angiogenesis induced by Kaposi sarcoma-associated herpesvirus is mediated by EZH2
by He, Meilan and Zhang, Wei and Bakken, Thomas and Schutten, Melissa and Toth, Zsolt and Jung, Jae U and Gill, Parkash and Cannon, Mark and Gao, Shou-Jiang
Cancer Research, ISSN 0008-5472, 07/2012, Volume 72, Issue 14, pp. 3582 - 3592
EZH2 is a component of the epigenetic regulator PRC2 that suppresses gene expression. Elevated expression of EZH2 is common in human cancers and is associated... 
DNA METHYLATION | ONCOLOGY | ENDOTHELIAL-CELLS | EPIGENETIC REPRESSION | GROUP PROTEIN EZH2 | GENE-EXPRESSION | HISTONE METHYLTRANSFERASE EZH2 | TUMOR ANGIOGENESIS | NF-KAPPA-B | LYTIC REPLICATION | PRIMARY INFECTION | Up-Regulation | Antigens, Viral - metabolism | Humans | NF-kappa B - metabolism | Viral Proteins - metabolism | DNA-Binding Proteins - metabolism | Angiogenesis Inducing Agents - metabolism | Herpesviridae Infections - genetics | Endothelial Cells - virology | Herpesvirus 8, Human - physiology | Cell Line | Endothelial Cells - metabolism | Gene Expression Regulation | Herpesvirus 8, Human - genetics | Nuclear Proteins - metabolism | Sarcoma, Kaposi - blood supply | Sarcoma, Kaposi - virology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Enhancer of Zeste Homolog 2 Protein | Ephrin-B2 - genetics | Transcription Factors - metabolism | Polycomb Repressive Complex 2 | Neovascularization, Pathologic - genetics | Sarcoma, Kaposi - genetics | Virus Latency - genetics
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12. Full Text The pleiotropic effects of Kaposi's sarcoma herpesvirus
by Schulz, Thomas F
The Journal of Pathology, ISSN 0022-3417, 01/2006, Volume 208, Issue 2, pp. 187 - 198
Kaposi's sarcoma herpesvirus (KSHV), or human herpesvirus 8 (HHV8), is an essential factor in the pathogenesis of Kaposi's sarcoma (KS), multicentric... 
immunosuppression | multicentric Castleman's disease | Kaposi's sarcoma herpesvirus | Kaposi's sarcoma | primary effusion lymphoma | Immunosuppression | Multicentric Castleman's disease | Primary effusion lymphoma | MICROVASCULAR ENDOTHELIAL-CELLS | PATHOLOGY | PRIMARY PULMONARY-HYPERTENSION | HUMAN-HERPESVIRUS-8 INFECTION | MULTICENTRIC CASTLEMANS-DISEASE | CELLULAR GENE-EXPRESSION | 8 INTERLEUKIN-6 HOMOLOG | MOTHER-TO-CHILD | IMMUNODEFICIENCY-VIRUS TYPE-1 | EPSTEIN-BARR-VIRUS | Genes, Viral - genetics | Virus Replication - genetics | Genome, Viral - genetics | Humans | Lymphoma - genetics | Viral Proteins - genetics | Herpesvirus 8, Human - genetics | Sarcoma, Kaposi - virology | Castleman Disease - virology | Sarcoma, Kaposi - epidemiology | Sarcoma, Kaposi - genetics | Lymphoma - virology
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