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male (494) 494
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calcium signaling - drug effects (145) 145
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endoplasmic reticulum - metabolism (112) 112
inhibition (111) 111
terpenes - pharmacology (110) 110
activation (109) 109
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heart failure (106) 106
myocardial contraction - drug effects (106) 106
myocytes, cardiac - metabolism (104) 104
ryanodine receptor calcium release channel - metabolism (103) 103
expression (101) 101
myocytes, cardiac - drug effects (101) 101
binding sites (97) 97
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endoplasmic-reticulum (92) 92
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cardiovascular system (85) 85
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Nature, ISSN 0028-0836, 05/2011, Volume 473, Issue 7348, pp. 528 - 531
Journal Article
Cancer Letters, ISSN 0304-3835, 2015, Volume 371, Issue 1, pp. 30 - 37
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 42, pp. 30181 - 30191
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 129, Issue 7, pp. 1337 - 1349
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 2013, Volume 304, Issue 6, pp. C508 - C518
Younce CW, Burmeister MA, Ayala JE. Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and... 
Heart | Glucagon-like peptide-1 | Hyperglycemia | CARDIAC-FUNCTION | PEPTIDE-1 RECEPTOR | OXIDATIVE STRESS | PHYSIOLOGY | GLP-1 | CONTRACTILE DYSFUNCTION | ER STRESS | glucagon-like peptide-1 | DIABETIC CARDIOMYOPATHY | heart | CELL BIOLOGY | hyperglycemia | ENDOTHELIAL-CELLS | ZINC-FINGER PROTEIN | Receptors, Glucagon - antagonists & inhibitors | Diabetic Cardiomyopathies - metabolism | Apoptosis - drug effects | Peptide Fragments - pharmacology | Exenatide | RNA, Messenger - biosynthesis | Isoquinolines - pharmacology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors | Phosphorylation - drug effects | Transcription Factor CHOP - biosynthesis | Calcium-Binding Proteins - metabolism | Receptors, Glucagon - agonists | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Endoplasmic Reticulum Stress - drug effects | Colforsin - pharmacology | Heat-Shock Proteins - metabolism | Cells, Cultured | Hydrogen Peroxide - pharmacology | Rats | Receptors, Glucagon - metabolism | Sulfonamides - pharmacology | Unfolded Protein Response | Hypoglycemic Agents - pharmacology | Peptides - pharmacology | Hyperglycemia - metabolism | Membrane Proteins | Animals | Glucagon-Like Peptide-1 Receptor | Myocytes, Cardiac - physiology | Tunicamycin - pharmacology | Glucose - metabolism | Thapsigargin - pharmacology | Protein Kinase Inhibitors - pharmacology | Venoms - pharmacology | Enzyme Activation | Oxidative Stress - drug effects | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Transcription Factor CHOP - metabolism | HSP70 Heat-Shock Proteins | Care and treatment | Heart cells | Physiological aspects | Stress (Physiology) | Dosage and administration | Health aspects | Endoplasmic reticulum | Apoptosis
Journal Article
Steroids, ISSN 0039-128X, 05/2015, Volume 97, pp. 2 - 7
The skin irritating principle from was isolated, named thapsigargin and the structure elucidated. By inhibiting the sarco/endoplasmic reticulum Ca ATPase... 
Thapsigargin | Prodrug | Sarco/endoplasmic reticulum (SERCA) | Targeting drugs | Prostate specific antigen (PSA) | Prostate specific membrane antigen (PSMA) | ANALOGS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SARCOPLASMIC-RETICULUM | TRILOBOLIDE | CA2+-ATPASE | PROSTATE-CANCER CELLS | CALCIUM | ENDOCRINOLOGY & METABOLISM | BINDING-SITE | LIBERATING SESQUITERPENE LACTONES | THAPSIA-GARGANICA L | Apoptosis - drug effects | Humans | Soft Tissue Neoplasms - drug therapy | Male | Prodrugs - isolation & purification | Prodrugs - chemistry | Neovascularization, Pathologic - pathology | Enzyme Inhibitors - chemistry | Sarcoplasmic Reticulum Calcium-Transporting ATPases - antagonists & inhibitors | Apiaceae - chemistry | Molecular Structure | Prostatic Neoplasms - drug therapy | Thapsigargin - chemistry | Prostatic Neoplasms - pathology | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Enzyme Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - chemistry | Enzyme Inhibitors - isolation & purification | Thapsigargin - isolation & purification | Animals | Neovascularization, Pathologic - drug therapy | Soft Tissue Neoplasms - pathology | Thapsigargin - pharmacology | Cell Proliferation - drug effects | Mice | Antineoplastic Agents, Phytogenic - pharmacology | Prodrugs - pharmacology | Antineoplastic Agents, Phytogenic - isolation & purification | Tumors | endoplasmic reticulum (SERCA) | Sarco
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 6/2008, Volume 181, Issue 7, pp. 1107 - 1116
Journal Article
Journal Article
Journal Article
Journal Article