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Drug Discovery Today, ISSN 1359-6446, 05/2012, Volume 17, Issue 9-10, pp. 505 - 513
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2018, Volume 1824, pp. 49 - 66
Saturation transfer difference (STD) NMR has emerged as one of the key technologies in lead optimization during drug design. Unlike most biophysical assays... 
Epitope mapping | Screening | Nuclear magnetic resonance spectroscopy | Saturation transfer difference NMR | Ligand-based NMR | Epitope Mapping - methods | Epitopes - chemistry | Proteins - chemistry | Nuclear Magnetic Resonance, Biomolecular - methods
Journal Article
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 04/2016, Volume 590, Issue 7, pp. 943 - 953
O‐acetylserine sulfhydrylase (OASS), the enzyme catalysing the last step of cysteine biosynthesis in bacteria, is involved in antibiotic resistance and biofilm... 
cysteine biosynthesis | Saturation Transfer Difference NMR | cysteine synthase | MYCOBACTERIUM-TUBERCULOSIS | SERINE ACETYLTRANSFERASE | LIGAND-BINDING | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | CELL BIOLOGY | BIOPHYSICS | CYSTEINE SYNTHASE COMPLEX | PURIFICATION | BIENZYME COMPLEX-FORMATION | SALMONELLA-TYPHIMURIUM | DATURA-INNOXIA | Epitope Mapping | Bacterial Proteins - chemistry | Isoenzymes - chemistry | Peptide Library | Antimicrobial Cationic Peptides - metabolism | Cysteine Synthase - genetics | Cysteine Synthase - metabolism | Cysteine Synthase - chemistry | Isoenzymes - metabolism | Anti-Bacterial Agents - chemistry | Enzyme Inhibitors - chemistry | Haemophilus influenzae - enzymology | Nuclear Magnetic Resonance, Biomolecular | Protein Interaction Domains and Motifs | Salmonella typhimurium - enzymology | Binding Sites | Oligopeptides - chemistry | Cysteine Synthase - antagonists & inhibitors | Recombinant Proteins - metabolism | Bacterial Proteins - antagonists & inhibitors | Enzyme Inhibitors - metabolism | Antimicrobial Cationic Peptides - chemistry | Isoenzymes - genetics | Antimicrobial Cationic Peptides - pharmacology | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Recombinant Proteins - chemistry | Anti-Bacterial Agents - metabolism | Oligopeptides - metabolism | Hydrogen Bonding | Bacterial Proteins - metabolism | Protein Conformation | Anti-Bacterial Agents - pharmacology | Molecular Docking Simulation | Structural Homology, Protein | Oligopeptides - pharmacology | Isoenzymes - antagonists & inhibitors
Journal Article
Journal Article
Journal Article
RSC Advances, ISSN 2046-2069, 10/2015, Volume 5, Issue 16, pp. 86919 - 86926
The human form of UDP-xylose synthase ( h UXS1A) is studied with respect to its substrate and co-enzyme binding in binary and ternary complexes using... 
LIGAND-BINDING | CARBOXY-LYASE | SPECTROSCOPY | FUNCTIONAL CLONING | BIOSYNTHESIS | ESCHERICHIA-COLI | GLUCOSE DEHYDROGENASE | STD-NMR | GLUCURONIC ACID DECARBOXYLASE | DIPHOSPHATE D-XYLOSE | CHEMISTRY, MULTIDISCIPLINARY | Human | Proteins | Binding | Enzymes | Magnetization | Saturation | Nuclear magnetic resonance | Substrates
Journal Article
RSC Advances, ISSN 2046-2069, 2014, Volume 4, Issue 14, pp. 7347 - 7351
A simple method is presented that optimizes the STD NMR Gaussian pulse to deliver significant increases in STD amplification factors with minimal perturbation... 
DESIGN | LIGAND-BINDING | X-RAY CRYSTALLOGRAPHY | RECOGNITION | DRUG DISCOVERY | RECEPTOR | CHEMISTRY, MULTIDISCIPLINARY | Amplification | Saturation | Ligands | Gaussian | Perturbation | Excitation | NMR spectroscopy | Optimization
Journal Article
Journal of Photochemistry and Photobiology. B, Biology, ISSN 1011-1344, 12/2016, Volume 165, p. 24
As a natural dietary polyphenol, 3,4,5-tri-O-caffeoylquinic acid (3,4,5-triCQA) exhibits numerous stronger pharmacological activities than that of its... 
Drugs | Nuclear magnetic resonance--NMR | Molecular structure | Enthalpy | Fluorescence | Entropy | Hydrophobicity | Molecular docking | Antioxidants | Caffeoylquinic acid | Emission spectra | Cosmetics | Food | Human serum albumin | Spectroscopy | Saturation | Albumin | Pharmacology | Serum albumin | Secondary structure | Electrostatic properties | Quenching | Studies | Diet | Acids | Affinity | Protein structure | Binding sites
Journal Article
Journal Article