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by Zhou, LJ and Huang, QX and Lei, HT and Wang, YX and Wang, Q and Xu, ZL and Wang, H and Sun, YM
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, ISSN 0251-0790, 10/2012, Volume 33, Issue 10, pp. 2269 - 2274
The total RNA was extracted from a hybridoma cell line (12C2) secreting monoclonal antibodies (MAb) against O,O-diethyl phosphorothioate pesticides (DPPs) and... 
O,O-Diethyl phosphorothioate pesticides | ENVIRONMENTAL-ANALYSIS | RECOGNITION | ORGANOPHOSPHORUS PESTICIDES | Broad-specificity | SENSITIVITY | RECOMBINANT ANTIBODIES | Single chain Fv (scFv) | CHEMISTRY, MULTIDISCIPLINARY | LIBRARIES | Phage-display | HAPTENS | IMMUNOASSAY | SELECTION | RESIDUES
Journal Article
mAbs, ISSN 1942-0862, 01/2015, Volume 7, Issue 3, pp. 584 - 604
To harness the potent tumor-killing capacity of T cells for the treatment of CD19(+) malignancies, we constructed AFM11, a humanized tetravalent bispecific... 
Non-Hodgkin lymphoma | ALL | CD3 | T cells | Bispecific antibodies | NHL, non-Hodgkin lymphoma | CHO, Chinese hamster ovary | ACTIVATION | MWCO, molecular weight cut-off | FC-RECEPTORS | MONOCLONAL-ANTIBODY | PROLIFERATION | BBB, blood-brain barrier | WBA, whole body autoradiography | KD, dissociation constant | ECL, electrochemiluminescence | FACS, fluorescence-activated cell sorting | LYMPHOMA | CCS, cell culture supernatant | SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis | ANALYSIS TOOL | i.v., intravenous | ORR, overall response rate | PI, propidium iodide | TNF, tumor necrosis factor | VH, variable heavy | Vss, volume of distribution at steady state | PBS, phosphate buffered saline | FcRn, neonatal Fc receptor | Fab, fragment antigen-binding | ctrl., control | t(1/2), terminal elimination half-life | BITE ANTIBODY BLINATUMOMAB | IgG, immunoglobulin G | B-ALL, B-precursor acute lymphoblastic leukemia | NK, natural killer | E:T, effector:target | CLL, chronic lymphocytic leukemia | IL, interleukin | MALIGNANCIES | s.c., subcutaneous | His, histidine | FR, framework region | EC50, half maximal effective concentration | FCS, fetal calf serum | MEDICINE, RESEARCH & EXPERIMENTAL | CONSTRUCT | kd, dissociation rate constant | w/o, without | Fc, fragment crystallizable | LMF, low molecular weight forms | VL, variable light | HMF, high molecular weight forms | FcgR, Fc gamma receptor | F, fluorescence | SABC, standardized antibody binding capacity | SE-HPLC, size exclusion high-pressure liquid chromatography | CD, cluster of differentiation | CL, clearance | ACUTE LYMPHOBLASTIC-LEUKEMIA | SD, standard deviation | SEC, size exclusion chromatography | PBMC, peripheral blood mononuclear cell | scFv, single-chain variable fragment | IFN, interferon | MSD, MesoScale Discovery | BiTE, bispecific T cell engager | PHA, phytohemagglutinin | Fv, variable fragment | CAR, chimeric antigen receptor | HSA, human serum albumin | AUCtot, total area under the curve | PES, polyethersulfone | CNS, central nervous system | TandAb, tandem diabody | CDR, complementarity determining region | ka, association rate constant | DMSO, dimethyl sulfoxide | SPR, surface plasmon resonance | NOD/scid, nonobese diabetic/severe combined immunodeficiency | Cmax, maximal concentration | Cricetulus | Humans | Male | Neoplasms, Experimental - pathology | Antibodies, Neoplasm - pharmacology | Neoplasms, Experimental - immunology | HEK293 Cells | Antigens, CD19 - immunology | CHO Cells | Antibodies, Neoplasm - immunology | Cricetinae | Single-Chain Antibodies - pharmacology | Antibodies, Bispecific - pharmacology | Jurkat Cells | Mice, SCID | Antibodies, Bispecific - immunology | Xenograft Model Antitumor Assays | Animals | CD3 Complex - immunology | Antibodies, Bispecific - chemistry | Mice, Inbred NOD | Antibodies, Neoplasm - chemistry | Mice | Neoplasms, Experimental - drug therapy | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology
Journal Article
Journal Article
Molecular Immunology, ISSN 0161-5890, 01/2019, Volume 105, pp. 181 - 189
Journal Article
Journal Article
International Reviews of Immunology, ISSN 0883-0185, 3/2015, Volume 34, Issue 2, pp. 154 - 187
Cancer immunotherapy comprises different therapeutic strategies that exploit the use of distinct components of the immune system, with the common goal of... 
ALL: acute lymphoblastic leukemia | HvG: host versus graft | CLL: chronic lymphocytic leukemia | DC: dendritic cell | GVHD: graft-vs.-host disease | NFAT: nuclear factor of activated T cell | ACI: adoptive cellular immunotherapy | FITC: fluorescein isothiocyanate | HSV: herpes simplex virus | reg | cancer testis antigens | Ad: adenovirus | Ly-CM: lymphocyte-conditioned medium | helper T cell | TIL: tumor-infiltrating lymphocyte | IL-1, IL-2: interleukin-1, interleukin-2 | HLA: human leukocyte antigen | CTA: cancer testis antigen | AKAP4: A-kinase anchoring protein 4 | AlloSCT: allogeneic stem cell transplant | AAV: adeno-associated virus | CAReTC: chimeric antigen receptor-engineered T cell | ITR: inverted terminal repeat | CTL: cytotoxic T lymphocyte | TCR: T-cell receptors | TRAF: TNF receptor-associated factor | AML: acute myeloid leukemia | TRUCK: T cells redirected for universal cytokine killing | effector memory T cell | TAA: tumor-associating antigen | scFv: single-chain variable fragment | ERK: extracellular signal-regulated kinase | CAR: chimeric antigen receptor | FAP: fibroblast activation protein | central memory T cell | immunotherapy | rAAV: recombinant AAV | ASP: AKAP-associated sperm protein | CEA: carcinoembryonic antigen | cancer stem cells | EBV: Epstein-Bar virus | CAIX: carbonic anhydrase-IX | NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells | NK: natural killer | stem cell memory T cell | SIRS: systemic inflammatory response syndrome | SP17: sperm protein 17 | regulatory T cell | effector T cell | MHC: major histocompatibility complex | PKA: protein A-kinase | HAMA: human anti-mouse antibodies | HSCT: hematopoietic stem cell transplant | NKG2D: natural killer receptor G2D | LAK: lymphokine activated killer cell | chimeric antigen receptors | JNK: c-Jun N-terminal kinase | PD-1: programmed death-1 | SCM | NHL: Non-Hodgkin's lymphoma | TNF: tumor necrosis factor | TE: effector T cell | TEM: effector memory T cell | TCM: central memory T cell | ScFv: single-chain variable fragment | TSCM: stem cell memory T cell | RAAV: recombinant AAV | Treg: regulatory T cell | TH: helper T cell | VECTOR INTEGRATION | IN-VIVO PERSISTENCE | HUMAN INTERLEUKIN-2 | SERIOUS ADVERSE EVENT | CANCER-TESTIS ANTIGEN | MODIFIED T-CELLS | IMMUNOLOGY | ANTITUMOR-ACTIVITY | ENHANCED SURVIVAL | TUMOR-TRANSFORMING GENE | RETROVIRAL VECTOR | T-Lymphocytes - physiology | Neoplasms - therapy | Animals | Genetic Engineering | Immunotherapy, Adoptive | Receptors, Antigen, T-Cell - metabolism | Neoplasms - immunology | Humans | Recombinant Fusion Proteins - genetics | Receptors, Antigen, T-Cell - genetics | T-Lymphocytes - transplantation
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 2011, Volume 438, Issue 3, pp. 475 - 483
HS (heparan sulfate) has been shown to be an important mediator of Plasmodium sporozoite homing and invasion of the liver, but the role of this... 
Anopheles | Glycobiology | Cell invasion | Malaria | Heparan sulfate (HS) | Glycosaminoglycan (GAG) | CELLS | PEPTIDE-O-XYLOSYLTRANSFERASE | CARBONIC-ANHYDRASE | glycosaminoglycan (GAG) | BIOCHEMISTRY & MOLECULAR BIOLOGY | CIRCUMSPOROZOITE PROTEIN | FUNCTIONAL-CHARACTERIZATION | malaria | MALARIA PARASITES | XT-II | ANONYMOUS PROTEIN | cell invasion | heparan sulfate (HS) | A-DOMAIN | EXPRESSION | glycobiology | Pentosyltransferases - genetics | Animals | Anopheles - parasitology | RNA Interference | Heparan Sulfate Proteoglycans - metabolism | Anopheles - genetics | Sporozoites - metabolism | Plasmodium falciparum - metabolism | Plasmodium falciparum - growth & development | Pentosyltransferases - metabolism | Salivary Glands - parasitology | dsGFP, GFP dsRNA | RNAi, RNA interference | dsRNA, double-stranded RNA | RT, reverse transcription | HSPG, HS proteoglycan | IdoA2S, L-iduronic acid 2-O-sulfate | CSP, circumsporozoite protein | AMPD, 2-amino-2-methyl-1,3-propanediol | TSR, thrombospondin type 1 repeat domain | MALDI–TOF, matrix-assisted laser-desorption ionization–time-of-flight | scFv, single-chain variable fragment | CS, chondroitin sulfate | dsAgOXT1, AgOXT1 dsRNA | GFP, green fluorescent protein | GlcNS, N-sulfated N-acetylglucosamine | VSV, vesicular stomatitis virus | MS, tandem MS | GAG, glycosaminoglycan | HSGAG, HS glycosaminoglycan | TRAP, thrombospondin-related adhesion protein | DAPI, 4′,6-diamidino-2-phenylindole | glycos-aminoglycan (GAG) | HS, heparan sulfate | XT-I, xylosyltransferase I | AgLDH, Anopheles gambiaeL-lactate dehydrogenase | AgOXT1, Anopheles gambiae peptide-O-xylosyltransferase 1 | RP-HPLC, reverse-phase HPLC | CSPG, CS proteoglycan | rAgOXT1, recombinant AgOXT1 | Xyl, xylose
Journal Article
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, ISSN 0251-0790, 11/2017, Volume 38, Issue 11, pp. 2070 - 2076
Six commonly used force fields and three commonly used solvent water models were employed, respectively, for EGFRvIII and its corresponding scFv antibody (MR1)... 
MUTANT | Root mean square deviation (RMSD) | mechanics/Poisson-Boltzmann surface area (MM-PBSA) | Isothermal titration calorimetry (ITC) | ANTIBODY | Molecular dynamics (MD) simulation | Molecular | Single-chain variable fragment (scFv) | CHEMISTRY, MULTIDISCIPLINARY | ANTIGEN | MM/PBSA
Journal Article
Cell Regeneration, ISSN 2045-9769, 12/2018, Volume 7, Issue 2, pp. 40 - 44
As three decades ago, it was reported that adoptive T cell immunotherapy by infusion of autologous tumor infiltrating lymphocytes (TILs) mediated objective... 
Anti-leukemia T cell | T cell reprogramming | TCR-T | CAR-T | T cell immunotherapy
Journal Article