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Drug Discovery Today, ISSN 1359-6446, 04/2012, Volume 17, Issue 7-8, pp. 310 - 324
Journal Article
Pest Management Science, ISSN 1526-498X, 02/2018, Volume 74, Issue 2, pp. 282 - 292
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2015, Volume 1289, pp. 57 - 73
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2019, Volume 180, pp. 509 - 523
A series of novel xanthine derivatives incorporating benzoic acid moieties were rapidly generated by using strategy of scaffold-hopping from our previously... 
Benzoic acid | Xanthine derivatives | Prodrug | Scaffold-hopping | DPP-4 inhibitor
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2019, Volume 29, Issue 18, pp. 2575 - 2580
PI3Kδ mediates key immune cell signaling pathways and is a target of interest for multiple indications in immunology and oncology. Here we report a... 
Oxindole | PI3Kδ | Structure-based drug design | Scaffold-hopping | CHEMISTRY, MEDICINAL | DELTA | CHEMISTRY, ORGANIC | DOSE-ESCALATION | POTENT | PATHWAY | PHASE-1 | INFLAMMATION | UMBRALISIB | CHRONIC LYMPHOCYTIC-LEUKEMIA | LYMPHOMA | PI3K delta | LEAD
Journal Article
ChemMedChem, ISSN 1860-7179, 01/2019, Volume 14, Issue 2, pp. 237 - 254
We recently reported the discovery of isothiazolo[4,3‐b]pyridine‐based inhibitors of cyclin G associated kinase (GAK) displaying low nanomolar binding affinity... 
isothiazolo[4,3-b]pyridines | scaffold hopping | cyclin G associated kinase | medicinal chemistry | nitrogen heterocycles | GAK | CHEMISTRY, MEDICINAL | PHARMACOLOGY & PHARMACY | CLATHRIN | Pyridines | Organic chemistry | Inhibitors | Antiviral activity | Cyclin G | Affinity | Scaffolds
Journal Article
Journal of Chemical Theory and Computation, ISSN 1549-9618, 2017, Volume 13, Issue 1, pp. 42 - 54
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2017, Volume 139, pp. 936 - 946
Journal Article
Journal Article
Mini-Reviews in Medicinal Chemistry, ISSN 1389-5575, 11/2006, Volume 6, Issue 11, pp. 1217 - 1229
Journal Article
Journal Article
Molecular Informatics, ISSN 1868-1743, 05/2010, Volume 29, Issue 5, pp. 366 - 385
Bioisosteric replacement and scaffold hopping are twin methods used in drug design to improve the synthetic accessibility, potency and drug like properties of... 
Hopping | Drug design | Scaffold | Bioisostere | Isostere | Chemotype | ORGANIZING NEURAL-NETWORKS | REDUCED GRAPHS | CRYSTALLOGRAPHIC DATA | CHEMISTRY, MEDICINAL | ALLOSTERIC MODULATORS | GENERIC CHEMICAL STRUCTURES | MEDICINAL CHEMISTRY | COMBINATORIAL LIBRARY DESIGN | DE-NOVO DESIGN | BIOLOGICAL-ACTIVITY | MATHEMATICAL & COMPUTATIONAL BIOLOGY
Journal Article