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Journal of the American College of Cardiology, ISSN 0735-1097, 06/2017, Volume 69, Issue 22, pp. 2759 - 2768
Journal Article
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, p. 1077
Our studies in HUVECs show that ox-LDL induced autophagy and damaged mtDNA leading to TLR9 expression. LOX-1 antibody or the ROS inhibitor apocynin attenuated... 
HEART | APOPTOSIS | ATHEROGENESIS | ARTERY ENDOTHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | RECEPTOR | DEGRADATION | OXIDIZED-LDL | LOX-1 | Human Umbilical Vein Endothelial Cells | Leukocyte Common Antigens - metabolism | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Toll-Like Receptor 9 - genetics | Autophagy - drug effects | Antigens, CD - metabolism | Inflammation - metabolism | RNA Interference | Diet, High-Fat | Endodeoxyribonucleases - metabolism | Receptors, LDL - deficiency | Beclin-1 | DNA Damage - drug effects | Receptors, LDL - genetics | Atherosclerosis - pathology | Endodeoxyribonucleases - antagonists & inhibitors | Scavenger Receptors, Class E - genetics | DNA, Mitochondrial - metabolism | Cells, Cultured | Lipoproteins, LDL - pharmacology | Receptors, LDL - metabolism | Atherosclerosis - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Scavenger Receptors, Class E - metabolism | Endodeoxyribonucleases - genetics | Animals | Antigens, Differentiation, Myelomonocytic - metabolism | Mice | Oxidative Stress - drug effects | Scavenger Receptors, Class E - deficiency | Toll-Like Receptor 9 - metabolism | RNA, Small Interfering - metabolism | Lipoproteins (low density) | Deoxyribonuclease | Oxidative stress | Reactive oxygen species | High cholesterol diet | DNA damage | siRNA | Mitochondrial DNA | Inflammation | LOX-1 protein | Autophagy | TLR9 protein | Cholesterol | CD45 antigen | Clonal deletion | Arteriosclerosis | Rodents | Atherosclerosis | Toll-like receptors | Lipoprotein (low density) receptors | Phagocytosis
Journal Article
Cardiovascular Research, ISSN 0008-6363, 07/2018, Volume 114, Issue 8, pp. 1145 - 1153
Journal Article
Circulation Research, ISSN 0009-7330, 06/2007, Volume 100, Issue 11, pp. 1634 - 1642
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0137924
Background Lipocalin (LCN) 2 is associated with multiple acute and chronic inflammatory diseases but the underlying molecular and cellular mechanisms remain... 
MORTALITY | CYTOKINES | SCAVENGER RECEPTOR | PROTEIN | MYOCARDIAL-INFARCTION | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | NECROSIS-FACTOR-ALPHA | GELATINASE-ASSOCIATED LIPOCALIN | EXPRESSION | POLARIZATION | Oncogene Proteins - blood | Oncogene Proteins - genetics | Humans | Male | Acute-Phase Proteins - genetics | Coronary Artery Disease - blood | Lipocalins - blood | Lipocalins - genetics | Female | Scavenger Receptors, Class A - genetics | Foam Cells - pathology | Foam Cells - metabolism | Cell Line | Receptors, LDL - genetics | Scavenger Receptors, Class E - genetics | Bone Marrow Cells - pathology | Receptors, LDL - metabolism | Proto-Oncogene Proteins - genetics | Mice, Knockout | Coronary Angiography | Scavenger Receptors, Class E - metabolism | Coronary Artery Disease - diagnostic imaging | Animals | Lipocalin-2 | Coronary Artery Disease - genetics | Mice | Proto-Oncogene Proteins - blood | Bone Marrow Cells - metabolism | Scavenger Receptors, Class A - metabolism | Tumor necrosis factor | Low density lipoproteins | Cardiac patients | Lectins | Hostages | Research | Macrophages | Coronary heart disease | Lipoproteins (low density) | Atherogenesis | Heart attacks | Angiography | High cholesterol diet | Zoology | Paracrine signalling | Smooth muscle | Cardiovascular disease | Medical schools | Inflammatory diseases | High fat diet | Receptors | Rodents | Atherosclerosis | Bone marrow | Scavenger receptors | Tumor necrosis factor-TNF | Lipoprotein (low density) receptors | Autocrine signalling | Lesions | Cardiology | Heart diseases | Cytokines | Lipocalin | Neutrophils | Coronary artery | Animal sciences | Inflammation | Tumor necrosis factor-α | Coronary artery disease | Patients | LOX-1 protein | Cholesterol | Monocytes | Lipoproteins | Airway systems | Arteriosclerosis | Liquid oxygen | Coronary vessels | TNF inhibitors | Receptor density | Plasma levels | Laboratory animals | Cell migration
Journal Article
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 5, p. 1101
Atherosclerosis, a chronic inflammatory disease, is a major contributor to cardiovascular diseases. Ursolic acid (UA) is a phytonutrient with widely biological... 
LOX-1 | HUVECs | Atherosclerosis | ROS | Human Umbilical Vein Endothelial Cells | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Apolipoproteins E - deficiency | Atherosclerosis - genetics | Humans | Male | NF-kappa B - metabolism | Aorta - metabolism | Lipopolysaccharides - antagonists & inhibitors | Myeloid Differentiation Factor 88 - antagonists & inhibitors | Toll-Like Receptor 4 - antagonists & inhibitors | Disease Models, Animal | Atherosclerosis - pathology | NF-kappa B - antagonists & inhibitors | Atherosclerosis - drug therapy | Scavenger Receptors, Class E - genetics | Signal Transduction | Anti-Inflammatory Agents - pharmacology | Aorta - drug effects | Mice, Inbred C57BL | Gene Expression Regulation | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Inflammation | Scavenger Receptors, Class E - antagonists & inhibitors | Toll-Like Receptor 4 - metabolism | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Scavenger Receptors, Class E - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Animals | NF-kappa B - genetics | Apolipoproteins E - genetics | Lipopolysaccharides - pharmacology | Mice | Myeloid Differentiation Factor 88 - metabolism | RNA, Small Interfering - metabolism | Medical services | mRNA | Lipopolysaccharides | Proteins | Signal transduction | Biological effects | Atherogenic diet | Apolipoprotein E | Toll-like receptors | Aorta | Inhibition | Pretreatment | Heart diseases | NF-κB protein | Evaluation | Simvastatin | TLR4 protein | Gene expression | LOX-1 protein | Signaling | Acids | Liquid oxygen | Arteriosclerosis | MyD88 protein | In vivo methods and tests | Ursolic acid | Cardiovascular diseases | atherosclerosis
Journal Article
Cancer Letters, ISSN 0304-3835, 11/2017, Volume 408, pp. 60 - 70
Metastatic spread of cancer cells is the most life-threatening aspect of breast cancer and involves multiple steps including cell migration. We recently found... 
TNFα | Breast cancer | TBC1D3 | Cell migration | Oxidized low density lipoprotein receptor 1 | TNF alpha | POSSIBLE INVOLVEMENT | LOW-DENSITY-LIPOPROTEIN | EPITHELIAL-MESENCHYMAL TRANSITION | LUNG-CANCER | TUMOR-NECROSIS-FACTOR | OXIDIZED LDL RECEPTOR-1 | MESSENGER-RNA | ONCOLOGY | PROSTATE-CANCER | LOX-1 EXPRESSION | VASCULAR ENDOTHELIAL-CELLS | Proto-Oncogene Proteins - metabolism | Tumor Necrosis Factor-alpha - metabolism | RNA, Small Interfering - genetics | Cell Proliferation | Scavenger Receptors, Class E - genetics | Humans | Tumor Necrosis Factor-alpha - genetics | Gene Expression Regulation, Neoplastic | NF-kappa B - metabolism | Proto-Oncogene Proteins - genetics | Scavenger Receptors, Class E - antagonists & inhibitors | GTPase-Activating Proteins - metabolism | Breast Neoplasms - drug therapy | Scavenger Receptors, Class E - metabolism | Breast Neoplasms - enzymology | NF-kappa B - genetics | Breast Neoplasms - pathology | Female | GTPase-Activating Proteins - genetics | Tumor Cells, Cultured | Apoptosis | Cell Movement | Tumor necrosis factor receptors | Transcription | Leukocyte migration | Activation | Metastasis | Kinases | Metastases | Cell adhesion & migration | Proteins | Signal transduction | Epidermal growth factor | Down-regulation | Lipoprotein (low density) receptors | Tumor necrosis factor-TNF | Inhibition | Immunoglobulins | TRAF6 protein | Cytokines | Inflammation | Gene expression | Insulin | Caffeic acid | Lipoproteins | Inhibitors | Breast | Low density lipoprotein receptors | TNF inhibitors | Receptor density | Prostate cancer | Cancer
Journal Article