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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 11/2019, Volume 20, Issue 22, p. 5785
.... The present study aimed to investigate the effects of SC on varicocele (VC)-induced testicular dysfunction and the potential molecular mechanism associated with VC-induced germ cell apoptosis... 
SPERMATOGENESIS | TESTOSTERONE | mitochondria | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | apoptosis | testis | CHEMISTRY, MULTIDISCIPLINARY | endoplasmic reticulum stress | CISPLATIN | INFLAMMATION | cytokines | GROWTH-FACTOR | EXPRESSION | Schisandra chinensis Baillon | oxidative stress | varicocele | EXTRACT | MOTILITY | Plant Extracts - chemistry | Spermatogenesis - drug effects | Varicocele - drug therapy | Reactive Oxygen Species - metabolism | Endoplasmic Reticulum Stress - drug effects | Apoptosis - drug effects | Plant Extracts - pharmacology | Schisandra - chemistry | Humans | Varicocele - physiopathology | Rats | Male | Antioxidants - pharmacology | Mitochondria - drug effects | Rats, Sprague-Dawley | Sperm Motility - drug effects | Animals | Signal Transduction - drug effects | Testis - physiopathology | Oxidative Stress - drug effects | Oxidative stress | Motility | Sperm | Crosstalk | Homeostasis | Cardiovascular disease | Hormones | Proteins | Antioxidants | Hepatitis | Signal transduction | Mitochondria | Chinese medicine | Protein folding | Luteinizing hormone | Folding | Injuries | Enzymes | Follicle-stimulating hormone | Level (quantity) | Wound healing | Kidneys | Cytokines | Platelet aggregation | Inflammation | Anti-inflammatory agents | Fatty acids | Cough | Testosterone | Infertility | Morphology | Testes | Cardiovascular diseases | Endoplasmic reticulum | Apoptosis | schisandra chinensis baillon
Journal Article
Drug Design, Development and Therapy, ISSN 1177-8881, 04/2015, Volume 9, pp. 2001 - 2027
A number of drugs and herbal compounds have been documented to cause hepatoxicity... 
Bcl-2 | Herbal medicine | mTOR | RAW 264.7 cell | Liver toxicity | AML-12 cell | CANCER-CELLS | UNITED-STATES | RAT KUPFFER CELLS | CHEMISTRY, MEDICINAL | HERBAL HEPATOTOXICITY | CYCLE ARREST | TNF-ALPHA PRODUCTION | INDUCED LIVER-INJURY | liver toxicity | SCHISANDRIN-B | PHARMACOLOGY & PHARMACY | MICE | herbal medicine | Cell Line | Cell Survival - drug effects | Cyclooctanes - toxicity | Apoptosis - drug effects | G1 Phase - drug effects | Polycyclic Compounds - toxicity | Lignans - pharmacology | Autophagy - drug effects | Cell Division - drug effects | Mitochondria, Liver - drug effects | Polycyclic Compounds - pharmacology | Animals | Lignans - toxicity | Signal Transduction - drug effects | Macrophages - drug effects | Cyclooctanes - pharmacology | Mice | S Phase - drug effects | Cell Cycle - drug effects | Chemical and Drug Induced Liver Injury - pathology | Hepatocytes - drug effects | Development and progression | Plant products | Schisandra | Care and treatment | Liver diseases | Health aspects | Cytochrome | Biotechnology | Phosphorylation | Bax protein | Bcl-2 protein | Laboratories | Liver | Science | AKT protein | Cytotoxicity | Kinases | Macrophages | Cyclin D1 | Phosphatase | Autophagy | Caspase-3 | Proteins | Signal transduction | Chinese medicine | Cell growth | Bcl-x protein | Ribose | Penicillin | Cell cycle | Trends | Safety | Hepatotoxicity | G1 phase | Herbs | Adenosine | Adenosine diphosphate | Poly(ADP-ribose) polymerase | Caspase | Pharmacology | Rapamycin | Lymphoma | 1-Phosphatidylinositol 3-kinase | Cyclin-dependent kinase 2 | Polymerase | Molecular modelling | Lymphocytes B | Hepatocytes | Cyclin-dependent kinase inhibitor p27 | Lymphomas | Phagocytosis | Apoptosis | B-cell lymphoma
Journal Article
Journal Article
Journal Article
Bioscience, biotechnology, and biochemistry, ISSN 1347-6947, 2014, Volume 73, Issue 11, pp. 2384 - 2392
We investigated to determine what effects, if any, the respective water extracts of Radix scutellariae (RS... 
glucose homeostasis | hyperplasia | β-cell mass | insulin secretion | hypertrophy | Glucose homeostasis | Hyperplasia | Hypertrophy | Insulin secretion | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOOD SCIENCE & TECHNOLOGY | BERBERINE | INDUCTION | RECEPTOR SUBSTRATE-2 | beta-cell mass | BETA-CELL FUNCTION | GLUCAGON-LIKE PEPTIDE-1 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | MASS | RESISTANCE | TRADITIONAL CHINESE MEDICINE | SECRETION | CHEMISTRY, APPLIED | Diabetes Mellitus - blood | Diabetes Mellitus - pathology | Gene Expression Regulation, Enzymologic - drug effects | Islets of Langerhans - drug effects | Schisandra - chemistry | Humans | Body Weight - drug effects | Drugs, Chinese Herbal - pharmacology | Male | Insulin - blood | Adipose Tissue - metabolism | Islets of Langerhans - metabolism | Epididymis - drug effects | Cyclic AMP - metabolism | Insulin Secretion | Cell Line | Glucose Tolerance Test | Intracellular Space - drug effects | Glucagon-Like Peptide 1 - metabolism | Pancreatectomy | Diabetes Mellitus - metabolism | Rats | Energy Intake - drug effects | Rats, Sprague-Dawley | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Intracellular Space - metabolism | Polygonatum - chemistry | Glucose - metabolism | Cell Proliferation - drug effects | Insulin-Secreting Cells - pathology | Blood Glucose - metabolism | Adipose Tissue - drug effects | Diabetes Mellitus - surgery
Journal Article
Journal Article
中国药理学报:英文版, ISSN 1671-4083, 2016, Volume 37, Issue 3, pp. 382 - 389
.... We previously reported that schisandrol B (SolB) isolated from Schisandra sphenanthera produced a protective effect against acetaminophen (APAP... 
五味子 | HepG2细胞 | 激活 | 小鼠 | 诱导 | 信号转导通路 | 对乙酰氨基酚 | 急性肝损伤 | acetaminophen | liver injury | glutathione | hepatotoxicity | NRF2; antioxidant resporse element | Schisandra sphenanthera | schisandrol B | OXIDATIVE STRESS | TRANSPORTERS | CHINENSIS | DRUG-METABOLIZING-ENZYMES | CHEMISTRY, MULTIDISCIPLINARY | INHIBITION | NRF2 | antioxidant resporse element | CYP-MEDIATED BIOACTIVATION | RESISTANCE | PHARMACOLOGY & PHARMACY | Dioxoles - therapeutic use | Liver - pathology | Schisandra - chemistry | Humans | Male | Antioxidant Response Elements - drug effects | Protective Agents - therapeutic use | Lignans - therapeutic use | Analgesics, Non-Narcotic - toxicity | Liver - drug effects | NF-E2-Related Factor 2 - genetics | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - prevention & control | Dioxoles - isolation & purification | Acetaminophen - toxicity | Liver - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Protective Agents - isolation & purification | Cyclooctanes - therapeutic use | Hep G2 Cells | Lignans - isolation & purification | Gene Expression Regulation - drug effects | Animals | Signal Transduction - drug effects | Chemical and Drug Induced Liver Injury - metabolism | NF-E2-Related Factor 2 - metabolism | Cyclooctanes - isolation & purification | Mice | Index Medicus | Original
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 5, p. e0127177
Journal Article
Cell Biochemistry and Biophysics, ISSN 1085-9195, 3/2015, Volume 71, Issue 2, pp. 803 - 811
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2009, Volume 37, Issue 12, pp. 2399 - 2407
Journal Article