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FASEB Journal, ISSN 0892-6638, 11/2008, Volume 22, Issue 11, pp. 4022 - 4032
During helminth infections, alternatively activated macrophages (AAMacs) are key to promoting Th2 responses and suppressing Th1-driven inflammatory pathology.... 
Antioxidant | Innate immunity | Immune modulation | antioxidant | FASCIOLA-HEPATICA | SCHISTOSOMA-MANSONI | BIOCHEMISTRY & MOLECULAR BIOLOGY | THIOREDOXIN PEROXIDASE | BIOCHEMICAL-CHARACTERIZATION | CELL BIOLOGY | LIVER FLUKE | innate immunity | BIOLOGY | PARASITIC HELMINTH | INFECTION | immune modulation | CATHEPSIN L1 | EXPRESSION | T-CELLS | Schistosomiasis mansoni - genetics | Schistosomiasis mansoni - immunology | Peroxiredoxins - metabolism | Interleukin-13 - immunology | Fasciola hepatica - enzymology | Th2 Cells - immunology | Peroxiredoxins - immunology | Schistosoma mansoni - genetics | Interleukin-13 - biosynthesis | Signal Transduction - immunology | Interleukin-4 - biosynthesis | Peroxiredoxins - genetics | Schistosomiasis mansoni - enzymology | Female | Helminth Proteins - metabolism | Macrophages - immunology | Disease Models, Animal | Recombinant Proteins - metabolism | Immunization | Schistosoma mansoni - enzymology | Macrophage Activation - immunology | Cells, Cultured | Schistosoma mansoni - immunology | Helminth Proteins - genetics | Recombinant Proteins - genetics | Signal Transduction - genetics | Fasciola hepatica - genetics | Fascioliasis - genetics | Th2 Cells - metabolism | Mice, Knockout | Fasciola hepatica - immunology | Interleukin-4 - immunology | Antigens, Differentiation - biosynthesis | Macrophages - metabolism | Animals | Fascioliasis - immunology | Recombinant Proteins - immunology | Helminth Proteins - immunology | Immunization, Passive | Fascioliasis - enzymology | Mice | Mice, Inbred BALB C | Antigens, Differentiation - immunology | Index Medicus | Research Communications
Journal Article
PLoS Medicine, ISSN 1549-1277, 06/2007, Volume 4, Issue 6, pp. 1071 - 1086
Background Schistosomiasis-infection with helminth parasites in the genus Schistosoma, including S. mansoni-is a widespread, devastating tropical disease... 
MEDICINE, GENERAL & INTERNAL | INHIBITION | TRYPANOTHIONE REDUCTASE | MITOCHONDRIAL | PLASMODIUM-FALCIPARUM | ESCHERICHIA-COLI | OLTIPRAZ | SELENOCYSTEINE | MAMMALIAN SELENOPROTEIN | MAJOR METABOLITE | MANNICH-BASES | Schistosomicides - pharmacology | Multienzyme Complexes - metabolism | Male | Schistosomicides - therapeutic use | RNA Interference | Schistosomiasis mansoni - prevention & control | Drug Design | Female | Auranofin - therapeutic use | Schistosoma mansoni - growth & development | NADH, NADPH Oxidoreductases - metabolism | Auranofin - pharmacology | Recombinant Proteins - metabolism | Schistosoma mansoni - drug effects | NADH, NADPH Oxidoreductases - genetics | Recombinant Proteins - antagonists & inhibitors | Oxidation-Reduction | Schistosoma mansoni - enzymology | Mice, Inbred C57BL | Naphthoquinones - therapeutic use | Naphthoquinones - pharmacology | Multienzyme Complexes - genetics | Multienzyme Complexes - antagonists & inhibitors | Animals | Schistosomiasis mansoni - parasitology | Signal Transduction - drug effects | Mice | NADH, NADPH Oxidoreductases - antagonists & inhibitors | Kinetics | Schistosomiasis | Enzymes | Reducing agents (Chemistry) | Drug targeting | Genetic aspects | Drug therapy | Health aspects | Methods | Index Medicus | Infectious Diseases | Biochemistry | Drugs and adverse drug reactions | Microbiology | Medicine in Developing Countries
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 2015, Volume 212, Issue 10, pp. 1787 - 1797
Journal Article
The Journal of Immunology, ISSN 0022-1767, 12/2001, Volume 167, Issue 11, pp. 6533 - 6544
Type 2 cytokines regulate fibrotic liver pathology in mice infected with Schistosoma mansoni. Switching the immune response to a type 1-dominant reaction has... 
LIVER ARGINASE | TH2 CYTOKINES | HEALING WOUNDS | MYCOBACTERIUM-AVIUM INFECTION | IMMUNOLOGY | MURINE SCHISTOSOMIASIS | MARROW-DERIVED MACROPHAGES | HYDROXY-L-ARGININE | HEPATIC-FIBROSIS | T-CELLS | SCHISTOSOMA-MANSONI EGGS | Granuloma - prevention & control | Lung Diseases, Parasitic - immunology | Arginase - metabolism | Eflornithine - pharmacology | Th2 Cells - immunology | Nitric Oxide Synthase Type II | Schistosomiasis mansoni - enzymology | Disease Models, Animal | Tuberculosis - pathology | Proline - biosynthesis | Enzyme Inhibitors - pharmacology | Macrophage Activation | Mice, Knockout | Granuloma - pathology | Enzyme Induction - genetics | Macrophages - metabolism | Up-Regulation - immunology | Lung Diseases, Parasitic - enzymology | Liver Cirrhosis - pathology | Granuloma - immunology | Mice | Nitric Oxide Synthase - metabolism | Enzyme Activation - genetics | Arginine - metabolism | Schistosomiasis mansoni - genetics | Liver - enzymology | Schistosomiasis mansoni - immunology | Tuberculosis - enzymology | Interleukin-12 - physiology | Lung Diseases, Parasitic - pathology | Arginase - biosynthesis | Enzyme Induction - immunology | Liver Cirrhosis - enzymology | Th1 Cells - immunology | Enzyme Activation - immunology | Granuloma - enzymology | Enzyme Induction - drug effects | Female | Nitric Oxide Synthase - biosynthesis | Ovum - immunology | Arginase - antagonists & inhibitors | Macrophages - immunology | Mice, Inbred C57BL | Cells, Cultured | Up-Regulation - genetics | Mycobacterium avium - immunology | Enzyme Activation - drug effects | Tuberculosis - immunology | Ornithine Decarboxylase Inhibitors | Animals | Tuberculosis - genetics | Th1 Cells - enzymology | Schistosomiasis mansoni - pathology | Lung Diseases, Parasitic - genetics | Th2 Cells - enzymology | g-Interferon | Arg-1 protein | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 10/2014, Volume 426, Issue 20, pp. 3442 - 3453
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2011, Volume 286, Issue 41, pp. 35770 - 35781
Journal Article
Parasitology, ISSN 0031-1820, 09/2017, Volume 144, Issue 10, pp. 1356 - 1364
The Schistosoma mansoni cercarial elastase (SmCE) has previously been shown to be poorly immunogenic in mice. However, a minority of mice were able to produce... 
enzyme | Schistosoma mansoni | vaccine | GST fusion protein | recombinant | antigen | cercarial elastase | immunogenicity | ADULT WORMS | HOST-PARASITE RELATIONSHIP | JAPONICUM | CLEAVAGE | MICE | INFECTION | GLUTATHIONE-S-TRANSFERASE | PROTEINS | PROTEASE | PARASITOLOGY | Immunogenicity, Vaccine | Immunoglobulin G - blood | Male | Schistosoma japonicum - enzymology | Schistosoma mansoni - genetics | Glutathione Transferase - genetics | Schistosomiasis mansoni - prevention & control | Mice, Inbred CBA | Pancreatic Elastase - genetics | Schistosoma mansoni - growth & development | Schistosomiasis - immunology | Schistosoma mansoni - enzymology | Parasite Load | Schistosomiasis - parasitology | Glutathione Transferase - metabolism | Schistosoma mansoni - immunology | Pancreatic Elastase - metabolism | Recombinant Proteins - genetics | Cercaria - genetics | Cercaria - immunology | Animals | Recombinant Proteins - immunology | Schistosomiasis - blood | Mice | Cercaria - enzymology | Transformation | IgG antibody | Aluminum | Immunoglobulin G | Antibodies | Homology | Infections | Mollusks | Vaccines | Parasites | Tropical diseases | Antibody response | Proteins | Schistosomiasis | Immunology | Glutathione transferase | Life sciences | Elastase | Glutathione | Recombinant | Rabbits | Medical research | Enzymes | Antigens | Immunization | Parasitology | Immunoglobulins | Cloning | Chromatography | Immunogenicity | Adsorption | Plasmids | Aluminum hydroxide | Laboratory animals | Alum | Index Medicus
Journal Article
PLoS Neglected Tropical Diseases, ISSN 1935-2727, 01/2016, Volume 10, Issue 1, pp. e0004356 - e0004356
Background Schistosoma flatworm parasites cause schistosomiasis, a chronic and debilitating disease of poverty in developing countries. Praziquantel is... 
CANCER-CELLS | PRAZIQUANTEL | SELECTIVE INHIBITOR | VOLASERTIB | LIBRARY | LEADS | BOX | PROTEIN-KINASES | DISCOVERY | PARASITOLOGY | TROPICAL MEDICINE | SMALL-MOLECULE INHIBITOR | Schistosomicides - pharmacology | Structure-Activity Relationship | Adenosine Triphosphate | Benzimidazoles - chemistry | Cell Cycle Proteins - antagonists & inhibitors | Mesocricetus | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Molecular Structure | Binding Sites | Schistosomicides - chemistry | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Schistosoma mansoni - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Cricetinae | Schistosoma mansoni - enzymology | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Gene Expression Regulation, Enzymologic | Animals | Benzimidazoles - pharmacology | Protein Conformation | Drugs | Schistosomiasis | Molecular targeted therapy | Benzimidazoles | Patient outcomes | Structure-activity relationship (Pharmacology) | Drug therapy | Structure-activity relationships | Phosphotransferases | Health aspects | Methods | Testing | Index Medicus | Cluster analysis | Developing countries | Cell division | Principal components analysis | Parasites | LDCs | Kinases | Clustering | Cancer therapies | Biological activity | Parasitic diseases | Drug dosages | Cancer
Journal Article