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Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 78 - 81
Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the haematopoietic stem cell (HSC) compartment. Most MPN patients have a common... 
TYROSINE KINASE JAK2 | JAK2-V617F | ACTIVATING MUTATION | POLYCYTHEMIA-VERA | BONE | MULTIDISCIPLINARY SCIENCES | Neuroprotective Agents - therapeutic use | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Sympathetic Nervous System - drug effects | Humans | Hematopoietic Stem Cells - pathology | Myeloproliferative Disorders - pathology | Sympathetic Nervous System - physiopathology | Adrenergic beta-3 Receptor Agonists - pharmacology | Neuroprotective Agents - pharmacology | Interleukin-1beta - metabolism | Neoplastic Stem Cells - pathology | Female | Sympathetic Nervous System - pathology | Schwann Cells - drug effects | Hematopoietic Stem Cells - drug effects | Nerve Fibers - pathology | Mesenchymal Stromal Cells - drug effects | Stem Cell Niche | Janus Kinase 2 - genetics | Nerve Fibers - drug effects | Schwann Cells - pathology | Myeloproliferative Disorders - drug therapy | Receptors, Adrenergic, beta-3 - metabolism | Disease Progression | Neoplasms - drug therapy | Nestin - metabolism | Adrenergic beta-3 Receptor Agonists - therapeutic use | Animals | Mice | Mesenchymal Stromal Cells - pathology | Neoplasms - pathology | Complications and side effects | Development and progression | Health aspects | Peripheral nerve diseases | Hematopoietic stem cells | Myeloproliferative disorders | Tumors | Studies | Mutation | Kinases | Rodents | Stem cells | Apoptosis | Index Medicus
Journal Article
Experimental Neurology, ISSN 0014-4886, 2007, Volume 207, Issue 2, pp. 267 - 274
Experimentally, peripheral nerve repair can be enhanced by Schwann cell transplantation but the clinical application is limited by donor site morbidity and the... 
Peripheral nerve | Regeneration | Axon | Adult stem cell | Glia | Schwann cell | PROGENITORS | PERIPHERAL-NERVE REGENERATION | adult stem cell | peripheral nerve | regeneration | BONE-MARROW | TISSUE | MUSCLE | glia | NEUROSCIENCES | TRANSPLANTATION | MULTI-LINEAGE CELLS | axon | EXPRESSION | MARROW STROMAL CELLS | TRANSDIFFERENTIATION | Adult Stem Cells - physiology | Cell Proliferation | Neurites - physiology | Cell Count | Adipose Tissue - cytology | Rats | Neurons - cytology | Neuregulin-1 - pharmacology | Coculture Techniques - methods | Glial Fibrillary Acidic Protein - metabolism | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Animals | Time Factors | Cell Differentiation - drug effects | Schwann Cells - physiology | Myelin Proteins - metabolism | Cell Differentiation - physiology | Neurites - drug effects | Neuroblastoma - pathology | Adult Stem Cells - drug effects | Genetic aspects | Stem cells | Index Medicus | Adult Stem Cells/drug effects/physiology | Cell Differentiation/drug effects/physiology | Rats; Sprague-Dawley | Coculture Techniques/methods | Neurons/cytology | Neurites/drug effects/physiology | Glial Fibrillary Acidic Protein/metabolism | Myelin Proteins/metabolism | Nerve Tissue Proteins/metabolism | Neuregulin-1/pharmacology | Neuroblastoma/pathology | Adipose Tissue/cytology | Schwann Cells/physiology
Journal Article
Glia, ISSN 0894-1491, 12/2006, Volume 54, Issue 8, pp. 840 - 849
We have investigated the phenotypic and bioassay characteristics of bone marrow mesenchymal stromal cells (MSCs) differentiated along a Schwann cell lineage... 
differentiation | glial growth factor | mesenchymal stem cells | neuronal co‐culture | Schwann cells | Glial growth factor | Neuronal co-culture | Differentiation | Mesenchymal stem cells | PROGENITOR CELLS | MOUSE-BRAIN | PERIPHERAL-NERVE REGENERATION | ADULT SENSORY NEURONS | NEURAL STEM | SPINAL-CORD | NEUROSCIENCES | NESTIN | IN-VITRO | HUMAN BONE-MARROW | neuronal co-culture | MARROW STROMAL CELLS | Neurites - physiology | Coculture Techniques | Alkaline Phosphatase - metabolism | Rats, Inbred Lew | Cell Communication - physiology | Glial Fibrillary Acidic Protein - metabolism | Cell Lineage - drug effects | Schwann Cells - cytology | Mesenchymal Stromal Cells - cytology | Neurites - ultrastructure | Glial Cell Line-Derived Neurotrophic Factor - pharmacology | Up-Regulation - physiology | Stromal Cells - drug effects | Bone Marrow Cells - drug effects | Cell Differentiation - physiology | Receptor, Nerve Growth Factor - metabolism | Animals, Newborn | Biomarkers - metabolism | Mesenchymal Stromal Cells - drug effects | Bone Marrow Cells - cytology | Stromal Cells - metabolism | Cells, Cultured | Mesenchymal Stromal Cells - metabolism | Rats | S100 Proteins - metabolism | Schwann Cells - metabolism | Cell Lineage - physiology | Cell Shape - drug effects | Up-Regulation - drug effects | Phenotype | Animals | Cell Differentiation - drug effects | Cell Shape - physiology | Bone Marrow Cells - metabolism | Stromal Cells - cytology | Index Medicus | Cell Lineage/drug effects/physiology | Schwann Cells/cytology/metabolism | Cells; Cultured | S100 Proteins/metabolism | Cell Differentiation/drug effects/physiology | Neurites/physiology/ultrastructure | Cell Shape/drug effects/physiology | Animals; Newborn | Biological Markers/metabolism | Stromal Cells/cytology/drug effects/metabolism | Up-Regulation/drug effects/physiology | Cell Communication/physiology | Glial Fibrillary Acidic Protein/metabolism | Mesenchymal Stem Cells/cytology/drug effects/metabolism | Receptor; Nerve Growth Factor/metabolism | Glial Cell Line-Derived Neurotrophic Factor/pharmacology | Bone Marrow Cells/cytology/drug effects/metabolism | Alkaline Phosphatase/metabolism | Rats; Inbred Lew
Journal Article
Nature Neuroscience, ISSN 1097-6256, 01/2013, Volume 16, Issue 1, pp. 48 - 54
After peripheral nerve injury, axons regenerate and become remyelinated by resident Schwann cells. However, myelin repair never results in the original myelin... 
MAINTENANCE | PERIPHERAL-NERVE REGENERATION | MYELIN SHEATH THICKNESS | GROWTH | INJURY | PROLIFERATION | ENSHEATHMENT | MECHANISMS | RECEPTORS | EXPRESSION | NEUROSCIENCES | Electric Stimulation | Recovery of Function - drug effects | Evoked Potentials, Motor - drug effects | Ki-67 Antigen - metabolism | Ganglia, Spinal - cytology | RNA, Messenger - metabolism | Neuregulin-1 - genetics | Time Factors | Statistics, Nonparametric | Neurons - metabolism | Disease Models, Animal | Animals, Newborn | Myelin Basic Protein - metabolism | Neurons - chemistry | Enzyme Inhibitors - pharmacology | Rats | Sciatic Neuropathy - pathology | Mice, Transgenic | S100 Proteins - metabolism | Schwann Cells - metabolism | Signal Transduction - genetics | Schwann Cells - ultrastructure | Signal Transduction - drug effects | Axons - pathology | NAV1.6 Voltage-Gated Sodium Channel - metabolism | Mice | Locomotion - genetics | Evoked Potentials, Motor - physiology | Culture Media, Conditioned - pharmacology | Demyelinating Diseases - metabolism | Myelin Sheath - metabolism | Octamer Transcription Factor-6 - metabolism | Hedgehog Proteins - genetics | Axons - ultrastructure | Sciatic Nerve - cytology | Demyelinating Diseases - etiology | Neurons - drug effects | Schwann Cells - drug effects | Microscopy, Electron, Transmission | Recovery of Function - genetics | Myelin Sheath - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Cells, Cultured | Axons - drug effects | Animals | Neuregulin-1 - metabolism | Early Growth Response Protein 2 - metabolism | Sciatic Neuropathy - physiopathology | Cell Proliferation - drug effects | Myelin P0 Protein - metabolism | Neurons | Schwann cells | Physiological aspects | Genetic aspects | Research | Myelin sheath | Gene expression | Index Medicus
Journal Article
Biomaterials, ISSN 0142-9612, 2016, Volume 87, pp. 18 - 31
Abstract Myelination of Schwann cells (SCs) is critical for the success of peripheral nerve regeneration, and biomaterials that can promote SCs' neurotrophin... 
Advanced Basic Science | Dentistry | Conductive polyurethane | Neurotrophins secretion | Peripheral nerve tissue engineering | Biomaterials-approach | Schwann cells | Myelin gene expressions | HYDROGELS | MATERIALS SCIENCE, BIOMATERIALS | STIMULATION | ENGINEERING, BIOMEDICAL | SKELETAL-MUSCLE TISSUE | REGENERATION | POLY(GLYCEROL SEBACATE) | CONDUCTING POLYMERS | POLYLACTIDE | DEGRADATION | BIOMEDICAL APPLICATIONS | ELECTROSPUN SCAFFOLDS | Biocompatible Materials - metabolism | Cell Line | Polyurethanes - chemistry | Biocompatible Materials - chemistry | Myelin Sheath - drug effects | Rats | Biocompatible Materials - pharmacology | Electric Conductivity | Nerve Growth Factors - metabolism | Schwann Cells - metabolism | Peripheral Nerves - drug effects | PC12 Cells | Schwann Cells - cytology | Myelin Sheath - metabolism | Up-Regulation - drug effects | Polyurethanes - pharmacology | Animals | Peripheral Nerves - physiology | Nerve Growth Factors - genetics | Polyurethanes - metabolism | Nerve Regeneration - drug effects | Schwann Cells - drug effects | Tissue Engineering | Glycerin | Engineering schools | Biological products | Aniline | Tissue engineering | Genes | Glycerol | Genetic engineering | Gene expression | Polyurethanes | Anopheles | Index Medicus | Polyurethane resins | Surgical implants | Biomedical materials | Myelin | Peripheral nerves | Secretions | Biomaterials
Journal Article
Experimental Neurology, ISSN 0014-4886, 2007, Volume 203, Issue 1, pp. 42 - 54
Paclitaxel-induced peripheral neuropathy (PN) can be a significant problem for patients receiving chemotherapeutic regimens for the treatment of breast,... 
Axonopathy | Neurotoxicity | Breast cancer | Ganglionopathy | Neuropathic pain | Microglia | axonopathy | TACTILE ALLODYNIA | breast cancer | SPINAL-CORD | SATELLITE CELLS | OVARIAN-CANCER | BONE CANCER PAIN | ACTIVATING TRANSCRIPTION FACTOR-3 | ganglionopathy | DORSAL-ROOT GANGLION | NEUROSCIENCES | NERVE GROWTH-FACTOR | neuropathic pain | neurotoxicity | MESSENGER-RNA | SCIATIC-NERVE | microglia | Hyperalgesia - chemically induced | Microglia - metabolism | Posterior Horn Cells - drug effects | Peripheral Nervous System Diseases - chemically induced | Posterior Horn Cells - metabolism | Injections, Intravenous | Antigens, Differentiation, Myelomonocytic - drug effects | Male | CD11b Antigen | Peripheral Nervous System Diseases - physiopathology | Glial Fibrillary Acidic Protein - metabolism | Peripheral Nerves - drug effects | Satellite Cells, Perineuronal - metabolism | Antigens, CD - metabolism | Chemotaxis, Leukocyte - physiology | Hyperalgesia - pathology | Activating Transcription Factor 3 - drug effects | Paclitaxel - toxicity | Chemotaxis, Leukocyte - drug effects | Microglia - pathology | Neurons, Afferent - pathology | Peripheral Nervous System Diseases - pathology | Disease Models, Animal | Schwann Cells - drug effects | Neurons, Afferent - drug effects | Microglia - drug effects | Rats | Schwann Cells - pathology | Schwann Cells - metabolism | Antigens, CD - drug effects | Activating Transcription Factor 3 - metabolism | Peripheral Nerves - pathology | Rats, Sprague-Dawley | Hyperalgesia - physiopathology | Peripheral Nerves - physiopathology | Antineoplastic Agents, Phytogenic - toxicity | Satellite Cells, Perineuronal - drug effects | Macrophages - metabolism | Animals | Antigens, Differentiation, Myelomonocytic - metabolism | Glial Fibrillary Acidic Protein - drug effects | Ganglia, Spinal - pathology | Posterior Horn Cells - pathology | Macrophages - drug effects | Neurons, Afferent - metabolism | Ganglia, Spinal - drug effects | Satellite Cells, Perineuronal - pathology | Ganglia, Spinal - metabolism | Antimitotic agents | Chemotherapy | Infiltration (Military science) | Neurosciences | Neurons | Oncology, Experimental | Lung cancer | Research | Macrophages | Antineoplastic agents | Intermediate filament proteins | Cancer | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 07/2015, Volume 35, Issue 27, pp. 9879 - 9888
Elucidation of the cellular identity of neuronal precursors provides mechanistic insights into the development and pathophysiology of the nervous system. In... 
Oligoganglionosis | RET | Enteric nervous system | Neurogenesis | Neural crest cells | Schwann cells | STEM-CELLS | INTESTINAL AGANGLIONOSIS | PERIPHERAL-NERVES | NEUROTROPHIC FACTOR | ADULT MICE | GLIAL-CELLS | NEUROSCIENCES | MOUSE EMBRYO | neural crest cells | neurogenesis | enteric nervous system | oligoganglionosis | CREST-DERIVED CELLS | PRECURSORS | Tyrosine 3-Monooxygenase - metabolism | Enteric Nervous System - cytology | Proto-Oncogene Proteins c-ret - metabolism | Embryo, Mammalian | Enteric Nervous System - growth & development | Homeodomain Proteins - metabolism | Glial Cell Line-Derived Neurotrophic Factor Receptors - metabolism | Hedgehog Proteins - metabolism | Neurogenesis - genetics | Hedgehog Proteins - genetics | Glial Cell Line-Derived Neurotrophic Factor - pharmacology | Neurons - physiology | Ubiquitin Thiolesterase - metabolism | Schwann Cells - physiology | Neurogenesis - drug effects | Cell Differentiation - physiology | Schwann Cells - drug effects | Animals, Newborn | Enteric Nervous System - metabolism | Mice, Inbred C57BL | Cells, Cultured | Enteric Nervous System - embryology | Mice, Transgenic | Glial Cell Line-Derived Neurotrophic Factor Receptors - genetics | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Animals | Cell Differentiation - drug effects | Neurogenesis - physiology | Stem Cells - drug effects | Stem Cells - physiology | Mice | Proto-Oncogene Proteins c-ret - genetics | Index Medicus
Journal Article
Journal Article
Biomaterials, ISSN 0142-9612, 2012, Volume 33, Issue 25, pp. 5901 - 5913
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 5/2008, Volume 181, Issue 4, pp. 625 - 637
Schwann cell myelination depends on Krox-20/Egr2 and other promyelin transcription factors that are activated by axonal signals and control the generation of... 
Myelination | Neuroscience | Transcription factors | Myelin | Neurons | Lymphocytes | B lymphocytes | Schwann cells | Nerves | Cultured cells | IN-VITRO | NERVES | PERIPHERAL NERVOUS-SYSTEM | WALLERIAN DEGENERATION | GENE-EXPRESSION | PROLIFERATION | SCHWANN-CELL MYELINATION | DIFFERENTIATION | GLIAL-CELLS | MACROPHAGE RECRUITMENT | CELL BIOLOGY | Wallerian Degeneration - pathology | Coculture Techniques | Myelin Sheath - metabolism | DNA-Binding Proteins - metabolism | MAP Kinase Kinase 7 - metabolism | Octamer Transcription Factor-6 - metabolism | HMGB Proteins - metabolism | Phosphorylation - drug effects | SOXB1 Transcription Factors | Schwann Cells - drug effects | Animals, Newborn | Cell Dedifferentiation - drug effects | Myelin Sheath - pathology | Proto-Oncogene Proteins c-jun - genetics | Rats | Schwann Cells - pathology | Down-Regulation - drug effects | Cyclic AMP - pharmacology | Transcription Factors - metabolism | Up-Regulation - drug effects | Animals | Proto-Oncogene Proteins c-jun - metabolism | Ganglia, Spinal - pathology | Early Growth Response Protein 2 - metabolism | Mice | Myelin Proteins - metabolism | Schwann Cells - enzymology | Ganglia, Spinal - metabolism | DNA binding proteins | Observations | Properties | Cellular control mechanisms | Brain | Adenosine | Cellular biology | Cells | Index Medicus
Journal Article