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Nature Medicine, ISSN 1078-8956, 08/2012, Volume 18, Issue 8, pp. 1262 - 1270
Profibrotic cells that develop upon injury generate permanent scar tissue and impair organ recovery, though their origin and fate are unclear. Here we show... 
MEDICINE, RESEARCH & EXPERIMENTAL | PERIPHERAL-NERVES | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIVER FIBROSIS | MESENCHYMAL STEM-CELLS | BETA | CELL BIOLOGY | SKELETAL-MUSCLE | IN-VIVO | MELTRIN ALPHA | SCHWANN-CELLS | NEURAL CREST | EXPRESSION | Ear, External - injuries | Freund's Adjuvant - toxicity | Stromal Cells - pathology | Ear, External - pathology | Muscle, Skeletal - metabolism | Muscle, Skeletal - injuries | Wound Healing | Gene Knockdown Techniques | Parabiosis | Myofibroblasts - metabolism | ADAM12 Protein | Ear, External - metabolism | ADAM Proteins - analysis | Collagen - biosynthesis | Receptor, Platelet-Derived Growth Factor alpha - analysis | Genes, Reporter | Myofibroblasts - pathology | Acute Disease | Dermis - metabolism | Specific Pathogen-Free Organisms | Leg Injuries - metabolism | Stromal Cells - metabolism | ADAM Proteins - deficiency | Cobra Cardiotoxin Proteins - toxicity | Mice, Transgenic | Adipocytes - pathology | Blood Vessels - cytology | Leg Injuries - pathology | Cell Lineage | Animals | Fibrosis | Dermis - pathology | Cicatrix - pathology | Dermis - injuries | Mice | Muscle, Skeletal - pathology | ADAM Proteins - genetics | Crosses, Genetic | Care and treatment | Growth | Stem cells | Genetic aspects | Research | Diagnosis | Gene expression | Cell differentiation | Proteins | Blood vessels | Signal transduction | Cell growth | Injuries | Index Medicus | Blood Vessels | Cobra Cardiotoxin Proteins | Dermis | Adipocytes | Cicatrix | Life Sciences | Stromal Cells | Immunology | Leg Injuries | ADAM Proteins | Ear, External | Freund's Adjuvant | Receptor, Platelet-Derived Growth Factor alpha | Collagen | Muscle, Skeletal | Myofibroblasts
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 512, Issue 1, pp. 78 - 81
Myeloproliferative neoplasms (MPNs) are diseases caused by mutations in the haematopoietic stem cell (HSC) compartment. Most MPN patients have a common... 
TYROSINE KINASE JAK2 | JAK2-V617F | ACTIVATING MUTATION | POLYCYTHEMIA-VERA | BONE | MULTIDISCIPLINARY SCIENCES | Neuroprotective Agents - therapeutic use | Apoptosis - drug effects | Neoplastic Stem Cells - drug effects | Sympathetic Nervous System - drug effects | Humans | Hematopoietic Stem Cells - pathology | Myeloproliferative Disorders - pathology | Sympathetic Nervous System - physiopathology | Adrenergic beta-3 Receptor Agonists - pharmacology | Neuroprotective Agents - pharmacology | Interleukin-1beta - metabolism | Neoplastic Stem Cells - pathology | Female | Sympathetic Nervous System - pathology | Schwann Cells - drug effects | Hematopoietic Stem Cells - drug effects | Nerve Fibers - pathology | Mesenchymal Stromal Cells - drug effects | Stem Cell Niche | Janus Kinase 2 - genetics | Nerve Fibers - drug effects | Schwann Cells - pathology | Myeloproliferative Disorders - drug therapy | Receptors, Adrenergic, beta-3 - metabolism | Disease Progression | Neoplasms - drug therapy | Nestin - metabolism | Adrenergic beta-3 Receptor Agonists - therapeutic use | Animals | Mice | Mesenchymal Stromal Cells - pathology | Neoplasms - pathology | Complications and side effects | Development and progression | Health aspects | Peripheral nerve diseases | Hematopoietic stem cells | Myeloproliferative disorders | Tumors | Studies | Mutation | Kinases | Rodents | Stem cells | Apoptosis | Index Medicus
Journal Article
Neuron, ISSN 0896-6273, 08/2012, Volume 75, Issue 4, pp. 633 - 647
The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription... 
SCIATIC-NERVE | MYELINATION | RAT | SIGNALING PATHWAY | PERIPHERAL NERVOUS-SYSTEM | WALLERIAN DEGENERATION | IN-VIVO | AXONAL REGENERATION | DORSAL-ROOT GANGLION | NEUROSCIENCES | NEGATIVE REGULATOR | Nerve Regeneration - physiology | Benzofurans | Cell Movement - genetics | Motor Neurons - pathology | Motor Neurons - ultrastructure | Spinal Cord - pathology | Sciatic Neuropathy - therapy | Adenoviridae - genetics | Disease Models, Animal | Microfluidic Analytical Techniques | Macrophages - ultrastructure | Microscopy, Electron, Transmission | Macrophages - pathology | Myelin Sheath - pathology | Gene Expression Regulation - genetics | Proto-Oncogene Proteins c-jun - genetics | Sciatic Neuropathy - pathology | Mice, Transgenic | Schwann Cells - pathology | Schwann Cells - metabolism | Motor Neurons - metabolism | Macrophages - metabolism | Animals | Schwann Cells - ultrastructure | Analysis of Variance | Proto-Oncogene Proteins c-jun - metabolism | Sciatic Neuropathy - physiopathology | Genetic Vectors - physiology | Mice | Myelin Sheath - ultrastructure | Sciatic Neuropathy - metabolism | Neurons | Neurosciences | Medical research | Genotype & phenotype | Transcription factors | Rodents | Leprosy | Grants | Mammals | Gene expression | Index Medicus | Regeneration | Myelin | Neurodegeneration | Peripheral nerves | Schwann cells | Recovery of function | c-Jun protein | Trophic factors | Injuries | Radicals | Cell adhesion molecules | Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2010, Volume 107, Issue 28, pp. 12704 - 12709
Various types of induced pluripotent stem (iPS) cells have been established by different methods, and each type exhibits different biological properties.... 
Spinal cord | Neurons | Induced pluripotent stem cells | Medical treatment | Schwann cells | Neural stem cells | Transplantation | Embryonic stem cells | Cellular differentiation | Tissue grafting | Axonal regrowth | Neural stem/progenitor cell | Regenerative medicine | Cell transplantation | Remyelination | FUNCTIONAL RECOVERY | DIRECTED DIFFERENTIATION | regenerative medicine | MULTIDISCIPLINARY SCIENCES | PROMOTE RECOVERY | MOUSE | ADULT-RATS | FIBROBLASTS | axonal regrowth | cell transplantation | neural stem/progenitor cell | NEURAL STEM/PROGENITOR CELLS | CENTRAL-NERVOUS-SYSTEM | PRECURSORS | remyelination | PARKINSONS-DISEASE | Motor Activity - physiology | Neurons - pathology | Astrocytes - pathology | Neurons - cytology | Spinal Cord Injuries - pathology | Neurons - transplantation | Oligodendroglia - physiology | Recovery of Function - physiology | Female | Astrocytes - transplantation | Axons - transplantation | Oligodendroglia - cytology | Spinal Cord - cytology | Cell Differentiation - physiology | Spinal Cord - transplantation | Mice, Inbred C57BL | Cells, Cultured | Spinal Cord Injuries - surgery | Cell Transplantation | Spinal Cord - surgery | Regeneration | Animals | Axons - pathology | Stem Cells - pathology | Mice | Spinal Cord Injuries - physiopathology | Induced Pluripotent Stem Cells | Oligodendroglia - transplantation | Care and treatment | Spinal cord injuries | Research | Stem cells | Brain | Transplants & implants | Rodents | Diabetes | Tumors | Index Medicus | Biological Sciences | neural stem | progenitor cell
Journal Article
Cell Stem Cell, ISSN 1934-5909, 2010, Volume 6, Issue 6, pp. 578 - 590
After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—there is often spontaneous regeneration of myelin sheaths, mainly by... 
STEMCELL | PDGF ALPHA-RECEPTOR | MULTIPLE-SCLEROSIS LESIONS | NEURAL PROGENITOR | REMYELINATION OCCURS | EMBRYONIC SPINAL-CORD | CENTRAL-NERVOUS-SYSTEM | INTRASPINAL INJECTION | RAT-BRAIN | NG2 PROTEOGLYCAN | PRECURSOR CELLS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Oligodendroglia - metabolism | Demyelinating Diseases - genetics | Astrocytes - pathology | Central Nervous System - pathology | Demyelinating Diseases - metabolism | Central Nervous System - surgery | Lysophosphatidylcholines - administration & dosage | Multiple Sclerosis - physiopathology | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Nerve Tissue Proteins - biosynthesis | Female | Demyelinating Diseases - chemically induced | Adult Stem Cells - pathology | Demyelinating Diseases - pathology | Receptor, Fibroblast Growth Factor, Type 3 - biosynthesis | Disease Models, Animal | Multiple Sclerosis - metabolism | Receptor, Platelet-Derived Growth Factor alpha - biosynthesis | Demyelinating Diseases - physiopathology | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Cells, Cultured | Mice, Transgenic | Multiple Sclerosis - genetics | Schwann Cells - pathology | Oligodendrocyte Transcription Factor 2 | Schwann Cells - metabolism | Nerve Regeneration | Nerve Tissue Proteins - genetics | Oligodendroglia - pathology | Adult Stem Cells - metabolism | Animals | Microscopy | Receptor, Platelet-Derived Growth Factor alpha - genetics | Central Nervous System - drug effects | Multiple Sclerosis - pathology | Mice | Integrases - genetics | Astrocytes - metabolism | Index Medicus
Journal Article
Neuroscience, ISSN 0306-4522, 2014, Volume 284, pp. 470 - 482
Highlights • Pre- and post-somatic segments of type I spiral ganglion neurons (SGNs) are unmyelinated in man. • Following hair cell loss and retrograde nerve... 
Neurology | spiral ganglion neurons | collagen IV | laminin-β2 | immunohistochemistry | human cochlea | non-myelinated Schwann cells | Immunohistochemistry | Laminin-β2 | Spiral ganglion neurons | Collagen IV | Non-myelinated Schwann cells | Human cochlea | SURVIVAL | NERVE | IMMUNOHISTOCHEMICAL LOCALIZATION | DORSAL-ROOT GANGLIA | ELECTRON-MICROSCOPY | laminin-beta 2 | NEUROSCIENCES | SATELLITE GLIAL-CELLS | HEARING-LOSS | BASAL LAMINA | CORTI LOSS | immuno-histochemistry | HUMAN INNER-EAR | Satellite Cells, Perineuronal - cytology | Neurons - pathology | Humans | Middle Aged | Male | Neurons - cytology | Satellite Cells, Perineuronal - metabolism | Basement Membrane - pathology | Spiral Ganglion - cytology | Schwann Cells - cytology | Spiral Ganglion - pathology | Adult | Female | Neurons - metabolism | Imaging, Three-Dimensional | Microscopy, Electron, Transmission | Microscopy, Electron, Scanning | Basement Membrane - cytology | Schwann Cells - pathology | Schwann Cells - metabolism | Spiral Ganglion - metabolism | Basement Membrane - metabolism | Collagen - metabolism | Microscopy, Confocal | Cochlear Implantation | Laminin - metabolism | Satellite Cells, Perineuronal - pathology | Deafness | Ganglion | Neurons | Analysis | Index Medicus | Cx43, connexin 43 | ECM, extracellular matrix | CI, cochlear implants | SGN, spiral ganglion neuron | BM, basement membrane | NMSC, non-myelinated Schwann cell | NIHL, noise-induced hearing loss | PBS, phosphate-buffered saline | SEM, scanning electron microscopy | IHC, immunohistochemistry | SGC, satellite glial cell | EDTA, ethylene-diamine-tetra-acetic acid | SG, spiral ganglion | type I ganglion cells, large afferent neurons innervating inner hair cell | Nav1.6, Na+-channels | TEM, transmission electron microscopy | LM, light microscopy | MBP, myelin basic protein | AIS, axonal initial segment | type II ganglion cells, small afferent neurons innervating outer hair cells | Basic Medicine | Neurosciences | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Kirurgi | Clinical Medicine | Surgery | Medicinska och farmaceutiska grundvetenskaper | Neurovetenskaper
Journal Article
Experimental Neurology, ISSN 0014-4886, 2007, Volume 204, Issue 1, pp. 443 - 453
Journal Article