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Biochemical Pharmacology, ISSN 0006-2952, 11/2014, Volume 92, Issue 1, pp. 73 - 89
Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia associated with the metabolic syndrome and type 2 diabetes. In spite... 
Natural product | Nuclear receptor | Diabetes | Nutrition | PPAR gamma | INSULIN ACTION ENHANCER | NECROSIS-FACTOR-ALPHA | LOWERS BLOOD-PRESSURE | IMPROVES GLYCEMIC CONTROL | ADIPOCYTE DIFFERENTIATION | PHARMACOLOGY & PHARMACY | RED-CLOVER EXTRACT | GLUCOSE-UPTAKE | NF-KAPPA-B | LIVER-X-RECEPTOR | ADIPOSE-TISSUE | Biological Products - chemistry | Humans | PPAR gamma - agonists | Models, Molecular | Protein Binding | Biological Products - pharmacology | Molecular Structure | PPAR gamma - metabolism | Energy Metabolism - drug effects | DIO, diet-induced obesity | PPAR, peroxisome proliferator-activated receptor | TNF-α, tumor necrosis factor alpha | RXR, retinoid X receptor | CAP, c-Cbl-associated protein | DCM, dichloromethane | NF-κB, nuclear factor-kappaB | 9-(S)-HODE, (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid | AF-2, activation function-2 | Part of the Special Issue | MeOH, methanol | LDL, low-density lipoprotein | Cdk5, cyclin-dependent kinase 5 | DPP-4, dipeptidylpeptidase 4 | HUVEC, human umbilical vein endothelial cells | Glut4, glucose transporter type 4 | FDA, Food and Drug Administration | LBD, ligand-binding domain | EMA, European Medicines Agency | TCM, traditional Chinese medicine | PPRE, peroxisome proliferator response element | Metabolism 2014 – Alterations of metabolic pathways as therapeutic targets | PDB, protein data bank | SPPARMs, selective PPARγ modulators | HDL, high-density lipoprotein | MAPK, mitogen-activated protein kinase
Journal Article
EBioMedicine, ISSN 2352-3964, 07/2016, Volume 9, Issue C, pp. 61 - 76
PPARγ has emerged as a master regulator of macrophage polarization and is the molecular target of the thiazolidinedione drugs. Here we show that apigenin binds... 
NF-κB | Macrophage polarization | Apigenin | Obesity-related inflammation | PPARγ | MEDICINE, RESEARCH & EXPERIMENTAL | INDUCIBLE CYCLOOXYGENASE | P65 PHOSPHORYLATION | METABOLIC SYNDROME | RECEPTOR-GAMMA | NITRIC-OXIDE SYNTHASE | PPAR gamma | NF-kappa B | ANTIINFLAMMATORY PROPERTIES | INSULIN-RESISTANCE | MOUSE MACROPHAGES | NF-KAPPA-B | ALTERNATIVE ACTIVATION | Inflammation - pathology | Obesity - immunology | Male | Metabolic Syndrome - metabolism | NF-kappa B - metabolism | PPAR gamma - metabolism | Apigenin - chemistry | Adipose Tissue - metabolism | Inflammation - complications | Inflammation - metabolism | Metabolic Syndrome - immunology | Protein Interaction Domains and Motifs | Thiazolidinediones - pharmacology | Macrophages, Peritoneal - drug effects | Macrophages - immunology | Disease Models, Animal | Cell Line | Cytokines - metabolism | Signal Transduction | Macrophage Activation - immunology | Obesity - complications | Macrophages, Peritoneal - immunology | Immunophenotyping | Inflammation - immunology | Obesity - metabolism | Obesity - pathology | Macrophages - metabolism | Phenotype | Animals | PPAR gamma - agonists | Biomarkers | Protein Binding | Macrophages - drug effects | Mice | Macrophage Activation - drug effects | Macrophages, Peritoneal - metabolism | Apigenin - pharmacology | PPAR gamma - chemistry
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2006, Volume 398, Issue 2, pp. 153 - 168
Adipose tissue is a major endocrine organ that exerts a profound influence on whole-body homoeostasis. Two types of adipose tissue exist in mammals: WAT (white... 
Brown adipose tissue (BAT) | White adipose tissue (WAT) | Transcription | Signalling | Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) | transcription | brown adipose tissue (BAT) | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIET-INDUCED OBESITY | MICE LACKING | MESSENGER-RNA | white adipose tissue (WAT) | MITOCHONDRIAL UNCOUPLING PROTEIN | peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC-1 alpha) | ACTIVATED-RECEPTOR-GAMMA | GENE-EXPRESSION | PPAR-GAMMA | LARGE-T-ANTIGEN | LIVER-X-RECEPTORS | signalling | ADIPOSE-TISSUE | Ion Channels | Signal Transduction | Membrane Proteins - genetics | Humans | Gene Expression Regulation | Adipose Tissue - cytology | Mitochondrial Proteins | Adipose Tissue - metabolism | Carrier Proteins - genetics | Adipose Tissue, Brown - cytology | Animals | Carrier Proteins - metabolism | Adipose Tissue, Brown - metabolism | Cell Differentiation | Membrane Proteins - metabolism | Uncoupling Protein 1 | NRF, nuclear respiratory factor | T3, 3,5,3′-tri-iodothyronine | RXR, retinoid X receptor | Cidea, cell death-inducing DFF45-like effector A | SRC-1, steroid receptor co-activator 1 | ChIP, chromatin immunoprecipitation | PKB, protein kinase B | ES, embryonic stem | FABP, fatty acid-binding protein | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | 4E-BP1, 4E-binding protein 1 | SV40, simian virus 40 | TAg, large T antigen | PRMT1, protein arginine methyltransferase 1 | AR, adrenergic receptor | SREBP-1, sterol regulatory element-binding protein 1 | peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) | PKA, cAMP-dependent protein kinase | RIP140, receptor interacting protein 140 | T4, thyroxine | Dio2, type 2 iodothyronine deiodinase | eNOS, epithelial NO synthase | LRH-1, liver receptor homologue 1 | SNS, sympathetic nervous system | NCoR, nuclear receptor co-repressor | UCP1, uncoupling protein 1 | WAT, white adipose tissue | ERR, oestrogen-related receptor | LXR, liver X receptor | TR, thyroid hormone receptor | Tfam, mitochondrial transcription factor A | CIP, p300 | pRB, retinoblastoma protein | MAPK, mitogen-activated protein kinase | IRS, insulin receptor substrate | co-integrator-associated protein | PPAR, peroxisome proliferator-activated receptor | SIRT, sirtuin | SV, stromal-vascular | Review | CBP | IGF-1R, IGF-1 receptor | NO, nitric oxide | SHP, small heterodimer partner | Rb, retinoblastoma gene | PGC-1, PPARγ co-activator 1 | S6K, S6 kinase | TZD, thiazolidinedione | CPT-1b, carnitine palmitoyltransferase 1b | enhancer-binding protein | PRC, PGC-1-related co-activator | BAT, brown adipose tissue | EBP, CCAAT | CREB, cAMP response element-binding protein | Foxc2, forkhead box C2 | SPPARM, selective PPARγ modulator | CBP, CREB-binding protein | TIF2, transcriptional intermediary factor 2 | GABP, GA-binding protein | MEF, mouse embryo fibroblast
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 12/2019, Volume 20, Issue 23, p. 5878
Journal Article
Journal of Diabetes Investigation, ISSN 2040-1116, 07/2017, Volume 8, Issue 4, pp. 446 - 452
Journal Article