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ACS Medicinal Chemistry Letters, ISSN 1948-5875, 01/2016, Volume 7, Issue 1, pp. 83 - 88
A series of selective androgen receptor modulators (SARMs) containing the 1-(trifluoromethyl)­benzyl alcohol core have been optimized for androgen receptor... 
androgen receptor | LLE | ligand efficiency | selective androgen receptor modulator | SARM | WOMEN | IMPACT | CHEMISTRY, MEDICINAL | ACID | DRUG DISCOVERY | MEN | METRICS
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2014, Volume 9, Issue 7, p. e103202
Introduction: The androgen receptor (AR) is the most highly expressed steroid receptor in breast cancer with 75-95% of estrogen receptor (ER)-positive and... 
ACTIVATION | THERAPY | ENOBOSARM | PROSTATE-SPECIFIC ANTIGEN | TAMOXIFEN | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | PHYSICAL FUNCTION | DOUBLE-BLIND | EXPRESSION | PREVENTS BONE LOSS | Mesenchymal Stromal Cells - drug effects | Humans | Receptors, Androgen - metabolism | Mesenchymal Stromal Cells - metabolism | Xenograft Model Antitumor Assays | Neoplasm Metastasis | Animals | Triple Negative Breast Neoplasms - genetics | Signal Transduction - drug effects | Tumor Burden - drug effects | Mice, Nude | Triple Negative Breast Neoplasms - metabolism | Paracrine Communication - drug effects | Triple Negative Breast Neoplasms - pathology | Cell Line, Tumor | Female | Cell Proliferation - drug effects | Mice | Gene Expression Regulation, Neoplastic - drug effects | Selective Estrogen Receptor Modulators - pharmacology | Disease Models, Animal | Androgens | DNA microarrays | Growth | Analysis | Stem cells | Estrogen | Development and progression | Breast cancer | Metastasis | Tumor proteins | Tamoxifen | Health aspects | Cell culture | Mesenchyme | p53 Protein | Estrogens | Estrogen receptors | Paracrine signalling | Fuel consumption | Kinases | Cancer therapies | Modulators | Metastases | Interleukin 6 | Proteins | Dihydrotestosterone | Historical account | Inhibition | Research & development--R&D | Cyclin-dependent kinases | Gene expression | Collagenase 3 | Augmented reality | Side effects | Womens health | Weight reduction | Breast | PTEN protein | Tumors | Cancer | Research & development | R&D
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 13, pp. 3330 - 3349
We previously reported that 4-(pyrrolidin-1-yl)benzonitrile derivative was a selective androgen receptor modulator (SARM) that exhibited anabolic effects on... 
Testosterone | Hershberger assay | Selective androgen receptor modulators (SARMs) | Androgen receptor | Sexual behavior | Nitriles | Structure | Crystals | Index Medicus
Journal Article
BIOORGANIC & MEDICINAL CHEMISTRY, ISSN 0968-0896, 07/2017, Volume 25, Issue 13, pp. 3330 - 3349
We previously reported that 4-(pyrrolidin-1-yl)benzonitrile derivative lb was a selective androgen receptor modulator (SARM) that exhibited anabolic effects on... 
CACHEXIA | CHEMISTRY, MEDICINAL | Selective androgen receptor modulators (SARMs) | STEROIDS | SAFETY | BIOCHEMISTRY & MOLECULAR BIOLOGY | Sexual behavior | MUSCLE | CHEMISTRY, ORGANIC | Hershberger assay | Testosterone | POTENT | Androgen receptor | MEN | HORMONE-REPLACEMENT THERAPY | BINDING | PROGRAM
Journal Article
Drug Testing and Analysis, ISSN 1942-7603, 08/2015, Volume 7, Issue 8, pp. 673 - 683
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 10/2006, Volume 14, Issue 19, pp. 6525 - 6538
Journal Article
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 05/2013, Volume 54, Issue 18, pp. 2239 - 2242
-Dephenylandarine and -dephenylostarine, two SARM metabolites relevant for doping control analysis, were synthesized in their endogenous ( )-forms as well as... 
Arylpropionamides | Amide bond formation | Andarine/ostarine metabolites | Selective androgen receptor modulators | MASS-SPECTROMETRIC CHARACTERIZATION | RESOLUTION | ASYMMETRIC HALOLACTONIZATION REACTION | CHEMISTRY, ORGANIC | DOPING CONTROL PURPOSES | DISCOVERY | PRODUCTS | URINARY METABOLITES | CANDIDATES | EFFICIENT | CARBOXYLIC-ACIDS | Metabolites
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 02/2009, Volume 24, Issue 2, pp. 231 - 240
Recent clinical trials with bisphosphonates and PTH have not supported the hypothesis that combination treatments with antiresorptive and anabolic agents would... 
Journal Article