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Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6771 - 6771
Lymphatic endothelial cells (LECs) directly express peripheral tissue antigens and induce CD8 T-cell deletional tolerance. LECs express MHC-II molecules,... 
DENDRITIC-CELLS | THYMIC EPITHELIAL-CELLS | MHC-CLASS-II | MULTIDISCIPLINARY SCIENCES | APOPTOTIC CELLS | GENE-EXPRESSION | CLONAL DELETION | MICE | INVARIANT CHAIN | SELF-TOLERANCE | CUTTING EDGE | beta-Galactosidase - immunology | Antigens, CD - immunology | CD8-Positive T-Lymphocytes - cytology | Cathepsin L - genetics | Cathepsin L - immunology | Dendritic Cells - immunology | Antigens, CD - genetics | Hemagglutinins - immunology | Peripheral Tolerance - genetics | CD4-Positive T-Lymphocytes - immunology | Bone Marrow Cells - immunology | Antigens, Differentiation, B-Lymphocyte - immunology | Antigens, Differentiation, B-Lymphocyte - genetics | Gene Expression | Signal Transduction | Bone Marrow Cells - cytology | CD4-Positive T-Lymphocytes - cytology | Mice, Inbred C57BL | Antigen Presentation - genetics | Mice, Transgenic | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Endothelial Cells - immunology | Hemagglutinins - genetics | Animals | Histocompatibility Antigens Class II - immunology | Endothelial Cells - cytology | Clonal Anergy - genetics | Antigens - immunology | Dendritic Cells - cytology | Mice | Histocompatibility Antigens Class II - genetics | Primary Cell Culture | Programmed Cell Death 1 Receptor - immunology | beta-Galactosidase - genetics | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | Antigens - genetics | Index Medicus | Basic Medicine | Immunologi inom det medicinska området | Medical and Health Sciences | Medicin och hälsovetenskap | Immunology in the medical area | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Nature Immunology, ISSN 1529-2908, 11/2001, Volume 2, Issue 11, pp. 1032 - 1039
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2011, Volume 108, Issue 28, pp. 11554 - 11559
Impaired immune functions leading to primary immunodeficiencies often correlate with paradoxical autoimmune complications; patients with hyper-IgM syndromes... 
Germ cells | Reactivity | Dendritic cells | B lymphocytes | Stem cells | Cell lines | Antibodies | AIDS | Pluripotent stem cells | Central tolerance | BAFF | SOMATIC HYPERMUTATION | HYPER-IGM SYNDROME | MULTIDISCIPLINARY SCIENCES | MOUSE | CLASS-SWITCH RECOMBINATION | MICE | EXPRESSION | T-CELLS | SYSTEMIC AUTOIMMUNITY | DEFICIENCY CAUSES | Job Syndrome - immunology | Cytidine Deaminase - immunology | Job Syndrome - genetics | Self Tolerance - immunology | Humans | Middle Aged | Child, Preschool | Molecular Sequence Data | Male | Precursor Cells, B-Lymphoid - immunology | Job Syndrome - enzymology | Case-Control Studies | T-Lymphocytes, Regulatory - immunology | Young Adult | Precursor Cells, B-Lymphoid - enzymology | Self Tolerance - genetics | Antibodies, Antinuclear - blood | Adult | Female | Child | Immunoglobulin M - genetics | Amino Acid Sequence | B-Lymphocytes - enzymology | Cytidine Deaminase - genetics | Antibodies, Antinuclear - genetics | B-Lymphocytes - immunology | Immunoglobulin M - blood | Adolescent | Cytidine Deaminase - deficiency | B-Cell Activating Factor - blood | Mutation | T-Lymphocytes, Regulatory - enzymology | Autoimmunity | Amines | Physiological aspects | Nucleosides | Genetic aspects | B cells | Health aspects | Immunoglobulins | Autoimmune diseases | Correlation analysis | Cells | Index Medicus | Biological Sciences
Journal Article
Immunity, ISSN 1074-7613, 09/2012, Volume 37, Issue 3, pp. 451 - 462
Although the proapoptotic BH3-only protein, Bim, is required for deletion of autoreactive thymocytes, Bim-deficient mice do not succumb to extensive... 
PROGRAMMED CELL-DEATH | LYMPHOCYTE DEVELOPMENT | AIRE DEFICIENCY | APOPTOTIC RESPONSES | BAX | DEFICIENT MICE | IMMUNOLOGY | FAMILY-MEMBER BIM | AUTOIMMUNE-DISEASE | EXPRESSION | T-CELLS | Proto-Oncogene Proteins c-bcl-2 - immunology | Self Tolerance - immunology | Thymocytes - metabolism | Autoimmunity - genetics | Apoptosis - genetics | Male | Mice, 129 Strain | Tumor Suppressor Protein p53 - genetics | Cell Differentiation - genetics | Flow Cytometry | Bcl-2-Like Protein 11 | T-Lymphocytes - metabolism | Autoimmunity - immunology | Self Tolerance - genetics | Tumor Suppressor Proteins - genetics | Proto-Oncogene Proteins - immunology | Apoptosis Regulatory Proteins - genetics | Female | Apoptosis Regulatory Proteins - immunology | Membrane Proteins - genetics | Mice, Inbred C57BL | Membrane Proteins - immunology | Mice, Transgenic | Proto-Oncogene Proteins - genetics | Tumor Suppressor Protein p53 - immunology | Tumor Suppressor Proteins - immunology | Mice, Knockout | Thymocytes - immunology | Cell Differentiation - immunology | Animals | Apoptosis - immunology | Autoantigens - immunology | T-Lymphocytes - immunology | Mice | Proto-Oncogene Proteins c-bcl-2 - genetics | Proteins | Autoimmunity | Antigens | Molecular genetics | Analysis | Oncology, Experimental | Research | T cells | Cancer | Lymphocytes | Rodents | Histology | Autoimmune diseases | Immune system | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2017, Volume 214, Issue 11, pp. 3183 - 3195
During alpha beta T cell development, the thymus medulla represents an essential microenvironment for T cell tolerance. This functional specialization is... 
MEDICINE, RESEARCH & EXPERIMENTAL | DIFFERENTIAL REQUIREMENT | LYMPHOTOXIN-BETA-RECEPTOR | EPITHELIAL-CELLS | DENDRITIC CELLS | POSITIVE SELECTION | NEGATIVE SELECTION | IMMUNOLOGY | T-CELL DEVELOPMENT | THYMOCYTES | NF-KAPPA-B | SELF-TOLERANCE | Forkhead Transcription Factors - immunology | Central Tolerance - immunology | T-Lymphocytes, Regulatory - metabolism | Epithelial Cells - metabolism | Dendritic Cells - immunology | T-Lymphocytes, Regulatory - immunology | DNA-Binding Proteins - metabolism | Lymphotoxin beta Receptor - metabolism | Forkhead Transcription Factors - metabolism | Thymus Gland - metabolism | Transcription Factors - immunology | Dendritic Cells - metabolism | DNA-Binding Proteins - immunology | Organogenesis - immunology | Nerve Tissue Proteins - immunology | Mice, Inbred C57BL | Central Tolerance - genetics | Mice, Transgenic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Microscopy, Confocal | Animals | Lymphotoxin beta Receptor - genetics | Autoantigens - immunology | Epithelial Cells - immunology | Thymus Gland - immunology | Thymus Gland - embryology | Lymphotoxin beta Receptor - immunology | Lymphotoxin | Antigens | Regulators | Dendritic cells | Epithelial cells | Autoantigens | Medulla | Negative selection | Lymphocytes T | Topology | Immunological tolerance | Organogenesis | Thymus | Specialization | Clonal deletion | Deletion | Foxp3 protein | Clonal selection | AIRE protein | Dendritic structure | Index Medicus | 317 | 300
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2010, Volume 107, Issue 1, pp. 181 - 186
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 7, pp. 737 - 745
Aire is a transcriptional regulator that induces the promiscuous expression of thousands of tissue-restricted antigens (TRAs) in medullary thymic epithelial... 
REPERTOIRE | TARGET GENES | MICE DEVELOP |