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The Journal of biological chemistry, ISSN 1083-351X, 09/2009, Volume 284, Issue 36, pp. 24035 - 24048
The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1β, macrophages need... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Toll-Like Receptor 2 - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Immunity, Innate - genetics | Extracellular Matrix - metabolism | Caspase 1 - metabolism | Male | Ureteral Obstruction - metabolism | Interleukin-1beta - genetics | Inflammation - metabolism | Kidney - metabolism | Carrier Proteins - immunology | Signal Transduction | Proteoglycans - immunology | Extracellular Matrix Proteins - genetics | Proteoglycans - metabolism | Toll-Like Receptor 4 - genetics | Biglycan | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Ureteral Obstruction - immunology | Macrophages - metabolism | Receptors, Purinergic P2 - metabolism | Toll-Like Receptor 2 - immunology | Mice | Proteoglycans - genetics | Extracellular Matrix - immunology | Kidney - immunology | Caspase 1 - immunology | Extracellular Matrix - genetics | Receptors, Purinergic P2 - genetics | Ureteral Obstruction - genetics | Interleukin-1beta - biosynthesis | Lung - metabolism | Receptors, Purinergic P2 - immunology | Extracellular Matrix Proteins - metabolism | Macrophages - immunology | Carrier Proteins - biosynthesis | Interleukin-1beta - immunology | Inflammation - immunology | Protein Structure, Tertiary - genetics | Receptors, Purinergic P2X7 | Carrier Proteins - genetics | Immunity, Innate - immunology | Animals | Caspase 1 - genetics | Extracellular Matrix Proteins - immunology | Receptors, Purinergic P2X4 | Inflammation - genetics | Lung - immunology | Animal models | Reactive oxygen species | Oligomerization | Proteoglycans | Transcription | Lung | Inflammation | Macrophages | Kidney | Stress | Caspase-1 | Purine P2X receptors | Signal transduction | Cell activation | TLR2 protein | Interleukin 1 | Toll-like receptors | Extracellular matrix | Sepsis | Cooperativity | Injuries | Index Medicus | Glycobiology and Extracellular Matrices
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 06/2013, Volume 288, Issue 23, pp. 16225 - 16234
Sepsis-associated immunosuppression (SAIS) is regarded as one of main causes for the death of septic patients at the late stage because of the decreased innate... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Interferon-beta - immunology | Humans | Tumor Necrosis Factor-alpha - genetics | Intracellular Signaling Peptides and Proteins - immunology | Male | Monocytes - immunology | Lipopolysaccharides - immunology | Gene Knockdown Techniques | Ubiquitin-Protein Ligases - immunology | Sepsis - pathology | Reactive Oxygen Species - immunology | Monocytes - pathology | Tumor Necrosis Factor-alpha - immunology | Interferon-beta - genetics | Female | Tumor Necrosis Factor alpha-Induced Protein 3 | Hydro-Lyases - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Macrophages - immunology | Immune Tolerance - drug effects | Cysteine Endopeptidases | Sepsis - immunology | DNA-Binding Proteins - immunology | Lipopolysaccharides - toxicity | Histones - immunology | Immunity, Innate - drug effects | Interleukin-6 - genetics | Macrophages - pathology | Gene Expression Regulation - genetics | Gene Expression Regulation - immunology | DNA-Binding Proteins - genetics | Nuclear Proteins - immunology | Proteins - immunology | Sepsis - genetics | Gene Expression Regulation - drug effects | Proteins - genetics | Animals | Histones - genetics | Interleukin-6 - immunology | Mice | Ubiquitin-Protein Ligases - genetics | Hydro-Lyases - immunology | Index Medicus | Toll-like Receptors (TLR) | Immunology | Reactive Oxygen Species (ROS) | Innate Immunity | Endotoxin Tolerance | ROS | Inflammation | Macrophages | A20 | Immune Responsive Gene 1
Journal Article
PLoS pathogens, ISSN 1553-7366, 05/2011, Volume 7, Issue 5, pp. e1002027 - e1002027
Journal Article
PloS one, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e54600 - e54600
Background and Aim: Assessment of serum concentration of lipopolysaccharide (LPS)-binding protein (LBP) has been suggested as a useful biomarker to indicate... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Age Factors | Obesity - immunology | Humans | Middle Aged | Male | Acute-Phase Proteins - genetics | Obesity - blood | Obesity - genetics | Inflammation - blood | Metabolic Syndrome - blood | Adult | Female | Metabolic Syndrome - immunology | Carrier Proteins - blood | Genetic Association Studies | Membrane Glycoproteins - blood | Toll-Like Receptor 4 - genetics | Inflammation - immunology | Immunity, Innate | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Metabolic Syndrome - genetics | Adolescent | Inflammation - genetics | Lipopolysaccharide Receptors - genetics | Polymorphism, Single Nucleotide | Obesity | Blood cholesterol | Liver | Genetic aspects | Research | Mitogens | Genetic polymorphisms | Protein binding | Immunoassay | Demography | Low concentrations | Genes | Body weight | Source studies | Alcohol | Cardiovascular disease | Males | Metabolic syndrome | CD14 antigen | Lipopolysaccharides | Interleukin 6 | Proteins | Demographics | Microorganisms | Rodents | Toll-like receptors | Measurement methods | Population | Bioindicators | Lipoproteins (high density) | Interleukin 8 | Age | Immune system | Consumption | Lipopolysaccharide-binding protein | Immune response | Cytokines | Internal medicine | Abnormalities | Glycoproteins | Inflammation | TLR4 protein | Cholesterol | Serum levels | Lipoproteins | Biomarkers | Alcoholic beverages | Sepsis | Adults | Lifestyles | Metabolic disorders | Smoking | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, pp. e64845 - e64845
... evidence indicates that genetic factors, environmental triggers and immune dysregulation may be involved in its development [6]. Attacks of gout are triggered... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Leukocytes, Mononuclear - metabolism | Hyperuricemia - pathology | Globulins - metabolism | Humans | Middle Aged | Male | Arthritis, Gouty - genetics | RNA, Messenger - metabolism | Case-Control Studies | Interleukin-1beta - blood | Ethnic Groups - genetics | Interleukin-11 - blood | Female | Genetic Predisposition to Disease - genetics | RNA, Messenger - genetics | Toll-Like Receptor 4 - genetics | Interleukin-11 - metabolism | Signal Transduction - genetics | Toll-Like Receptor 4 - metabolism | Asian Continental Ancestry Group - ethnology | Hyperuricemia - genetics | Hyperuricemia - blood | Arthritis, Gouty - pathology | Arthritis, Gouty - blood | Polymorphism, Single Nucleotide | RNA | Genes | Genetic research | Arthritis | Genetic aspects | Inflammation | Single nucleotide polymorphisms | Glaucoma | Laboratories | Cardiovascular disease | Lipids | Leukocytes (mononuclear) | mRNA | Single-nucleotide polymorphism | Family medical history | Dermatitis | Gene polymorphism | Proteins | Signal transduction | Immunology | Interleukin 1 | Toll-like receptors | Peripheral blood mononuclear cells | Rheumatism | Lipid metabolism | Genotypes | Immune system | Rheumatology | Uric acid | TLR4 protein | Metabolism | Gene expression | Patients | Asthma | Crohns disease | Inflammatory bowel disease | Studies | Signaling | Hospitals | Rheumatoid arthritis | Sepsis | Prostate cancer | Polymorphism | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e100169 - e100169
... respiratory distress syndrome, are complex disorders that are precipitated by the interplay of both environmental factors (such as mechanical ventilation) and genetic... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Luciferases - metabolism | Humans | Middle Aged | Stress, Mechanical | Acute Lung Injury - genetics | Male | Sp1 Transcription Factor - metabolism | Interferon Regulatory Factor-7 - genetics | Luciferases - genetics | Cell Cycle Proteins - genetics | Adult | Female | Acute Lung Injury - metabolism | Lung - metabolism | Nuclear Proteins - genetics | Binding Sites | Genes, Reporter | Promoter Regions, Genetic | Lung - pathology | Ventilator-Induced Lung Injury - genetics | Endothelial Cells - metabolism | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Nuclear Proteins - metabolism | Ventilator-Induced Lung Injury - pathology | Gene Dosage | Acute Lung Injury - pathology | Interferon Regulatory Factor-7 - metabolism | Mice, Knockout | Mechanotransduction, Cellular | Animals | Sp1 Transcription Factor - genetics | Protein Binding | Heterozygote | Aged | Mice | Polymorphism, Single Nucleotide | Endothelial Cells - pathology | Ventilator-Induced Lung Injury - metabolism | Ubiquitin | Analysis | Lung diseases | Luciferase | Genetic aspects | Biological response modifiers | Genetic polymorphisms | Protein binding | Phosphorylation | Genomics | DNA damage | Critical care | AKT protein | Single-nucleotide polymorphism | Regulatory sequences | Gene deletion | Ubiquitination | Clonal deletion | Humidity | Injuries | Deoxyribonucleic acid--DNA | Stresses | Ventilators | Pulmonary arteries | Cloning | Gene expression | Sp1 protein | Endothelial cells | Stress | Medicine | Studies | Interferon regulatory factor 7 | Genetic variance | Sleep | Gadd45A protein | Respiratory distress syndrome | Lungs | Interferon | Interferon regulatory factor | Binding sites | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article