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PLoS Pathogens, ISSN 1553-7366, 05/2011, Volume 7, Issue 5, p. e1002027
During infection Neisseria meningitidis (Nm) encounters multiple environments within the host, which makes rapid adaptation a crucial factor for meningococcal... 
HUMAN EPITHELIAL-CELLS | FACTOR-H-BINDING | MICROBIOLOGY | SEROGROUP-B MENINGOCOCCUS | GENOME | PATHOGENIC NEISSERIAE | VACCINE CANDIDATES | VIROLOGY | OUTER-MEMBRANE PROTEIN | GENE-EXPRESSION | STAPHYLOCOCCUS-AUREUS | SERINE-PROTEASE | PARASITOLOGY | Adaptation, Physiological | Sequence Deletion | Virulence Factors - genetics | Genes, Bacterial - genetics | Humans | Neisseria meningitidis, Serogroup B - physiology | Transcriptome | Male | Neisseria meningitidis, Serogroup B - genetics | Meningococcal Infections - microbiology | Antigens, Bacterial - genetics | Bacteremia - microbiology | Bacteremia - blood | RNA, Bacterial - genetics | Adult | Female | Neisseria meningitidis, Serogroup B - pathogenicity | Bacterial Proteins - genetics | Up-Regulation - genetics | Down-Regulation - genetics | Neisseria meningitidis, Serogroup B - growth & development | Genome, Bacterial - genetics | Gene Expression Regulation, Bacterial - genetics | Host-Pathogen Interactions - genetics | Models, Biological | Meningococcal Infections - blood | Cluster Analysis | Causes of | Sepsis | Neisseria meningitidis | Genetic aspects | Research | Health aspects | Microbiology | Pathogenesis | Mortality | Genomes | Gene expression | Blood | Proteins | Studies | Evolutionary biology | Mutagenesis | DNA methylation | Meningitis | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 06/2013, Volume 1832, Issue 6, pp. 848 - 863
Sepsis is characterized by systematic inflammation and contributes to cardiac dysfunction. This study was designed to examine the effect of protein kinase B... 
Heart | ER stress | Sepsis | Akt | Contractile function | Apoptosis | OXIDATIVE STRESS | CONTRACTILE DYSFUNCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | ENDOPLASMIC-RETICULUM STRESS | AUTOPHAGY | GROWTH-FACTOR I | SIGNAL-TRANSDUCTION | SYNTHASE | BIOPHYSICS | INFLAMMATORY RESPONSE | NF-KAPPA-B | Caspase 9 - genetics | Apoptosis - drug effects | Calcium - metabolism | Heat-Shock Proteins - biosynthesis | Myocardial Contraction - drug effects | bcl-2-Associated X Protein - biosynthesis | Apoptosis - genetics | Glycogen Synthase Kinase 3 beta | Heat-Shock Proteins - genetics | Phosphorylation - genetics | Caspase 3 - genetics | Phosphorylation - drug effects | Transcription Factor CHOP - biosynthesis | Proto-Oncogene Proteins c-akt - metabolism | Apoptosis Regulatory Proteins - biosynthesis | Lipopolysaccharides - toxicity | Endoplasmic Reticulum Stress - drug effects | Mice, Transgenic | Glycogen Synthase Kinase 3 - genetics | Eukaryotic Initiation Factor-2 - genetics | Mice | Enzyme Activation - genetics | Transcription Factor CHOP - genetics | Eukaryotic Initiation Factor-2 - biosynthesis | Microtubule-Associated Proteins - genetics | bcl-X Protein - genetics | Extracellular Signal-Regulated MAP Kinases - metabolism | Endoplasmic Reticulum Stress - genetics | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Myocardial Contraction - genetics | MAP Kinase Signaling System - genetics | Apoptosis Regulatory Proteins - genetics | Caspase 3 - biosynthesis | bcl-X Protein - biosynthesis | bcl-2-Associated X Protein - genetics | Beclin-1 | Gene Expression Regulation - genetics | Myocardium - pathology | Transcription Factors - biosynthesis | Transcription Factors - genetics | Enzyme Activation - drug effects | Glycogen Synthase Kinase 3 - metabolism | Microtubule-Associated Proteins - biosynthesis | Gene Expression Regulation - drug effects | Autophagy-Related Protein 7 | Myocardium - enzymology | Animals | MAP Kinase Signaling System - drug effects | Caspase 9 - biosynthesis
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 09/2012, Volume 342, Issue 3, pp. 654 - 664
Nodakenin, a coumarin isolated from the roots of Angelicae gigas, has been reported to possess neuroprotective, antiaggregatory, antibacterial, and... 
ACTIVATION | CYTOKINES | CYCLOOXYGENASE-2 | RAW264.7 CELLS | NITRIC-OXIDE SYNTHASE | KINASE | SEPTIC SHOCK | PHARMACOLOGY & PHARMACY | MEDIATORS | SEPSIS | ANGELICA-GIGAS | Transcription, Genetic - drug effects | Interleukin-6 - antagonists & inhibitors | Tumor Necrosis Factor-alpha - genetics | Male | NF-kappa B - metabolism | TNF Receptor-Associated Factor 6 - antagonists & inhibitors | Interleukin-1beta - genetics | Promoter Regions, Genetic - drug effects | Mitogen-Activated Protein Kinase Kinases - metabolism | Inflammation - metabolism | Phosphorylation - genetics | Drug Interactions | Ubiquitination - drug effects | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Phosphorylation - drug effects | TNF Receptor-Associated Factor 6 - genetics | Interleukin-6 - metabolism | Interleukin-1beta - antagonists & inhibitors | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Interleukin-6 - genetics | Anti-Inflammatory Agents - pharmacology | Dinoprostone - genetics | MAP Kinase Kinase Kinases - genetics | MAP Kinase Kinase Kinases - metabolism | Signal Transduction - genetics | Down-Regulation - genetics | Coumarins - pharmacology | Dinoprostone - metabolism | Macrophages - metabolism | Signal Transduction - drug effects | Nitric Oxide - genetics | Lipopolysaccharides - pharmacology | Mice | Transcription, Genetic - genetics | Dinoprostone - antagonists & inhibitors | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Mitogen-Activated Protein Kinase Kinases - genetics | Shock, Septic - prevention & control | I-kappa B Proteins - metabolism | I-kappa B Proteins - genetics | Shock, Septic - metabolism | I-kappa B Kinase - metabolism | I-kappa B Kinase - antagonists & inhibitors | Inflammation - drug therapy | Nitric Oxide Synthase Type II - antagonists & inhibitors | I-kappa B Proteins - antagonists & inhibitors | Shock, Septic - drug therapy | Glucosides - pharmacology | Nitric Oxide - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | I-kappa B Kinase - genetics | Down-Regulation - drug effects | Animals | NF-kappa B - genetics | Nitric Oxide Synthase Type II - genetics | Cyclooxygenase 2 - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Inflammation - genetics | Macrophages - drug effects | Nitric Oxide - metabolism | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Ubiquitination - genetics
Journal Article
PLoS Pathogens, ISSN 1553-7366, 09/2010, Volume 6, Issue 9, p. e1001088
Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes... 
SUBSTITUTION STRAINS | PREPULSE INHIBITION | MOUSE STRAIN | MICROBIOLOGY | NEUTROPHIL RECRUITMENT | LUNG DEFENSES | CAPSULAR POLYSACCHARIDE | QUANTITATIVE TRAIT LOCI | VIROLOGY | 5TH COMPONENT | PSEUDOMONAS-AERUGINOSA | COMPLEX TRAITS | PARASITOLOGY | Neutrophils - cytology | Oligonucleotide Array Sequence Analysis | Chromosomes, Mammalian - genetics | Mice, Inbred A | Staphylococcal Infections - pathology | Humans | Male | Gene Expression Profiling | Macrophages, Peritoneal - cytology | Flow Cytometry | Sepsis - pathology | Apoptosis Regulatory Proteins - genetics | Staphylococcal Infections - microbiology | Neutrophils - microbiology | Neutrophils - metabolism | Biomarkers - metabolism | Staphylococcus aureus - genetics | Genetic Predisposition to Disease | Staphylococcal Infections - genetics | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Chromosome Mapping | Reverse Transcriptase Polymerase Chain Reaction | Staphylococcus aureus - pathogenicity | Blotting, Western | Sepsis - genetics | Apoptosis Regulatory Proteins - metabolism | Phenotype | Animals | Macrophages, Peritoneal - microbiology | Apoptosis Regulatory Proteins - antagonists & inhibitors | Polymorphism, Single Nucleotide - genetics | Chemokines - metabolism | Mice | Macrophages, Peritoneal - metabolism | Sepsis - microbiology | Quantitative Trait Loci - genetics | Genetic susceptibility | Staphylococcus aureus infections | Genetic aspects | Research | Macrophages | Chromosomes | Identification and classification | Risk factors | Medical research | Cell culture | Genetics | Staphylococcus infections | Sepsis | Standard deviation | Genomes | Experiments | Chemokines | Pharmaceuticals
Journal Article
Clinical Immunology, ISSN 1521-6616, 2016, Volume 163, pp. 60 - 65
Abstract Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic autoimmune disease characterized by early-onset... 
Allergy and Immunology | Autoimmunity | IPEX | Mutation | FOXP3 | Primary immunodeficiency | X-LINKED SYNDROME | ENTEROPATHY | STABILITY | IMMUNOLOGY | IMMUNE DYSREGULATION | DIMER | SEQUENCE | DISEASE | REGULATORY T-CELLS | POLYENDOCRINOPATHY | IMMUNODYSREGULATION | Eczema - genetics | Eczema - immunology | Immune System Diseases - genetics | Humans | Diabetes Mellitus, Type 1 - congenital | Infant | Male | Meningoencephalitis - immunology | Thrombocytopenia - genetics | Immunoglobulin E - immunology | Diarrhea - immunology | Eosinophilia - genetics | Fatal Outcome | Hepatomegaly - immunology | Genetic Diseases, X-Linked - genetics | Diabetes Mellitus, Type 1 - immunology | Dimerization | Hemorrhage - genetics | Sepsis - immunology | Splenomegaly - genetics | Growth Disorders - immunology | Hemorrhage - immunology | Splenomegaly - immunology | Thrombocytopenia - immunology | Immune System Diseases - immunology | Leukocytosis - immunology | Meningoencephalitis - genetics | Diabetes Mellitus, Type 1 - genetics | Models, Molecular | Klebsiella Infections - genetics | Hepatomegaly - genetics | Forkhead Transcription Factors - genetics | Sepsis - genetics | Lung Diseases - immunology | Genetic Diseases, X-Linked - immunology | Immune System Diseases - congenital | Thymus Gland - abnormalities | Lung Diseases - genetics | Eosinophilia - immunology | Diarrhea - genetics | Klebsiella Infections - immunology | Phenylalanine - genetics | Hydrophobic and Hydrophilic Interactions | Growth Disorders - genetics | Leukocytosis - genetics
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2015, Volume 125, Issue 2, pp. 665 - 680
Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | GLUCOSE-METABOLISM | ATP-CITRATE LYASE | UCP2 | SEPTIC SHOCK | CELL-GROWTH | CRITICALLY-ILL PATIENTS | INTENSIVE INSULIN THERAPY | CANCER | MITOCHONDRIAL UNCOUPLING PROTEINS | Fatty Acid Synthase, Type I - genetics | Fatty Acid Synthase, Type I - biosynthesis | Lipids - genetics | Inflammasomes - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Ion Channels - genetics | Caspase 1 - metabolism | Mitochondrial Proteins - genetics | Interleukin-1beta - genetics | Lipids - biosynthesis | Sepsis - pathology | Interleukin-1beta - metabolism | Mitochondrial Proteins - metabolism | Sepsis - metabolism | Macrophages - pathology | Down-Regulation - genetics | Inflammasomes - genetics | Sepsis - genetics | Mice, Knockout | Carrier Proteins - genetics | Enzyme Induction - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Sepsis - chemically induced | Ion Channels - metabolism | Caspase 1 - genetics | Sepsis - therapy | Mice | Uncoupling Protein 2 | Interleukin-18 - genetics | Interleukin-18 - metabolism | Cellular proteins | Immune response | Synthesis | Sepsis | Development and progression | Lipids | Genetic aspects | Properties | Enzymes | Cytokines | Pathogenesis | Mortality | Glucose | Metabolism | Gene expression | Fatty acids | Proteins | Studies | Metabolites | Consent | Rodents
Journal Article