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Cell host & microbe, ISSN 1931-3128, 11/2018, Volume 24, Issue 5, pp. 689 - 702.e7
... (FADD, RIPK1, RIPK3, and caspase 8) and autophagy (ATG5, ATG7, and SQSTM1) proteins. Genetic or pharmacological inhibition of autophagy induction, but not autophagy-mediated... 
caspase 8 | autophagy | HIV | CD4+ T cell | SMAC mimetics | apoptosis | XIAP | Fas | RIPK1 | BIRC2 | CD4+ T cell | Parasitology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Virology | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | HIV-1 - pathogenicity | Apoptosis - drug effects | Autophagy-Related Protein 7 - metabolism | Cyclohexanes - pharmacology | Humans | Caspase 8 - metabolism | Autophagy - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Autophagy - drug effects | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV-1 - physiology | Mitochondrial Proteins - metabolism | Baculoviral IAP Repeat-Containing 3 Protein - metabolism | Cell Death | Indoles - pharmacology | Inhibitor of Apoptosis Proteins - metabolism | Sequestosome-1 Protein - metabolism | Cell Line | HIV-1 - drug effects | Dipeptides - pharmacology | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Protein Ligases - metabolism | Benzoquinones - pharmacology | Pyrroles - pharmacology | Apoptosis Regulatory Proteins | X-Linked Inhibitor of Apoptosis Protein - metabolism | Autophagy-Related Protein 5 - metabolism | Apoptosis - physiology | Beclin-1 - metabolism | Proteins | Medical colleges | Trout | Communicable diseases | T cells | HIV (Viruses) | Health aspects | HIV infection | Apoptosis | Index Medicus
Journal Article
Cancer discovery, ISSN 2159-8290, 04/2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 08/2017, Volume 292, Issue 33, pp. 13795 - 13808
.... Here, we report that phosphorylation of autophagy-associated protein p62 by AMP-activated protein kinase (AMPK... 
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | AMP-Activated Protein Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Humans | Protein Transport - drug effects | Hippocampus - drug effects | Neural Stem Cells - cytology | Recombinant Fusion Proteins - metabolism | Autophagy - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Gene Deletion | Phosphorylation - drug effects | Sequestosome-1 Protein - metabolism | Adult Stem Cells - drug effects | Autophagy-Related Protein 7 - antagonists & inhibitors | Cell Survival - drug effects | Nerve Tissue Proteins - antagonists & inhibitors | Adult Stem Cells - cytology | AMP-Activated Protein Kinases - antagonists & inhibitors | Sequestosome-1 Protein - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Recombinant Fusion Proteins - chemistry | Enzyme Activation - drug effects | Hippocampus - cytology | Autophagy-Related Protein 7 - genetics | Nerve Tissue Proteins - genetics | AMP-Activated Protein Kinases - chemistry | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Point Mutation | Sequestosome-1 Protein - genetics | Adult Stem Cells - metabolism | Animals | Protein Kinase Inhibitors - pharmacology | Neural Stem Cells - metabolism | AMP-Activated Protein Kinases - genetics | Amino Acid Substitution | Index Medicus | AMP-activated kinase (AMPK) | mitophagy | autophagy | phosphorylation | p62 (sequestosome 1 (SQSTM1)) | Protein Synthesis and Degradation
Journal Article
PloS one, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173676 - e0173676
.... Chronic administration of the PPARa agonist FB substantially reduced the levels of multiple autophagy proteins in the liver... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | TOR Serine-Threonine Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Fibroblast Growth Factors - genetics | Autophagy-Related Protein 5 - genetics | fas Receptor - metabolism | Autophagy - drug effects | Fibroblast Growth Factors - metabolism | TOR Serine-Threonine Kinases - genetics | Liver - drug effects | fas Receptor - genetics | Autophagy - genetics | Proto-Oncogene Proteins c-akt - metabolism | Forkhead Box Protein O1 - metabolism | Signal Transduction | Liver - metabolism | PPAR alpha - genetics | Ubiquitin-Conjugating Enzymes - genetics | Stearoyl-CoA Desaturase - genetics | Mice, Knockout | Triglycerides - metabolism | Sequestosome-1 Protein - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Stearoyl-CoA Desaturase - metabolism | Mice | PPAR alpha - metabolism | Autophagy-Related Proteins - antagonists & inhibitors | Blood Glucose - metabolism | Autophagy-Related Proteins - metabolism | Forkhead Box Protein O1 - genetics | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Fenofibrate - pharmacology | Cysteine Endopeptidases - metabolism | Autophagy-Related Proteins - genetics | Sequestosome-1 Protein - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Autophagy-Related Protein 7 - antagonists & inhibitors | Mice, Inbred C57BL | Autophagy-Related Protein 7 - genetics | Gene Expression Regulation - drug effects | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | PPAR alpha - agonists | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Beclin-1 - metabolism | Transcription factors | Adipose tissue | Liver | Body weight | AKT protein | Biochemistry | Glucose | Assaying | Proteins | Signal transduction | Temperature effects | Fibroblasts | Physiology | Acetylation | Inhibition | Growth factors | Hepatotoxicity | Activation analysis | Methanol | Starvation | Ethanol | AMP | Metabolism | Insulin | Fatty acids | Studies | Acetaminophen | Food intake | Weight reduction | Animal welfare | Circulation | Drugs | Biotechnology | Drug abuse | Laboratories | Centrifugation | Glass | Homeostasis | Activation | Biology | Kinases | AMP-activated protein kinase | Autophagy | Nutrient status | Rodents | Nutrients | Oxidation | Heart diseases | Age | Epinephrine | AKT1 protein | Fasting | Chloroform | Diabetes mellitus | Cardiomyocytes | Acclimatization | Triglycerides | Pharmacology | Nitrogen | Calories | Medicine | Nuclear fuels | Protein kinase | Insulin resistance | Diabetes | Index Medicus
Journal Article
Molecular cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 1, pp. 15 - 27
Journal Article
Journal Article
The Journal of cell biology, ISSN 1540-8140, 04/2009, Volume 185, Issue 2, pp. 305 - 321
Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes... 
Starvation | Transferrins | 3T3 cells | Small interfering RNA | HeLa cells | Antibodies | CHO cells | Endosomes | Golgi apparatus | P branes | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Mannose-Binding Lectins - metabolism | RNA, Small Interfering - genetics | Membrane Glycoproteins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Ubiquitin - metabolism | Autophagy - physiology | Coat Protein Complex I - metabolism | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Protein Subunits - metabolism | Lysosomal-Associated Membrane Protein 1 - genetics | Membrane Proteins - metabolism | Protein Subunits - genetics | Biomarkers - metabolism | Cell Line | Membrane Proteins - genetics | Lysosomal-Associated Membrane Protein 2 - genetics | Phagosomes - metabolism | Ubiquitin - genetics | Coat Protein Complex I - genetics | Membrane Glycoproteins - genetics | Animals | Mannose-Binding Lectins - genetics | Adaptor Proteins, Signal Transducing - genetics | Recombinant Fusion Proteins - genetics | Golgi Apparatus - metabolism | Lysosomal-Associated Membrane Protein 1 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Transferrin - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | RNA, Small Interfering - metabolism | Ubiquitin | Gas vesicles | Physiological aspects | Research | Phagocytosis | Proteins | Studies | Membranes | Biochemistry | Cells | Index Medicus
Journal Article
Nature cell biology, ISSN 1476-4679, 07/2010, Volume 12, Issue 8, pp. 781 - 790
Journal Article
Molecular medicine reports, ISSN 1791-2997, 08/2019, Volume 20, Issue 2, pp. 1443 - 1450
.... The protein expression levels of microtubule-associated protein... 
Oncology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | RNA, Small Interfering - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Microtubule-Associated Proteins - metabolism | Humans | Nerve Growth Factors - metabolism | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Nerve Growth Factors - pharmacology | TOR Serine-Threonine Kinases - genetics | Human Umbilical Vein Endothelial Cells - cytology | Cell Cycle Proteins - genetics | Autophagy - genetics | Eye Proteins - genetics | Phosphorylation - drug effects | Nuclear Proteins - genetics | Sequestosome-1 Protein - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Serpins - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Serpins - metabolism | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Serpins - pharmacology | Sequestosome-1 Protein - genetics | Eye Proteins - metabolism | Nerve Growth Factors - genetics | Nuclear Proteins - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - metabolism | Eye Proteins - pharmacology | RNA, Small Interfering - metabolism
Journal Article