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Cancer discovery, ISSN 2159-8290, 04/2017, Volume 7, Issue 4, pp. 400 - 409
Entrectinib, a potent oral inhibitor of the tyrosine kinases TRKA/B/C, ROS1, and ALK, was evaluated in two phase I studies in patients with advanced or... 
Life Sciences & Biomedicine | Oncology | Science & Technology | Benzamides - pharmacokinetics | Colorectal Neoplasms - genetics | Humans | Middle Aged | Receptor, trkA - antagonists & inhibitors | Male | Receptor, trkB - genetics | Indazoles - administration & dosage | Protein Kinase Inhibitors - adverse effects | Mammary Analogue Secretory Carcinoma - genetics | Dose-Response Relationship, Drug | Benzamides - administration & dosage | Membrane Glycoproteins - antagonists & inhibitors | Receptor, trkC - genetics | Anaplastic Lymphoma Kinase | Melanoma - genetics | Colorectal Neoplasms - drug therapy | Receptor, trkB - antagonists & inhibitors | Aged, 80 and over | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Adult | Female | Benzamides - adverse effects | Carcinoma, Non-Small-Cell Lung - pathology | Crizotinib | Protein Kinase Inhibitors - pharmacokinetics | Proto-Oncogene Proteins - antagonists & inhibitors | Pyridines - administration & dosage | Carcinoma, Non-Small-Cell Lung - genetics | Receptor, trkC - antagonists & inhibitors | Melanoma - pathology | Mammary Analogue Secretory Carcinoma - drug therapy | Membrane Glycoproteins - genetics | Protein Kinase Inhibitors - administration & dosage | Sequestosome-1 Protein - genetics | Pyrazoles - administration & dosage | Indazoles - pharmacokinetics | Receptor Protein-Tyrosine Kinases - genetics | Oncogene Proteins, Fusion - genetics | Melanoma - drug therapy | Adolescent | Receptor, trkA - genetics | Oncogene Proteins, Fusion - antagonists & inhibitors | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | Indazoles - adverse effects | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus
Journal Article
PloS one, ISSN 1932-6203, 04/2017, Volume 12, Issue 4, pp. e0173676 - e0173676
.... Chronic administration of the PPARa agonist FB substantially reduced the levels of multiple autophagy proteins in the liver... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | TOR Serine-Threonine Kinases - metabolism | Autophagy-Related Protein 7 - metabolism | Fibroblast Growth Factors - genetics | Autophagy-Related Protein 5 - genetics | fas Receptor - metabolism | Autophagy - drug effects | Fibroblast Growth Factors - metabolism | TOR Serine-Threonine Kinases - genetics | Liver - drug effects | fas Receptor - genetics | Autophagy - genetics | Proto-Oncogene Proteins c-akt - metabolism | Forkhead Box Protein O1 - metabolism | Signal Transduction | Liver - metabolism | PPAR alpha - genetics | Ubiquitin-Conjugating Enzymes - genetics | Stearoyl-CoA Desaturase - genetics | Mice, Knockout | Triglycerides - metabolism | Sequestosome-1 Protein - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | Autophagy-Related Protein 5 - metabolism | Beclin-1 - genetics | Stearoyl-CoA Desaturase - metabolism | Mice | PPAR alpha - metabolism | Autophagy-Related Proteins - antagonists & inhibitors | Blood Glucose - metabolism | Autophagy-Related Proteins - metabolism | Forkhead Box Protein O1 - genetics | Autophagy-Related Protein 5 - antagonists & inhibitors | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Fenofibrate - pharmacology | Cysteine Endopeptidases - metabolism | Autophagy-Related Proteins - genetics | Sequestosome-1 Protein - metabolism | Sterol Regulatory Element Binding Protein 1 - metabolism | Autophagy-Related Protein 7 - antagonists & inhibitors | Mice, Inbred C57BL | Autophagy-Related Protein 7 - genetics | Gene Expression Regulation - drug effects | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | PPAR alpha - agonists | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Beclin-1 - metabolism | Transcription factors | Adipose tissue | Liver | Body weight | AKT protein | Biochemistry | Glucose | Assaying | Proteins | Signal transduction | Temperature effects | Fibroblasts | Physiology | Acetylation | Inhibition | Growth factors | Hepatotoxicity | Activation analysis | Methanol | Starvation | Ethanol | AMP | Metabolism | Insulin | Fatty acids | Studies | Acetaminophen | Food intake | Weight reduction | Animal welfare | Circulation | Drugs | Biotechnology | Drug abuse | Laboratories | Centrifugation | Glass | Homeostasis | Activation | Biology | Kinases | AMP-activated protein kinase | Autophagy | Nutrient status | Rodents | Nutrients | Oxidation | Heart diseases | Age | Epinephrine | AKT1 protein | Fasting | Chloroform | Diabetes mellitus | Cardiomyocytes | Acclimatization | Triglycerides | Pharmacology | Nitrogen | Calories | Medicine | Nuclear fuels | Protein kinase | Insulin resistance | Diabetes | Index Medicus
Journal Article
Neurobiology of Aging, ISSN 0197-4580, 2015, Volume 36, Issue 4, pp. 1764.e9 - 1764.e18
Journal Article
American journal of physiology. Lung cellular and molecular physiology, ISSN 1522-1504, 01/2015, Volume 308, Issue 1, pp. L33 - L47
Mutation of threonine for isoleucine at codon 73 (I73T) in the human surfactant protein C (hSP-C) gene ( SFTPC... 
Surfactant protein | Pulmonary fibrosis | Alveolar epithelium | Autophagy | Amphisome | alveolar epithelium | autophagy | amphisome | surfactant protein | pulmonary fibrosis | Respiratory System | Physiology | Life Sciences & Biomedicine | Science & Technology | Proteostasis Deficiencies - metabolism | Lung Diseases, Interstitial - metabolism | Vacuoles - ultrastructure | Lung Diseases, Interstitial - pathology | Microtubule-Associated Proteins - genetics | Sequestosome-1 Protein | Humans | Lysosomes - genetics | Genetic Diseases, Inborn - genetics | Infant | rab GTP-Binding Proteins - genetics | Genetic Diseases, Inborn - pathology | Mutation, Missense | Mitochondria - ultrastructure | Lysosomes - metabolism | ATP-Binding Cassette Transporters - genetics | Mitochondria - genetics | HEK293 Cells | ATP-Binding Cassette Transporters - metabolism | Membrane Potential, Mitochondrial - genetics | Female | Genetic Diseases, Inborn - metabolism | Microfilament Proteins - genetics | Vacuoles - genetics | Gene Expression Regulation - genetics | Proteostasis Deficiencies - pathology | Pulmonary Surfactant-Associated Protein C - metabolism | Mitochondria - metabolism | Microtubule-Associated Proteins - biosynthesis | rab GTP-Binding Proteins - biosynthesis | Ubiquitin-Protein Ligases - biosynthesis | Lysosomes - ultrastructure | Autophagy-Related Protein 8 Family | Proteostasis Deficiencies - genetics | Microfilament Proteins - biosynthesis | Lung Diseases, Interstitial - genetics | Adaptor Proteins, Signal Transducing - genetics | Pulmonary Surfactant-Associated Protein C - genetics | Vacuoles - metabolism | Adaptor Proteins, Signal Transducing - biosynthesis | Ubiquitin-Protein Ligases - genetics | Amino Acid Substitution | Autophagy (Cytology) | Usage | Genetic aspects | Epithelium | Health aspects | Lung diseases | Proteins | ABC transporters | Mutation | Biomass | Surfactants | Cells | Index Medicus | Call for Papers
Journal Article
The Journal of cell biology, ISSN 1540-8140, 04/2009, Volume 185, Issue 2, pp. 305 - 321
Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes... 
Starvation | Transferrins | 3T3 cells | Small interfering RNA | HeLa cells | Antibodies | CHO cells | Endosomes | Golgi apparatus | P branes | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Mannose-Binding Lectins - metabolism | RNA, Small Interfering - genetics | Membrane Glycoproteins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Ubiquitin - metabolism | Autophagy - physiology | Coat Protein Complex I - metabolism | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Protein Subunits - metabolism | Lysosomal-Associated Membrane Protein 1 - genetics | Membrane Proteins - metabolism | Protein Subunits - genetics | Biomarkers - metabolism | Cell Line | Membrane Proteins - genetics | Lysosomal-Associated Membrane Protein 2 - genetics | Phagosomes - metabolism | Ubiquitin - genetics | Coat Protein Complex I - genetics | Membrane Glycoproteins - genetics | Animals | Mannose-Binding Lectins - genetics | Adaptor Proteins, Signal Transducing - genetics | Recombinant Fusion Proteins - genetics | Golgi Apparatus - metabolism | Lysosomal-Associated Membrane Protein 1 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Transferrin - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | RNA, Small Interfering - metabolism | Ubiquitin | Gas vesicles | Physiological aspects | Research | Phagocytosis | Proteins | Studies | Membranes | Biochemistry | Cells | Index Medicus
Journal Article
Molecular medicine reports, ISSN 1791-2997, 08/2019, Volume 20, Issue 2, pp. 1443 - 1450
.... The protein expression levels of microtubule-associated protein... 
Oncology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | RNA, Small Interfering - genetics | Human Umbilical Vein Endothelial Cells - metabolism | Microtubule-Associated Proteins - genetics | TOR Serine-Threonine Kinases - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Microtubule-Associated Proteins - metabolism | Humans | Nerve Growth Factors - metabolism | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Nerve Growth Factors - pharmacology | TOR Serine-Threonine Kinases - genetics | Human Umbilical Vein Endothelial Cells - cytology | Cell Cycle Proteins - genetics | Autophagy - genetics | Eye Proteins - genetics | Phosphorylation - drug effects | Nuclear Proteins - genetics | Sequestosome-1 Protein - metabolism | Human Umbilical Vein Endothelial Cells - drug effects | Serpins - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Serpins - metabolism | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Nuclear Proteins - metabolism | Signal Transduction - genetics | Serpins - pharmacology | Sequestosome-1 Protein - genetics | Eye Proteins - metabolism | Nerve Growth Factors - genetics | Nuclear Proteins - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - genetics | Adaptor Proteins, Signal Transducing - metabolism | Eye Proteins - pharmacology | RNA, Small Interfering - metabolism
Journal Article
Autophagy, ISSN 1554-8635, 10/2018, Volume 15, Issue 4, pp. 652 - 667
EBV has been reported to impair monocyte in vitro differentiation into dendritic cells (DCs) and reduce cell survival. In this study, we added another layer of... 
monocytes | SQSTM1/p62 | autophagy | dendritic cells | ROS | STAT3 | EBV | ATG5 | NFE2L2 | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Reactive Oxygen Species - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Humans | Cell Survival - genetics | Apoptosis - genetics | Monocytes - metabolism | rab GTP-Binding Proteins - genetics | Autophagy-Related Protein 5 - genetics | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Kelch-Like ECH-Associated Protein 1 - genetics | Cell Differentiation - genetics | Mitochondrial Proteins - metabolism | NF-E2-Related Factor 2 - genetics | Autophagy - genetics | Dendritic Cells - virology | Sequestosome-1 Protein - metabolism | Dendritic Cells - metabolism | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | rab GTP-Binding Proteins - metabolism | Herpesvirus 4, Human - physiology | Interleukin-4 - metabolism | Kelch-Like ECH-Associated Protein 1 - metabolism | Mitochondria - metabolism | Signal Transduction - genetics | Autophagosomes - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Autophagosomes - virology | Transcription Factors - metabolism | Monocytes - virology | Sequestosome-1 Protein - genetics | NF-E2-Related Factor 2 - metabolism | Autophagy-Related Protein 5 - metabolism | RNA, Small Interfering | Index Medicus
Journal Article
Nature cell biology, ISSN 1476-4679, 07/2010, Volume 12, Issue 8, pp. 781 - 790
Journal Article
Journal Article