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Science, ISSN 0036-8075, 1/2011, Volume 331, Issue 6016, pp. 456 - 461
Adenosine monophosphate—activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and... 
Birds of prey | Medical research | Phosphorylation | Starvation | Mitochondria | Hepatocytes | Complementary DNA | Liver | REPORTS | Cell lines | Vehicles | TARGET | CATALYTIC SUBUNIT | METFORMIN | COMPLEX | METABOLISM | ROLES | MULTIDISCIPLINARY SCIENCES | DISEASE | C-ELEGANS | AUTOPHAGY | DOMAINS | AMP-Activated Protein Kinases - metabolism | Mitochondria, Liver - metabolism | Sequestosome-1 Protein | Humans | Caenorhabditis elegans Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Hepatocytes - metabolism | Autophagy | Autophagy-Related Protein-1 Homolog | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Caenorhabditis elegans - metabolism | Signal Transduction | Cell Survival | Liver - metabolism | Metformin - pharmacology | Protein-Serine-Threonine Kinases - genetics | Phenformin - pharmacology | Transcription Factors - metabolism | Insulin - metabolism | Animals | Energy Metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Mitochondria, Liver - ultrastructure | Cell Line, Tumor | Mice | Protein-Serine-Threonine Kinases - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Caenorhabditis elegans Proteins - genetics | Autophagy (Cytology) | Research | Properties | Protein kinases
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 4/2009, Volume 185, Issue 2, pp. 305 - 321
Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes... 
Starvation | Transferrins | 3T3 cells | Small interfering RNA | HeLa cells | Antibodies | CHO cells | Endosomes | Golgi apparatus | P branes | CORE MACHINERY | TRANSPORT | UNFOLDED PROTEIN RESPONSE | MULTIVESICULAR BODIES | MEMBRANE | EPSILON-COP | ENDOCYTIC PATHWAYS | BETA-COP | CELL MUTANT | GOLGI-COMPLEX | CELL BIOLOGY | Mannose-Binding Lectins - metabolism | RNA, Small Interfering - genetics | Membrane Glycoproteins - metabolism | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Ubiquitin - metabolism | Autophagy - physiology | Coat Protein Complex I - metabolism | Recombinant Fusion Proteins - metabolism | Endosomes - metabolism | Protein Subunits - metabolism | Lysosomal-Associated Membrane Protein 1 - genetics | Membrane Proteins - metabolism | Protein Subunits - genetics | Biomarkers - metabolism | Cell Line | Membrane Proteins - genetics | Lysosomal-Associated Membrane Protein 2 - genetics | Phagosomes - metabolism | Ubiquitin - genetics | Coat Protein Complex I - genetics | Membrane Glycoproteins - genetics | Animals | Mannose-Binding Lectins - genetics | Adaptor Proteins, Signal Transducing - genetics | Recombinant Fusion Proteins - genetics | Golgi Apparatus - metabolism | Lysosomal-Associated Membrane Protein 1 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Transferrin - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | RNA, Small Interfering - metabolism | Ubiquitin | Gas vesicles | Physiological aspects | Research | Phagocytosis
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 1, pp. 15 - 27
The multifunctional, stress-inducible molecular chaperone HSP70 has important roles in aiding protein folding and maintaining protein homeostasis. HSP70... 
PROTEINS | CHEMBIO | CELLCYCLE | CANCER-CELLS | HSP70 | CHAPERONE-MEDIATED AUTOPHAGY | NEGATIVE REGULATION | LYSOSOMAL MEMBRANE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEAT-SHOCK RESPONSE | APAF-1 APOPTOSOME | P53 PROTEINS | P62 | CELL-DEATH | CELL BIOLOGY | HSP70 Heat-Shock Proteins - antagonists & inhibitors | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | NF-kappa B - metabolism | Cathepsin L - metabolism | Autophagy - drug effects | DNA-Binding Proteins - metabolism | Caspases - metabolism | Lysosomes - metabolism | Protein Binding - drug effects | Lymphoma - pathology | Protein Interaction Domains and Motifs | Cell Death - drug effects | Lysosomes - drug effects | Cell Survival - drug effects | HSP40 Heat-Shock Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | HSP70 Heat-Shock Proteins - genetics | Mice, Transgenic | Mice, Inbred Strains | Sulfonamides - pharmacology | Apoptotic Protease-Activating Factor 1 - metabolism | HSP70 Heat-Shock Proteins - metabolism | Transcription Factors - metabolism | Animals | Sulfonamides - therapeutic use | Lymphoma - prevention & control | Sulfonamides - metabolism | Cell Line, Tumor | Mice | Adaptor Proteins, Signal Transducing - metabolism | Protein Multimerization - drug effects | Protein Binding - physiology | Proteins | Heat shock proteins | Analysis | Tumors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 12455 - 12468
Autophagy and apoptosis are two evolutionarily conserved processes that regulate cell fate in response to cytotoxic stress. However, the functional... 
PROGRAMMED CELL-DEATH | INHIBITION | BECLIN-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIF-1 | MITOCHONDRIA | DEGRADATION | MEDIATED CLEAVAGE | MACROAUTOPHAGY | CHLOROQUINE | SPHINGOSINE KINASE | Death Domain Receptor Signaling Adaptor Proteins - physiology | Autophagy-Related Proteins | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Sequestosome-1 Protein | Humans | Protein Multimerization | Caspase 3 - metabolism | Caspase 8 - metabolism | Leukemia, Myeloid, Acute | Autophagy | Heat-Shock Proteins - genetics | Cell Membrane - metabolism | Tumor Cells, Cultured | Pyrazoles - pharmacology | Cell Survival - drug effects | Hydrazines - pharmacology | Lysosome-Associated Membrane Glycoproteins - metabolism | Heat-Shock Proteins - metabolism | Cells, Cultured | Fas-Associated Death Domain Protein - metabolism | Ubiquitin-Conjugating Enzymes - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Gene Knockout Techniques | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Protein Transport | Cell Membrane - enzymology | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Animals | Autophagy-Related Protein 5 | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | Protein Binding | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Apoptosis | Caspase-8 | Bortezomib | Cell Death | Caspase | Sphingolipid | SKI-I | p62 | Sequestosome 1 | Atg5 | Cell Biology
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 8, p. e23367
Background: Recent studies have demonstrated that activation of autophagy increases the lifespan of organisms from yeast to flies. In contrast to the lifespan... 
LIFE-SPAN EXTENSION | PATHOGENESIS | OXIDATIVE STRESS | INHIBITION | DISRUPTION | MULTIDISCIPLINARY SCIENCES | GENES | RESISTANCE | MITOCHONDRIAL DYSFUNCTION | SUPPRESSION | CELL BIOLOGY | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Sequestosome-1 Protein | Humans | Cellular Senescence - drug effects | Male | Autophagy - physiology | Phosphoproteins - metabolism | Fibroblasts - ultrastructure | Tumor Suppressor Protein p53 - genetics | Small Ubiquitin-Related Modifier Proteins - genetics | Toluene - analogs & derivatives | RNA Interference | Time Factors | beta-Galactosidase - metabolism | Autophagy - genetics | Toluene - pharmacology | Child | Fibroblasts - metabolism | Autophagy-Related Protein 12 | Cellular Senescence - genetics | Ubiquitin-Activating Enzymes - genetics | Lysosome-Associated Membrane Glycoproteins - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Benzothiazoles - pharmacology | Small Ubiquitin-Related Modifier Proteins - metabolism | Cells, Cultured | Tumor Suppressor Protein p53 - metabolism | Cellular Senescence - physiology | Signal Transduction - genetics | Microscopy, Electron | Ubiquitin-Activating Enzymes - metabolism | Blotting, Western | Autophagy-Related Protein 7 | Acetylcysteine - pharmacology | Lysosome-Associated Membrane Glycoproteins - genetics | Signal Transduction - physiology | Fibroblasts - cytology | Primary Cell Culture | Adaptor Proteins, Signal Transducing - metabolism | Lysosomal-Associated Membrane Protein 2 | Acetylcysteine | Tumor proteins | Genetic translation | Cells | Protein binding | TOR protein | Huntingtons disease | Senescence | Phosphorylation | Yeast | p53 Protein | Impairment | Galactosidase | Viruses | Homology | Activation | Biochemistry | Autophagy | Fibroblasts | Aging | Cytokines | LAMP-2 protein | Translation initiation | Rapamycin | Ribosomal protein S6 | siRNA | Mammals | Membrane proteins | Medicine | Life span | Morphology | Initiation factor eIF-4E | Molecular biology | Alzheimers disease | Phagocytosis | Apoptosis
Journal Article
Science, ISSN 0036-8075, 7/2011, Volume 333, Issue 6039, pp. 228 - 233
Journal Article
Immunity, ISSN 1074-7613, 08/2012, Volume 37, Issue 2, pp. 223 - 234
Autophagy is a fundamental biological process of the eukaryotic cell contributing to diverse cellular and physiological functions including cell-autonomous... 
IMMUNITY | MYCOBACTERIUM-TUBERCULOSIS INFECTION | MUTANT HUNTINGTIN | P62/SQSTM1 | ADAPTER | INNATE | KAPPA-B | IMMUNOLOGY | PROTEINS | HUNTINGTONS-DISEASE | CELL | Green Fluorescent Proteins | Phosphorylation | Mycobacterium bovis - immunology | Microtubule-Associated Proteins - genetics | Sequestosome-1 Protein | Humans | rab GTP-Binding Proteins - genetics | Serine - immunology | Autophagy - immunology | Phagosomes - immunology | Interleukin-1beta - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adaptor Proteins, Signal Transducing - immunology | Macrophages - immunology | Protein-Serine-Threonine Kinases - metabolism | Phagosomes - drug effects | Heat-Shock Proteins - metabolism | Phagosomes - metabolism | Interleukin-1beta - immunology | Microtubule-Associated Proteins - antagonists & inhibitors | Serine - metabolism | Heat-Shock Proteins - immunology | Tuberculosis - immunology | Microscopy, Confocal | Autophagy-Related Protein 7 | Macrophages - metabolism | Animals | rab GTP-Binding Proteins - immunology | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Mice | RNA, Small Interfering | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Research | Universities and colleges | Macrophages | Oncology, Experimental | Cancer | Proteins | Antimicrobial agents | Microscopy | Kinases | Autophagy | Rodents
Journal Article
Journal Article
Annual Review of Biochemistry, ISSN 0066-4154, 6/2017, Volume 86, Issue 1, pp. 193 - 224
Autophagy and the ubiquitin-proteasome system are the two major quality control pathways responsible for cellular homeostasis. As such, they provide protection... 
xenophagy | proteasome | mitophagy | autophagy | chaperone | ubiquitination | aggrephagy | organelle homeostasis | UPS | p62-Keap1-Nrf2 | proteostasis | P62-Keap1-Nrf2 | Ubiquitination | Xenophagy | Proteostasis | Aggrephagy | Chaperone | Organelle homeostasis | Mitophagy | Autophagy | Proteasome | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | YEAST 26S PROTEASOME | QUALITY-CONTROL | SELECTIVE AUTOPHAGY | TRANSCRIPTION FACTOR NRF1 | MITOCHONDRIAL DYNAMICS | SYNUCLEIN IMPAIRS MACROAUTOPHAGY | N-TERMINAL DOMAIN | UBIQUITIN LIGASE MARCH5 | Molecular Chaperones - metabolism | Humans | Ubiquitin - metabolism | Homeostasis | Eukaryotic Cells - metabolism | Kelch-Like ECH-Associated Protein 1 - chemistry | Mitochondrial Degradation - genetics | Kelch-Like ECH-Associated Protein 1 - genetics | Proteolysis | NF-E2-Related Factor 2 - genetics | Autophagy - genetics | Sequestosome-1 Protein - chemistry | Sequestosome-1 Protein - metabolism | Signal Transduction | Gene Expression Regulation | Molecular Chaperones - genetics | Kelch-Like ECH-Associated Protein 1 - metabolism | Ubiquitin - genetics | Sequestosome-1 Protein - genetics | NF-E2-Related Factor 2 - metabolism | Protein Conformation | Eukaryotic Cells - cytology | NF-E2-Related Factor 2 - chemistry | Proteasome Endopeptidase Complex - metabolism | Physiological aspects | Autophagy (Cytology) | Genetic aspects | Research | Ubiquitin-proteasome system
Journal Article