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Journal Article
Nature Genetics, ISSN 1061-4036, 12/2015, Volume 47, Issue 12, pp. 1475 - 1481
Tumors have high energetic and anabolic needs for rapid cell growth and proliferation(1), and the serine biosynthetic pathway was recently identified as an... 
PATHWAYS | ACTIVATION | GLUTAMINE | ADENOCARCINOMA | GENETICS & HEREDITY | GENE-EXPRESSION | SENSITIVITY | TUMOR-GROWTH | TUMORIGENESIS | CARCINOMA | KEAP1 MUTATIONS | RNA, Small Interfering - genetics | NF-E2-Related Factor 2 - antagonists & inhibitors | Cell Proliferation | Lung Neoplasms - mortality | Humans | Lung Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Lung Neoplasms - pathology | Serine - biosynthesis | Immunoenzyme Techniques | Adenocarcinoma - metabolism | Carcinoma, Non-Small-Cell Lung - secondary | Biomarkers, Tumor - metabolism | NF-E2-Related Factor 2 - genetics | Adenocarcinoma - genetics | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Lung Neoplasms - genetics | Carcinoma, Non-Small-Cell Lung - genetics | RNA, Messenger - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Non-Small-Cell Lung - mortality | Adenocarcinoma - secondary | Blotting, Western | Xenograft Model Antitumor Assays | Animals | NF-E2-Related Factor 2 - metabolism | Biomarkers, Tumor - genetics | Mice | Adenocarcinoma - mortality | Apoptosis | Transcription factors | Cell metabolism | Development and progression | Genetic aspects | Genetic transcription | Lung cancer, Non-small cell | Properties | Health aspects | Medical research | Enzymes | Lung cancer | Biosynthesis | RNA polymerase | Metabolism | Gene expression | Experiments | Metabolites | Scientific imaging | Tumorigenesis | Labeling | Bioinformatics | Mass spectrometry
Journal Article
Oncogene, ISSN 0950-9232, 10/2014, Volume 33, Issue 42, pp. 5039 - 5046
Journal Article
Microbiology (United Kingdom), ISSN 1350-0872, 2018, Volume 164, Issue 12, pp. 1471 - 1480
The principal mechanism of reducing sulfur into organic compounds is via the synthesis of L-cysteine. Cysteine is used for protein and glutathione synthesis,... 
Sulfate reduction | Meningitis | Cysteine | Cysteine biosynthesis | Gonorrhoea | Neisseria | MYCOBACTERIUM-TUBERCULOSIS | gonorrhoea | SERINE ACETYLTRANSFERASE | O-ACETYLSERINE SULFHYDRYLASE | cysteine | meningitis | MICROBIOLOGY | sulfate reduction | IDENTIFICATION | FREE-RADICALS | CYSB PROTEIN | SULFATE | SALMONELLA-TYPHIMURIUM | INHIBITORS | cysteine biosynthesis | MENINGITIDIS
Journal Article
PLoS Biology, ISSN 1544-9173, 12/2015, Volume 13, Issue 12, p. e1002309
Metformin is a biguanide widely prescribed to treat Type II diabetes that has gained interest as an antineoplastic agent. Recent work suggests that metformin... 
DIABETES-MELLITUS | LKB1-AMPK PATHWAY | ATP CITRATE LYASE | RESPIRATORY-CHAIN | ACTIVATED PROTEIN-KINASE | REDUCTIVE GLUTAMINE-METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | COMPLEX 1 | ALPHA-KETOGLUTARATE | AMPK | TUMOR-GROWTH | Neoplasms - metabolism | AMP-Activated Protein Kinases - metabolism | Humans | Drug Resistance, Neoplasm | Phosphoproteins - metabolism | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Eukaryotic Initiation Factors - genetics | Eukaryotic Initiation Factors - metabolism | Metformin - pharmacology | Cells, Cultured | Citric Acid Cycle - drug effects | Protein-Serine-Threonine Kinases - genetics | Electron Transport Chain Complex Proteins - genetics | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Phosphoproteins - genetics | Hypoglycemic Agents - pharmacology | Mice, Knockout | Neoplasms - drug therapy | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Embryo, Mammalian - cytology | Electron Transport Chain Complex Proteins - metabolism | Lipid Metabolism - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Mutation | Neoplasms - pathology | AMP-Activated Protein Kinases - genetics | Life Sciences | Cellular Biology | Cancer | Cell growth | Insulin-like growth factors | Kinases | Cancer therapies
Journal Article