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Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPTOR | BINDING PARTNER | RAG GTPASES | TOS MOTIF | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PIK-RELATED KINASES | CELL-GROWTH | P70 S6 KINASE | RAPAMYCIN COMPLEX-1 | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure | Index Medicus
Journal Article
Nature chemical biology, ISSN 1552-4450, 12/2014, Volume 10, Issue 12, pp. 1066 - 1072
Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these... 
RHEUMATOID-ARTHRITIS | DESIGN | LIGANDS | BIOCHEMISTRY & MOLECULAR BIOLOGY | REACTIVITY | KINASE INHIBITORS | GENERATION | OPTIMIZATION | ELECTROPHILES | PREDICTION | TOOL | Small Molecule Libraries - pharmacology | Humans | Bacterial Proteins - chemistry | Molecular Probes - pharmacology | Janus Kinase 3 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | beta-Lactamases - genetics | Janus Kinase 3 - chemistry | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Cysteine - metabolism | Bacterial Proteins - antagonists & inhibitors | Bacterial Proteins - genetics | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Cysteine - chemistry | beta-Lactamase Inhibitors - pharmacology | Ribosomal Protein S6 Kinases, 90-kDa - chemistry | Serine - chemistry | Drug Discovery | Serine - metabolism | Gram-Negative Bacteria - enzymology | Gram-Negative Bacteria - drug effects | Small Molecule Libraries - chemistry | beta-Lactamases - chemistry | Molecular Probes - chemistry | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Gram-Negative Bacteria - growth & development | Janus Kinase 3 - genetics | Hydrophobic and Hydrophilic Interactions | Protein Binding | Ligands | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | COS Cells | beta-Lactamase Inhibitors - chemistry | Proteins | Chemical bonds | Biochemistry | Crystal structure | Index Medicus | boronic acid | covalent virtual screening | JAK3 kinase | covalent fragments | covalent inhibition | beta-lactamase | RSK2 kinase | cyanoacrylamide | reversible covalent | covalent electrophile | MSK1 kinase
Journal Article
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 02/2013, Volume 12, Issue 2, pp. 573 - 584
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2013, Volume 8, Issue 1, pp. e53343 - e53343
Kunitz-type serine protease inhibitors are involved in various physiological processes, such as ion channel blocking, blood coagulation, fibrinolysis, and... 
VENOM | KING COBRA | MULTIDISCIPLINARY SCIENCES | PSEUDONAJA-TEXTILIS | SILK PROTEIN | CHYMOTRYPSIN INHIBITOR | MOLECULAR-CLONING | BOOPHILUS-MICROPLUS | EXPRESSION | ARANEUS-VENTRICOSUS | PEPTIDE | Factor Xa - chemistry | Chymotrypsin - metabolism | Molecular Sequence Data | Baculoviridae - genetics | Tissue Plasminogen Activator - chemistry | Pancreatic Elastase - antagonists & inhibitors | Antifibrinolytic Agents - metabolism | Trypsin Inhibitors - chemistry | Serine Proteinase Inhibitors - chemistry | Spiders - metabolism | Aprotinin - genetics | Conserved Sequence | Antifibrinolytic Agents - chemistry | Spiders - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Gene Expression | Fibrinolysin - antagonists & inhibitors | Recombinant Proteins - chemistry | Arthropod Proteins - genetics | Recombinant Proteins - genetics | Trypsin - metabolism | Arthropod Proteins - chemistry | Fibrinolysin - chemistry | Sequence Alignment | Animals | Thrombin - chemistry | Trypsin Inhibitors - genetics | Chymotrypsin - antagonists & inhibitors | Pancreatic Elastase - chemistry | Aprotinin - chemistry | Serine Proteinase Inhibitors - genetics | Enzymes | Care and treatment | Protease inhibitors | Physiological aspects | Hydrolases | Inflammation | Research | Health aspects | Risk factors | Blood coagulation | Serine | Thrombin | Amino acids | Baculovirus | Plasmin | t-Plasminogen activator | Proteins | Protease | Ion channels | Elastase | Inhibition | Recombinant | Natural resources | Proteinase inhibitors | Potassium channels | Fibrinolysis | Chymotrypsin | Trypsin | Insects | Proteases | Lysine | Venom | Insect cells | Serine proteinase | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2012, Volume 55, Issue 21, pp. 9312 - 9330
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer's... 
TAU EXON 10 | FUNCTIONAL-LINK | CHEMISTRY, MEDICINAL | DYRK1A OVEREXPRESSION | DOWN-SYNDROME | INTRACELLULAR TARGETS | NEUROFIBRILLARY DEGENERATION | DUAL-SPECIFICITY | PHOSPHATIDYLINOSITOL 3,5-BISPHOSPHATE | AFFINITY-CHROMATOGRAPHY | GLYCOGEN-SYNTHASE KINASE | Stereoisomerism | Humans | Imidazoles - chemistry | Alkaloids - chemical synthesis | Crystallography, X-Ray | Structure-Activity Relationship | Dioxoles - chemical synthesis | Protein Kinase Inhibitors - chemistry | Neuroprotective Agents - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Tyrosine Kinases - chemistry | Dioxoles - pharmacology | Molecular Structure | Pyramidal Cells - drug effects | Cell Death - drug effects | Imidazoles - chemical synthesis | Porifera - chemistry | Pyramidal Cells - cytology | Cell Line | Protein Kinase Inhibitors - chemical synthesis | Brain - cytology | Recombinant Proteins - antagonists & inhibitors | Alkaloids - pharmacology | Neuroprotective Agents - chemistry | Glutamic Acid - pharmacology | Models, Molecular | Rats | Recombinant Proteins - chemistry | Cyclin-Dependent Kinase 2 - chemistry | Imidazoles - pharmacology | Dioxoles - chemistry | Rats, Sprague-Dawley | Brain - drug effects | Neuroprotective Agents - chemical synthesis | Amyloid beta-Protein Precursor - genetics | Animals | Chromatography, Affinity | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | In Vitro Techniques | Alkaloids - chemistry | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Organic chemistry | Chemical Sciences
Journal Article
Green Chemistry, ISSN 1463-9262, 1/2011, Volume 13, Issue 11, pp. 37 - 347
Journal Article
Journal Article