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Drugs, ISSN 0012-6667, 11/2015, Volume 75, Issue 17, pp. 1993 - 2016
Through years of evolutionary selection pressures, organisms have developed potent toxins that coincidentally have marked antineoplastic activity. These... 
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | IMMUNOTOXIN RFB4(DSFV)-PE38 BL22 | PEGYLATED LIPOSOMAL DOXORUBICIN | EPOTHILONE-B ANALOG | DRUG-RESISTANT PHENOTYPE | GEMTUZUMAB OZOGAMICIN | PHASE-I TRIAL | METASTATIC BREAST-CANCER | ERIBULIN MESYLATE E7389 | PHARMACOLOGY & PHARMACY | TOXICOLOGY | ANTI-MESOTHELIN IMMUNOTOXIN | CHRONIC MYELOID-LEUKEMIA | Dioxoles - therapeutic use | Diphtheria Toxin - pharmacology | Recombinant Fusion Proteins - pharmacology | Furans - pharmacology | Humans | Recombinant Fusion Proteins - therapeutic use | Interleukin-2 - therapeutic use | Epothilones - pharmacology | Drug Discovery - methods | Antineoplastic Agents - therapeutic use | Biological Products - pharmacology | Epothilones - therapeutic use | Harringtonines - therapeutic use | Furans - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | Diphtheria Toxin - therapeutic use | Immunoconjugates - pharmacology | Cytochalasins - pharmacology | Dioxoles - pharmacology | Immunoconjugates - therapeutic use | Antineoplastic Agents - pharmacology | Ketones - therapeutic use | Cytochalasins - therapeutic use | Biological Products - therapeutic use | Ketones - pharmacology | Tetrahydroisoquinolines - pharmacology | Tetrahydroisoquinolines - therapeutic use | Withanolides - pharmacology | Harringtonines - pharmacology | Interleukin-2 - pharmacology | Withanolides - therapeutic use | Antimitotic agents | Care and treatment | Chemotherapy | Usage | Clinical trials | Dosage and administration | Diagnosis | Antineoplastic agents | Cancer | Index Medicus | Review
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2011, Volume 31, Issue 24, pp. 8905 - 8919
Astrocytes show a complex structural and physiological interplay with neurons and respond to neuronal activation in vitro and in vivo with intracellular... 
SLICE CULTURES | TRANSMITTER RELEASE | D-SERINE | SYNAPTIC-TRANSMISSION | SEMLIKI-FOREST-VIRUS | METABOTROPIC GLUTAMATE RECEPTORS | RAT HIPPOCAMPUS | LONG-TERM POTENTIATION | NEUROSCIENCES | IN-SITU | CA1 PYRAMIDAL NEURONS | Glycine - analogs & derivatives | Calcium - metabolism | Channelrhodopsins | Male | Peptide Fragments - pharmacology | Phosphopyruvate Hydratase - metabolism | Green Fluorescent Proteins - genetics | Glial Fibrillary Acidic Protein - metabolism | Piperidines - pharmacology | Neurons - physiology | Statistics, Nonparametric | Female | Tetrodotoxin - pharmacology | Electric Stimulation - methods | Transduction, Genetic - methods | Pyrazoles - pharmacology | Animals, Newborn | Mice, Inbred C57BL | Bacterial Proteins - genetics | Morpholines - pharmacology | Sodium Channel Blockers - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Tetanus Toxin - pharmacology | Calcium Channel Blockers - pharmacology | Hippocampus - cytology | Naphthalenes - pharmacology | Action Potentials - physiology | Carbenoxolone - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Patch-Clamp Techniques | Animals | Analysis of Variance | Glycine - pharmacology | Photic Stimulation - methods | Models, Biological | Benzoxazines - pharmacology | Benzoates - pharmacology | Luminescent Proteins - genetics | Mice | Pyridines - pharmacology | Aspartic Acid - analogs & derivatives | In Vitro Techniques | Aspartic Acid - pharmacology | Astrocytes - metabolism
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2002, Volume 137, Issue 7, pp. 1021 - 1030
The mechanism(s) by which vascular endothelial growth factor (VEGF) induces endothelial nitric oxide synthase (eNOS) activation remain(s) unclear up to a... 
eNOS | PAF | PI3K | VEGF | PLC | PLA2 | PKC | PLA | PROTEIN-KINASE-C | ANGIOGENESIS | PERMEABILITY | PHOSPHORYLATION | NITRIC-OXIDE SYNTHASE | CALMODULIN | CALCIUM | PAF SYNTHESIS | PHARMACOLOGY & PHARMACY | PLATELET-ACTIVATING-FACTOR | GROWTH-FACTOR | Endothelium, Vascular - cytology | Vascular Endothelial Growth Factors | Platelet Activating Factor - pharmacology | Protein-Serine-Threonine Kinases | Type C Phospholipases - metabolism | Endothelium, Vascular - drug effects | Endothelial Growth Factors - pharmacology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, Cell Surface - antagonists & inhibitors | Lactones - pharmacology | Platelet Membrane Glycoproteins - antagonists & inhibitors | Calcium - antagonists & inhibitors | Time Factors | Cattle | Protein Kinase C - metabolism | Phosphorylation - drug effects | Chromones - pharmacology | Enzyme Inhibitors - pharmacology | Nitric Oxide Synthase Type III | Receptors, G-Protein-Coupled | Chelating Agents - pharmacology | Serine - metabolism | 1-Methyl-3-isobutylxanthine - pharmacology | Ginkgolides | Platelet Activating Factor - metabolism | Cyclic GMP - metabolism | Endothelium, Vascular - metabolism | Intercellular Signaling Peptides and Proteins - pharmacology | Nitric Oxide Synthase - metabolism | Vascular Endothelial Growth Factor A | Maleimides - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - metabolism | Nitroprusside - pharmacology | Type C Phospholipases - antagonists & inhibitors | Dose-Response Relationship, Drug | Egtazic Acid - analogs & derivatives | Indoles - pharmacology | Lymphokines - pharmacology | Nitric Oxide Donors - pharmacology | Ionophores - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Proto-Oncogene Proteins - metabolism | Cells, Cultured | Morpholines - pharmacology | Protein Kinase C - antagonists & inhibitors | Calcimycin - pharmacology | Proto-Oncogene Proteins c-akt | Animals | Egtazic Acid - pharmacology | Androstadienes - pharmacology | Diterpenes | Signal Transduction - physiology | Nitric Oxide - metabolism | Papers
Journal Article
Cell Reports, ISSN 2211-1247, 09/2016, Volume 16, Issue 10, pp. 2576 - 2592
The mechanisms underlying Zika virus (ZIKV)-related microcephaly and other neurodevelopment defects remain poorly understood. Here, we describe the derivation... 
NEURAL PROGENITORS | LONG-TERM | HUMAN BRAIN | ADAPTER | CENTRAL-NERVOUS-SYSTEM | INFECTION | MICE | BINDING KINASE 1 | ORGANOIDS | INNATE IMMUNITY | CELL BIOLOGY | Neocortex - pathology | Neurons - pathology | Transcription, Genetic - drug effects | Brain - embryology | Neuroglia - ultrastructure | Neuroglia - pathology | Humans | Brain - virology | Centrosome - drug effects | Gene Expression Profiling | Microcephaly - virology | Neural Stem Cells - ultrastructure | Zika Virus Infection - virology | Neural Stem Cells - immunology | Neuroepithelial Cells - immunology | Neuroprotective Agents - pharmacology | Spinal Cord - pathology | Microcephaly - pathology | Neuroepithelial Cells - virology | Nucleosides - pharmacology | Fetus - virology | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Protein-Serine-Threonine Kinases - metabolism | Zika Virus - pathogenicity | Proto-Oncogene Proteins - metabolism | Zika Virus - ultrastructure | Neurons - virology | Virus Replication - drug effects | Neuroepithelial Cells - ultrastructure | Immunity, Innate - drug effects | Zika Virus Infection - pathology | Neural Stem Cells - virology | Zika Virus - physiology | Zika Virus - drug effects | Mitochondria - metabolism | Mitochondria - drug effects | Receptor Protein-Tyrosine Kinases - metabolism | Neural Stem Cells - enzymology | Centrosome - metabolism | Mitosis - drug effects | Brain - pathology | Protein Kinase Inhibitors - pharmacology | Neuroglia - virology | Neuroepithelial Cells - drug effects | Neurons/pathology | Zika Virus/pathogenicity | Mitochondria/metabolism | Virus Replication/drug effects | Microcephaly/pathology | Neurons/drug effects | Protein-Serine-Threonine Kinases/metabolism | Neural Stem Cells/immunology | Neuroglia/ultrastructure | Neuroepithelial Cells/drug effects | Neuroepithelial Cells/virology | Life Sciences | Brain/pathology | Zika Virus/drug effects | Brain/embryology | Mitochondria/drug effects | Fetus/virology | Neocortex/pathology | Neuroglia/pathology | Cell Death/drug effects | Mitosis/drug effects | Transcription, Genetic/drug effects | Nucleosides/pharmacology | Neural Stem Cells/enzymology | Neural Stem Cells/ultrastructure | Neuroepithelial Cells/ultrastructure | Receptor Protein-Tyrosine Kinases/metabolism | Microcephaly/virology | Proto-Oncogene Proteins/metabolism | Neuroprotective Agents/pharmacology | Zika Virus/ultrastructure | Neuroepithelial Cells/immunology | Brain/virology | Immunity, Innate/drug effects | Spinal Cord/pathology | Zika Virus/physiology | Neuroglia/virology | Microbiology and Parasitology | Zika Virus Infection/pathology | Neurons/virology | Zika Virus Infection/virology | Neural Stem Cells/virology | Centrosome/drug effects | Protein Kinase Inhibitors/pharmacology | Centrosome/metabolism | Phosphorylation/drug effects
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2012, Volume 15, Issue 5, pp. 746 - 753
Endocannabinoid mediated spike timing dependent depression (t-LTD) is crucially involved in the development of the sensory neocortex. t-LTD at excitatory... 
D-SERINE | NEUROTRANSMITTER RELEASE | INHIBITORY SYNAPSES | PYRAMIDAL CELLS | SYNAPTIC-TRANSMISSION | RAT SOMATOSENSORY CORTEX | LONG-TERM POTENTIATION | GLIAL-CELLS | PRESYNAPTIC NMDA | NEUROSCIENCES | PLASTICITY | Electric Stimulation | Rats, Wistar | Calcium - metabolism | 2-Amino-5-phosphonovalerate - pharmacology | Long-Term Synaptic Depression - drug effects | Excitatory Postsynaptic Potentials - drug effects | Piperidines - pharmacology | Time Factors | Tetrodotoxin - pharmacology | Pyrazoles - pharmacology | Animals, Newborn | Astrocytes - drug effects | Long-Term Synaptic Depression - physiology | Synapses - drug effects | Synapses - physiology | Morpholines - pharmacology | Probability | Rats | Sodium Channel Blockers - pharmacology | Synapses - ultrastructure | Excitatory Amino Acid Antagonists - pharmacology | Biophysics | Calcium Channel Blockers - pharmacology | Naphthalenes - pharmacology | Astrocytes - ultrastructure | Astrocytes - physiology | Patch-Clamp Techniques | Animals | Signal Transduction - drug effects | Benzoxazines - pharmacology | Thalamus - cytology | Neocortex - cytology | Signal Transduction - physiology | Glutamic Acid - metabolism | Receptor, Cannabinoid, CB1 - antagonists & inhibitors | Dizocilpine Maleate - pharmacology | In Vitro Techniques | Methyl aspartate | Depression, Mental | Physiological aspects | Genetic aspects | Research | Risk factors | Synapses
Journal Article
Cancer Letters, ISSN 0304-3835, 2016, Volume 383, Issue 2, pp. 309 - 317
Abstract In previous studies we demonstrated that targeting the nuclear exporter protein exportin-1 (CRM1/XPO1) by a selective inhibitor of nuclear export... 
Hematology, Oncology and Palliative Medicine | NHL | XPO1 | Selective inhibitors of nuclear export | SINE | CRM1 | Exportin-1 | SURVIVAL | DRUG-RESISTANCE | MODEL | CANCER | STRATEGIES | ONCOLOGY | LINE | CHOP | PROTEINS | Vincristine - pharmacology | TOR Serine-Threonine Kinases - metabolism | Transcription Factor RelA - antagonists & inhibitors | Apoptosis - drug effects | Humans | Lymphoma, Non-Hodgkin - enzymology | Lymphoma, Non-Hodgkin - pathology | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | TOR Serine-Threonine Kinases - antagonists & inhibitors | Dexamethasone - pharmacology | Time Factors | Oxadiazoles - pharmacology | Acrylamides - pharmacology | Lymphoma, Non-Hodgkin - drug therapy | Cell Survival - drug effects | Hydrazines - pharmacology | Everolimus - pharmacology | Mice, SCID | Mice, Inbred ICR | Drug Synergism | Triazoles - pharmacology | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Signal Transduction - drug effects | Transcription Factor RelA - metabolism | Tumor Burden - drug effects | Active Transport, Cell Nucleus - drug effects | Cyclophosphamide - pharmacology | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Prednisone - pharmacology | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Karyopherins - antagonists & inhibitors | Doxorubicin - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | International trade | Cyclophosphamide | Care and treatment | Dexamethasone | Analysis | Lymphomas | Prednisone | Exports | Steroids | Cancer | Drugs | TOR protein | Animal models | Laboratories | Toxicity | Xenotransplantation | Clinical trials | Cytotoxicity | Kinases | Experiments | Anticancer properties | Proteins | Cell growth | Antitumor agents | Cell cycle | Xenografts | Biocompatibility | Localization | Drug dosages | NF-κB protein | Chronic lymphatic leukemia | Hematology | Pharmacology | Chemical compounds | Patients | Lymphoma | Nuclear transport | Studies | Inhibitors | Response rates | In vivo methods and tests | Apoptosis
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 05/2005, Volume 25, Issue 9, pp. 3553 - 3562
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
EARLY EMBRYONIC LETHALITY | DAMAGE CHECKPOINT | CELL-DIVISION | XENOPUS EGG EXTRACTS | ACTIVATION | COMPLEX | CYCLIN-E | BIOCHEMISTRY & MOLECULAR BIOLOGY | IONIZING-RADIATION | S-PHASE CHECKPOINT | CDC25A | CELL BIOLOGY | RNA, Small Interfering - genetics | Phosphorylation | Protein Kinases - genetics | DNA Replication - drug effects | Humans | Staurosporine - analogs & derivatives | DNA-Binding Proteins - metabolism | DNA Damage - physiology | Caffeine - pharmacology | Cell Cycle Proteins - genetics | Roscovitine | Replication Protein A | Protein Kinases - pharmacology | Chromosomal Proteins, Non-Histone - metabolism | Protein-Serine-Threonine Kinases - physiology | Purines - pharmacology | DNA, Single-Stranded - metabolism | RNA, Small Interfering - pharmacology | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ataxia Telangiectasia Mutated Proteins | DNA Replication - physiology | Protein Kinases - physiology | Protein-Serine-Threonine Kinases - drug effects | Checkpoint Kinase 2 | Checkpoint Kinase 1 | Protein Kinase Inhibitors - pharmacology | Histones - metabolism | Cell Cycle Proteins - physiology | Staurosporine - pharmacology | Gene Expression | RNA; Small Interfering/genetics/pharmacology | Caffeine/pharmacology | Protein Kinases/genetics/pharmacology/physiology | Protein-Serine-Threonine Kinases/drug effects/physiology | Purines/pharmacology | Tumor Suppressor Protein p53/metabolism | DNA Replication/drug effects/physiology | DNA-Binding Proteins/metabolism | Histones/metabolism | Cell Cycle Proteins/genetics/metabolism/physiology | DNA; Single-Stranded/metabolism | Chromosomal Proteins; Non-Histone/metabolism | Protein Kinase Inhibitors/pharmacology | Staurosporine/analogs & derivatives/pharmacology | DNA Damage/physiology
Journal Article
British Journal of Cancer, ISSN 0007-0920, 05/2014, Volume 110, Issue 10, pp. 2479 - 2488
Background: Mesothelioma is a notoriously chemotherapy-resistant neoplasm, as is evident in the dismal overall survival for patients with those of... 
ACTIVATION | GROWTH-FACTOR-RECEPTOR | FACTOR SCATTER FACTOR | MALIGNANT PLEURAL MESOTHELIOMA | PHASE-II | tyrosine kinases | ANTITUMOR-ACTIVITY | MET RECEPTOR | PI3K/AKT/MDM2 | PI3K/AKT/mTOR | INHIBITION | ONCOLOGY | C-MET | mesothelioma | Mesothelioma - pathology | Nitriles - pharmacology | Humans | Neoplasm Proteins - physiology | Receptor Protein-Tyrosine Kinases - physiology | Neoplasm Proteins - antagonists & inhibitors | Molecular Targeted Therapy | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | MAP Kinase Signaling System | TOR Serine-Threonine Kinases - antagonists & inhibitors | raf Kinases - physiology | RNA Interference | TOR Serine-Threonine Kinases - physiology | Antineoplastic Agents - pharmacology | Chromones - pharmacology | Everolimus | Butadienes - pharmacology | Sirolimus - analogs & derivatives | RNA, Small Interfering - pharmacology | Morpholines - pharmacology | Imidazoles - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Sirolimus - pharmacology | Indazoles - pharmacology | Signal Transduction - drug effects | Mesothelioma - enzymology | Cell Line, Tumor | Phosphatidylinositol 3-Kinases - physiology | Protein Kinase Inhibitors - pharmacology | Cell Cycle - drug effects | Drug Screening Assays, Antitumor | Translational Therapeutics | PI3K | mTOR | MDM2 | AKT
Journal Article
Journal Article