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animals (80) 80
index medicus (67) 67
mice (45) 45
humans (43) 43
serine c-palmitoyltransferase - genetics (43) 43
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serine c-palmitoyltransferase - metabolism (38) 38
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sphingolipids - biosynthesis (17) 17
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acyltransferases - metabolism (14) 14
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hereditary sensory and autonomic neuropathies - genetics (10) 10
insulin resistance (10) 10
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1. Full Text Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis
by Li, Zhiqiang and Kabir, Inamul and Jiang, Hui and Zhou, Hongwen and Libien, Jenny and Zeng, Jianying and Stanek, Albert and Ou, Peiqi and Li, Kailyn R and Zhang, Shane and Bui, Hai H and Kuo, Ming‐Shang and Park, Tae‐Sik and Kim, Benjamin and Worgall, Tilla S and Huan, Chongmin and Jiang, Xian‐Cheng
Hepatology, ISSN 0270-9139, 12/2016, Volume 64, Issue 6, pp. 2089 - 2102
Serine palmitoyltransferase is the key enzyme in sphingolipid biosynthesis. Mice lacking serine palmitoyltransferase are embryonic lethal. We prepared... 
PALMITOYL-COA TRANSFERASE | CELL-CELL JUNCTIONS | SPHINGOLIPID METABOLISM | COLON-CANCER | PARTIAL-HEPATECTOMY | CHARACTERIZING OBSTRUCTIVE-JAUNDICE | MICE | BETA-CATENIN | GASTROENTEROLOGY & HEPATOLOGY | HEREDITARY SENSORY NEUROPATHY | N-CADHERIN | Serine C-Palmitoyltransferase - deficiency | Animals | Liver - enzymology | Age Factors | Adherens Junctions - physiology | Mice | Carcinogenesis | Rodents | Tumorigenesis | β-catenin | Sphingomyelin | Adherens junctions | Lipid rafts | Cell polarity | Sptlc2 liver-specific knockout mice | Cadherin | Albumin-Cre recombinase
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2. Full Text Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1
by Garofalo, Kevin and Penno, Anke and Schmidt, Brian P and Lee, Ho-Joon and Frosch, Matthew P and Von Eckardstein, Arnold and Brown, Robert H and Hornemann, Thorsten and Eichler, Florian S
Journal of Clinical Investigation, ISSN 0021-9738, 12/2011, Volume 121, Issue 12, pp. 4735 - 4745
Hereditary sensory and autonomic neuropathy type 1 (HSAN1) causes sensory loss that predominantly affects the lower limbs, often preceded by hyperpathia and... 
SPHINGOLIPID METABOLISM | MEDICINE, RESEARCH & EXPERIMENTAL | SPTLC1 | PALMITOYLTRANSFERASE | CERAMIDE SYNTHASE | DISEASE | HSAN-I | MUTATIONS | ACCUMULATION | INHIBITOR | DEFICIENCY
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3. Full Text Regulation of plasma cholesterol esterification by sphingomyelin: Effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity
by Subbaiah, Papasani Venkata and Jiang, Xian-Cheng and Belikova, Natalia A and Aizezi, Buzulagu and Huang, Zhi Hua and Reardon, Catherine A
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 06/2012, Volume 1821, Issue 6, pp. 908 - 913
Although sphingomyelin (SM) is the most abundant phospholipid in the plasma, next to phosphatidylcholine (PC), its physiological function in plasma is unclear.... 
LDL receptor deficient mouse | Apo E deficient mouse | Sphingomyelin synthase 2 deficiency | Serine palmitoyl transferase deficiency | Cholesteryl ester composition | LCAT activity | ACTIVATION | FATTY-ACID SPECIFICITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ARACHIDONIC-ACID | DEFICIENCY | CELL BIOLOGY | BIOPHYSICS | RISK-FACTOR | METABOLISM | SUBSTRATE | ESTERS | MODULATION | HIGH-DENSITY-LIPOPROTEINS | Cholesterol Esters - metabolism | Apolipoproteins E - deficiency | Transferases (Other Substituted Phosphate Groups) - genetics | Cholesterol - blood | Substrate Specificity | Serine C-Palmitoyltransferase - genetics | Phosphatidylcholines - metabolism | Apolipoproteins E - metabolism | Cholesterol Esters - blood | Transferases (Other Substituted Phosphate Groups) - metabolism | Lipids - blood | Mass Spectrometry | Receptors, LDL - deficiency | Transferases (Other Substituted Phosphate Groups) - deficiency | Receptors, LDL - genetics | Serine C-Palmitoyltransferase - deficiency | Phosphatidylcholines - blood | Sphingomyelins - metabolism | Mice, Inbred C57BL | Receptors, LDL - metabolism | Serine C-Palmitoyltransferase - metabolism | Cholesterol - metabolism | Esterification | Mice, Knockout | Animals | Apolipoproteins E - genetics | Sphingomyelins - blood | Mice | Phosphatidylcholine-Sterol O-Acyltransferase - metabolism | Phosphatidylcholine-Sterol O-Acyltransferase - blood | Lecithin | Laws, regulations and rules | Analysis | Low density lipoproteins | Physiological aspects | Genetic research | Esters | Phospholipids | Plant lipids | Cholesterol
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4. Full Text Sphingolipids modulate the function of human serotonin 1A receptors: Insights from sphingolipid-deficient cells
by Jafurulla, Md and Bandari, Suman and Pucadyil, Thomas J and Chattopadhyay, Amitabha
Biochimica et biophysica acta. Biomembranes, ISSN 0005-2736, 04/2017, Volume 1859, Issue 4, pp. 598 - 604
Sphingolipids are essential components of eukaryotic cell membranes and are known to modulate a variety of cellular functions. It is becoming increasingly... 
Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology | Cricetulus | Humans | Receptor, Serotonin, 5-HT1A - genetics | Serotonin 5-HT1 Receptor Agonists - pharmacology | Serine C-Palmitoyltransferase - genetics | Gene Deletion | Cell Membrane - metabolism | Sphingosine - metabolism | 8-Hydroxy-2-(di-n-propylamino)tetralin - metabolism | Cell Membrane - drug effects | Genes, Reporter | Receptor, Serotonin, 5-HT1A - metabolism | CHO Cells | Serine C-Palmitoyltransferase - deficiency | Signal Transduction | Bacterial Proteins - genetics | Gene Expression Regulation | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Serotonin 5-HT1 Receptor Agonists - metabolism | Sphingosine - pharmacology | Guanosine 5'-O-(3-Thiotriphosphate) - metabolism | Animals | Membrane Lipids - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Kinetics | Luminescent Proteins - metabolism
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5. Full Text Redirection of sphingolipid metabolism toward de novo synthesis of ethanolamine in Leishmania
by Pompey, Justine M and Saba, Julie D and Key, Phillip and Beverley, Stephen M and Bandhuvula, Padmavathi and Hsu, Fong-Fu and Zhang, Kai and Turk, John
The EMBO Journal, ISSN 0261-4189, 02/2007, Volume 26, Issue 4, pp. 1094 - 1104
In most eukaryotes, sphingolipids (SLs) are critical membrane components and signaling molecules. However, mutants of the trypanosomatid protozoan Leishmania... 
metacyclogenesis | sphingosine‐1‐phosphate lyase | phosphatidylethanolamine | virulence | sphingolipid | Sphingolipid | Phosphatidylethanolamine | Sphingosine-1- phosphate lyase | Virulence | Metacyclogenesis | TRYPANOSOMA-BRUCEI | BIOCHEMISTRY & MOLECULAR BIOLOGY | PARASITIC PROTOZOA | ANCHORED PROTEINS | PLASMA-MEMBRANE | CELL BIOLOGY | YEAST SACCHAROMYCES-CEREVISIAE | SIGNAL-TRANSDUCTION | PHOSPHATIDYLSERINE DECARBOXYLASE | sphingosine-1-phosphate lyase | SURFACE-COAT | LIPID RAFTS | Aldehyde-Lyases - deficiency | Leishmania major - genetics | Molecular Sequence Data | Serine C-Palmitoyltransferase - genetics | Biosynthetic Pathways - genetics | Base Sequence | Mass Spectrometry | Cloning, Molecular | Leishmania major - pathogenicity | Female | Aldehyde-Lyases - genetics | Foot - pathology | Microscopy, Electron, Transmission | Serine C-Palmitoyltransferase - deficiency | Ethanolamine - metabolism | Sphingolipids - metabolism | Leishmania major - ultrastructure | Mutation - genetics | Foot - microbiology | Sequence Analysis, DNA | Biological Evolution | Metabolic Networks and Pathways - genetics | Animals | Leishmania major - metabolism | Mice | Mice, Inbred BALB C | Signal transduction | Molecules | Eukaryotes | Membranes | Mutation
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6. Full Text Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression
by Ruangsiriluk, Wanida and Grosskurth, Shaun E and Ziemek, Daniel and Kuhn, Max and Des Etages, Shelley G and Francone, Omar L
Journal of Lipid Research, ISSN 0022-2275, 08/2012, Volume 53, Issue 8, pp. 1459 - 1471
Dysregulation of ceramide synthesis has been associated with metabolic disorders such as atherosclerosis and diabetes. We examined the changes in lipid... 
Dihydroceramide desaturase | Human hepatocytes | apoB secretion | Ceramide | Sphingolipids | Microarray | Lipidomic | Serine palmitoyl transferase | LDL receptor | human hepatocytes | LIVER INFLAMMATION | OXIDATIVE STRESS | CHOLESTEROL | sphingolipids | BIOCHEMISTRY & MOLECULAR BIOLOGY | serine palmitoyl transferase | DIHYDROCERAMIDE DESATURASE ACTIVITY | DEFICIENT MICE | dihydroceramide desaturase | MAMMALIAN SERINE-PALMITOYLTRANSFERASE | KNOCKOUT MICE | INDUCED INSULIN-RESISTANCE | lipidomic | ceramide | microarray | DISEASE | Cell Line | Serine C-Palmitoyltransferase - deficiency | Ceramides - metabolism | Oxidoreductases - genetics | Humans | Gene Silencing | Serine C-Palmitoyltransferase - genetics | Transcriptome - genetics | Ceramides - biosynthesis | Gene Knockdown Techniques | Gene Expression Regulation, Enzymologic - genetics | Cell Line, Tumor | Transcription, Genetic - genetics | Oxidoreductases - deficiency | Homeostasis - genetics
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7. Full Text Liver-specific Deficiency of Serine Palmitoyltransferase Subunit 2 Decreases Plasma Sphingomyelin and Increases Apolipoprotein E Levels
by Zhiqiang Li and Yan Li and Mahua Chakraborty and Yifan Fan and Hai H. Bui and David A. Peake and Ming-Shang Kuo and Xiao Xiao and Guoqing Cao and Xian-Cheng Jiang
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 39, pp. 27010 - 27019
Sphingomyelin (SM) is one of the major lipid components of plasma lipoproteins. Serine palmitoyltransferase (SPT) is the key enzyme in SM biosynthesis. Mice... 
PALMITOYL-COA TRANSFERASE | LIPID EMULSIONS | RICH MEMBRANE RAFTS | ATHEROGENIC LIPOPROTEINS | RISK-FACTOR | SPHINGOLIPID SYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHOLESTEROL ACYLTRANSFERASE REACTION | MICE | CORONARY-ARTERY-DISEASE | HIGH-DENSITY-LIPOPROTEINS | Immunohistochemistry | Serine C-Palmitoyltransferase - deficiency | Liver - enzymology | Liver - metabolism | Cells, Cultured | Serine C-Palmitoyltransferase - genetics | Chromatography, High Pressure Liquid | Hepatocytes - metabolism | Lipoproteins - blood | Serine C-Palmitoyltransferase - metabolism | Cholesterol - metabolism | Blotting, Western | Mice, Knockout | Hepatocytes - cytology | Macrophages - metabolism | Animals | Apolipoproteins E - blood | Lipids - blood | Mass Spectrometry | Sphingomyelins - blood | Cell Membrane - metabolism | Liver - cytology | Mice | Lipids and Lipoproteins | Metabolism, Regulation, and Signaling
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8. Full Text The Variant p.(Arg183Trp) in SPTLC2 Causes Late-Onset Hereditary Sensory Neuropathy
by Suriyanarayanan, Saranya and Suriyanarayanan, Saranya and Auranen, Mari and Auranen, Mari and Toppila, Jussi and Toppila, Jussi and Paetau, Anders and Paetau, Anders and Shcherbii, Maria and Shcherbii, Maria and Palin, Eino and Palin, Eino and Wei, Yu and Wei, Yu and Lohioja, Tarja and Lohioja, Tarja and Schlotter-Weigel, Beate and Schlotter-Weigel, Beate and Schön, Ulrike and Schön, Ulrike and Abicht, Angela and Abicht, Angela and Rautenstrauss, Bernd and Rautenstrauss, Bernd and Tyynismaa, Henna and Tyynismaa, Henna and Walter, Maggie C and Walter, Maggie C and Hornemann, Thorsten and Hornemann, Thorsten and Ylikallio, Emil and Ylikallio, Emil
NeuroMolecular Medicine, ISSN 1535-1084, 3/2016, Volume 18, Issue 1, pp. 81 - 90
Hereditary sensory and autonomic neuropathy 1 (HSAN1) is an autosomal dominant disorder that can be caused by variants in SPTLC1 or SPTLC2, encoding subunits... 
Neurology | Neurosciences | Biomedicine | Hereditary sensory autonomic neuropathy | Sphingolipid | Internal Medicine | Neuropathy | Serine palmitoyl-CoA transferase | BIOMARKERS | DEOXYSPHINGOLIPIDS | SERINE PALMITOYLTRANSFERASE | GENETIC-VARIANTS | MUTATIONS | TYPE-1 | NEUROSCIENCES | Haplotypes | Amino Acid Sequence | Serine C-Palmitoyltransferase - deficiency | Humans | Middle Aged | Small Fiber Neuropathy - genetics | Late Onset Disorders - genetics | Molecular Sequence Data | Substrate Specificity | Male | Serine C-Palmitoyltransferase - genetics | Mutation, Missense | Serine C-Palmitoyltransferase - metabolism | Sphingolipids - blood | Genes, Dominant | Pedigree | Axons - pathology | Age of Onset | Finland | Female | Hereditary Sensory and Autonomic Neuropathies - genetics | Aged | Germany | Amino Acid Substitution | Amino acids | Resveratrol | Index Medicus
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9. Analysis of development of lesions in mice with serine palmitoyltransferase (SPT) deficiency -Sptlc2 conditional knockout mice
by Ohta, Etsuko and Ohira, Takashi and Matsue, Kenta and Ikeda, Yuika and Fujii, Kenji and Ohwaki, Kenji and Osuka, Sou and Hirabayashi, Yoshio and Sasaki, Minoru
Experimental animals, 10/2009, Volume 58, Issue 5, p. 515
Serine palmitoyltransferase (SPT) is the enzyme which catalyzes the first step of the biosynthesis of sphingolipids. However, the precise roles of SPT in vivo... 
Sphingolipids - biosynthesis | Cell Proliferation | Intestine, Small - pathology | Serine C-Palmitoyltransferase - physiology | Cell Count | Male | Necrosis | Atrophy | Hematopoiesis | Organ Size - genetics | Thymus Gland - pathology | Female | Reticulocytes - pathology | Spleen - pathology | Serine C-Palmitoyltransferase - deficiency | Mice, Knockout | Lymphoid Tissue - pathology | Lymphocytes - pathology | Animals | Sphingolipids - genetics | Intestine, Large - pathology | Tamoxifen - pharmacology | Mice | Chimera | Intestinal Mucosa - pathology
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10. Full Text Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1
by Garofalo, Kevin and Penno, Anke and Schmidt, Brian P and Lee, Ho-Joon and Frosch, Matthew P and von Eckardstein, Arnold and Brown, Robert H and Hornemann, Thorsten and Eichler, Florian S
The Journal of clinical investigation, 12/2011, Volume 121, Issue 12, p. 4735
Hereditary sensory and autonomic neuropathy type 1 (HSAN1) causes sensory loss that predominantly affects the lower limbs, often preceded by hyperpathia and... 
Infertility, Male - drug therapy | Stereoisomerism | Humans | Middle Aged | Depression, Chemical | Lipids | Male | Serine C-Palmitoyltransferase - genetics | Mutation, Missense | Dose-Response Relationship, Drug | Young Adult | Infertility, Male - genetics | Pain Perception - drug effects | Hereditary Sensory and Autonomic Neuropathies - metabolism | Adult | Female | Sciatic Nerve - drug effects | Serine C-Palmitoyltransferase - deficiency | Alanine - toxicity | Administration, Oral | Sciatic Nerve - pathology | Mice, Transgenic | Sphingolipids - metabolism | Psychomotor Performance - drug effects | Serine - chemistry | Point Mutation | Pilot Projects | Serine - administration & dosage | Sphingosine - analogs & derivatives | Animals | Hereditary Sensory and Autonomic Neuropathies - drug therapy | Neurotoxins - biosynthesis | Sphingosine - biosynthesis | Hereditary Sensory and Autonomic Neuropathies - genetics | Aged | Mice | Serine - therapeutic use
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11. Full Text Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection
by Orchard, Robert C and Wilen, Craig B and Virgin, Herbert W
Nature Microbiology, ISSN 2058-5276, 10/2018, Volume 3, Issue 10, pp. 1109 - 1114
Cellular susceptibility to viral infections is in part determined by the presence of a host cellular receptor. Here we use murine norovirus as a model to... 
CELLS | RESPONSES | DOMAIN | VIRUS | REPLICATION | ENTRY | SUSCEPTIBILITY | MICROBIOLOGY | CERAMIDE | GASTROENTERITIS | Norovirus - physiology | Sphingolipids - biosynthesis | Cell Line | Serine C-Palmitoyltransferase - deficiency | Receptors, Immunologic - chemistry | Caliciviridae Infections - virology | Receptors, Virus - metabolism | Humans | Protein Conformation - drug effects | Sphingolipids - metabolism | Ceramides - chemistry | Serine C-Palmitoyltransferase - genetics | Ceramides - pharmacology | Virus Attachment - drug effects | Host-Pathogen Interactions | Animals | Receptors, Virus - chemistry | Caliciviridae Infections - metabolism | Cell Membrane - metabolism | Mice | Viral Tropism | Receptors, Immunologic - metabolism | Tropism | Serine palmitoyltransferase | Serine | Ceramide | Infections | Biosynthesis | Intracellular | Palmitoyltransferase | Cell surface | Viral infections | Conformation
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12. Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice
by Hojjati, Mohammad Reza and Li, Zhiqiang and Jiang, Xian-Cheng
Biochimica et biophysica acta, ISSN 0006-3002, 10/2005, Volume 1737, Issue 1, p. 44
Sphingolipids play a very important role in cell membrane formation, signal transduction, and plasma lipoprotein metabolism, and all these functions may have... 
Serine C-Palmitoyltransferase - deficiency | Liver - enzymology | Sphingomyelins - metabolism | Liver - metabolism | Mice, Inbred C57BL | Ceramides - blood | Male | Sphingolipids - metabolism | Sphingolipids - blood | Animals | Female | Heterozygote | Mice | Genetic Vectors | Serine C-Palmitoyltransferase - biosynthesis | Chimera
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13. Full Text Adipocyte-specific deficiency of de novo sphingolipid biosynthesis leads to lipodystrophy and insulin resistance
by Lee, Su-Yeon and Lee, Hui-Young and Song, Jae-Hwi and Kim, Goon-Tae and Jeon, Suwon and Song, Yoo-Jeong and Lee, Jae Sung and Hur, Jang-Ho and Oh, Hyun Hee and Park, Shi-Young and Shim, Soon-Mi and Yoo, Hyun Joo and Lee, Byung Cheon and Jiang, Xian-Cheng and Choi, Cheol Soo and Park, Tae-Sik
Diabetes, ISSN 0012-1797, 10/2017, Volume 66, Issue 10, pp. 2596 - 2609
Sphingolipids have been implicated in the etiology of chronic metabolic diseases. Here, we investigated whether sphingolipid biosynthesis is associated with... 
METABOLIC SYNDROME | FATTY LIVER-DISEASE | SERINE PALMITOYLTRANSFERASE | IN-VIVO | ENDOCRINOLOGY & METABOLISM | PPAR-GAMMA | CONGENITAL GENERALIZED LIPODYSTROPHY | KNOCKOUT MICE | HEPATIC STEATOSIS | SPHINGOSINE KINASE | ADIPOSE-TISSUE | Lysophospholipids - metabolism | Adipose Tissue - cytology | Adipocytes - cytology | Male | Serine C-Palmitoyltransferase - genetics | Lipodystrophy - etiology | Adipogenesis - physiology | Adipose Tissue - metabolism | Cell Differentiation - genetics | Insulin Resistance - physiology | Sphingosine - metabolism | Adipogenesis - genetics | Cell Differentiation - physiology | Sterol Regulatory Element Binding Protein 1 - metabolism | Cell Proliferation - genetics | Cell Proliferation - physiology | Lipodystrophy - metabolism | Serine C-Palmitoyltransferase - metabolism | Mice, Knockout | Sphingosine - analogs & derivatives | Animals | Sterol Regulatory Element Binding Protein 1 - genetics | Adipocytes - metabolism | Insulin Resistance - genetics | Mice | Obesity | Fat cells | Synthesis | Insulin resistance | Lipodystrophy | Reports | Lipids | Sphingolipids | Research
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14. Full Text Barrier Abnormality Due to Ceramide Deficiency Leads to Psoriasiform Inflammation in a Mouse Model
by Nakajima, Kimiko and Terao, Mika and Takaishi, Mikiro and Kataoka, Sayo and Goto-Inoue, Naoko and Setou, Mitsutoshi and Horie, Kyoji and Sakamoto, Fumiko and Ito, Masaaki and Azukizawa, Hiroaki and Kitaba, Shun and Murota, Hiroyuki and Itami, Satoshi and Katayama, Ichiro and Takeda, Junji and Sano, Shigetoshi
Journal of Investigative Dermatology, ISSN 0022-202X, 11/2013, Volume 133, Issue 11, pp. 2555 - 2565
It has been recognized that ceramides are decreased in the epidermis of patients with psoriasis and atopic dermatitis. Here, we generated Sptlc2 (serine... 
ATOPIC-DERMATITIS | SERINE PALMITOYLTRANSFERASE | STRATUM-CORNEUM | DELTA T-CELLS | PALMITOYL TRANSFERASE-ACTIVITY | CYTOKINE | SKIN | PERMEABILITY BARRIER | IDENTIFICATION | EPIDERMAL SPHINGOLIPID SYNTHESIS | DERMATOLOGY | Langerhans Cells - pathology | Dermatitis - immunology | Humans | Male | Serine C-Palmitoyltransferase - genetics | Interleukins - metabolism | Interleukin-23 - genetics | Interleukins - genetics | Interleukin-23 - metabolism | Psoriasis - pathology | T-Lymphocytes - metabolism | Langerhans Cells - immunology | Psoriasis - metabolism | Female | T-Lymphocytes - pathology | Disease Models, Animal | Psoriasis - immunology | Epidermis - metabolism | Epidermis - pathology | Water - metabolism | Ceramides - deficiency | Serine C-Palmitoyltransferase - metabolism | Mice, Knockout | Dermatitis - pathology | Interleukin-17 - metabolism | Keratinocytes - pathology | Animals | Keratinocytes - metabolism | T-Lymphocytes - immunology | Mice | Langerhans Cells - metabolism | Dermatitis - metabolism
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15. Full Text Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction
by Lee, Su-Yeon and Kim, Jung Ran and Hu, Yunying and Khan, Raffay and Kim, Su-Jung and Bharadwaj, Kalyani G and Davidson, Mercy M and Choi, Cheol-Soo and Shin, Kyong-Oh and Lee, Yong-Moon and Park, Woo-Jin and Park, In-Sun and Jiang, Xian-Cheng and Goldberg, Ira J and Park, Tae-Sik
Journal of Biological Chemistry, ISSN 0021-9258, 05/2012, Volume 287, Issue 22, pp. 18429 - 18439
The role of serine palmitoyltransferase (SPT) and de novo ceramide biosynthesis in cardiac ceramide and sphingomyelin metabolism is unclear. To determine... 
PALMITOYL-COA TRANSFERASE | SPHINGOLIPID METABOLISM | SYNTHASE 2 | ACTIVATION | INSULIN-RESISTANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HEART-FAILURE | IN-VIVO | SPHINGOMYELIN | KEY ENZYME | FATTY-ACIDS | Heart - physiopathology | In Situ Nick-End Labeling | Ceramides - metabolism | Mice, Inbred C57BL | Cells, Cultured | Serine C-Palmitoyltransferase - genetics | Serine C-Palmitoyltransferase - metabolism | Blotting, Western | Mice, Knockout | Myocardium - enzymology | Animals | Lipids - blood | Mice | Blood Glucose - metabolism | Ceramide | Heart Failure | Phospholipid | Sphingolipid | Lipids | Fatty Acid
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