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Journal of Cell Biology, ISSN 0021-9525, 07/2017, Volume 216, Issue 7, pp. 2027 - 2045
Mitochondrial stress activates a mitonuclear response to safeguard and repair mitochondrial function and to adapt cellular metabolism to stress. Using a... 
CELLS | TRANSLATIONAL REGULATION | ACTIVATION | UNFOLDED PROTEIN RESPONSE | DIFFERENTIAL EXPRESSION | INHIBITION | INDUCED LONGEVITY | DEPENDENT LON PROTEASE | ER-STRESS | C-ELEGANS | CELL BIOLOGY | Mitochondrial Diseases - pathology | Epigenesis, Genetic | Humans | Mitochondrial Diseases - metabolism | Stress, Physiological | Transcriptome | Mitochondrial Proteins - genetics | Gene Regulatory Networks | Protein Interaction Maps | Ribosomal Proteins - metabolism | Transfection | Time Factors | Mitochondrial Proteins - metabolism | Proteolysis | Membrane Potential, Mitochondrial | Serine Endopeptidases - genetics | Proteomics - methods | Genomics - methods | Disease Models, Animal | Mitochondrial Diseases - genetics | Genetic Predisposition to Disease | Signal Transduction | Ribosomal Proteins - genetics | Computational Biology | Gene Expression Regulation | Activating Transcription Factor 4 - genetics | Endopeptidase Clp - genetics | Proteome | Endopeptidase Clp - metabolism | Mitochondria - metabolism | Mitochondria - pathology | High-Temperature Requirement A Serine Peptidase 2 | Mice, Knockout | Phenotype | Animals | Activating Transcription Factor 4 - metabolism | Energy Metabolism | Mice | Serine Endopeptidases - metabolism | HeLa Cells | Proteasome Endopeptidase Complex - metabolism | Genetic research | Physiological aspects | Gene expression | Analysis | Cells | Stresses | Regulators | Genes | Activating transcription factor 4 | Activation | Mammals | Metabolism | Mammalian cells | Proteins | Quantitative trait loci | Mitochondria | Ribosomal proteins | Cellular communication | Protein folding | Rodents | Stress response | Index Medicus | 19 | s | 47 | 29
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 08/2014, Volume 20, Issue 16, pp. 4262 - 4273
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2015, Volume 34, Issue 3, pp. 307 - 325
The protein kinase PINK 1 was recently shown to phosphorylate ubiquitin (Ub) on Ser65, and phosphoUb activates the E3 ligase Parkin allosterically. Here, we... 
PINK1 | phosphorylation | deubiquitinase | ubiquitin | Parkin | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | 63-LINKED POLYUBIQUITIN CHAINS | DAMAGED MITOCHONDRIA | CELL BIOLOGY | E3 LIGASE | ACTIVATE PARKIN | BINDING PROTEINS | CROSS-REACTIVITY | CONJUGATING ENZYME | REVEALS | Phosphorylation - physiology | Ubiquitin-Specific Proteases - genetics | Humans | Endosomal Sorting Complexes Required for Transport - genetics | Mitochondrial Proteins - genetics | Phosphoproteins - metabolism | Polyubiquitin - genetics | Allosteric Regulation - physiology | Mitochondrial Proteins - metabolism | Protein Multimerization - physiology | Ubiquitin Thiolesterase - metabolism | TNF Receptor-Associated Factor 6 - genetics | Ubiquitination - physiology | Ubiquitin-Specific Proteases - metabolism | Polyubiquitin - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin-Protein Ligases - metabolism | Serine - genetics | Ubiquitin-Conjugating Enzymes - genetics | Phosphoproteins - genetics | Transcription Factors - genetics | Ubiquitin Thiolesterase - genetics | Serine - metabolism | Hydrolysis | Transcription Factors - metabolism | Endopeptidases - genetics | Ubiquitin-Conjugating Enzymes - metabolism | Adaptor Proteins, Signal Transducing - genetics | TNF Receptor-Associated Factor 6 - metabolism | Thiolester Hydrolases - genetics | Thiolester Hydrolases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Ubiquitin-Protein Ligases - genetics | Enzymes | Phosphorylation | Kinases | Crystal structure | Index Medicus
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 03/2008, Volume 4, Issue 3, pp. 203 - 213
Newly replicated Plasmodium falciparum parasites escape from host erythrocytes through a tightly regulated process that is mediated by multiple classes of... 
CYSTEINE PROTEASE | PARASITOPHOROUS VACUOLE | VINYL SULFONES | STREPTOLYSIN-O | MEROZOITES | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL INVASION | I CATHEPSIN-C | SERINE-PROTEASE | SUBTILISIN-LIKE PROTEASE-1 | ANTIGEN | Cysteine Endopeptidases - chemistry | Plasmodium falciparum - enzymology | Parasitic Sensitivity Tests | Protozoan Proteins - antagonists & inhibitors | Stereoisomerism | Humans | Molecular Conformation | Subtilisins - chemistry | Plasmodium falciparum - drug effects | Cysteine Endopeptidases - drug effects | Sulfones - pharmacology | Serine Endopeptidases - drug effects | Dose-Response Relationship, Drug | Antigens, Protozoan - metabolism | Protease Inhibitors - pharmacology | Antigens, Protozoan - drug effects | Cysteine Endopeptidases - metabolism | Protozoan Proteins - metabolism | Isocoumarins - pharmacology | Sulfones - chemistry | Malaria, Falciparum - metabolism | Protozoan Proteins - chemistry | Subtilisins - metabolism | Plasmodium falciparum - physiology | Peptides - chemistry | Protease Inhibitors - chemistry | Serine Endopeptidases - chemistry | Subtilisins - antagonists & inhibitors | Peptides - pharmacology | Host-Parasite Interactions - drug effects | Malaria, Falciparum - parasitology | Animals | Small Molecule Libraries | Erythrocytes - metabolism | Serine Endopeptidases - metabolism | Erythrocytes - parasitology | Isocoumarins - chemistry | Biochemistry | Biomedical research | Parasites | Malaria | Proteases | Erythrocytes | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 03/2012, Volume 366, Issue 12, pp. 1108 - 1118
A monoclonal antibody to PCSK9 was studied in two single-dose trials in healthy volunteers and one multiple-dose trial in patients with familial or nonfamilial... 
POPULATION | MEDICINE, GENERAL & INTERNAL | STATIN | MICE | MUTATIONS | Proprotein Convertases - antagonists & inhibitors | Injections, Intravenous | Heptanoic Acids - therapeutic use | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Injections, Subcutaneous | Serine Endopeptidases - immunology | Adult | Cholesterol, LDL - blood | Female | Hyperlipoproteinemia Type II - drug therapy | Drug Therapy, Combination | Pyrroles - therapeutic use | Proprotein Convertases - metabolism | Receptors, LDL - metabolism | Lipoproteins - blood | Anticholesteremic Agents - adverse effects | Proprotein Convertases - immunology | Hyperlipoproteinemia Type II - metabolism | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Least-Squares Analysis | Serine Endopeptidases - metabolism | Receptors, LDL - drug effects | Hypercholesterolemia - metabolism | Proprotein Convertase 9 | Drugs | Dose-response relationship (Biochemistry) | Hypercholesterolemia | Monoclonal antibodies | Cholesterol, LDL | Dosage and administration | Product/Service Evaluations | Research | Drug therapy | Health aspects | Studies | Lipoproteins (low density) | Kexin | Serine | Atorvastatin | Cardiovascular disease | Subtilisin | Low density lipoprotein | Cholesterol | Index Medicus | Abridged Index Medicus
Journal Article
Science, ISSN 0036-8075, 11/2012, Volume 338, Issue 6108, pp. 818 - 822
Journal Article
Science, ISSN 0036-8075, 5/2008, Volume 320, Issue 5879, pp. 1088 - 1092
Journal Article
Nature, ISSN 0028-0836, 08/2010, Volume 466, Issue 7309, pp. 941 - 946
DNA double-strand breaks (DSBs) pose a potent threat to genome integrity. These lesions also contribute to the efficacy of radiotherapy and many cancer... 
REPAIR PROTEINS | COMPLEX | ENZYME | SPECIFICITY | STRUCTURAL BASIS | MULTIDISCIPLINARY SCIENCES | DOUBLE-STRAND BREAKS | CHAINS | MAMMALIAN-CELLS | BINDING | STATISTICAL-MODEL | Chromatin - metabolism | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | DNA Repair - physiology | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - antagonists & inhibitors | DNA Breaks, Double-Stranded | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Cysteine Endopeptidases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cysteine Endopeptidases - deficiency | Ubiquitination - physiology | Protein-Serine-Threonine Kinases - metabolism | Chromatin - chemistry | Cell Line | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Ubiquitin - genetics | Ataxia Telangiectasia Mutated Proteins | Ubiquitin-Conjugating Enzymes - metabolism | Cysteine Endopeptidases - genetics | Cell Line, Tumor | Protein Binding | Ubiquitin-Conjugating Enzymes - antagonists & inhibitors | Ubiquitin-Protein Ligases - genetics | Ubiquitin | Amino acids | Genetic aspects | Models | Chemical properties | DNA damage | Proteins | Enzymes | Genetics | Mutation | DNA repair | Index Medicus
Journal Article