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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2012, Volume 340, Issue 2, pp. 228 - 236
Proprotein convertase substilisin/kexin type 9 (PCSK9) promotes the degradation of low-density lipoprotein (LDL) receptor (LDLR) and thereby increases serum... 
LDL CHOLESTEROL | FAMILIAL HYPERCHOLESTEROLEMIA | PLASMA-CHOLESTEROL | GENE | IN-VIVO | RECEPTOR | DEGRADATION | PHARMACOLOGY & PHARMACY | MICE | SUBTILISIN/KEXIN TYPE-9 | SECRETED PCSK9 | Cholesterol, Dietary - administration & dosage | Cholesterol - blood | Macaca fascicularis | Male | Simvastatin - pharmacology | Epitopes - immunology | Fluorobenzenes - pharmacology | Liver - drug effects | Cholesterol, Dietary - pharmacology | Dietary Fats - administration & dosage | Serine Endopeptidases - immunology | Liver - metabolism | Models, Molecular | Receptors, LDL - metabolism | Rosuvastatin Calcium | Cholesterol, LDL - drug effects | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Mice, Knockout | Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Cell Line, Tumor | Cholesterol, HDL - blood | Mice | Proprotein Convertase 9 | Proprotein Convertases - antagonists & inhibitors | Simvastatin - therapeutic use | Serine Endopeptidases - pharmacology | Hypercholesterolemia - drug therapy | Dose-Response Relationship, Drug | Dietary Fats - pharmacology | Antibodies, Monoclonal, Humanized - pharmacology | Primates | Proprotein Convertases - pharmacology | Cholesterol, LDL - blood | Female | Antibodies, Monoclonal, Humanized - adverse effects | Hypercholesterolemia - blood | Antibodies, Monoclonal, Humanized - therapeutic use | Cholesterol, HDL - drug effects | Mice, Inbred C57BL | Proprotein Convertases - immunology | Drug Therapy, Combination - methods | Animals | Sulfonamides - therapeutic use | Pyrimidines - therapeutic use | Serine Endopeptidases - blood | Hypercholesterolemia - chemically induced | Antibodies, Monoclonal, Humanized - immunology | Catalytic Domain - immunology | Fluorobenzenes - therapeutic use
Journal Article
Journal of Bioscience and Bioengineering, ISSN 1389-1723, 06/2016, Volume 121, Issue 6, pp. 614 - 618
A rhizosphere strain of the bacterium N4 secretes the serine protease PN4, whose molecular mass is approximately 42 kDa. The optimal temperature for the enzyme... 
Stenotrophomonas maltophilia | Serine protease | Nematocidal activity | Biocontrol | FOOD SCIENCE & TECHNOLOGY | BREVIBACILLUS-LATEROSPORUS G4 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | NEMATODES | ENZYMES | PURIFICATION | PATHOGENIC FACTOR | SERINE-PROTEASE | CHITINASE | BIOLOGICAL-CONTROL | BACILLUS | STRAIN | Temperature | Molecular Weight | Bacterial Proteins - chemistry | Molecular Sequence Data | Serine Endopeptidases - pharmacology | Substrate Specificity | Endopeptidases - chemistry | Stenotrophomonas maltophilia - genetics | Cloning, Molecular | Serine Endopeptidases - genetics | Protein Domains | Antinematodal Agents - metabolism | Antinematodal Agents - pharmacology | Rhabditida - drug effects | Amino Acid Sequence | Endopeptidases - metabolism | Bacterial Proteins - genetics | Enzyme Stability | Serine Endopeptidases - chemistry | Antinematodal Agents - chemistry | Bacterial Proteins - pharmacology | Animals | Caenorhabditis elegans - drug effects | Endopeptidases - genetics | Bacterial Proteins - metabolism | Serine Endopeptidases - metabolism | Endopeptidases - pharmacology | Hydrogen-Ion Concentration | Stenotrophomonas maltophilia - enzymology | Keratin | Protease inhibitors | Casein | Cloning | Genes | Thrombin | Amino acids | Genetic aspects | Enzymes | Biological control | Albumin | Pests | Biocides | Zinc compounds
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2011, Volume 31, Issue 7, pp. 2352 - 2360
The extracellular matrix molecule Reelin is known to control neuronal migration during development. Recent evidence suggests that it also plays a role in the... 
APOE RECEPTOR 2 | PRESYNAPTIC CALCIUM | CORTICAL-NEURONS | SIGNALING PATHWAY | BRAIN-DEVELOPMENT | RADIAL NEURONAL MIGRATION | GRANULE CELL DISPERSION | CAJAL-RETZIUS CELLS | SYNAPTIC PLASTICITY | NEUROSCIENCES | RAT HIPPOCAMPAL-FORMATION | Action Potentials - genetics | CA1 Region, Hippocampal - cytology | Humans | Nerve Tissue Proteins - deficiency | Green Fluorescent Proteins - genetics | Presynaptic Terminals - ultrastructure | LDL-Receptor Related Proteins - genetics | Serine Endopeptidases - immunology | Excitatory Postsynaptic Potentials - genetics | Animals, Newborn | Synapses - drug effects | Serine Endopeptidases - deficiency | Electron Microscope Tomography - methods | Enzyme Inhibitors - pharmacology | Neurotransmitter Agents - metabolism | Mice, Transgenic | Synapses - ultrastructure | Mutation - genetics | Clathrin - metabolism | Patch-Clamp Techniques | Cell Adhesion Molecules, Neuronal - pharmacology | Mice | Synaptic Vesicles - metabolism | Extracellular Matrix Proteins - deficiency | R-SNARE Proteins - metabolism | Serine Endopeptidases - physiology | Serine Endopeptidases - pharmacology | Culture Media, Conditioned - pharmacology | Cell Adhesion Molecules, Neuronal - physiology | Excitatory Postsynaptic Potentials - drug effects | Cell Adhesion Molecules, Neuronal - deficiency | Synapses - metabolism | Transfection - methods | Nerve Tissue Proteins - pharmacology | Action Potentials - drug effects | Receptors, LDL - genetics | Nerve Tissue Proteins - physiology | Nerve Tissue Proteins - immunology | Synaptic Vesicles - ultrastructure | Gene Expression Regulation - genetics | Mice, Inbred C57BL | Extracellular Matrix Proteins - pharmacology | Extracellular Matrix Proteins - physiology | Nerve Tissue Proteins - genetics | Antibodies - pharmacology | Gene Expression Regulation - drug effects | Integrin beta1 - metabolism | Nerve Tissue Proteins - metabolism | Animals | Extracellular Matrix Proteins - immunology | Presynaptic Terminals - metabolism | Synaptosomal-Associated Protein 25 - metabolism | In Vitro Techniques | Cell Adhesion Molecules, Neuronal - immunology | Cell Line, Transformed
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 01/2009, Volume 29, Issue 1, pp. 288 - 299
The extracellular matrix protein Reelin, secreted by Cajal-Retzius cells in the marginal zone of the cortex, controls the radial migration of cortical neurons.... 
APOE RECEPTOR 2 | Reelin signaling | cofilin | PHOSPHATIDYLINOSITOL 3-KINASE | TYROSINE KINASE | cortical lamination | BRAIN-DEVELOPMENT | radial migration | CAJAL-RETZIUS | reeler mutant | DEVELOPING CEREBRAL-CORTEX | CORTICAL DEVELOPMENT | NEUROSCIENCES | actin cytoskeleton | CELL-MIGRATION | DENTATE GYRUS | RADIAL GLIAL SCAFFOLD | Embryo, Mammalian | LDL-Receptor Related Proteins | Humans | Actins - metabolism | Serine Endopeptidases - physiology | Serine Endopeptidases - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Cell Adhesion Molecules, Neuronal - physiology | Cell Movement - genetics | Mice, Neurologic Mutants | Lim Kinases - metabolism | Transfection - methods | Nerve Tissue Proteins - pharmacology | Neurons - physiology | Receptors, LDL - deficiency | src-Family Kinases - metabolism | Receptors, Lipoprotein - deficiency | Cerebral Cortex - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Nerve Tissue Proteins - physiology | Subcellular Fractions - drug effects | Cells, Cultured | Enzyme Inhibitors - pharmacology | Extracellular Matrix Proteins - pharmacology | Extracellular Matrix Proteins - physiology | Mice, Transgenic | Down-Regulation - drug effects | Mutation - genetics | Nerve Tissue Proteins - genetics | Serine - metabolism | Cell Movement - drug effects | Animals | Cofilin 1 - metabolism | Cell Adhesion Molecules, Neuronal - pharmacology | Mice | Receptors, Cell Surface - genetics
Journal Article
Arthritis & Rheumatology, ISSN 2326-5191, 08/2017, Volume 69, Issue 8, pp. 1601 - 1611
Objective To assess the ability of matriptase, a type II transmembrane serine proteinase, to promote aggrecan loss from the cartilage of patients with... 
INTERGLOBULAR DOMAIN | ACTIVATED RECEPTOR 2 | COLLAGEN | INHIBITION | ONCOSTATIN-M | MATRIX-METALLOPROTEINASE | HUMAN CHONDROCYTES | DEGRADATION | RHEUMATOLOGY | MURINE OSTEOARTHRITIS | EXPRESSION | Immunohistochemistry | Humans | Middle Aged | Serine Endopeptidases - pharmacology | Male | Gene Expression Profiling | ADAMTS4 Protein - drug effects | ADAMTS5 Protein - metabolism | Low Density Lipoprotein Receptor-Related Protein-1 - drug effects | Cartilage, Articular - metabolism | Matrix Metalloproteinases - drug effects | Aged, 80 and over | Menisci, Tibial - surgery | Female | Membrane Proteins - metabolism | Aggrecans - drug effects | Real-Time Polymerase Chain Reaction | Endopeptidases - metabolism | ADAMTS5 Protein - drug effects | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Antibodies, Neutralizing - pharmacology | ADAMTS4 Protein - metabolism | Aggrecans - metabolism | Recombinant Proteins - pharmacology | Blotting, Western | Cartilage, Articular - pathology | Animals | Membrane Proteins - antagonists & inhibitors | Osteoarthritis, Knee - pathology | Aged | Endopeptidases - drug effects | Mice | Serine Endopeptidases - metabolism | Matrix Metalloproteinases - metabolism | Cartilage, Articular - drug effects | In Vitro Techniques | Osteoarthritis, Knee - metabolism | Knee | Proteinase | Serine | Antibodies | Matrix metalloproteinase | Promotion | Damage prevention | Western blotting | Cartilage | Biomedical materials | Proteolysis | Surgery | Cleavage | Biocompatibility | Metalloproteinase | Inhibition | Conditioning | Recombinant | Explants | Damage assessment | Meniscus | Fragments | Media | Gene expression | Polymerase chain reaction | Neutralizing | Collagen | Stem cells | Receptor density | Disks | Serine proteinase | Aggrecan | Osteoarthritis | Destabilization | In vitro methods and tests | Cartilage diseases
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2009, Volume 106, Issue 37, pp. 15938 - 15943
Abnormal processing of the amyloid precursor protein (APP) and β-amyloid (Aβ) plaque accumulation are defining features of Alzheimer disease (AD), a... 
Oligomers | Circles | Receptors | Phosphorylation | N methyl D aspartate receptors | Neurons | Long term potentiation | Amyloids | Alzheimers disease | Synapses | NMDA receptor | Alzheimer disease | Apolipoprotein E | Aβ oligomer | Long-term potentiation | APOE RECEPTOR 2 | LIPOPROTEIN RECEPTORS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | APOLIPOPROTEIN-E | VLDL RECEPTOR | TYPE-4 ALLELE | HIPPOCAMPAL DEVELOPMENT | A beta oligomer | IN-VIVO | apolipoprotein E | SECRETED OLIGOMERS | long-term potentiation | Alzheimer Disease - etiology | Synaptic Transmission - physiology | Amyloid beta-Peptides - pharmacology | Humans | Serine Endopeptidases - physiology | Serine Endopeptidases - pharmacology | Peptide Fragments - pharmacology | Low Density Lipoprotein Receptor-Related Protein-1 - physiology | Hippocampus - drug effects | Cell Adhesion Molecules, Neuronal - physiology | Neuronal Plasticity - physiology | Long-Term Potentiation - drug effects | Nerve Tissue Proteins - pharmacology | Long-Term Potentiation - physiology | Amyloid beta-Peptides - physiology | Alzheimer Disease - physiopathology | Nerve Tissue Proteins - physiology | Synapses - physiology | Brain - physiopathology | Mice, Inbred C57BL | Extracellular Matrix Proteins - pharmacology | Extracellular Matrix Proteins - physiology | Recombinant Proteins - pharmacology | Receptors, N-Methyl-D-Aspartate - physiology | Amyloid beta-Peptides - antagonists & inhibitors | Animals | Cell Adhesion Molecules, Neuronal - pharmacology | Signal Transduction - physiology | Mice | Models, Neurological | Hippocampus - physiology | In Vitro Techniques | Biological Sciences
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2010, Volume 185, Issue 12, pp. 7681 - 7690
A second-degree epidermal scald burn in mice elicits an inflammatory response mediated by natural IgM directed to nonmuscle myosin with complement activation... 
ISCHEMIA-REPERFUSION INJURY | SKELETAL-MUSCLE | SUBSTRATE-SPECIFICITY | SERINE PROTEASES | TRYPTASE MMCP-6 | ANGIOTENSIN-II GENERATION | TRICHINELLA-SPIRALIS | CARBOXYPEPTIDASE-A | IMMUNOLOGY | BETA-CHYMASES | INNATE IMMUNITY | Leukocyte Elastase - metabolism | Chymases - pharmacology | Leukocyte Elastase - pharmacology | Humans | Chymases - immunology | Immunoglobulin M - metabolism | Burns - enzymology | Serine Endopeptidases - genetics | Serine Endopeptidases - immunology | Epidermis - enzymology | Immunoglobulin M - genetics | Tryptases - immunology | Myosins - immunology | Carboxypeptidases A - immunology | Leukocyte Elastase - genetics | Mast Cells - enzymology | Proto-Oncogene Proteins c-kit | Cicatrix - genetics | Models, Immunological | Tryptases - pharmacology | Mice | Mice, Inbred BALB C | Burns - genetics | Tryptases - metabolism | Cicatrix - immunology | Chymases - metabolism | Serine Endopeptidases - pharmacology | Immunoglobulin M - immunology | Cell Degranulation - genetics | Mice, Mutant Strains | Myosins - metabolism | Tryptases - genetics | Mast Cells - immunology | Epidermis - pathology | Carboxypeptidases A - metabolism | Inflammation | Cell Degranulation - immunology | Myosins - genetics | Chymases - genetics | Animals | Epidermis - immunology | Burns - pathology | Mast Cells - pathology | Cicatrix - enzymology | Carboxypeptidases A - genetics | Cicatrix - pathology | Serine Endopeptidases - metabolism | Burns - immunology | Leukocyte Elastase - immunology | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2005, Volume 280, Issue 41, pp. 34661 - 34666
Journal Article
Journal of Proteome Research, ISSN 1535-3893, 10/2005, Volume 4, Issue 5, pp. 1732 - 1741
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2007, Volume 27, Issue 8, pp. 1803 - 1811
Dentate granule cell (DGC) neurogenesis persists throughout life in the mammalian hippocampal dentate gyrus and increases after epileptogenic insults. The DGC... 
Epileptogenesis | Neuronal migration | Reelin | Neurogenesis | Hippocampus | Neural stem cell | APOE RECEPTOR 2 | neural stem cell | LIPOPROTEIN RECEPTORS | hippocampus | TEMPORAL-LOBE EPILEPSY | SEIZURE-INDUCED NEUROGENESIS | DENTATE GRANULE CELLS | NEUROSCIENCES | POSTNATAL NEUROGENESIS | LAMINAR ORGANIZATION | ADULT-RAT | neuronal migration | epileptogenesis | PILOCARPINE MODEL | neurogenesis | RADIAL GLIAL SCAFFOLD | Neurons - pathology | Serine Endopeptidases - pharmacology | Male | LDL-Receptor Related Protein-Associated Protein - pharmacology | Nerve Tissue Proteins - pharmacology | Cell Adhesion Molecules, Neuronal - metabolism | Extracellular Matrix Proteins - metabolism | Animals, Newborn | Nerve Tissue Proteins - antagonists & inhibitors | Cell Adhesion Molecules, Neuronal - antagonists & inhibitors | Dentate Gyrus - metabolism | Extracellular Matrix Proteins - antagonists & inhibitors | Cells, Cultured | Status Epilepticus - pathology | Extracellular Matrix Proteins - pharmacology | Rats | Hippocampus - pathology | Mice, Inbred Strains | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Cell Movement - drug effects | Hippocampus - metabolism | Animals | Interneurons - metabolism | Signal Transduction - drug effects | Cell Adhesion Molecules, Neuronal - pharmacology | Status Epilepticus - physiopathology | Stem Cells - pathology | Mice | Serine Endopeptidases - metabolism | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | Status Epilepticus - metabolism | Dentate Gyrus - pathology | Hippocampus - physiopathology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2012, Volume 287, Issue 25, pp. 21335 - 21345
Journal Article