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Circulation Research, ISSN 0009-7330, 03/2014, Volume 114, Issue 6, pp. 1022 - 1036
Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has attracted a lot of attention from the scientific community and... 
hyperlipoproteinemia type II | clinical trials | LDL cholesterol | phase III as topic | PLASMA PCSK9 | PROPROTEIN CONVERTASE PCSK9 | CARDIAC & CARDIOVASCULAR SYSTEMS | AUTOSOMAL-DOMINANT HYPERCHOLESTEROLEMIA | SUBTILISIN/KEXIN TYPE 9 | PCSK9-MEDIATED DEGRADATION | MONOCLONAL-ANTIBODY | OF-FUNCTION MUTATIONS | MESSENGER-RNA | PERIPHERAL VASCULAR DISEASE | CHOLESTEROL HOMEOSTASIS | LIPOPROTEIN-RECEPTOR LDLR | HEMATOLOGY | Proprotein Convertases - antagonists & inhibitors | Hepatitis C - metabolism | Vertebrates - genetics | Humans | Serine Endopeptidases - physiology | Male | Risk | Hepatocytes - metabolism | Molecular Targeted Therapy | Cardiovascular Diseases - genetics | Proprotein Convertases - genetics | Endosomes - metabolism | Clinical Trials, Phase III as Topic | Lysosomes - metabolism | Insulin Resistance - physiology | Serine Endopeptidases - genetics | Cardiovascular Diseases - blood | Adult | Cholesterol, LDL - blood | Female | Lipoproteins, LDL - metabolism | Hyperlipoproteinemia Type II - drug therapy | Chromosomes, Human, Pair 1 - genetics | Child | Disease Models, Animal | Genetic Predisposition to Disease | Serine Endopeptidases - deficiency | Cardiovascular Diseases - metabolism | Rodentia | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Proprotein Convertases - chemistry | Organ Specificity | Proprotein Convertases - deficiency | Gene Expression Regulation, Enzymologic | Hyperlipoproteinemia Type II - metabolism | Pregnancy | Proprotein Convertases - physiology | Animals | Diet | Protein Processing, Post-Translational | Mutation | Aging - metabolism | Hyperlipoproteinemia Type II - genetics | Proprotein Convertase 9
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2015, Volume 132, Issue 17, pp. 1648 - 1666
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in the regulation of cholesterol homeostasis. By binding to hepatic low-density... 
Antibodies, monoclonal | Clinical trial | PCSK9 protein, human | antibodies, monoclonal | clinical trial | CARDIAC & CARDIOVASCULAR SYSTEMS | LOWERING THERAPY | MONOCLONAL-ANTIBODY | DENSITY-LIPOPROTEIN-CHOLESTEROL | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | STATIN-INTOLERANT PATIENTS | HEALTHY-VOLUNTEERS | CORONARY-HEART-DISEASE | PLASMA LDL CHOLESTEROL | PCSK9 GENE | Proprotein Convertases - antagonists & inhibitors | Cardiovascular Diseases - prevention & control | Humans | Serine Endopeptidases - physiology | Antibodies, Monoclonal - therapeutic use | Intestines - metabolism | Structure-Activity Relationship | Cardiovascular Diseases - enzymology | Molecular Targeted Therapy | Cardiovascular Diseases - genetics | Proprotein Convertases - genetics | Incidence | Brain - metabolism | RNA Interference | Oligonucleotides, Antisense - therapeutic use | Serine Endopeptidases - genetics | Cardiovascular Diseases - epidemiology | Protein Structure, Tertiary | Genetic Predisposition to Disease | Antibodies, Monoclonal, Humanized - therapeutic use | Serine Endopeptidases - deficiency | Liver - metabolism | Receptors, LDL - metabolism | Serine Endopeptidases - chemistry | Clinical Trials as Topic | Proprotein Convertases - chemistry | Proprotein Convertases - deficiency | Proprotein Convertases - physiology | Animals | RNA, Small Interfering - therapeutic use | Adipocytes - metabolism | Cholesterol, LDL - metabolism | Hyperlipoproteinemias - genetics | Mice | Peptide Fragments - therapeutic use | Mutation | Proprotein Convertase 9 | Monoclonal antibodies | Clinical trials | Usage | Care and treatment | Dosage and administration | Cardiovascular diseases
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2012, Volume 122, Issue 4, pp. 1262 - 1270
Individuals with type 2 diabetes have an increased risk of atherosclerosis. One factor underlying this is dyslipidemia, which in hyperinsulinemic subjects with... 
NONHUMAN-PRIMATES | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | TARGET GENES | ACTIVATION | PLASMA-CHOLESTEROL | DIABETIC DYSLIPIDEMIA | INSULIN-RESISTANCE | LIVER | TRANSPLANT RECIPIENTS | UP-REGULATION | Liver Transplantation | Insulin - physiology | Multiprotein Complexes | Serine Endopeptidases - physiology | Hepatocyte Nuclear Factor 4 - physiology | Mechanistic Target of Rapamycin Complex 1 | RNA Interference | Insulin Resistance - physiology | Receptor, Insulin - genetics | Serine Endopeptidases - genetics | Hyperinsulinism - genetics | Proprotein Convertases | Postoperative Complications | Hyperinsulinism - metabolism | Proteins - physiology | Receptors, LDL - genetics | Serine Endopeptidases - deficiency | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Proto-Oncogene Proteins c-akt - physiology | Receptor, Insulin - physiology | Receptor, Insulin - antagonists & inhibitors | Sirolimus - pharmacology | Mice, Knockout | Gene Expression Regulation - drug effects | Animals | Receptors, LDL - biosynthesis | Mice, Obese | Mice | TOR Serine-Threonine Kinases | Hepatocyte Nuclear Factor 1-alpha - physiology | Proteins - antagonists & inhibitors | Proprotein Convertase 9 | Measurement | Liver | Physiological aspects | Low density lipoprotein receptors | Cellular signal transduction | Research | Properties | Insulin | Health aspects
Journal Article
Journal Article
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 12/2009, Volume 119, Issue 12, pp. 3613 - 3625
Membrane-bound proteases have recently emerged as critical mediators of tumorigenesis, angiogenesis, and metastasis. However, the mechanisms by which they... 
MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | SUBSTRATE-SPECIFICITY | COLLAGEN TYPE-I | DIPEPTIDYL-PEPTIDASE-IV | K-RAS | REMODELING INTERFACE | EPITHELIAL CANCERS | SERINE-PROTEASE | MONOCLONAL-ANTIBODY | REACTIVE STROMAL FIBROBLASTS | Neoplasm Transplantation | Cell Proliferation | Colonic Neoplasms - prevention & control | Stromal Cells - pathology | Lung Neoplasms - metabolism | Serine Endopeptidases - physiology | Lung Neoplasms - pathology | Colonic Neoplasms - metabolism | Pyrrolidines - pharmacology | Membrane Proteins - deficiency | Protease Inhibitors - pharmacology | Membrane Proteins - physiology | Mice, Mutant Strains | Serine Endopeptidases - genetics | Female | Gelatinases - deficiency | Adamantane - analogs & derivatives | Lung Neoplasms - blood supply | Adamantane - pharmacology | Gelatinases - antagonists & inhibitors | Serine Endopeptidases - deficiency | Colonic Neoplasms - blood supply | Membrane Proteins - genetics | Mice, Inbred C57BL | Gelatinases - physiology | Mice, Transgenic | Transplantation, Isogeneic | Mice, Knockout | Collagen - metabolism | Animals | Lung Neoplasms - prevention & control | Membrane Proteins - antagonists & inhibitors | Gelatinases - genetics | Colonic Neoplasms - pathology | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Genes, ras | Care and treatment | Colon cancer | Growth | Collagen | Lung cancer | Targeting (Nuclear strategy) | Thrombin | Research | Metastasis | Cancer
Journal Article
Journal Article