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Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5843, pp. 1390 - 1393
Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 610 - 614
Serotonin or 5-hydroxytryptamine (5-HT) regulates a wide spectrum of human physiology through the 5-HT receptor family. We report the crystal structures of the... 
Receptors | Sand sheets | Hydrogen bonds | Serotonin receptors | REPORTS | Ligands | Agonists | Indoles | Grants | LSD | Binding sites | LIGANDS | PROTEIN-COUPLED RECEPTOR | PHARMACOLOGY | MULTIDISCIPLINARY SCIENCES | MUTATION | CARDIAC VALVULOPATHY | VALVULAR HEART-DISEASE | SCHIZOPHRENIA | DISORDERS | FENFLURAMINE | AGONIST | Pindolol - chemistry | Humans | Lysergic Acid Diethylamide - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Propranolol - metabolism | Serotonin 5-HT1 Receptor Agonists - chemistry | Ergotamine - chemistry | Ergotamine - metabolism | Receptor, Serotonin, 5-HT1B - genetics | Receptor, Serotonin, 5-HT1B - metabolism | Binding Sites | Amino Acid Sequence | Tryptamines - chemistry | Norfenfluramine - metabolism | Dihydroergotamine - chemistry | Protein Structure, Secondary | Models, Molecular | Dihydroergotamine - metabolism | Lysergic Acid Diethylamide - chemistry | Propranolol - chemistry | Serotonin 5-HT1 Receptor Agonists - metabolism | Pindolol - analogs & derivatives | Protein Folding | Norfenfluramine - chemistry | Hydrogen Bonding | Mutagenesis | Tryptamines - metabolism | Receptor, Serotonin, 5-HT1B - chemistry | Hydrophobic and Hydrophilic Interactions | Protein Conformation | Molecular Docking Simulation | Pindolol - metabolism | Physiological aspects | Research | G proteins | Serotonin | Molecular biology | Ligands (Biochemistry) | Neurons | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 01/2017, Volume 541, Issue 7637, pp. 421 - 424
Journal Article
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7552, pp. 322 - 327
Na+/Cl--coupled biogenic amine transporters are the primary targets of therapeutic and abused drugs, ranging from antidepressants to the psychostimulants... 
BIOGENIC-AMINE TRANSPORTERS | COCAINE BINDING | SEROTONIN TRANSPORTER | SUBSTRATE TRANSPORT | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | RAT-BRAIN SYNAPTOSOMES | CONFORMATIONAL DYNAMICS | ALTERNATING-ACCESS | TRANSMITTER UPTAKE | MAMMALIAN-CELLS | Dopamine - chemistry | Dopamine Plasma Membrane Transport Proteins - metabolism | Cocaine - metabolism | Molecular Conformation | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Methamphetamine - chemistry | Sodium - metabolism | Antidepressive Agents - metabolism | Antidepressive Agents - chemistry | Chlorides - metabolism | Central Nervous System Stimulants - metabolism | Dextroamphetamine - chemistry | Protein Stability | Binding Sites | Dopamine - metabolism | Cocaine - chemistry | Dextroamphetamine - metabolism | Neurotransmitter Agents - metabolism | Models, Molecular | Phenethylamines - metabolism | Cocaine - analogs & derivatives | Methamphetamine - metabolism | Neurotransmitter Agents - chemistry | Animals | Dopamine - analogs & derivatives | Drosophila melanogaster - chemistry | Central Nervous System Stimulants - chemistry | Ligands | Physiological aspects | Neurotransmitters | Dopamine | Research | Neurological research | Biological transport | Methamphetamines | Mutagenesis | Antidepressants | Nervous system | Cocaine | Binding sites
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 5/2013, Volume 340, Issue 6132, pp. 615 - 619
Journal Article