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Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2011, Volume 54, Issue 9, pp. 3206 - 3221
The synthesis and structure−activity relationship of a novel series of compounds with combined effects on 5-HT3A and 5-HT1A receptors and on the serotonin... 
FREELY MOVING RATS | ARYL BROMIDES | SEROTONIN REUPTAKE INHIBITORS | IN-VIVO MICRODIALYSIS | CHEMISTRY, MEDICINAL | PALLADIUM-CATALYZED SYNTHESIS | 5-HT1A RECEPTORS | MOOD DISORDERS | DRUG DISCOVERY | FRONTAL-CORTEX | ANTIDEPRESSANT-LIKE BEHAVIOR | Xenopus | Humans | Microsomes, Liver - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Sulfides - chemistry | Serotonin 5-HT1 Receptor Agonists - pharmacology | Sulfides - chemical synthesis | Piperazines - chemistry | Structure-Activity Relationship | Hippocampus - drug effects | Serotonin Uptake Inhibitors - chemical synthesis | Receptors, Serotonin, 5-HT1 - metabolism | Serotonin 5-HT1 Receptor Agonists - chemistry | Antidepressive Agents - chemistry | Oocytes - drug effects | Antidepressive Agents - pharmacology | Radioligand Assay | Serotonin 5-HT3 Receptor Antagonists - chemistry | Receptor, Serotonin, 5-HT1A - metabolism | Depressive Disorder, Major - drug therapy | Sulfides - pharmacology | Cell Line | Recombinant Proteins - antagonists & inhibitors | Drug Partial Agonism | Drug Stability | Rats | Serotonin Uptake Inhibitors - chemistry | Serotonin 5-HT1 Receptor Agonists - chemical synthesis | Recombinant Proteins - agonists | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Serotonin 5-HT3 Receptor Antagonists - chemical synthesis | Serotonin Plasma Membrane Transport Proteins - metabolism | Hippocampus - metabolism | Animals | Oocytes - physiology | Receptors, Serotonin, 5-HT3 - metabolism | Serotonin - metabolism | Antidepressive Agents - chemical synthesis | Piperazines - chemical synthesis | Serotonin 5-HT3 Receptor Antagonists - pharmacology | In Vitro Techniques | Serotonin Uptake Inhibitors - pharmacology
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2013, Volume 168, Issue 6, pp. 1456 - 1470
Background and Purpose To evaluate the ability of cannabidiolic acid (CBDA) to reduce nausea and vomiting and enhance 5‐HT1A receptor activation in animal... 
motion‐induced vomiting | taste reactivity | rat | anticipatory nausea | conditioned gaping | emesis | shrew | toxin‐induced vomiting | cannabidiolic acid | 5‐HT1A receptor | motion-induced vomiting | receptor | 5-HT | toxin-induced vomiting | MOTION-INDUCED EMESIS | LITHIUM-PAIRED CONTEXT | CHEMOTHERAPY-INDUCED NAUSEA | INDUCED CONDITIONED REJECTION | HOUSE MUSK SHREW | CANNABINOID CB1 | ARRIVE GUIDELINES | TASTE REACTIVITY TEST | PHARMACOLOGY & PHARMACY | INDUCED SICKNESS | 5-HT1A receptor | Nausea - chemically induced | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Antiemetics - antagonists & inhibitors | Cannabinoids - antagonists & inhibitors | Brain Stem - metabolism | Serotonin 5-HT1 Receptor Agonists - pharmacology | Male | Brain Stem - drug effects | Brain - metabolism | Receptor, Cannabinoid, CB1 - agonists | Serotonin 5-HT1 Receptor Agonists - chemistry | Shrews | Antiemetics - therapeutic use | Motion Sickness - physiopathology | Cannabinoid Receptor Antagonists - pharmacology | Behavior, Animal - drug effects | Female | Motion Sickness - prevention & control | Neurons - metabolism | Neurons - drug effects | Vomiting - prevention & control | Receptor, Serotonin, 5-HT1A - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - agonists | Rats | Random Allocation | Serotonin 5-HT1 Receptor Agonists - therapeutic use | Rats, Sprague-Dawley | Brain - drug effects | Nausea - prevention & control | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Vomiting - chemically induced | Cannabinoids - therapeutic use | Animals | Nausea - etiology | Receptor, Serotonin, 5-HT1A - chemistry | Vomiting - etiology | Mice | Prevention | Nausea | Gastrointestinal agents | Lithium compounds | Research Papers
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2014, Volume 124, Issue 3, pp. 1340 - 1349
Journal Article
Journal Article
Psychopharmacology, ISSN 0033-3158, 6/2011, Volume 215, Issue 3, pp. 505 - 512
The interaction between two non-psychotropic cannabinoids, cannabidiol (CBD) and cannabigerol (CBG), which have been reported to act as a 5-hydroxytryptamine... 
Neurosciences | Cannabinoids | Biomedicine | Serotonin | Vomiting | Cannabidiol | Phytocannabinoid | Nausea | Pharmacology/Toxicology | Psychiatry | 5-HT 1A | Cannabigerol | 5-HT1A | INTERFERES | PSYCHIATRY | HOUSE MUSK SHREW | RECEPTOR MECHANISM | MODEL | ESTABLISHMENT | NEUROSCIENCES | CONDITIONED REJECTION REACTIONS | LEAST SHREW | DELTA-9-TETRAHYDROCANNABINOL | PHARMACOLOGY & PHARMACY | CISPLATIN-INDUCED EMESIS | EXPRESSION | Cannabidiol - administration & dosage | Cannabidiol - isolation & purification | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Antiemetics - administration & dosage | Serotonin 5-HT1 Receptor Agonists - pharmacology | Male | Dose-Response Relationship, Drug | Cannabis - chemistry | Drug Interactions | Shrews | Antiemetics - isolation & purification | Saccharin - administration & dosage | Serotonin 5-HT1 Receptor Antagonists - administration & dosage | Cannabinoids - administration & dosage | Rats | Cannabidiol - pharmacology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Rats, Sprague-Dawley | Cannabinoids - pharmacology | Cannabinoids - isolation & purification | Animals | Serotonin 5-HT1 Receptor Antagonists - isolation & purification | Serotonin 5-HT1 Receptor Agonists - administration & dosage | Avoidance Learning - drug effects | Serotonin 5-HT1 Receptor Agonists - isolation & purification | Antiemetics - pharmacology | Animal experimentation | Phenols | Marijuana | Gastrointestinal agents | Neurotransmitters | Psychopharmacology
Journal Article
Neuroscience Research, ISSN 0168-0102, 09/2017, Volume 122, pp. 17 - 24
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2012, Volume 55, Issue 4, pp. 1572 - 1582
A series of new pyridobenzoxazepine derivatives with various heterocyclic amine side chains were synthesized to explore two main parameters related to the... 
NOREPINEPHRINE REUPTAKE | GLUTAMATE RECEPTORS | CHEMISTRY, MEDICINAL | ATYPICAL ANTIPSYCHOTIC ACTIVITY | DOPAMINE RELEASE | PYRIDOBENZODIAZEPINE DERIVATIVES | N-DESMETHYLCLOZAPINE | PROTEIN-COUPLED RECEPTORS | DISCRIMINATIVE STIMULUS | MAJOR METABOLITE | PREFRONTAL CORTEX | Brain - anatomy & histology | Cricetulus | Pyridines - chemistry | Receptors, Dopamine D4 - agonists | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Humans | Receptors, Adrenergic, alpha-2 - metabolism | Serotonin 5-HT1 Receptor Agonists - pharmacology | Male | Piperazines - chemistry | Structure-Activity Relationship | Receptors, Dopamine D2 - metabolism | Antipsychotic Agents - chemical synthesis | Brain - metabolism | Serotonin 5-HT1 Receptor Antagonists - chemical synthesis | Oxazepines - chemical synthesis | Serotonin 5-HT1 Receptor Agonists - chemistry | Radioligand Assay | Serotonin 5-HT1 Receptor Antagonists - chemistry | Receptor, Serotonin, 5-HT1A - metabolism | CHO Cells | Cricetinae | Receptors, Dopamine D2 - agonists | Pyridines - chemical synthesis | Models, Molecular | Rats | Serotonin 5-HT1 Receptor Agonists - chemical synthesis | Organ Specificity | Piperazines - pharmacology | Rats, Sprague-Dawley | Oxazepines - pharmacology | Brain - drug effects | Animals | Antipsychotic Agents - chemistry | Piperazines - chemical synthesis | Receptors, Dopamine D4 - metabolism | Pyridines - pharmacology | Antipsychotic Agents - pharmacology | In Vitro Techniques | Receptor, Serotonin, 5-HT2A - metabolism | Oxazepines - chemistry
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2013, Volume 56, Issue 20, pp. 7851 - 7861
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 12/2010, Volume 649, Issue 1-3, pp. 154 - 160
The purpose of this study was to investigate the possible antinociceptive effect of Heterotheca inuloides in inflammatory pain and to identify the main... 
Heterotheca inuloides | Inflammation | 7-hydroxy-3,4-dihydrocadalin | Pain | Formalin test | Inflammatory hyperalgesia | STIMULATION | RAT | SUBTYPE MESSENGER-RNAS | 7 hydroxy 3 4-dihydrocadalin | DORSAL-ROOT GANGLION | SESQUITERPENES | FORMALIN | PHARMACOLOGY & PHARMACY | INFLAMMATORY PAIN | EXPRESSION | FLOWERS | CONSTITUENTS | Hyperalgesia - chemically induced | Inflammation - chemically induced | Analgesics - pharmacology | Plant Extracts - chemistry | Sesquiterpenes - isolation & purification | Rats, Wistar | Plant Extracts - pharmacology | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Serotonin 5-HT1 Receptor Agonists - pharmacology | Receptors, Serotonin, 5-HT1 - metabolism | Dose-Response Relationship, Drug | Asteraceae - chemistry | Serotonin 5-HT1 Receptor Agonists - chemistry | Sesquiterpenes - analysis | Female | Molecular Structure | Phytotherapy | Analgesics - isolation & purification | Serotonin 5-HT1 Receptor Agonists - analysis | Sesquiterpenes - chemistry | Hyperalgesia - prevention & control | Rats | Plant Extracts - isolation & purification | Analgesics - analysis | Animals | Analgesics - chemistry | Inflorescence - chemistry | Mexico | Inflammation - prevention & control | Sesquiterpenes - pharmacology | Medicine, Traditional | Pain Measurement | Serotonin 5-HT1 Receptor Agonists - isolation & purification
Journal Article