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Neuropharmacology, ISSN 0028-3908, 08/2013, Volume 71, pp. 83 - 97
Serotonin (5-HT) is a neurotransmitter that is involved in many behavioral functions, including the organization of defense, and its putative pathological... 
Fear | Zebrafish | Anxiety | Serotonin | Scototaxis | Geotaxis | 5-HYDROXYTRYPTAMINE RELEASE | RAT | 5-HT1A RECEPTOR ANTAGONISTS | REUPTAKE INHIBITORS | DORSAL RAPHE | ADULT ZEBRAFISH | ELEVATED PLUS-MAZE | T-MAZE | NEUROSCIENCES | IN-VIVO | PHARMACOLOGY & PHARMACY | BRAIN | Anti-Anxiety Agents - administration & dosage | Fenclonine - administration & dosage | Spiro Compounds - therapeutic use | Anxiety - drug therapy | Piperidones - therapeutic use | Serotonin - chemistry | Brain - metabolism | Pyridines - adverse effects | Fenclonine - adverse effects | Behavior, Animal - drug effects | Hyperkinesis - chemically induced | Neurons - metabolism | Serotonin 5-HT1 Receptor Antagonists - administration & dosage | Anti-Anxiety Agents - therapeutic use | Buspirone - therapeutic use | Fluoxetine - adverse effects | Disease Models, Animal | Pyridines - administration & dosage | Nerve Tissue Proteins - agonists | Piperazines - therapeutic use | Piperazines - adverse effects | Extracellular Fluid - drug effects | Brain - drug effects | Serotonin Uptake Inhibitors - administration & dosage | Fluoxetine - administration & dosage | Piperazines - administration & dosage | Fenclonine - therapeutic use | Spiro Compounds - administration & dosage | Piperidones - adverse effects | Hyperkinesis - metabolism | Spiro Compounds - adverse effects | Dose-Response Relationship, Drug | Buspirone - administration & dosage | Protein Isoforms - metabolism | Protein Isoforms - agonists | Anti-Anxiety Agents - adverse effects | Buspirone - adverse effects | Fluoxetine - therapeutic use | Neurons - drug effects | Anxiety - metabolism | Pyridines - therapeutic use | Nerve Tissue Proteins - antagonists & inhibitors | Serotonin Uptake Inhibitors - therapeutic use | Serotonin Uptake Inhibitors - adverse effects | Serotonin 5-HT1 Receptor Agonists - therapeutic use | Serotonin 5-HT1 Receptor Agonists - adverse effects | Serotonin 5-HT1 Receptor Antagonists - adverse effects | Nerve Tissue Proteins - metabolism | Piperidones - administration & dosage | Extracellular Fluid - metabolism | Serotonin 5-HT1 Receptor Antagonists - therapeutic use | Animals | Serotonin - metabolism | Serotonin 5-HT1 Receptor Agonists - administration & dosage | Anxiety - chemically induced | Protein Isoforms - antagonists & inhibitors | Phenols | Buspirone hydrochloride | Fluoxetine
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e40187
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2011, Volume 54, Issue 9, pp. 3206 - 3221
The synthesis and structure−activity relationship of a novel series of compounds with combined effects on 5-HT3A and 5-HT1A receptors and on the serotonin... 
FREELY MOVING RATS | ARYL BROMIDES | SEROTONIN REUPTAKE INHIBITORS | IN-VIVO MICRODIALYSIS | CHEMISTRY, MEDICINAL | PALLADIUM-CATALYZED SYNTHESIS | 5-HT1A RECEPTORS | MOOD DISORDERS | DRUG DISCOVERY | FRONTAL-CORTEX | ANTIDEPRESSANT-LIKE BEHAVIOR | Xenopus | Humans | Microsomes, Liver - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Sulfides - chemistry | Serotonin 5-HT1 Receptor Agonists - pharmacology | Sulfides - chemical synthesis | Piperazines - chemistry | Structure-Activity Relationship | Hippocampus - drug effects | Serotonin Uptake Inhibitors - chemical synthesis | Receptors, Serotonin, 5-HT1 - metabolism | Serotonin 5-HT1 Receptor Agonists - chemistry | Antidepressive Agents - chemistry | Oocytes - drug effects | Antidepressive Agents - pharmacology | Radioligand Assay | Serotonin 5-HT3 Receptor Antagonists - chemistry | Receptor, Serotonin, 5-HT1A - metabolism | Depressive Disorder, Major - drug therapy | Sulfides - pharmacology | Cell Line | Recombinant Proteins - antagonists & inhibitors | Drug Partial Agonism | Drug Stability | Rats | Serotonin Uptake Inhibitors - chemistry | Serotonin 5-HT1 Receptor Agonists - chemical synthesis | Recombinant Proteins - agonists | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Serotonin 5-HT3 Receptor Antagonists - chemical synthesis | Serotonin Plasma Membrane Transport Proteins - metabolism | Hippocampus - metabolism | Animals | Oocytes - physiology | Receptors, Serotonin, 5-HT3 - metabolism | Serotonin - metabolism | Antidepressive Agents - chemical synthesis | Piperazines - chemical synthesis | Serotonin 5-HT3 Receptor Antagonists - pharmacology | In Vitro Techniques | Serotonin Uptake Inhibitors - pharmacology
Journal Article
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2018, Volume 28, Issue 4, pp. 606 - 611
[Display omitted] In previous study, a series of benzamides was identified as potent antipsychotic agents. As a continuation of the program to discover novel... 
Multi-receptor | PCP-induced hyperlocomotion | Antipsychotic | Pyridinecarboxamide | 5-HT1A receptor | receptor | 5-HT | CHEMISTRY, MEDICINAL | MECHANISM | SEROTONIN RECEPTORS | CHEMISTRY, ORGANIC | SCHIZOPHRENIA | INDUCED CATALEPSY | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Humans | Microsomes, Liver - metabolism | Male | Structure-Activity Relationship | Picolinic Acids - metabolism | Antipsychotic Agents - chemical synthesis | Serotonin 5-HT2 Receptor Antagonists - chemical synthesis | Serotonin 5-HT1 Receptor Antagonists - chemical synthesis | Serotonin 5-HT1 Receptor Antagonists - metabolism | Picolinic Acids - chemical synthesis | Picolinic Acids - chemistry | Molecular Structure | Serotonin 5-HT1 Receptor Antagonists - chemistry | Serotonin 5-HT2 Receptor Antagonists - chemistry | Picolinic Acids - pharmacology | Dopamine D2 Receptor Antagonists - chemical synthesis | Risperidone - pharmacology | Serotonin 5-HT2 Receptor Antagonists - pharmacology | Dopamine D2 Receptor Antagonists - chemistry | Mice, Inbred ICR | Serotonin 5-HT2 Receptor Antagonists - metabolism | Animals | Antipsychotic Agents - chemistry | Aripiprazole - pharmacology | Dopamine D2 Receptor Antagonists - metabolism | Dopamine D2 Receptor Antagonists - pharmacology | Antipsychotic Agents - metabolism | Antipsychotic Agents - pharmacology | Pyridine | Antipsychotic drugs | Research institutes | Analysis
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2013, Volume 168, Issue 6, pp. 1456 - 1470
Background and Purpose To evaluate the ability of cannabidiolic acid (CBDA) to reduce nausea and vomiting and enhance 5‐HT1A receptor activation in animal... 
motion‐induced vomiting | taste reactivity | rat | anticipatory nausea | conditioned gaping | emesis | shrew | toxin‐induced vomiting | cannabidiolic acid | 5‐HT1A receptor | motion-induced vomiting | receptor | 5-HT | toxin-induced vomiting | MOTION-INDUCED EMESIS | LITHIUM-PAIRED CONTEXT | CHEMOTHERAPY-INDUCED NAUSEA | INDUCED CONDITIONED REJECTION | HOUSE MUSK SHREW | CANNABINOID CB1 | ARRIVE GUIDELINES | TASTE REACTIVITY TEST | PHARMACOLOGY & PHARMACY | INDUCED SICKNESS | 5-HT1A receptor | Nausea - chemically induced | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Antiemetics - antagonists & inhibitors | Cannabinoids - antagonists & inhibitors | Brain Stem - metabolism | Serotonin 5-HT1 Receptor Agonists - pharmacology | Male | Brain Stem - drug effects | Brain - metabolism | Receptor, Cannabinoid, CB1 - agonists | Serotonin 5-HT1 Receptor Agonists - chemistry | Shrews | Antiemetics - therapeutic use | Motion Sickness - physiopathology | Cannabinoid Receptor Antagonists - pharmacology | Behavior, Animal - drug effects | Female | Motion Sickness - prevention & control | Neurons - metabolism | Neurons - drug effects | Vomiting - prevention & control | Receptor, Serotonin, 5-HT1A - metabolism | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - agonists | Rats | Random Allocation | Serotonin 5-HT1 Receptor Agonists - therapeutic use | Rats, Sprague-Dawley | Brain - drug effects | Nausea - prevention & control | Nerve Tissue Proteins - metabolism | Receptor, Cannabinoid, CB1 - metabolism | Vomiting - chemically induced | Cannabinoids - therapeutic use | Animals | Nausea - etiology | Receptor, Serotonin, 5-HT1A - chemistry | Vomiting - etiology | Mice | Prevention | Nausea | Gastrointestinal agents | Lithium compounds | Research Papers
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 12/2010, Volume 649, Issue 1-3, pp. 154 - 160
The purpose of this study was to investigate the possible antinociceptive effect of Heterotheca inuloides in inflammatory pain and to identify the main... 
Heterotheca inuloides | Inflammation | 7-hydroxy-3,4-dihydrocadalin | Pain | Formalin test | Inflammatory hyperalgesia | STIMULATION | RAT | SUBTYPE MESSENGER-RNAS | 7 hydroxy 3 4-dihydrocadalin | DORSAL-ROOT GANGLION | SESQUITERPENES | FORMALIN | PHARMACOLOGY & PHARMACY | INFLAMMATORY PAIN | EXPRESSION | FLOWERS | CONSTITUENTS | Hyperalgesia - chemically induced | Inflammation - chemically induced | Analgesics - pharmacology | Plant Extracts - chemistry | Sesquiterpenes - isolation & purification | Rats, Wistar | Plant Extracts - pharmacology | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Serotonin 5-HT1 Receptor Agonists - pharmacology | Receptors, Serotonin, 5-HT1 - metabolism | Dose-Response Relationship, Drug | Asteraceae - chemistry | Serotonin 5-HT1 Receptor Agonists - chemistry | Sesquiterpenes - analysis | Female | Molecular Structure | Phytotherapy | Analgesics - isolation & purification | Serotonin 5-HT1 Receptor Agonists - analysis | Sesquiterpenes - chemistry | Hyperalgesia - prevention & control | Rats | Plant Extracts - isolation & purification | Analgesics - analysis | Animals | Analgesics - chemistry | Inflorescence - chemistry | Mexico | Inflammation - prevention & control | Sesquiterpenes - pharmacology | Medicine, Traditional | Pain Measurement | Serotonin 5-HT1 Receptor Agonists - isolation & purification
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 11/2012, Volume 68, Issue 11, pp. 1465 - 1472
Buspirone, a partial 5HT1A agonist and D2 and D3 antagonist, has shown promising antiemetic efficacy when given parenterally in animal models, but its efficacy... 
Biomedicine | Buspirone | Pharmacology/Toxicology | Randomised clinical trial | Antiemetic | Postoperative nausea and vomiting | CATS | MANAGEMENT | 5-HT1A RECEPTORS | ONDANSETRON | AGONISTS | FLESINOXAN | PROPHYLAXIS | ANXIOLYTICS | PHARMACOLOGY & PHARMACY | 5-HT(1A) RECEPTOR | CISPLATIN-INDUCED EMESIS | Anti-Anxiety Agents - administration & dosage | Injections, Intravenous | Buspirone - blood | Dopamine Antagonists - pharmacokinetics | Humans | Middle Aged | Receptors, Dopamine D3 - metabolism | Antiemetics - administration & dosage | Male | Buspirone - pharmacokinetics | Receptors, Dopamine D2 - metabolism | Dopamine Antagonists - administration & dosage | Incidence | Dose-Response Relationship, Drug | Young Adult | Anti-Anxiety Agents - pharmacokinetics | Buspirone - administration & dosage | Antiemetics - pharmacokinetics | Antiemetics - therapeutic use | Aged, 80 and over | Adult | Anti-Anxiety Agents - adverse effects | Antiemetics - adverse effects | Female | Anti-Anxiety Agents - therapeutic use | Buspirone - adverse effects | Receptors, Dopamine D3 - antagonists & inhibitors | Buspirone - therapeutic use | Receptor, Serotonin, 5-HT1A - metabolism | Postoperative Nausea and Vomiting - epidemiology | Double-Blind Method | Dopamine Antagonists - therapeutic use | Serotonin 5-HT1 Receptor Agonists - therapeutic use | Serotonin 5-HT1 Receptor Agonists - adverse effects | Postoperative Nausea and Vomiting - prevention & control | Receptor, Serotonin, 5-HT1A - chemistry | Buspirone - analogs & derivatives | Dopamine Antagonists - adverse effects | Serotonin 5-HT1 Receptor Agonists - administration & dosage | Aged | Dopamine D2 Receptor Antagonists | Postoperative Nausea and Vomiting - blood | Prevention | Complications and side effects | Buspirone hydrochloride | Adults | Nausea | Analysis | Postoperative period | Vomiting | Clinical trials | Pharmacology | Drug therapy | Clinical outcomes
Journal Article