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Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 02/2018, Volume 28, Issue 4, pp. 606 - 611
In previous study, a series of benzamides was identified as potent antipsychotic agents. As a continuation of the program to discover novel antipsychotics,... 
Multi-receptor | PCP-induced hyperlocomotion | Antipsychotic | Pyridinecarboxamide | 5-HT1A receptor | receptor | 5-HT | CHEMISTRY, MEDICINAL | MECHANISM | SEROTONIN RECEPTORS | CHEMISTRY, ORGANIC | SCHIZOPHRENIA | INDUCED CATALEPSY | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Humans | Microsomes, Liver - metabolism | Male | Structure-Activity Relationship | Picolinic Acids - metabolism | Antipsychotic Agents - chemical synthesis | Serotonin 5-HT2 Receptor Antagonists - chemical synthesis | Serotonin 5-HT1 Receptor Antagonists - chemical synthesis | Serotonin 5-HT1 Receptor Antagonists - metabolism | Picolinic Acids - chemical synthesis | Picolinic Acids - chemistry | Molecular Structure | Serotonin 5-HT1 Receptor Antagonists - chemistry | Serotonin 5-HT2 Receptor Antagonists - chemistry | Picolinic Acids - pharmacology | Dopamine D2 Receptor Antagonists - chemical synthesis | Risperidone - pharmacology | Serotonin 5-HT2 Receptor Antagonists - pharmacology | Dopamine D2 Receptor Antagonists - chemistry | Mice, Inbred ICR | Serotonin 5-HT2 Receptor Antagonists - metabolism | Animals | Antipsychotic Agents - chemistry | Aripiprazole - pharmacology | Dopamine D2 Receptor Antagonists - metabolism | Dopamine D2 Receptor Antagonists - pharmacology | Antipsychotic Agents - metabolism | Antipsychotic Agents - pharmacology | Pyridine | Antipsychotic drugs | Research institutes | Analysis
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2012, Volume 55, Issue 4, pp. 1572 - 1582
A series of new pyridobenzoxazepine derivatives with various heterocyclic amine side chains were synthesized to explore two main parameters related to the... 
SERINE RESIDUES | CHEMISTRY, MEDICINAL | ATYPICAL ANTIPSYCHOTIC ACTIVITY | DOPAMINE RELEASE | PYRIDOBENZODIAZEPINE DERIVATIVES | N-DESMETHYLCLOZAPINE | DRUG DISCOVERY | RECEPTOR | DISCRIMINATIVE STIMULUS | MAJOR METABOLITE | PREFRONTAL CORTEX | Brain - anatomy & histology | Cricetulus | Pyridines - chemistry | Receptors, Dopamine D4 - agonists | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Humans | Receptors, Adrenergic, alpha-2 - metabolism | Serotonin 5-HT1 Receptor Agonists - pharmacology | Male | Piperazines - chemistry | Structure-Activity Relationship | Receptors, Dopamine D2 - metabolism | Antipsychotic Agents - chemical synthesis | Brain - metabolism | Serotonin 5-HT1 Receptor Antagonists - chemical synthesis | Oxazepines - chemical synthesis | Serotonin 5-HT1 Receptor Agonists - chemistry | Radioligand Assay | Serotonin 5-HT1 Receptor Antagonists - chemistry | Receptor, Serotonin, 5-HT1A - metabolism | CHO Cells | Cricetinae | Receptors, Dopamine D2 - agonists | Pyridines - chemical synthesis | Models, Molecular | Rats | Serotonin 5-HT1 Receptor Agonists - chemical synthesis | Organ Specificity | Piperazines - pharmacology | Rats, Sprague-Dawley | Oxazepines - pharmacology | Brain - drug effects | Animals | Antipsychotic Agents - chemistry | Piperazines - chemical synthesis | Receptors, Dopamine D4 - metabolism | Pyridines - pharmacology | Antipsychotic Agents - pharmacology | In Vitro Techniques | Receptor, Serotonin, 5-HT2A - metabolism | Oxazepines - chemistry
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2017, Volume 136, pp. 246 - 258
Journal Article
Journal Article
Journal Article
European Neuropsychopharmacology, ISSN 0924-977X, 2015, Volume 25, Issue 8, pp. 1314 - 1323
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2012, Volume 55, Issue 1, pp. 23 - 36
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 11/2011, Volume 339, Issue 2, pp. 567 - 578
Journal Article
Expert Opinion on Therapeutic Patents, ISSN 1354-3776, 08/2012, Volume 22, Issue 8, pp. 887 - 902
Journal Article
Chemical Biology & Drug Design, ISSN 1747-0277, 03/2013, Volume 81, Issue 3, pp. 389 - 398
A series of 3,4,5‐trimethoxycinnamic acid derivatives was prepared and evaluated for antinarcotic effects on morphine dependence in mice and binding affinities... 
binding affinity | coupling reaction | 3,4,5‐trimethoxycinnamic acids | pERK | morphine | 5‐HT1A receptor | receptor | 3,4,5-trimethoxycinnamic acids | Morphine | Binding affinity | PERK | 5-HT1 | Coupling reaction | PRECIPITATED MORPHINE-WITHDRAWAL | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | RATS | OPIATE WITHDRAWAL | TAIL-FLICK RESPONSE | ANTINOCICEPTION | IN-VITRO | 5-trimethoxycinnamic acids | NEURONS | MICE | EXPRESSION | 5-HT1A receptor | 5-HYDROXYTRYPTAMINE (HT)1A RECEPTORS | Analgesics - pharmacology | Cricetulus | Pyridines - chemistry | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Piperazines - chemistry | Serotonin 5-HT1 Receptor Antagonists - chemical synthesis | Analgesics - chemical synthesis | Cinnamates - chemical synthesis | Behavior, Animal - drug effects | Cinnamates - chemistry | Serotonin 5-HT1 Receptor Antagonists - chemistry | Drug Evaluation, Preclinical | Receptor, Serotonin, 5-HT1A - metabolism | CHO Cells | Cricetinae | Mice, Inbred C57BL | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Cells, Cultured | Receptors, Serotonin - chemistry | Cinnamates - pharmacology | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Animals | Receptor, Serotonin, 5-HT1A - chemistry | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Analgesics - chemistry | Protein Binding | Mice | Pyridines - pharmacology | Mitogen-Activated Protein Kinase 1 - metabolism | Amides | Esters | Ketones | Analysis
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