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Journal of medicinal chemistry, ISSN 0022-2623, 02/2014, Volume 57, Issue 3, pp. 1000 - 1013
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 2011, Volume 108, Issue 29, pp. 12137 - 12142
Inhibitors of the serotonin transporter (SERT) and norepinephrine transporter (NET) are widely used in the treatment of major depressive disorder. Although... 
Tricyclic antidepressive agents | Antidepressants | Norepinephrine plasma membrane transport proteins | Reuptake | Serotonin plasma membrane transport proteins | Norepinephrine | Enantiomers | Experimental procedures | Binding sites | Chemicals | Monoamine | Neurotransmitter | SLC6 transporter | HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CITALOPRAM | MONOAMINE TRANSPORTERS | monoamine | BACTERIAL HOMOLOG | SUBSTRATE | DOPAMINE | BINDING-SITE | LEUT | neurotransmitter | STRUCTURAL DOMAINS | Humans | Cercopithecus aethiops | Molecular Sequence Data | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | DNA Mutational Analysis | Norepinephrine Plasma Membrane Transport Proteins - genetics | Base Sequence | Radioligand Assay | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Crystallization | Models, Molecular | Binding Sites - genetics | Genetic Vectors - genetics | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Propylamines - metabolism | COS Cells | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Benzofurans - metabolism | Biological Sciences
Journal Article
Nature (London), ISSN 1476-4687, 2019, Volume 569, Issue 7754, pp. 141 - 145
.... The transport activities of NSSs can be inhibited or modulated by cocaine and amphetamines(2,3), and genetic variants of NSSs are associated with several neuropsychiatric... 
FACING STATE | SITE | MOLECULAR-DYNAMICS | NEUROTRANSMITTER TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | VALIDATION | GENERAL FORCE-FIELD | X-RAY STRUCTURES | LEUT | BINDING | SOFTWARE NEWS | Binding, Competitive | Hallucinogens - pharmacology | Humans | Protein Conformation - drug effects | Hallucinogens - chemistry | Models, Molecular | Serotonin Plasma Membrane Transport Proteins - ultrastructure | Serotonin Uptake Inhibitors - chemistry | Ibogaine - pharmacology | Structure-Activity Relationship | Cryoelectron Microscopy | Serotonin Plasma Membrane Transport Proteins - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Ibogaine - chemistry | Serotonin - metabolism | Biological Transport - drug effects | Serotonin Uptake Inhibitors - pharmacology | Binding Sites - drug effects | Serotonin | Physiological aspects | Membrane proteins | Competition | Drug abuse | Mental disorders | Disorders | Homeostasis | Homology | Serotonin uptake inhibitors | Helices | Mental depression | Experiments | Ion diffusion | Proteins | Dopamine transporter | Anxiety | Noradrenaline | Dopamine | Narcotics | Attention deficit hyperactivity disorder | Unwinding | Substrate inhibition | Ibogaine | Electron microscopy | Substrates | Genetic variance | Autism | Serotonin transporter | Microscopy | Sodium | Natural products | Cocaine | Norepinephrine | Transport | Transporter | Binding sites | Cytoplasm
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2007, Volume 104, Issue 31, pp. 12761 - 12766
Journal Article
Psychopharmacology, ISSN 0033-3158, 1/2007, Volume 189, Issue 4, pp. 489 - 503
.... In rats, MDMA-mediated effects are attributed, in part, to selective high-affinity transport of MDMA into 5-HT neurons by the 5-HT transporter (SERT... 
Ecstasy | Biomedicine | Dopamine | Serotonin | Reuptake inhibitors | Transporters | Norepinephrine | Pharmacology/Toxicology | Trace amine receptors | Psychiatry | Monoamines | MDMA | norepinephrine | NONHUMAN-PRIMATES | SUBSTITUTED AMPHETAMINES | transporters | PSYCHIATRY | ecstasy | TRACE AMINES | MONOAMINE TRANSPORTERS | trace amine receptors | NEUROSCIENCES | serotonin | METHYLENEDIOXYMETHAMPHETAMINE MDMA | RAT-BRAIN SLICES | 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA | PARA-CHLOROAMPHETAMINE | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | reuptake inhibitors | dopamine | ABUSED DRUG MDMA | monoamines | Dopamine Plasma Membrane Transport Proteins - metabolism | Temperature | Dopamine Plasma Membrane Transport Proteins - drug effects | Stereoisomerism | Humans | Brain - metabolism | Dose-Response Relationship, Drug | Serotonin Agents - toxicity | Serotonin Plasma Membrane Transport Proteins - drug effects | Transfection | N-Methyl-3,4-methylenedioxyamphetamine - chemistry | Dopamine - metabolism | Binding, Competitive | Cell Line | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Serotonin Agents - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Brain - drug effects | N-Methyl-3,4-methylenedioxyamphetamine - metabolism | Neurotoxicity Syndromes - etiology | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - drug effects | Serotonin Agents - chemistry | Serotonin - metabolism | Neurotoxicity Syndromes - metabolism | N-Methyl-3,4-methylenedioxyamphetamine - toxicity | Kinetics | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - drug effects | Primates | Brain | Neurotransmitters | Neurotoxicity | Neurons
Journal Article
Molecular psychiatry, ISSN 1359-4184, 2002, Volume 7, Issue 1, pp. 21 - 26
Recent evidence enriches our understanding of the,molecular sites of action of cocaine reward and locomotor stimulation. Dopamine transporter blockade by... 
Reinforcement | Cocaine | Reward | Polygenic | Aversion | Knockout mouse | reward | cocaine | PSYCHIATRY | DEFICIT HYPERACTIVITY DISORDER | HUMAN DOPAMINE TRANSPORTER | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE POLYMORPHISMS | NEUROSCIENCES | MICE LACKING | VENTRAL TEGMENTAL AREA | NUCLEUS-ACCUMBENS | aversion | CORTICOTROPIN-RELEASING-FACTOR | polygenic | IN-VIVO | 6-HYDROXYDOPAMINE LESIONS | reinforcement | knockout mouse | PARKINSONS-DISEASE | Serotonin - physiology | Symporters - physiology | Norepinephrine - physiology | Humans | Nerve Tissue Proteins - deficiency | Motor Activity - drug effects | Serotonin Plasma Membrane Transport Proteins | Cocaine-Related Disorders - genetics | Membrane Transport Proteins - physiology | Genetic Variation | Membrane Glycoproteins - physiology | Membrane Transport Proteins - deficiency | Cocaine-Related Disorders - metabolism | Membrane Glycoproteins - antagonists & inhibitors | Dopamine - physiology | Membrane Transport Proteins - genetics | Symporters - antagonists & inhibitors | Dopamine Plasma Membrane Transport Proteins | Carrier Proteins - physiology | Nerve Tissue Proteins - antagonists & inhibitors | Genetic Predisposition to Disease | Nerve Tissue Proteins - physiology | Carrier Proteins - antagonists & inhibitors | Symporters - deficiency | Models, Psychological | Nerve Tissue Proteins - genetics | Membrane Transport Modulators | Membrane Glycoproteins - genetics | Mice, Knockout | Brain - drug effects | Carrier Proteins - genetics | Cocaine - pharmacology | Norepinephrine Plasma Membrane Transport Proteins | Animals | Membrane Transport Proteins - antagonists & inhibitors | Symporters - genetics | Brain - pathology | Mice | Models, Neurological | Membrane Glycoproteins - deficiency
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2004, Volume 306, Issue 5697, pp. 879 - 881
... is thought to mediate their therapeutic actions. A genetic variant that reduces expression of 5-HTT has been associated with elevated levels of neuroticism, anxiety-like... 
Psychological stress | Emotional expression | Serotonin receptors | Emotional maturity | Mood disorders | Reports | Mice | Adults | Behavioral neuroscience | Human genetics | Emotional development | MONOAMINE-OXIDASE | BRAIN-REGIONS | SEROTONIN TRANSPORTER | MATERNAL-CARE | ANXIETY | MULTIDISCIPLINARY SCIENCES | ANIMAL-MODEL | DORSAL RAPHE NUCLEUS | ENDOGENOUS-DEPRESSION | ANTIDEPRESSANT DRUGS | RECEPTOR-BINDING | Fluoxetine - toxicity | Humans | Stress, Physiological | Motor Activity - drug effects | Serotonin Plasma Membrane Transport Proteins | Brain - growth & development | Emotions - drug effects | Membrane Transport Proteins - physiology | Central Nervous System - growth & development | Membrane Glycoproteins - physiology | Membrane Glycoproteins - antagonists & inhibitors | Membrane Transport Proteins - genetics | Behavior, Animal - drug effects | Fluoxetine - adverse effects | Animals, Newborn | Nerve Tissue Proteins - antagonists & inhibitors | Nerve Tissue Proteins - physiology | Serotonin Uptake Inhibitors - toxicity | Serotonin Uptake Inhibitors - adverse effects | Random Allocation | Nerve Tissue Proteins - genetics | Membrane Transport Modulators | Feeding Behavior - drug effects | Membrane Glycoproteins - genetics | Polymorphism, Genetic | Brain - drug effects | Animals | Membrane Transport Proteins - antagonists & inhibitors | Central Nervous System - drug effects | Anxiety - chemically induced | Avoidance Learning - drug effects | Physiological aspects | Genetic aspects | Anxiety | Research | Depression, Mental | Mice as laboratory animals | Genotype & phenotype | Genetics | Neurotransmitters | Animal behavior | Rodents | Emotions
Journal Article
Molecular psychiatry, ISSN 1476-5578, 2014, Volume 19, Issue 6, pp. 688 - 698
Pharmacologic blockade of monoamine oxidase A (MAOA) or serotonin transporter (5-HTT) has antidepressant and anxiolytic efficacy in adulthood. Yet, genetically... 
anxiety | development | serotonin | aggression | depression | dopamine | BRAIN-SEROTONIN | RHESUS-MONKEYS | PSYCHIATRY | ENVIRONMENT INTERACTIONS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEFICIENT MICE | NEUROSCIENCES | GENE | SOMATOSENSORY CORTEX | MONOAMINE-OXIDASE-A | TRANSPORTER KNOCKOUT MICE | DORSAL RAPHE NUCLEUS | Aggression - physiology | Dopamine Plasma Membrane Transport Proteins - metabolism | Depression - physiopathology | Male | Brain - growth & development | Mice, 129 Strain | Brain - physiology | Dopaminergic Neurons - drug effects | Dopaminergic Neurons - physiology | Female | Dopamine - metabolism | Affect - drug effects | 3,4-Dihydroxyphenylacetic Acid - metabolism | Affect - physiology | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Amphetamine - pharmacology | Anxiety - physiopathology | Brain - drug effects | Dopamine Plasma Membrane Transport Proteins - antagonists & inhibitors | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Serotonin - metabolism | Central Nervous System Agents - pharmacology | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Aggression - drug effects | Monoamine Oxidase - metabolism | Passive-aggressive personality | Dopamine | Genetic susceptibility | Serotonin | Genetic research | Genetic aspects | Research | Properties | Mouse | Aggression | Development | Depression | Anxiety
Journal Article