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Nature (London), ISSN 0028-0836, 2013, Volume 503, Issue 7474, pp. 141 - 145
The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including... 
NEUROTRANSMITTER | HIGH-AFFINITY RECOGNITION | MECHANISM | DETERMINANTS | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | LEUT | HUMAN SEROTONIN TRANSPORTER | CHLORIDE | Antidepressive Agents, Tricyclic - metabolism | Humans | Protein Conformation - drug effects | Bacterial Proteins - chemistry | Crystallography, X-Ray | Plasma Membrane Neurotransmitter Transport Proteins - antagonists & inhibitors | Structure-Activity Relationship | Sodium - metabolism | Recombinant Fusion Proteins - metabolism | Mazindol - pharmacology | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Chlorides - metabolism | Biogenic Amines - metabolism | Sertraline - metabolism | Serotonin Uptake Inhibitors - metabolism | Bacterial Proteins - antagonists & inhibitors | Reproducibility of Results | Sertraline - pharmacology | Bacterial Proteins - genetics | Models, Molecular | Antidepressive Agents, Second-Generation - pharmacology | Mazindol - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Binding, Competitive - drug effects | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Antidepressive Agents, Tricyclic - pharmacology | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Mutation | Antidepressive Agents, Second-Generation - metabolism | Serotonin Uptake Inhibitors - pharmacology | Neurotransmitters | Carrier proteins | Physiological aspects | Serotonin uptake inhibitors | Pharmacology | Research | Molecular biology | Biogenic amines | Health aspects | Antidepressants, Tricyclic | Competition | Dopamine | Binding sites
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2007, Volume 317, Issue 5843, pp. 1390 - 1393
... (SERT, NET, and DAT, respectively) in the presynaptic membrane. The drug-binding site and the mechanism of this inhibition are poorly understood... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 532, Issue 7599, pp. 334 - 339
..., a group of G-protein-coupled receptors and ligand-gated ion channels that participate in both excitatory and inhibitory neurotransmission and modulate the release... 
HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | NOREPINEPHRINE TRANSPORTERS | N-LINKED GLYCOSYLATION | ALLOSTERIC BINDING | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | MEMBRANE-PROTEINS | DOPAMINE TRANSPORTER | Citalopram - pharmacology | Humans | Protein Conformation - drug effects | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Extracellular Space - metabolism | Antidepressive Agents - chemistry | Protein Binding - drug effects | Drug Design | Antidepressive Agents - pharmacology | Protein Stability | Allosteric Regulation - drug effects | Ions - chemistry | Serotonin Plasma Membrane Transport Proteins - immunology | Allosteric Site - drug effects | Models, Molecular | Ions - metabolism | Paroxetine - metabolism | Serotonin Plasma Membrane Transport Proteins - metabolism | Citalopram - chemistry | Intracellular Space - metabolism | Serotonin - metabolism | Ligands | Immunoglobulin Fab Fragments - immunology | Paroxetine - pharmacology | Paroxetine - chemistry | Drug metabolism | Paroxetine | Physiological research | Research | Serotonin | Binding sites (Biochemistry) | X rays | Mutation | Antidepressants | Binding sites | X-ray crystallography | Transporters in the nervous system | BASIC BIOLOGICAL SCIENCES | Membrane proteins
Journal Article
Psychopharmacology, ISSN 0033-3158, 1/2007, Volume 189, Issue 4, pp. 489 - 503
.... In rats, MDMA-mediated effects are attributed, in part, to selective high-affinity transport of MDMA into 5-HT neurons by the 5-HT transporter (SERT... 
Ecstasy | Biomedicine | Dopamine | Serotonin | Reuptake inhibitors | Transporters | Norepinephrine | Pharmacology/Toxicology | Trace amine receptors | Psychiatry | Monoamines | MDMA | norepinephrine | NONHUMAN-PRIMATES | SUBSTITUTED AMPHETAMINES | transporters | PSYCHIATRY | ecstasy | TRACE AMINES | MONOAMINE TRANSPORTERS | trace amine receptors | NEUROSCIENCES | serotonin | METHYLENEDIOXYMETHAMPHETAMINE MDMA | RAT-BRAIN SLICES | 3,4-METHYLENEDIOXYMETHAMPHETAMINE MDMA | PARA-CHLOROAMPHETAMINE | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | reuptake inhibitors | dopamine | ABUSED DRUG MDMA | monoamines | Dopamine Plasma Membrane Transport Proteins - metabolism | Temperature | Dopamine Plasma Membrane Transport Proteins - drug effects | Stereoisomerism | Humans | Brain - metabolism | Dose-Response Relationship, Drug | Serotonin Agents - toxicity | Serotonin Plasma Membrane Transport Proteins - drug effects | Transfection | N-Methyl-3,4-methylenedioxyamphetamine - chemistry | Dopamine - metabolism | Binding, Competitive | Cell Line | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Serotonin Agents - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Brain - drug effects | N-Methyl-3,4-methylenedioxyamphetamine - metabolism | Neurotoxicity Syndromes - etiology | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - drug effects | Serotonin Agents - chemistry | Serotonin - metabolism | Neurotoxicity Syndromes - metabolism | N-Methyl-3,4-methylenedioxyamphetamine - toxicity | Kinetics | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - drug effects | Primates | Brain | Neurotransmitters | Neurotoxicity | Neurons
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 2011, Volume 108, Issue 29, pp. 12137 - 12142
Inhibitors of the serotonin transporter (SERT) and norepinephrine transporter (NET) are widely used in the treatment of major depressive disorder. Although... 
Tricyclic antidepressive agents | Antidepressants | Norepinephrine plasma membrane transport proteins | Reuptake | Serotonin plasma membrane transport proteins | Norepinephrine | Enantiomers | Experimental procedures | Binding sites | Chemicals | Monoamine | Neurotransmitter | SLC6 transporter | HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CITALOPRAM | MONOAMINE TRANSPORTERS | monoamine | BACTERIAL HOMOLOG | SUBSTRATE | DOPAMINE | BINDING-SITE | LEUT | neurotransmitter | STRUCTURAL DOMAINS | Humans | Cercopithecus aethiops | Molecular Sequence Data | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | DNA Mutational Analysis | Norepinephrine Plasma Membrane Transport Proteins - genetics | Base Sequence | Radioligand Assay | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Crystallization | Models, Molecular | Binding Sites - genetics | Genetic Vectors - genetics | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Propylamines - metabolism | COS Cells | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Benzofurans - metabolism | Biological Sciences
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 02/2014, Volume 57, Issue 3, pp. 1000 - 1013
Journal Article
Physical chemistry chemical physics : PCCP, ISSN 1463-9084, 2018, Volume 20, Issue 9, pp. 6606 - 6616
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43694 - 43707
Journal Article
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 01/2009, Volume 121, Issue 1, pp. 89 - 99
Biogenic amine transporters for serotonin, norepinephrine and dopamine (SERT, NET and DAT respectively), are the key players terminating transmission of these... 
Dopamine transporter | Organic cation transporter | Norepinephrine transporter | Serotonin transporter | Antidepressants | Plasma membrane monoamine transporters | EXTRACELLULAR DOPAMINE | ORGANIC CATION TRANSPORTER-3 | HUMAN DOPAMINE TRANSPORTER | ULTRASTRUCTURAL-LOCALIZATION | PRELIMBIC PREFRONTAL CORTEX | MEMBRANE MONOAMINE TRANSPORTER | DEPRESSION-LIKE BEHAVIOR | IN-VIVO | PHARMACOLOGY & PHARMACY | RAT-BRAIN | Depression - physiopathology | Serotonin Plasma Membrane Transport Proteins - physiology | Equilibrative Nucleoside Transport Proteins - metabolism | Neurotransmitter Transport Proteins - metabolism | Organic Cation Transport Proteins - metabolism | Humans | Organic Cation Transport Proteins - physiology | Drug Discovery | Equilibrative Nucleoside Transport Proteins - physiology | Mice, Knockout - metabolism | Neurotransmitter Transport Proteins - physiology | Antidepressive Agents - therapeutic use | Serotonin Plasma Membrane Transport Proteins - metabolism | Depression - drug therapy | Serotonin Plasma Membrane Transport Proteins - genetics | Animals | Serotonin - metabolism | Neurotransmitter Transport Proteins - drug effects | Antidepressive Agents - pharmacology | Mice | Serotonin Uptake Inhibitors - pharmacology | Neurotransmitter Transport Proteins - genetics | plasma membrane monoamine transporters | antidepressants | dopamine transporter | norepinephrine transporter | serotonin transporter | organic cation transporter
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