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Nature, ISSN 0028-0836, 04/2016, Volume 532, Issue 7599, pp. 334 - 339
The serotonin transporter (SERT) terminates serotonergic signalling through the sodium-and chloride-dependent reuptake of neurotransmitter into presynaptic... 
HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | NOREPINEPHRINE TRANSPORTERS | N-LINKED GLYCOSYLATION | ALLOSTERIC BINDING | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | MEMBRANE-PROTEINS | DOPAMINE TRANSPORTER | Citalopram - pharmacology | Humans | Protein Conformation - drug effects | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Structure-Activity Relationship | Antidepressive Agents - metabolism | Citalopram - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Extracellular Space - metabolism | Antidepressive Agents - chemistry | Protein Binding - drug effects | Drug Design | Antidepressive Agents - pharmacology | Protein Stability | Allosteric Regulation - drug effects | Ions - chemistry | Serotonin Plasma Membrane Transport Proteins - immunology | Allosteric Site - drug effects | Models, Molecular | Ions - metabolism | Paroxetine - metabolism | Serotonin Plasma Membrane Transport Proteins - metabolism | Citalopram - chemistry | Intracellular Space - metabolism | Serotonin - metabolism | Ligands | Immunoglobulin Fab Fragments - immunology | Paroxetine - pharmacology | Paroxetine - chemistry | Drug metabolism | Paroxetine | Physiological research | Research | Serotonin | Binding sites (Biochemistry) | X rays | Mutation | Antidepressants | Binding sites | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7474, pp. 141 - 145
The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including... 
HIGH-AFFINITY RECOGNITION | NEUROTRANSMITTER TRANSPORTERS | MECHANISM | NOREPINEPHRINE TRANSPORTERS | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | LEUT | CONFORMATION | HUMAN SEROTONIN TRANSPORTER | Antidepressive Agents, Tricyclic - metabolism | Humans | Protein Conformation - drug effects | Bacterial Proteins - chemistry | Crystallography, X-Ray | Plasma Membrane Neurotransmitter Transport Proteins - antagonists & inhibitors | Structure-Activity Relationship | Sodium - metabolism | Recombinant Fusion Proteins - metabolism | Mazindol - pharmacology | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Chlorides - metabolism | Biogenic Amines - metabolism | Sertraline - metabolism | Serotonin Uptake Inhibitors - metabolism | Bacterial Proteins - antagonists & inhibitors | Reproducibility of Results | Sertraline - pharmacology | Bacterial Proteins - genetics | Models, Molecular | Antidepressive Agents, Second-Generation - pharmacology | Mazindol - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Binding, Competitive - drug effects | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Antidepressive Agents, Tricyclic - pharmacology | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Mutation | Antidepressive Agents, Second-Generation - metabolism | Serotonin Uptake Inhibitors - pharmacology | Neurotransmitters | Carrier proteins | Physiological aspects | Serotonin uptake inhibitors | Pharmacology | Research | Molecular biology | Biogenic amines | Health aspects | Antidepressants, Tricyclic | Competition | Dopamine | Binding sites | Index Medicus
Journal Article
Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5843, pp. 1390 - 1393
Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 11/2014, Volume 454, Issue 1, pp. 25 - 29
A ubiquitous feature of neurotransmitter transporters is the presence of short C-terminal PDZ binding motifs acting as important trafficking elements.... 
PDZ domain | MUPP1 | Neurotransmitter transporters | PDZ motif | LOCALIZATION | COMPLEX | PROTEIN | RECOGNITION | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOPAMINE TRANSPORTER | BIOPHYSICS | GLYCINE TRANSPORTERS | ASSOCIATION | DEVELOPMENTAL EXPRESSION | BRAIN | Dopamine Plasma Membrane Transport Proteins - metabolism | Glycine Plasma Membrane Transport Proteins - metabolism | Glycine Plasma Membrane Transport Proteins - chemistry | Molecular Sequence Data | Dopamine Plasma Membrane Transport Proteins - chemistry | Recombinant Fusion Proteins - metabolism | Brain - metabolism | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | GABA Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - genetics | Carrier Proteins - chemistry | Neurotransmitter Transport Proteins - genetics | GABA Plasma Membrane Transport Proteins - chemistry | Amino Acid Sequence | Neurotransmitter Transport Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Dopamine Plasma Membrane Transport Proteins - genetics | Sequence Homology, Amino Acid | Serotonin Plasma Membrane Transport Proteins - metabolism | Carrier Proteins - genetics | GABA Plasma Membrane Transport Proteins - genetics | Glycine Plasma Membrane Transport Proteins - genetics | Animals | Carrier Proteins - metabolism | PDZ Domains | Recombinant Fusion Proteins - genetics | Mice | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Neurotransmitter Transport Proteins - chemistry | GABA | Glycine | Investigations | Protein binding | Index Medicus
Journal Article
Science, ISSN 0036-8075, 9/2010, Volume 329, Issue 5998, pp. 1537 - 1541
The serotonin transporter (SERT) ensures the recapture of serotonin and is the pharmacological target of selective serotonin reuptake inhibitor (SSRI)... 
Receptors | MicroRNA | Serotonin agents | Neurons | Antidepressants | Serotonin receptors | REPORTS | Cell lines | Serotonin plasma membrane transport proteins | Adrenergic neurons | Locus coeruleus | LOCUS-COERULEUS | CELLS | RECEPTOR | RECOGNITION | RAT | MULTIDISCIPLINARY SCIENCES | Up-Regulation | Protein Biosynthesis | Humans | MicroRNAs - metabolism | Nerve Growth Factors - metabolism | Antidepressive Agents, Second-Generation - administration & dosage | Raphe Nuclei - metabolism | Serotonin Plasma Membrane Transport Proteins - genetics | Neurons - metabolism | 3' Untranslated Regions | Neurons - drug effects | Serotonin Uptake Inhibitors - metabolism | Cell Line | Fluoxetine - pharmacology | S100 Calcium Binding Protein beta Subunit | MicroRNAs - administration & dosage | Depression | S100 Proteins - metabolism | Antidepressive Agents, Second-Generation - pharmacology | Serotonin Plasma Membrane Transport Proteins - metabolism | Animals | Norepinephrine - metabolism | Raphe Nuclei - drug effects | Serotonin Uptake Inhibitors - administration & dosage | Serotonin - metabolism | Fluoxetine - administration & dosage | Fluoxetine - metabolism | Mice | MicroRNAs - genetics | HeLa Cells | Antidepressive Agents, Second-Generation - metabolism | Serotonin Uptake Inhibitors - pharmacology | Locus Coeruleus - metabolism | Pharmacogenetics | Serotonin | Physiological aspects | Serotonin uptake inhibitors | Dosage and administration | Research | Health aspects | Pharmacology | Index Medicus
Journal Article
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 06/2013, Volume 85, Issue 12, pp. 1803 - 1815
Journal Article
Molecular Psychiatry, ISSN 1359-4184, 06/2013, Volume 18, Issue 6, pp. 666 - 673
Bacterial colonisation of the intestine has a major role in the post-natal development and maturation of the immune and endocrine systems. These processes are... 
germ-free | microbiota | anxiety | serotonin | recolonisation | central nervous system | NERVOUS-SYSTEM | PSYCHIATRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | DEVELOPMENTAL ROLE | NEUROSCIENCES | MATERNAL SEPARATION MODEL | ANXIETY BEHAVIOR | TRYPTOPHAN-HYDROXYLASE ISOFORM | ANIMAL-MODELS | MICE | STRESS | IRRITABLE-BOWEL-SYNDROME | Tumor Necrosis Factor-alpha - metabolism | Body Weight | Male | Receptors, Serotonin - genetics | Tryptophan - metabolism | Microbiota | Serotonin Plasma Membrane Transport Proteins - genetics | Hippocampus - microbiology | Female | Brain-Derived Neurotrophic Factor - metabolism | Tryptophan Hydroxylase - metabolism | Disease Models, Animal | Stress, Psychological - blood | Gastrointestinal Tract - microbiology | Gene Expression Regulation - physiology | Hydroxyindoleacetic Acid - metabolism | Sex Characteristics | Gastrointestinal Tract - metabolism | Receptors, Serotonin - metabolism | Stress, Psychological - microbiology | Tryptophan Hydroxylase - genetics | Serotonin Plasma Membrane Transport Proteins - metabolism | Stress, Psychological - pathology | Hippocampus - metabolism | Animals | Analysis of Variance | Serotonin - metabolism | Lipopolysaccharides - pharmacology | Mice | Physiological aspects | Homeostasis | Research | Hippocampus (Brain) | Serotonin | Animal behavior | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 05/2015, Volume 521, Issue 7552, pp. 322 - 327
Na+/Cl--coupled biogenic amine transporters are the primary targets of therapeutic and abused drugs, ranging from antidepressants to the psychostimulants... 
BIOGENIC-AMINE TRANSPORTERS | COCAINE BINDING | SEROTONIN TRANSPORTER | SUBSTRATE TRANSPORT | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | RAT-BRAIN SYNAPTOSOMES | CONFORMATIONAL DYNAMICS | ALTERNATING-ACCESS | TRANSMITTER UPTAKE | MAMMALIAN-CELLS | Dopamine - chemistry | Dopamine Plasma Membrane Transport Proteins - metabolism | Cocaine - metabolism | Molecular Conformation | Crystallography, X-Ray | Dopamine Plasma Membrane Transport Proteins - chemistry | Methamphetamine - chemistry | Sodium - metabolism | Antidepressive Agents - metabolism | Antidepressive Agents - chemistry | Chlorides - metabolism | Central Nervous System Stimulants - metabolism | Dextroamphetamine - chemistry | Protein Stability | Binding Sites | Dopamine - metabolism | Cocaine - chemistry | Dextroamphetamine - metabolism | Neurotransmitter Agents - metabolism | Models, Molecular | Phenethylamines - metabolism | Cocaine - analogs & derivatives | Methamphetamine - metabolism | Neurotransmitter Agents - chemistry | Animals | Dopamine - analogs & derivatives | Drosophila melanogaster - chemistry | Central Nervous System Stimulants - chemistry | Ligands | Physiological aspects | Neurotransmitters | Dopamine | Research | Neurological research | Biological transport | Methamphetamines | Mutagenesis | Antidepressants | Nervous system | Cocaine | Binding sites | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43694 - 43707
Journal Article