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Journal Article
Science, ISSN 0036-8075, 9/2007, Volume 317, Issue 5843, pp. 1390 - 1393
Tricyclic antidepressants exert their pharmacological effect--inhibiting the reuptake of serotonin, norepinephrine, and dopamine--by directly blocking... 
Molecules | Salts | Neurotransmitters | Antidepressants | Reuptake | Serotonin plasma membrane transport proteins | Neurotransmitter transport proteins | Reports | Pharmacology | Inhibitory concentration 50 | Crystal structure | SENSITIVE DOPAMINE TRANSPORTER | NOREPINEPHRINE TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | ION-BINDING | MONOAMINE TRANSPORTERS | SEROTONIN | INHIBITORS | Dopamine - chemistry | Antidepressive Agents, Tricyclic - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Bacterial Proteins - chemistry | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Crystallography, X-Ray | Serotonin - chemistry | Dopamine Uptake Inhibitors - metabolism | Drosophila Proteins - metabolism | Antidepressive Agents, Tricyclic - chemistry | Neurotransmitter Uptake Inhibitors - metabolism | Desipramine - metabolism | Conserved Sequence | Binding Sites | Dopamine - metabolism | Serotonin Uptake Inhibitors - metabolism | Amino Acid Sequence | Cell Line | Leucine - metabolism | Norepinephrine Plasma Membrane Transport Proteins - antagonists & inhibitors | Models, Molecular | Serotonin Uptake Inhibitors - chemistry | Drosophila Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Leucine - chemistry | Sequence Homology, Amino Acid | Animals | Norepinephrine - metabolism | Desipramine - chemistry | Neurotransmitter Uptake Inhibitors - chemistry | Norepinephrine - chemistry | Serotonin - metabolism | Dopamine Uptake Inhibitors - chemistry | Protein Binding | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Protein Conformation | Norepinephrine Plasma Membrane Transport Proteins - metabolism | Norepinephrine Plasma Membrane Transport Proteins - chemistry | Leucine | Structure | Desipramine | Health aspects | Antidepressants, Tricyclic | Inhibitor drugs | Psychiatry | Binding sites
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 05/2016, Volume 26, Issue 10, pp. 2422 - 2427
Journal Article
Journal of Chromatography A, ISSN 0021-9673, 2007, Volume 1170, Issue 1, pp. 23 - 33
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2011, Volume 54, Issue 9, pp. 3206 - 3221
The synthesis and structure−activity relationship of a novel series of compounds with combined effects on 5-HT3A and 5-HT1A receptors and on the serotonin... 
FREELY MOVING RATS | ARYL BROMIDES | SEROTONIN REUPTAKE INHIBITORS | IN-VIVO MICRODIALYSIS | CHEMISTRY, MEDICINAL | PALLADIUM-CATALYZED SYNTHESIS | 5-HT1A RECEPTORS | MOOD DISORDERS | DRUG DISCOVERY | FRONTAL-CORTEX | ANTIDEPRESSANT-LIKE BEHAVIOR | Xenopus | Humans | Microsomes, Liver - metabolism | Receptor, Serotonin, 5-HT2C - metabolism | Sulfides - chemistry | Serotonin 5-HT1 Receptor Agonists - pharmacology | Sulfides - chemical synthesis | Piperazines - chemistry | Structure-Activity Relationship | Hippocampus - drug effects | Serotonin Uptake Inhibitors - chemical synthesis | Receptors, Serotonin, 5-HT1 - metabolism | Serotonin 5-HT1 Receptor Agonists - chemistry | Antidepressive Agents - chemistry | Oocytes - drug effects | Antidepressive Agents - pharmacology | Radioligand Assay | Serotonin 5-HT3 Receptor Antagonists - chemistry | Receptor, Serotonin, 5-HT1A - metabolism | Depressive Disorder, Major - drug therapy | Sulfides - pharmacology | Cell Line | Recombinant Proteins - antagonists & inhibitors | Drug Partial Agonism | Drug Stability | Rats | Serotonin Uptake Inhibitors - chemistry | Serotonin 5-HT1 Receptor Agonists - chemical synthesis | Recombinant Proteins - agonists | Piperazines - pharmacology | Receptors, Serotonin - metabolism | Serotonin 5-HT3 Receptor Antagonists - chemical synthesis | Serotonin Plasma Membrane Transport Proteins - metabolism | Hippocampus - metabolism | Animals | Oocytes - physiology | Receptors, Serotonin, 5-HT3 - metabolism | Serotonin - metabolism | Antidepressive Agents - chemical synthesis | Piperazines - chemical synthesis | Serotonin 5-HT3 Receptor Antagonists - pharmacology | In Vitro Techniques | Serotonin Uptake Inhibitors - pharmacology
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2009, Volume 52, Issue 21, pp. 6768 - 6781
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 09/2008, Volume 33, Issue 10, pp. 2303 - 2312
Quetiapine is an atypical antipsychotic drug that is also US FDA approved for treating bipolar depression, albeit by an unknown mechanism. To discover the... 
Antidepressant | N-Desalkylquetiapine | Norepinephrine reuptake inhibitor | Antipsychotic | Quetiapine | PSYCHIATRY | antidepressant | BIPOLAR-II DEPRESSION | quetiapine | SCHIZOPHRENIA | CLINICAL PHARMACOKINETICS | NEUROSCIENCES | ATYPICAL ANTIPSYCHOTIC-DRUGS | norepinephrine reuptake inhibitor | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | antipsychotic | MICE | SEROTONIN | INDUCED WEIGHT-GAIN | RECEPTORS | BLOCKADE | Brain Chemistry - drug effects | Serotonin 5-HT1 Receptor Agonists | Cricetulus | Humans | Depressive Disorder - drug therapy | Male | Antidepressive Agents - metabolism | Serotonin Receptor Agonists - pharmacology | Dose-Response Relationship, Drug | Adrenergic Uptake Inhibitors - chemistry | Dibenzothiazepines - chemistry | Antidepressive Agents - chemistry | Dibenzothiazepines - metabolism | Female | Antidepressive Agents - pharmacology | Drug Evaluation, Preclinical | Receptor, Serotonin, 5-HT1A - metabolism | CHO Cells | Disease Models, Animal | Cell Line | Cricetinae | Dibenzothiazepines - pharmacology | Mice, Inbred C57BL | Quetiapine Fumarate | Rats | Depressive Disorder - metabolism | Brain Chemistry - physiology | Mice, Knockout | Animals | Antipsychotic Agents - chemistry | Depressive Disorder - physiopathology | Vesicular Monoamine Transport Proteins - genetics | Adrenergic Uptake Inhibitors - pharmacology | Antipsychotic Agents - metabolism | Mice | Antipsychotic Agents - pharmacology
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 746 - 762
Journal Article
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 01/2017, Volume 195, pp. 10 - 19
Mesembrine alkaloids are considered to be the primary active constituents of the South African medicinal plant (L.) N.E.Br. (Aizoaceae), and it is used as the... 
Mesembrine | Alkaloid | Ethnopharmacology | Sceletium tortuosum | Pharmacology | Mesembrenone | AMARYLLIDACEAE ALKALOIDS | CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | ENANTIOSELECTIVE SYNTHESIS | EFFICIENT SYNTHESIS | FORMAL TOTAL-SYNTHESIS | SCELETIUM-TORTUOSUM ZEMBRIN | SEROTONIN REUPTAKE | QUATERNARY CARBON CENTERS | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | PHARMACOLOGY & PHARMACY | MISCELLANEOUS ALKALOIDS | ALLYLIC SUBSTITUTION | Indole Alkaloids - toxicity | Phosphodiesterase 4 Inhibitors - chemistry | Humans | Serotonin Uptake Inhibitors - toxicity | Serotonin Uptake Inhibitors - chemistry | Structure-Activity Relationship | Aizoaceae - chemistry | Phosphodiesterase 4 Inhibitors - pharmacology | Antidepressive Agents - isolation & purification | Antidepressive Agents - toxicity | Animals | Phosphodiesterase 4 Inhibitors - isolation & purification | Indole Alkaloids - isolation & purification | Antidepressive Agents - chemistry | Indole Alkaloids - pharmacology | Phosphodiesterase 4 Inhibitors - toxicity | Serotonin Uptake Inhibitors - isolation & purification | Antidepressive Agents - pharmacology | Molecular Structure | Phytotherapy | Indole Alkaloids - chemistry | Serotonin Uptake Inhibitors - pharmacology | Plants, Medicinal | Medicinal plants | Alkaloids | Medicine, Herbal | Antidepressants | Medicine, Botanic | Analysis
Journal Article
Journal Article