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Cellular Signalling, ISSN 0898-6568, 11/2013, Volume 25, Issue 11, pp. 2198 - 2209
While transforming growth factor-β (TGF-β1)-induced SMAD2/3 signaling is a critical event in the progression of chronic kidney disease, the role of non-SMAD... 
PAI-1 | TGF-β1 | Obstructive nephropathy | SMAD signaling | Renal fibrosis | p53 | P53 | Endothelium, Vascular - cytology | Receptor, Epidermal Growth Factor - agonists | Receptor, Epidermal Growth Factor - genetics | Reactive Oxygen Species - metabolism | Endothelium, Vascular - drug effects | Smad3 Protein - metabolism | Tumor Suppressor Protein p53 - genetics | Renal Insufficiency, Chronic - metabolism | Toluene - analogs & derivatives | Smad3 Protein - genetics | Receptor, Epidermal Growth Factor - metabolism | Isoquinolines - pharmacology | Smad2 Protein - genetics | Renal Insufficiency, Chronic - genetics | Myocytes, Smooth Muscle - drug effects | Toluene - pharmacology | Mink | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Signal Transduction | Benzothiazoles - pharmacology | Gene Expression Regulation | Smad2 Protein - metabolism | Tumor Suppressor Protein p53 - metabolism | Rats | Tyrphostins - pharmacology | Renal Insufficiency, Chronic - pathology | Pyrroles - pharmacology | Serpin E2 - genetics | Animals | Endothelium, Vascular - metabolism | Fibroblasts - drug effects | Fibrosis | Connective Tissue Growth Factor - genetics | Fibroblasts - cytology | Mice | Pyridines - pharmacology | Quinazolines - pharmacology | Serpin E2 - metabolism | Connective Tissue Growth Factor - metabolism
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 6/2012, Volume 385, Issue 6, pp. 605 - 619
The present study has been designed to investigate the effect of selective inhibitors of histone deacetylase and/or N-acetyl-Asp-Glu-Val-Asp-al (Ac-DEVD-CHO),... 
Histone deacetylase | Neurosciences | Biomedicine | Morphine dependence | Interleukin-1β converting enzyme | Isolated rat ileum | Pharmacology/Toxicology | Withdrawal syndrome | Interleukin-1βconverting enzyme | I DIABETIC-NEPHROPATHY | TOLERANCE | RATS | MORPHINE-WITHDRAWAL | DEPENDENCE | MOUSE MODEL | PHARMACOLOGY & PHARMACY | INHIBITORS | Interleukin-1 beta converting enzyme | EXPRESSION | MOLECULAR-MECHANISMS | CONVERTING-ENZYME | Analgesics, Opioid - pharmacology | Motor Activity - drug effects | Male | Behavior, Animal | Brain - metabolism | Ileum - drug effects | Female | Viral Proteins - pharmacology | Triglycerides - pharmacology | Hydroxamic Acids - pharmacology | Memantine - pharmacology | Morphine - pharmacology | Rats | Serpins - pharmacology | Brain - drug effects | Animals | Naloxone - pharmacology | Cysteine Proteinase Inhibitors - pharmacology | Narcotic Antagonists - pharmacology | Histone Deacetylase Inhibitors - pharmacology | Ileum - physiology | Mice | Histone Deacetylases - physiology | Histones - metabolism | Opioid-Related Disorders - physiopathology | In Vitro Techniques | Oligopeptides - pharmacology | Substance Withdrawal Syndrome - physiopathology | Animal experimentation | Drug abuse | Enzymes | Chemical inhibitors | Enzyme inhibitors | Interleukins | Analysis | Morphine | Precipitation (Meteorology)
Journal Article
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 04/2013, Volume 167, Issue 1, pp. 21 - 28
We are proposing folate-decorated polymeric nanoparticles as carriers of poorly soluble drug molecules for intracellular and prolonged delivery to retinal... 
Corticosteroid | Choroidal neovascularization | Ocular delivery | Receptor-mediated endocytosis | VEGF | GENE DELIVERY | DRUG-DELIVERY | MACULAR DEGENERATION | BLOCK-COPOLYMER MICELLES | ACETONIDE | CHEMISTRY, MULTIDISCIPLINARY | INTRAVITREAL INJECTION | PEDF | THERAPY | PHARMACOLOGY & PHARMACY | ENDOTHELIAL GROWTH-FACTOR | Folic Acid - pharmacology | Nanoparticles - chemistry | Epithelial Cells - drug effects | Humans | Polyethylene Glycols - chemistry | Vascular Endothelial Growth Factor A - genetics | Drug Carriers - chemistry | Lactones - pharmacology | Triamcinolone - pharmacology | Hypoxia - metabolism | Epithelial Cells - physiology | Eye Proteins - genetics | Lactones - chemistry | Polyethylene Glycols - pharmacology | Cell Line | Serpins - genetics | Anti-Inflammatory Agents - pharmacology | Folic Acid - chemistry | Angiogenesis Inhibitors - pharmacology | Triamcinolone - chemistry | Drug Carriers - pharmacology | Anti-Inflammatory Agents - chemistry | Nerve Growth Factors - genetics | Microscopy, Fluorescence | Retinal Pigment Epithelium - cytology | Angiogenesis Inhibitors - chemistry | Drugs | Ethylene glycol | Drug delivery systems | Corticosteroids | Epithelium | Folic acid | Vehicles | Macular degeneration | Nanoparticles | Neovascularization | Triamcinolone | Vascular endothelial growth factor | Steroids | Index Medicus | Cell culture
Journal Article
Peptides, ISSN 0196-9781, 09/2011, Volume 32, Issue 9, pp. 1866 - 1871
► 24 h after adipokines administration, feeding and gene expression were analyzed. ► Vaspin decreased food intake, while chemerin and omentin-1 had no effect.... 
Chemerin | Neuropeptide Y | Vaspin | Omentin-1 | Proopiomelanocortin | Feeding | METABOLIC SYNDROME | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROOPIOMELANOCORTIN MESSENGER-RNA | ARCUATE NUCLEUS | NEUROPEPTIDE-Y | ENERGY HOMEOSTASIS | LEPTIN ACTION | INSULIN-RESISTANCE | SERINE-PROTEASE INHIBITOR | PHARMACOLOGY & PHARMACY | LACTOFERRIN RECEPTORS | ADIPOSE-TISSUE | Chemokines - administration & dosage | Rats, Wistar | Humans | Male | Neuropeptide Y - genetics | Polymerase Chain Reaction - methods | Neuropeptide Y - metabolism | Chemokines - pharmacology | Hypothalamus - drug effects | Neuropeptides - genetics | Pro-Opiomelanocortin - genetics | Lectins - administration & dosage | Appetite Depressants - pharmacology | Intercellular Signaling Peptides and Proteins | Gene Expression Regulation | Rats | Lectins - pharmacology | Neuropeptides - metabolism | Recombinant Proteins - pharmacology | GPI-Linked Proteins - pharmacology | Agouti-Related Protein - metabolism | Cytokines - administration & dosage | Serpins - pharmacology | Recombinant Proteins - administration & dosage | Feeding Behavior - drug effects | Serpins - administration & dosage | Pro-Opiomelanocortin - metabolism | Eating - drug effects | Animals | Hypothalamus - cytology | Agouti-Related Protein - genetics | Mice | GPI-Linked Proteins - administration & dosage | Cytokines - pharmacology | Brain | Intermedin | Gene expression | Genes
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 09/2016, Volume 18, Issue Suppl 1, pp. 71 - 77
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2014, Volume 9, Issue 12, p. e113798
We have investigated the effects of light-emitting diode (LED)-induced phototoxicity (LIP) on cone-photoreceptors and their protection with brimonidine (BMD),... 
RETINAL GANGLION-CELLS | EPITHELIUM-DERIVED FACTOR | OPTICAL COHERENCE TOMOGRAPHY | MULTIDISCIPLINARY SCIENCES | RAT RETINA | ADULT ALBINO | FIBROBLAST-GROWTH-FACTOR | CILIARY NEUROTROPHIC FACTOR | PIGMENT-EPITHELIUM | SPATIAL-DISTRIBUTION | ALBINO SWISS MICE | Retinal Cone Photoreceptor Cells - radiation effects | Cell Survival - drug effects | Tomography, Optical Coherence | Light - adverse effects | Fibroblast Growth Factor 2 - pharmacology | Electronics | Brimonidine Tartrate | Cell Survival - radiation effects | Rats, Sprague-Dawley | Serpins - pharmacology | Nerve Growth Factors - pharmacology | Quinoxalines - pharmacology | Brain-Derived Neurotrophic Factor - pharmacology | Animals | Neuroprotective Agents - pharmacology | Time Factors | Retinal Cone Photoreceptor Cells - pathology | Retinal Cone Photoreceptor Cells - drug effects | Female | Disease Models, Animal | Eye Proteins - pharmacology | Circuit components | Brimonidine | Fibroblast growth factors | Ciliary neurotrophic factor | Light-emitting diodes | Neuroprotection | Brain | Fibroblast growth factor | Cornea | Pigment ePithelium-derived factor | Dark adaptation | Retina | Rods | Neurodegeneration | Circularity | Degeneration | Light emitting | Stains | Cross sections | Fibroblast growth factor 2 | Photoreception | Light emitting diodes | Epithelium | Light effects | Brain-derived neurotrophic factor | Optical Coherence Tomography | Cones | Phototoxicity | Retinal degeneration | Photoreceptors | Bone mineral density
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, p. e73737
Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid... 
CHRONIC HEART-FAILURE | CELLS | MYOCARDIAL FIBROSIS | TUMOR VIRUS PROMOTER | SPIRONOLACTONE | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | LOOP DIURETICS | PROTEINS | IDENTIFICATION | ANTAGONISTS | Receptors, Mineralocorticoid - genetics | Luciferases - metabolism | Tenascin - genetics | Orosomucoid - genetics | Receptors, Mineralocorticoid - metabolism | Humans | Transcriptional Activation - drug effects | Cercopithecus aethiops | Green Fluorescent Proteins - genetics | Luciferases - genetics | Cell Nucleus - metabolism | Spironolactone - pharmacology | Mineralocorticoid Receptor Antagonists - pharmacology | Plasminogen Activator Inhibitor 1 - genetics | Green Fluorescent Proteins - metabolism | Serpins - genetics | Myocytes, Cardiac - cytology | Diuretics - pharmacology | Protein-Serine-Threonine Kinases - genetics | Rats | Aldosterone - pharmacology | Reverse Transcriptase Polymerase Chain Reaction | Sulfonamides - pharmacology | Microscopy, Confocal | Animals | Immediate-Early Proteins - genetics | Myocytes, Cardiac - drug effects | Active Transport, Cell Nucleus - drug effects | Myocytes, Cardiac - metabolism | Mice | Cell Nucleus - drug effects | COS Cells | Heart failure | Corticosteroids | Spironolactone | Genes | Heart cells | Comparative analysis | Aldosterone | Health aspects | Steroids | Tenascin | Animal models | Heart attacks | Antagonists | Proteins | Reporter gene | Rodents | Diuretics | Physiology | Heart diseases | Hypertension | Translocation | Kidneys | Mortality | Polyamide-imides | Cardiomyocytes | Reabsorption | Coronary artery disease | Morbidity | Nuclear transport | Signaling | Sodium | Dogs | Fibrosis | Receptor mechanisms | Cardiovascular diseases | Life Sciences | Pharmacology | Pharmaceutical sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 45, pp. 18486 - 18499
The cornea is densely innervated to sustain the integrity of the ocular surface. Corneal nerve damage produced by aging, diabetes, refractive surgeries, and... 
EXPERIMENTAL SURGERY | phospholipase A | cornea | BIOCHEMISTRY & MOLECULAR BIOLOGY | brain-derived neurotrophic factor (BDNF) | neuropeptides | SPINAL-CORD | NGF | IDENTIFICATION | SENSORY NEURONS | PEDF | adipose triglyceride lipase | Sema7A | DRY EYE | INFLAMMATION | PEDF PLUS DHA | GROWTH-FACTOR | DHA | C-JUN | lipid signaling | Male | Receptors, Neuropeptide - metabolism | Eye Proteins - agonists | Trigeminal Ganglion - drug effects | Neuroprotective Agents - metabolism | Enzyme Inhibitors - administration & dosage | Nerve Growth Factors - pharmacology | Neuroprotective Agents - pharmacology | Cornea - pathology | Eye Proteins - antagonists & inhibitors | Organ Culture Techniques | Docosahexaenoic Acids - therapeutic use | Trigeminal Ganglion - pathology | Nerve Tissue Proteins - agonists | Trigeminal Nerve Injuries - drug therapy | Enzyme Inhibitors - pharmacology | Injections, Intraperitoneal | Nerve Growth Factors - administration & dosage | Serpins - pharmacology | Nerve Growth Factors - therapeutic use | Eye Proteins - metabolism | Nerve Regeneration - drug effects | Cornea - innervation | Eye Proteins - pharmacology | Neuroprotective Agents - therapeutic use | Administration, Ophthalmic | Cornea - physiology | Cornea - drug effects | Eye Proteins - administration & dosage | Receptors, Neuropeptide - agonists | Eye Proteins - genetics | Drug Therapy, Combination | Neuroprotective Agents - administration & dosage | Trigeminal Ganglion - physiology | Nerve Tissue Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Receptors, Neuropeptide - antagonists & inhibitors | Trigeminal Nerve - pathology | Eye Proteins - therapeutic use | Serpins - therapeutic use | Docosahexaenoic Acids - administration & dosage | Nerve Tissue Proteins - genetics | Serpins - administration & dosage | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Trigeminal Nerve - drug effects | Trigeminal Nerve - physiology | Animals | Phenylurea Compounds - administration & dosage | Phenylurea Compounds - pharmacology | Models, Neurological | Docosahexaenoic Acids - metabolism | Neurobiology
Journal Article
Journal of Dental Research, ISSN 0022-0345, 7/2010, Volume 89, Issue 7, pp. 689 - 694
Reactive oxygen species (ROS) are essential for the induction of T-cell apoptosis by butyric acid, an extracellular metabolite of periodontopathic bacteria. To... 
N-acetyl-L-Cysteine | Reactive oxygen species | Periodontitis | Apoptosis | Butyric acid | PERIODONTAL-DISEASES | ACTIVATION | INVOLVEMENT | DOWN-REGULATION | apoptosis | TUMOR-CELLS | DEATH | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | butyric acid | FLUID | CA2 | DENTISTRY, ORAL SURGERY & MEDICINE | reactive oxygen species | periodontitis | Free Radical Scavengers - pharmacology | Intracellular Signaling Peptides and Proteins - pharmacology | Apoptosis - drug effects | Caspases, Initiator - drug effects | Humans | Oxidative Stress - physiology | Reactive Oxygen Species - pharmacology | CASP8 and FADD-Like Apoptosis Regulating Protein - drug effects | Membrane Potential, Mitochondrial - drug effects | Apoptosis Inducing Factor - drug effects | Dose-Response Relationship, Drug | bcl-X Protein - drug effects | T-Lymphocytes - drug effects | Endoplasmic Reticulum - drug effects | bcl-Associated Death Protein - drug effects | Viral Proteins - pharmacology | Butyric Acid - pharmacology | Cytochromes c - drug effects | Jurkat Cells | Heat-Shock Proteins - drug effects | Mitochondria - drug effects | Caspase Inhibitors | Serpins - pharmacology | bcl-2-Associated X Protein - drug effects | Mitochondrial Proteins - pharmacology | Signal Transduction - drug effects | Cysteine Proteinase Inhibitors - pharmacology | Acetylcysteine - pharmacology | Proto-Oncogene Proteins c-bcl-2 - drug effects | Inhibitor of Apoptosis Proteins - pharmacology | Receptors, Death Domain - drug effects | Caspase 10 - drug effects
Journal Article