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The EMBO Journal, ISSN 0261-4189, 2011, Volume 30, Issue 4, pp. 770 - 782
Notch signalling is important for development and tissue homeostasis and activated in many human cancers. Nevertheless, mutations in Notch pathway components... 
miR‐200 | ZEB1 | EMT | Notch | stemness | miR-200 | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | PHENOTYPE | E-CADHERIN | MIR-200 FAMILY | REPRESSORS ZEB1 | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | Receptors, Notch - metabolism | Humans | Receptors, Notch - genetics | Gene Knockdown Techniques | Intercellular Signaling Peptides and Proteins - physiology | DNA-Binding Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Base Sequence | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Transcription Factors - physiology | DNA-Binding Proteins - antagonists & inhibitors | Membrane Proteins - genetics | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Homeodomain Proteins - genetics | Transcription Factors - metabolism | Models, Biological | Calcium-Binding Proteins - physiology | Homeodomain Proteins - antagonists & inhibitors | Nuclear Proteins - antagonists & inhibitors | Signal Transduction - physiology | MicroRNAs - genetics | Feedback, Physiological - physiology | MicroRNAs - physiology | Homeodomain Proteins - physiology | Calcium-Binding Proteins - genetics | Zinc Finger E-box-Binding Homeobox 1 | Proteins | Signal transduction | Cellular biology | Molecular biology | Gene expression | Cancer
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2008, Volume 105, Issue 29, pp. 9970 - 9975
The results of genetic studies in Arabidopsis indicate that three proteins, the RNase III DICER-Like1 (DCL1... 
Proteins | Enzymes | Treaties | MicroRNA | Double stranded RNA | RNA | Small interfering RNA | Nucleotide sequences | Protein precursors | Plants | Dicer | Biogenesis | Arabidopsis | ARABIDOPSIS-THALIANA | PLANT MICRORNA BIOGENESIS | MULTIDISCIPLINARY SCIENCES | NUCLEAR EXPORT | MICROPROCESSOR COMPLEX | biogenesis | MATURATION | DICER-LIKE PROTEINS | SMALL INTERFERING RNA | GENES | microRNA | TRANS-ACTING SIRNAS | C-ELEGANS | RNA-Binding Proteins - genetics | Insecta | Baculoviridae - genetics | MicroRNAs - metabolism | RNA, Plant - metabolism | Arabidopsis Proteins - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Serrate-Jagged Proteins | Cell Cycle Proteins - genetics | Membrane Proteins - metabolism | Calcium-Binding Proteins - metabolism | Recombinant Proteins - metabolism | Cell Line | Arabidopsis Proteins - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | RNA Processing, Post-Transcriptional | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Recombinant Proteins - genetics | RNA, Plant - genetics | Arabidopsis - metabolism | Arabidopsis - genetics | Animals | MicroRNAs - genetics | RNA-Binding Proteins - metabolism | Calcium-Binding Proteins - genetics | Physiological aspects | Genetic aspects | Biochemistry | Research | Properties | Binding proteins | Biological Sciences
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2012, Volume 109, Issue 31, pp. 12817 - 12821
Journal Article
Developmental cell, ISSN 1534-5807, 2012, Volume 22, Issue 3, pp. 501 - 514
... (Hes1, Hey1, Jagged1, VEGFR1, and Id1-3). Moreover, Id proteins act as competence factors for stalk cells and form complexes with Hes1, which augment Hes1 levels in the endothelium... 
DEFECTS | TIP CELLS | ANGIOGENESIS | VEGF | ENDOTHELIAL-CELLS | ID PROTEINS | HES1 | DEVELOPMENTAL BIOLOGY | DIFFERENTIATION | EXPRESSION | INHIBITS TUMOR-GROWTH | CELL BIOLOGY | Transcription Factor HES-1 | Humans | Intercellular Signaling Peptides and Proteins - biosynthesis | Intracellular Signaling Peptides and Proteins - metabolism | Inhibitor of Differentiation Proteins - biosynthesis | Inhibitor of Differentiation Protein 1 - biosynthesis | Serrate-Jagged Proteins | Smad5 Protein - metabolism | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Smad1 Protein - genetics | Membrane Proteins - metabolism | Smad5 Protein - genetics | Intracellular Signaling Peptides and Proteins - genetics | Jagged-1 Protein | Calcium-Binding Proteins - biosynthesis | Homeodomain Proteins - biosynthesis | Signal Transduction | Inhibitor of Differentiation Protein 2 - biosynthesis | Membrane Proteins - genetics | Down-Regulation | Cells, Cultured | Mice, Transgenic | Cell Cycle Proteins - biosynthesis | Vascular Endothelial Growth Factor Receptor-1 - biosynthesis | Mice, Knockout | Membrane Proteins - biosynthesis | Phenotype | Animals | Smad1 Protein - metabolism | Mice | Neovascularization, Physiologic | Proteins | Endothelial growth factors | Genes | Genetic aspects | Transforming growth factors | Vascular endothelial growth factor | Endothelium | Phenotypes | Dll4 | tip cell | lateral inhibition | sprouting angiogenesis | BMP | directed migration | Notch | stalk cell | mouse embryo | Smad | polarity
Journal Article
Cancer cell, ISSN 1535-6108, 2013, Volume 23, Issue 2, pp. 171 - 185
We report a paracrine effect whereby endothelial cells (ECs) promote the cancer stem cell (CSC) phenotype of human colorectal cancer (CRC) cells. We showed... 
COLON-CANCER | METASTASIS | ONCOLOGY | NOTCH | NICHE | SELF-RENEWAL | RECEPTOR | GROWTH-FACTOR | TUMOR ANGIOGENESIS | DIFFERENTIATION | ANGIOCRINE FACTORS | CELL BIOLOGY | ADAM17 Protein | RNA, Small Interfering - genetics | Immunoprecipitation | Receptors, Notch - metabolism | Colorectal Neoplasms - genetics | Humans | Calcium-Binding Proteins - antagonists & inhibitors | Culture Media, Conditioned - pharmacology | Drug Resistance, Neoplasm | Immunoblotting | Peptide Fragments - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Tumor Cells, Cultured | Liver Neoplasms - secondary | Colorectal Neoplasms - metabolism | Jagged-1 Protein | Biomarkers - metabolism | Calcium-Binding Proteins - metabolism | ADAM Proteins - antagonists & inhibitors | Liver Neoplasms - genetics | Signal Transduction | Endothelial Cells - metabolism | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Cell Communication | Xenograft Model Antitumor Assays | ADAM Proteins - metabolism | Phenotype | Animals | Membrane Proteins - antagonists & inhibitors | Mice, Nude | Liver Neoplasms - metabolism | Mice | ADAM Proteins - genetics | Colorectal Neoplasms - pathology | Endothelial Cells - pathology | Calcium-Binding Proteins - genetics | Genetic aspects | Colorectal cancer | Stem cells | Endothelium
Journal Article
Cancer research (Chicago, Ill.), ISSN 1538-7445, 2009, Volume 69, Issue 6, pp. 2400 - 2407
Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most difficult human malignancies to treat due, in part, to de novo and... 
TARGET | STEM-CELLS | GROWTH INHIBITION | INVASION | TUMOR PROGRESSION | ONCOLOGY | PROSTATE-CANCER | TAMOXIFEN RESISTANCE | DOWN-REGULATION | E-CADHERIN | NF-KAPPA-B | RNA, Small Interfering - genetics | Pancreatic Neoplasms - metabolism | Receptors, Notch - metabolism | Humans | Deoxycytidine - pharmacology | Drug Resistance, Neoplasm | Intercellular Signaling Peptides and Proteins - biosynthesis | NF-kappa B - metabolism | Receptor, Notch2 - genetics | Receptors, Notch - genetics | Proto-Oncogene Proteins - biosynthesis | Cell Movement - physiology | Pancreatic Neoplasms - drug therapy | Intercellular Signaling Peptides and Proteins - metabolism | Transfection | Receptors, Notch - biosynthesis | Serrate-Jagged Proteins | Antimetabolites, Antineoplastic - pharmacology | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Calcium-Binding Proteins - biosynthesis | Signal Transduction | Membrane Proteins - genetics | Down-Regulation | Pancreatic Neoplasms - pathology | Intercellular Signaling Peptides and Proteins - genetics | Receptor, Notch2 - metabolism | Epithelial Cells - pathology | Pancreatic Neoplasms - genetics | Proto-Oncogene Proteins - genetics | Membrane Proteins - biosynthesis | Phenotype | Receptor, Notch2 - biosynthesis | Mesoderm - pathology | RNA, Messenger | Deoxycytidine - analogs & derivatives | Receptor, Notch4 | Calcium-Binding Proteins - genetics | Index Medicus
Journal Article
BMC evolutionary biology, ISSN 1471-2148, 2009, Volume 9, Issue 1, pp. 249 - 249
Journal Article
Cell reports (Cambridge), ISSN 2211-1247, 2015, Volume 12, Issue 12, pp. 1968 - 1977
Breast cancers (BCs) typically express estrogen receptors (ERs) but frequently exhibit de novo or acquired resistance to hormonal therapies. Here, we show that... 
NOTCH | ESTROGEN | ADJUVANT TAMOXIFEN | RECEPTOR | CELL BIOLOGY | Estradiol - analogs & derivatives | Receptors, Estrogen - metabolism | Neoplastic Stem Cells - drug effects | Receptors, Notch - metabolism | Homeodomain Proteins - metabolism | Humans | Retinal Dehydrogenase - metabolism | p-Aminoazobenzene - analogs & derivatives | Receptors, Notch - genetics | Fulvestrant | Receptors, Notch - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Serrate-Jagged Proteins | p-Aminoazobenzene - pharmacology | Neoplastic Stem Cells - pathology | Estradiol - pharmacology | Jagged-1 Protein | Basic Helix-Loop-Helix Transcription Factors - genetics | Signal Transduction | Isoenzymes - genetics | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Benzazepines - pharmacology | Retinal Dehydrogenase - genetics | Breast Neoplasms - drug therapy | Drug Resistance, Neoplasm - genetics | Breast Neoplasms - genetics | Survival Analysis | Cell Line, Tumor | Retinal Dehydrogenase - antagonists & inhibitors | Mice | Calcium-Binding Proteins - genetics | Transcription Factor HES-1 | Gene Expression Regulation, Neoplastic | Cell Cycle Proteins - antagonists & inhibitors | Estrogen Receptor Antagonists - pharmacology | Intercellular Signaling Peptides and Proteins - metabolism | Isoenzymes - metabolism | Cell Cycle Proteins - genetics | Female | Membrane Proteins - metabolism | Calcium-Binding Proteins - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Receptors, Estrogen - genetics | Antineoplastic Agents, Hormonal - pharmacology | Intercellular Signaling Peptides and Proteins - genetics | Proto-Oncogene Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Aldehyde Dehydrogenase 1 | Homeodomain Proteins - genetics | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - pathology | Homeodomain Proteins - antagonists & inhibitors | Tamoxifen - pharmacology | Breast Neoplasms - mortality | Cell Proliferation - drug effects | Isoenzymes - antagonists & inhibitors | Receptor, Notch4 | Drug Resistance, Neoplasm - drug effects | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Cancer and Oncology | Medicin och hälsovetenskap | Cancer och onkologi
Journal Article
Molecular cell, ISSN 1097-2765, 2015, Volume 57, Issue 5, pp. 912 - 924
Mind bomb (Mib) proteins are large, multi-domain E3 ligases that promote ubiquitination of the cytoplasmic tails of Notch ligands... 
SYSTEM | MORPHOGENESIS | ACTIVATION | PROTEIN | UBIQUITIN LIGASE | DELTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIFFERENTIATION | SERRATE | INTRACELLULAR MOTIFS | DROSOPHILA | CELL BIOLOGY | Wnt1 Protein | Epitopes - metabolism | Receptors, Notch - metabolism | Humans | Intercellular Signaling Peptides and Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Receptors, Notch - genetics | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Drosophila melanogaster - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Serrate-Jagged Proteins | HEK293 Cells | Membrane Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Membrane Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Ubiquitin-Protein Ligases - metabolism | Models, Molecular | Drosophila Proteins - chemistry | Epitopes - genetics | Ubiquitin-Protein Ligases - chemistry | Blotting, Western | Sequence Homology, Amino Acid | Animals | Membrane Proteins - chemistry | Receptors, Notch - chemistry | Cell Line, Tumor | Protein Binding | Ligands | Epitopes - chemistry | Drosophila Proteins - genetics | Mutation | Ubiquitin-Protein Ligases - genetics | Calcium-Binding Proteins - genetics | Ubiquitin | Cellular signal transduction | Ligases | Antigenic determinants | Structure | Crystals | BASIC BIOLOGICAL SCIENCES
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 1/2013, Volume 110, Issue 5, pp. 1714 - 1719
Expression of the Notch ligand Jagged 1 (JAG1) and Notch activation promote poor-prognosis in breast cancer. We used high throughput screens to identify... 
Tumor cell line | Cell lines | Small interfering RNA | Breast cancer | Cells | Regulator genes | Genetic screening | Tumors | Mesenchymal stem cells | Cancer | EPITHELIAL-MESENCHYMAL TRANSITION | STEM-CELLS | IN-VITRO | ACTIVATED PROTEIN-KINASE | SIGNALING PATHWAY | TRIBBLES HOMOLOG | MULTIDISCIPLINARY SCIENCES | HYPOXIA | EXPRESSION | ESTROGEN-RECEPTOR | MAMMARY-GLAND | Humans | Breast Neoplasms - metabolism | MAP Kinase Signaling System | Intercellular Signaling Peptides and Proteins - metabolism | RNA Interference | Serrate-Jagged Proteins | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Female | Membrane Proteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Jagged-1 Protein | Calcium-Binding Proteins - metabolism | Cell Line | Membrane Proteins - genetics | Cell Cycle Proteins - metabolism | Intercellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Protein Kinase Inhibitors - isolation & purification | Receptor, Notch1 - metabolism | Mice, SCID | Reverse Transcriptase Polymerase Chain Reaction | Interleukin Receptor Common gamma Subunit - genetics | Blotting, Western | Hep G2 Cells | Mice, Knockout | Interleukin Receptor Common gamma Subunit - deficiency | Xenograft Model Antitumor Assays | Animals | Breast Neoplasms - genetics | Transforming Growth Factor beta - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Cell Line, Tumor | Mice, Inbred NOD | Mice | Protein Kinase Inhibitors - pharmacology | Receptor, Notch1 - genetics | Transforming Growth Factor beta - metabolism | Calcium-Binding Proteins - genetics | Biological Sciences
Journal Article
EMBO reports, ISSN 1469-3178, 2006, Volume 7, Issue 10, pp. 1052 - 1058
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2011, Volume 30, Issue 4, pp. 756 - 769
Notch signalling is crucial for the correct development and growth of numerous organs and tissues, and when subverted it can cause cancer. Loss of miR‐8/200... 
development | cancer | microRNA miR‐8 | Notch | miR‐200c | microRNA miR-8 | miR-200c | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | E-CADHERIN | BETA-CATENIN | MIR-200 FAMILY | CELL BIOLOGY | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER | COLORECTAL-CANCER | PROSTATE-CANCER | TRANSCRIPTIONAL REPRESSOR | Neoplasms - metabolism | Drosophila melanogaster - embryology | Multigene Family - physiology | Humans | Calcium-Binding Proteins - antagonists & inhibitors | MicroRNAs - metabolism | Receptors, Notch - genetics | Drosophila melanogaster - genetics | MicroRNAs - pharmacology | Growth and Development - drug effects | Intercellular Signaling Peptides and Proteins - physiology | Drosophila melanogaster - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Receptors, Notch - antagonists & inhibitors | Neoplasms - genetics | Membrane Proteins - physiology | Serrate-Jagged Proteins | Conserved Sequence | Membrane Proteins - metabolism | Jagged-1 Protein | Caco-2 Cells | Calcium-Binding Proteins - metabolism | Drosophila Proteins | Signal Transduction | Membrane Proteins - genetics | HCT116 Cells | Cells, Cultured | Gene Expression Regulation, Developmental - drug effects | Intercellular Signaling Peptides and Proteins - genetics | Animals | Membrane Proteins - antagonists & inhibitors | Calcium-Binding Proteins - physiology | Embryo, Nonmammalian | MicroRNAs - genetics | Growth and Development - genetics | MicroRNAs - physiology | Calcium-Binding Proteins - genetics | Proteins | Signal transduction | Cell growth | Gene expression | Molecular biology | Cancer | Cell proliferation
Journal Article