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Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7474, pp. 141 - 145
The biogenic amine transporters (BATs) regulate endogenous neurotransmitter concentrations and are targets for a broad range of therapeutic agents including... 
NEUROTRANSMITTER | HIGH-AFFINITY RECOGNITION | MECHANISM | DETERMINANTS | BACTERIAL HOMOLOG | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVE RECOGNITION | LEUT | HUMAN SEROTONIN TRANSPORTER | CHLORIDE | Antidepressive Agents, Tricyclic - metabolism | Humans | Protein Conformation - drug effects | Bacterial Proteins - chemistry | Crystallography, X-Ray | Plasma Membrane Neurotransmitter Transport Proteins - antagonists & inhibitors | Structure-Activity Relationship | Sodium - metabolism | Recombinant Fusion Proteins - metabolism | Mazindol - pharmacology | Serotonin Plasma Membrane Transport Proteins - chemistry | Serotonin Plasma Membrane Transport Proteins - genetics | Chlorides - metabolism | Biogenic Amines - metabolism | Sertraline - metabolism | Serotonin Uptake Inhibitors - metabolism | Bacterial Proteins - antagonists & inhibitors | Reproducibility of Results | Sertraline - pharmacology | Bacterial Proteins - genetics | Models, Molecular | Antidepressive Agents, Second-Generation - pharmacology | Mazindol - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - metabolism | Recombinant Fusion Proteins - chemistry | Plasma Membrane Neurotransmitter Transport Proteins - genetics | Binding, Competitive - drug effects | Serotonin Plasma Membrane Transport Proteins - metabolism | Norepinephrine - metabolism | Antidepressive Agents, Tricyclic - pharmacology | Recombinant Fusion Proteins - genetics | Bacterial Proteins - metabolism | Plasma Membrane Neurotransmitter Transport Proteins - chemistry | Mutation | Antidepressive Agents, Second-Generation - metabolism | Serotonin Uptake Inhibitors - pharmacology | Neurotransmitters | Carrier proteins | Physiological aspects | Serotonin uptake inhibitors | Pharmacology | Research | Molecular biology | Biogenic amines | Health aspects | Antidepressants, Tricyclic | Competition | Dopamine | Binding sites
Journal Article
Journal Article
The Journal of Clinical Pharmacology, ISSN 0091-2700, 12/2006, Volume 46, Issue 12, pp. 1426 - 1438
Cytochrome P450 2B6 (CYP2B6) is involved in the metabolism of drugs such as bupropion, efavirenz, propofol, and selegiline, among others. More than 200... 
HPLC/MS/MS | P450 2B6 | rhCYP2B6 | Drug‐drug interactions | in vitro | Drug-drug interactions | In vitro | Raloxifene Hydrochloride - pharmacology | Cytochrome P-450 Enzyme Inhibitors | Humans | Microsomes, Liver - metabolism | Sertraline - chemistry | Bupropion - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Antifungal Agents - chemistry | Xenobiotics - pharmacology | Reverse Transcriptase Inhibitors - chemistry | Xenobiotics - classification | Clotrimazole - metabolism | Platelet Aggregation Inhibitors - pharmacology | Oxazines - pharmacology | Antifungal Agents - pharmacology | Itraconazole - metabolism | Serotonin Uptake Inhibitors - metabolism | Clotrimazole - pharmacology | Serotonin Uptake Inhibitors - chemistry | Antidepressive Agents, Second-Generation - pharmacology | Clotrimazole - chemistry | Itraconazole - chemistry | Selective Estrogen Receptor Modulators - metabolism | Ticlopidine - analogs & derivatives | Raloxifene Hydrochloride - metabolism | Platelet Aggregation Inhibitors - chemistry | Oxazines - chemistry | Kinetics | Serotonin Uptake Inhibitors - pharmacology | Selective Estrogen Receptor Modulators - pharmacology | Bupropion - metabolism | Ticlopidine - pharmacology | Area Under Curve | Reverse Transcriptase Inhibitors - pharmacology | Ticlopidine - chemistry | Benzoxazines | Xenobiotics - pharmacokinetics | Itraconazole - pharmacology | Oxazines - metabolism | Microsomes, Liver - drug effects | Antifungal Agents - metabolism | Ticlopidine - metabolism | Molecular Structure | Platelet Aggregation Inhibitors - metabolism | Sertraline - metabolism | Sertraline - pharmacology | Selective Estrogen Receptor Modulators - chemistry | Algorithms | Bupropion - pharmacology | Reverse Transcriptase Inhibitors - metabolism | Antidepressive Agents, Second-Generation - metabolism | Raloxifene Hydrochloride - chemistry | Cytochrome P-450 CYP2B6 | Cytochromes | Research | Health aspects | Drug interactions
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2017, Volume 65, pp. 230 - 238
Journal Article
Toxicological Sciences, ISSN 1096-6080, 2012, Volume 127, Issue 2, pp. 582 - 591
Sertraline, a selective serotonin reuptake inhibitor, has been used for the treatment of depression. Although it is generally considered safe, cases of... 
Mitochondrial dysfunction | Rat primary hepatocytes | Isolated liver mitochondria | Liver toxicity | Sertraline | OXIDATIVE-PHOSPHORYLATION | INNER MEMBRANE | rat primary hepatocytes | ADENINE-NUCLEOTIDE TRANSLOCATOR | isolated liver mitochondria | PRIMARY HEPATOCYTES | mitochondrial dysfunction | INDUCED LIVER-INJURY | CA-2&-INDUCED MEMBRANE TRANSITION | CEREBELLAR GRANULE CELLS | PERMEABILITY TRANSITION | liver toxicity | GENE-EXPRESSION | TOXICOLOGY | OF-THE-LITERATURE | sertraline | L-Lactate Dehydrogenase - metabolism | Mitochondrial Diseases - pathology | Cyclosporine - pharmacology | Mitochondria, Liver - metabolism | Mitochondrial Diseases - metabolism | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Mitochondrial ADP, ATP Translocases - metabolism | Dose-Response Relationship, Drug | Oxidative Phosphorylation - drug effects | Time Factors | Adenosine Triphosphate - metabolism | Mitochondrial Diseases - chemically induced | Chemical and Drug Induced Liver Injury - pathology | Chemical and Drug Induced Liver Injury - etiology | Hepatocytes - drug effects | Chemical and Drug Induced Liver Injury - prevention & control | Mitochondrial Diseases - prevention & control | Mitochondrial Membrane Transport Proteins - metabolism | Mitochondria, Liver - pathology | Risk Assessment | Serotonin Uptake Inhibitors - toxicity | Cells, Cultured | Rats | Mitochondrial Membrane Transport Proteins - drug effects | Bongkrekic Acid - pharmacology | Rats, Sprague-Dawley | Antidepressive Agents - toxicity | Mitochondria, Liver - drug effects | Animals | Chemical and Drug Induced Liver Injury - metabolism | Electron Transport Chain Complex Proteins - metabolism | Sertraline - toxicity | Energy Metabolism - drug effects | Mitochondrial ADP, ATP Translocases - drug effects | Index Medicus
Journal Article
Journal Article
Journal of Clinical Psychiatry, ISSN 0160-6689, 09/2004, Volume 65, Issue 9, pp. 1228 - 1234
Journal Article
ELECTROPHORESIS, ISSN 0173-0835, 05/2018, Volume 39, Issue 9-10, pp. 1301 - 1308
Journal Article
Journal Article
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 03/2017, Volume 61, Issue 3
The efficacy of antimicrobial drugs against Mycobacterium tuberculosis, an intracellular bacterial pathogen, is generally first established by testing... 
Lysosomal trapping | Tuberculosis | Mycobacterium tuberculosis | Ion trapping | Mycobacteria | Antimicrobial agents | Acidic compartment accumulating | Pharmacokinetics | Accumulation | ACQUIRED-IMMUNODEFICIENCY-SYNDROME | ion trapping | PHAGOSOME MATURATION | accumulation | tuberculosis | PSYCHOTROPIC-DRUGS | MICROBIOLOGY | PERITONEAL-MACROPHAGES | CLOFAZIMINE CRYSTALS | mycobacteria | DRUG-RESISTANT TUBERCULOSIS | acidic compartment accumulating | SEROTONIN REUPTAKE INHIBITORS | antimicrobial agents | lysosomal trapping | CULTURED MACROPHAGES | pharmacokinetics | ALVEOLAR MACROPHAGES | WEAK BASES | PHARMACOLOGY & PHARMACY | Protons | Humans | Mycobacterium tuberculosis - drug effects | Anesthetics, Local - pharmacology | Microbial Sensitivity Tests | Ammonium Chloride - pharmacology | Hydrogen-Ion Concentration - drug effects | Macrolides - pharmacology | Biological Transport - drug effects | Anesthetics, Local - metabolism | Macrophages - microbiology | Sertraline - metabolism | Serotonin Uptake Inhibitors - metabolism | Fluoxetine - pharmacology | Sertraline - pharmacology | Clofazimine - metabolism | Dibucaine - metabolism | Macrophages - metabolism | Dibucaine - pharmacology | Antitubercular Agents - pharmacokinetics | Clofazimine - pharmacokinetics | Fluoxetine - metabolism | Macrophages - drug effects | Antitubercular Agents - metabolism | Serotonin Uptake Inhibitors - pharmacology | Mycobacterium tuberculosis - growth & development
Journal Article