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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 2014, Volume 349, Issue 3, pp. 480 - 486
Journal Article
Thorax, ISSN 0040-6376, 2012, Volume 67, Issue 1, pp. 26 - 34
Rationale Muscle atrophy confers a poor prognosis in patients with chronic obstructive pulmonary disease (COPD), yet the molecular pathways responsible are... 
HYPERTROPHY | OBSTRUCTIVE PULMONARY-DISEASE | MYOGENIC DIFFERENTIATION | ATROPHY | RESPIRATORY SYSTEM | ENDURANCE EXERCISE | IN-VIVO | TRANSCRIPTION | GENE-EXPRESSION | MICRORNA EXPRESSION | HUMAN SKELETAL-MUSCLE | Serum Response Factor - genetics | Genetic Predisposition to Disease | Follow-Up Studies | Signal Transduction | Muscular Diseases - metabolism | Down-Regulation | Humans | Male | MicroRNAs - biosynthesis | Pulmonary Disease, Chronic Obstructive - complications | Reverse Transcriptase Polymerase Chain Reaction | Serum Response Factor - biosynthesis | Disease Progression | Muscular Diseases - etiology | Biopsy | Fluorescent Antibody Technique | Female | Aged | MicroRNAs - genetics | Muscular Diseases - genetics | Pulmonary Disease, Chronic Obstructive - metabolism | Quadriceps Muscle - metabolism | Pulmonary Disease, Chronic Obstructive - genetics | Lung diseases, Obstructive | Usage | Causes of | Physiological aspects | Muscle cells | Genetic aspects | Pulmonary function tests | Diagnosis | Research | Genetic regulation | Index Medicus | lung volume reduction surgery | respiratory measurement | sleep apnoea | lung physiology | COPD exacerbations | COPD mechanisms | assisted ventilation | exercise | respiratory muscles | Muscle phenotype | long term oxygen therapy (LTOT) | lung cancer | allergic lung disease | COPD pathology | small cell lung cancer | non-small cell lung cancer | tuberculosis | asthma | sarcoidosis | systemic disease and lungs | non invasive ventilation | microRNA | Chronic Obstructive Pulmonary Disease | serum response factor | pulmonary rehabilitation | 1506 | COPD
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 2063 - 12
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 02/2017, Volume 127, Issue 2, pp. 670 - 680
We recently demonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle cells (SMCs) controls blood pressure by... 
MEDICINE, RESEARCH & EXPERIMENTAL | MUSCLE-CELL DIFFERENTIATION | TRANSCRIPTION | RHO | FOCAL ADHESION KINASE | MASKED HYPERTENSION | GTPASE-ACTIVATING PROTEIN | CARG ELEMENTS | CORONARY-ARTERY-DISEASE | VASCULAR SMOOTH-MUSCLE | GENOME-WIDE ASSOCIATION | Blood Pressure | Serum Response Factor - genetics | Muscle, Smooth, Vascular - metabolism | Sodium Chloride, Dietary - pharmacology | Humans | Myocytes, Smooth Muscle - pathology | rhoA GTP-Binding Protein - metabolism | GTPase-Activating Proteins - metabolism | rhoA GTP-Binding Protein - genetics | Muscle, Smooth, Vascular - physiopathology | Hypertension - chemically induced | Hypertension - genetics | Myocytes, Smooth Muscle - metabolism | Serum Response Factor - metabolism | rho GTP-Binding Proteins - genetics | Sodium Chloride, Dietary - adverse effects | Gene Expression Regulation | Mice, Transgenic | Hypertension - physiopathology | Hypertension - metabolism | Muscle, Smooth, Vascular - pathology | Animals | rho GTP-Binding Proteins - metabolism | CRISPR-Cas Systems | Mice | Polymorphism, Single Nucleotide | GTPase-Activating Proteins - genetics | Hypertension | Cellular proteins | Molecular targeted therapy | Care and treatment | Innovations | Development and progression | Genetic aspects | Gene expression | Health aspects | Genetic polymorphisms | Studies | Substance abuse treatment | Laboratories | Genes | Smooth muscle | Kinases | Experiments | Deoxyribonucleic acid--DNA | Veins & arteries | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2015, Volume 290, Issue 32, pp. 19641 - 19652
The JAK-STAT3 signaling pathway is one of the critical pathways regulating cell proliferation, differentiation, and apoptosis. Myocardin is regarded as a key... 
SIGNALING PATHWAYS | DEPENDENT TRANSCRIPTION | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERUM RESPONSE FACTOR | GENE-EXPRESSION | NEOINTIMA FORMATION | DIFFERENTIATION | VEGF-A | TUBE FORMATION | ENDOTHELIAL GROWTH-FACTOR | Serum Response Factor - genetics | Cell Proliferation | Muscle, Smooth, Vascular - metabolism | Muscle Contraction - genetics | Humans | Janus Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | Vascular Endothelial Growth Factor A - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Trans-Activators - genetics | Cell Differentiation | Myocytes, Smooth Muscle - drug effects | Nuclear Proteins - genetics | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Vascular Endothelial Growth Factor A - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Muscle, Smooth, Vascular - drug effects | Cell Line | Janus Kinases - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Serum Response Factor - metabolism | Gene Expression Regulation | Nuclear Proteins - metabolism | Muscle, Smooth, Vascular - cytology | Feedback, Physiological | Phenotype | Mitogen-Activated Protein Kinase 3 - metabolism | Trans-Activators - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Index Medicus | cardiovascular disease | transcription factor | transcription regulation | cardiovascular | cell signaling | Cell Biology
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2018, Volume 24, Issue 3, pp. 271 - 281
Journal Article
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 11/2011, Volume 301, Issue 5, pp. 656 - 666
Myofibroblast differentiation induced by transforming growth factor-β (TGF-β) and characterized by de novo expression of smooth muscle (SM)-specific proteins... 
Megakaryoblastic leukemia-1 translocation | Serum response factor activation | Human lung fibroblasts | Actin polymerization | Transforming growth factor-β | SMOOTH MUSCLE ACTIN | TRANSCRIPTION FACTORS | human lung fibroblasts | PHYSIOLOGY | PROTEIN-KINASE | PHENOTYPIC MODULATION | DEPENDENT GENE-EXPRESSION | transforming growth factor-beta | actin polymerization | serum response factor activation | EPITHELIAL-MESENCHYMAL TRANSITION | GROWTH-FACTOR-BETA | RESPIRATORY SYSTEM | TRANSFORMING GROWTH-FACTOR-BETA-1 | FOCAL ADHESION KINASE | megakaryoblastic leukemia-1 translocation | Serum Response Factor - genetics | Oncogene Proteins, Fusion - metabolism | Adenoviridae | Gene Expression - drug effects | Stress Fibers - drug effects | Humans | Actins - metabolism | Stress Fibers - pathology | Actins - genetics | DNA-Binding Proteins - metabolism | Myofibroblasts - metabolism | Muscle, Smooth - drug effects | rho-Associated Kinases - metabolism | Lung - metabolism | Pulmonary Fibrosis - metabolism | Real-Time Polymerase Chain Reaction | Genes, Reporter | Transforming Growth Factor beta1 - pharmacology | Myofibroblasts - pathology | Lung - pathology | Transduction, Genetic | Luciferases - analysis | Serum Response Factor - metabolism | Trans-Activators | rho-Associated Kinases - genetics | Smad Proteins - genetics | Lung - physiopathology | Pulmonary Fibrosis - pathology | Muscle, Smooth - metabolism | DNA-Binding Proteins - genetics | Myofibroblasts - drug effects | Blotting, Western | Stress Fibers - metabolism | Signal Transduction - drug effects | Cell Differentiation - drug effects | Oncogene Proteins, Fusion - genetics | Lung - drug effects | Fluorescent Antibody Technique | Muscle, Smooth - physiopathology | Pulmonary Fibrosis - physiopathology | Primary Cell Culture | Muscle, Smooth - pathology | Smad Proteins - metabolism | Index Medicus | transforming growth factor-β
Journal Article
Molecular Cell, ISSN 1097-2765, 12/2016, Volume 64, Issue 6, pp. 1048 - 1061
Journal Article