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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2004, Volume 10, Issue 7, pp. S2 - S9
The molecular bases underlying the pathogenesis of neurodegenerative diseases are gradually being disclosed. One problem that investigators face is... 
MEDICINE, RESEARCH & EXPERIMENTAL | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ONSET PARKINSONS-DISEASE | AXONAL-TRANSPORT | AMYLOID PRECURSOR PROTEIN | ALPHA-SYNUCLEIN | CELL BIOLOGY | A-BETA | MITOCHONDRIAL DYSFUNCTION | HUNTINGTONS-DISEASE | SUPEROXIDE-DISMUTASE | TRANSGENIC MICE | Protein Kinases - metabolism | Oncogene Proteins - genetics | Protein Kinases - genetics | Membrane Glycoproteins - metabolism | Humans | Huntington Disease - pathology | Membrane Glycoproteins - chemistry | Ubiquitin - metabolism | Nerve Degeneration - genetics | Protein Kinases - chemistry | Serum Amyloid A Protein - genetics | Serotonin Plasma Membrane Transport Proteins | Nerve Degeneration - metabolism | Alzheimer Disease - pathology | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Protein Denaturation | Carrier Proteins - chemistry | Parkinson Disease - metabolism | Parkinson Disease - pathology | Neurodegenerative Diseases - pathology | Serum Amyloid A Protein - metabolism | Oncogene Proteins - chemistry | Amyotrophic Lateral Sclerosis - genetics | Oncogene Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Intracellular Signaling Peptides and Proteins | Neurodegenerative Diseases - genetics | Neurodegenerative Diseases - metabolism | Parkinson Disease - genetics | Ubiquitin-Protein Ligases - chemistry | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | Protein Folding | Membrane Glycoproteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Protein Deglycase DJ-1 | Amyotrophic Lateral Sclerosis - pathology | Animals | Carrier Proteins - metabolism | Serum Amyloid A Protein - chemistry | Membrane Transport Proteins | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Huntington Disease - genetics | Alzheimer Disease - genetics | Ubiquitin-Protein Ligases - genetics
Journal Article
Cellular Signalling, ISSN 0898-6568, 2006, Volume 18, Issue 9, pp. 1351 - 1359
Follicle-stimulating hormone (FSH) is necessary and sufficient to induce maturation of ovarian follicles to a mature, preovulatory phenotype in the intact... 
Protein kinase A | Mitogen-activated protein kinase | Follicle-stimulating hormone | Female reproduction | Hypoxia-induced factor 1 | Histone H3 | histone H3 | SIDE-CHAIN CLEAVAGE | follicle-stimulating hormone | OVARIAN-FOLLICLE | ELEMENT-BINDING PROTEIN | HISTONE H3 PHOSPHORYLATION | hypoxia-induced factor 1 | STEROIDOGENIC FACTOR-I | TRANSCRIPTION FACTOR FKHR | female reproduction | P38 MAP KINASE | LUTEINIZING-HORMONE | CELL BIOLOGY | mitogen-activated protein kinase | FOLLICLE-STIMULATING-HORMONE | protein kinase A | GROWTH-FACTOR-I | Cyclic AMP-Dependent Protein Kinases - metabolism | Follicle Stimulating Hormone - metabolism | Tumor Suppressor Proteins - metabolism | Granulosa Cells - physiology | Gene Expression Regulation | Protein Tyrosine Phosphatases - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Animals | Forkhead Transcription Factors - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Female | Signal Transduction - physiology | p38 Mitogen-Activated Protein Kinases - metabolism | Enzyme Activation | Histones - metabolism | Tyrosine | Chromatin | Phosphatases | Corticosteroids | Peptides | Tuberous sclerosis | Glycoproteins | DNA binding proteins | Hormones | Gene expression | Phosphatidylinositol | Luteinizing hormone | Mitogens | Vascular endothelial growth factor | Protein kinases | Growth factors | Protein binding | GIOT-1, gonadotropin-inducible ovarian transcription factor-1 | p70S6K, p70 ribosomal S6 kinase | TGFβ, transforming growth factor β | EGF, epidermal growth factor | CREB, cAMP response element binding protein | PDE, phosphodiesterase | R, PKA regulatory subunits | GPCR, G-protein-coupled receptor | MAP2D, microtubule-associated protein 2D | Sp1 | Epac, exchange proteins activated by cAMP | PI3K, phosphatidylinositol 3-kinase | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | AKAP, A kinase anchoring protein | Sp3, specific protein 1 | PKI, PKA inhibitor peptide | PKC, protein kinase C | SCC, P450 cholesterol side chain cleavage | VEGF, vascular endothelial growth factor | CBP, CREB binding protein | ERK, extracellular regulated kinase | MNK, MAPK-interacting kinase | Aromatase, P450 aromatase | ChIP, chromatin immunoprecipitation assay | HIF-1, hypoxia-induced factor-1 | Egr-1, early growth response protein-1 | LH, luteinizing hormone | MEK, mitogen- and extracellular-regulated kinase kinase | TSC, tuberous sclerosis complex tumor suppressor gene | SF-1, steroidogenic factor-1 | SGK, serum glucocorticoid kinase | RSK, p90 ribosomal S6 protein kinase | LRH-1, liver receptor homolog-1 | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | PTP, protein tyrosine phosphatase | FSH, follicle-stimulating hormone | MK, MAPK-activated protein kinases
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 01/1999, Volume 19, Issue 1, pp. 136 - 146
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
TRANSCRIPTION FACTOR CREB | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TERNARY COMPLEX FACTORS | LONG-TERM POTENTIATION | GROWTH-FACTOR | B-RAF | SERUM RESPONSE ELEMENT | IMMEDIATE-EARLY GENES | DIFFERENTIAL REGULATION | CELL BIOLOGY | Phosphorylation | Protein-Tyrosine Kinases - metabolism | Transcriptional Activation | Male | Extracellular Space | MAP Kinase Kinase 1 | Brain - metabolism | Mitogen-Activated Protein Kinase Kinases | Corpus Striatum - pathology | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins | Mitogen-Activated Protein Kinases | Proto-Oncogene Proteins - metabolism | ets-Domain Protein Elk-1 | Glutamic Acid - pharmacology | Signal Transduction | Gene Expression Regulation | Rats | Rats, Sprague-Dawley | Proto-Oncogene Proteins c-raf - metabolism | Animals | Cyclic AMP Response Element-Binding Protein - metabolism | Brain - pathology | Proto-Oncogene Proteins c-fos - genetics | Glutamic Acid - metabolism | Transcription Factors | Kinetics | Mitogen-Activated Protein Kinase 1 | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Mitogen-Activated Protein Kinase 3 | Brain | Protein-Serine-Threonine Kinases | Neurons and Cognition | Life Sciences | Proto-Oncogene Proteins | Cyclic AMP Response Element-Binding Protein | Proto-Oncogene Proteins c-raf | Trans-Activation (Genetics) | Proto-Oncogene Proteins c-fos | Glutamic Acid | Corpus Striatum | Protein-Tyrosine Kinases | Ca(2+)-Calmodulin Dependent Protein Kinase | Cell Growth and Development
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2015, Volume 470, Issue 3, pp. 303 - 317
Alzheimer's disease (AD) is a fatal neurodegenerative disease affecting 36 million people worldwide. Genetic and biochemical research indicate that the... 
Amyloid-βpeptide | Protein degradation | Alzheimer's disease | Amyloid precursor protein (APP) | FE65 | Serum- and glucocorticoid-induced kinase 1 (SGK1) | Alzheimer Disease - etiology | Amyloid Precursor Protein Secretases - genetics | Phosphorylation | Cricetulus | Amyloid beta-Protein Precursor - chemistry | Humans | Cercopithecus aethiops | Aspartic Acid Endopeptidases - genetics | Immediate-Early Proteins - metabolism | Nerve Tissue Proteins - chemistry | Proteolysis | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Protein Interaction Domains and Motifs | Protein Stability | Nuclear Proteins - genetics | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | CHO Cells | Recombinant Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Recombinant Proteins - genetics | Nuclear Proteins - chemistry | Serine - chemistry | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Immediate-Early Proteins - genetics | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Protein Binding | Protein Processing, Post-Translational | Proteasome Endopeptidase Complex - metabolism | COS Cells | serum- and glucocorticoid-induced kinase 1 (SGK1) | amyloid precursor protein (APP) | protein degradation | amyloid-β peptide
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | HYDROPHOBIC MOTIF | cancer | serum and glucocorticoid protein kinase (SGK) | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article