Journal of Infectious Diseases, ISSN 0022-1899, 01/2015, Volume 211, Issue 1, pp. 80 - 90
Background. Administration of convalescent plasma, serum, or hyperimmune immunoglobulin may be of clinical benefit for treatment of severe acute respiratory...
meta-analysis | severe acute respiratory infection | MERS coronavirus | systematic review | convalescent plasma | INFECTIOUS DISEASES | AVIAN INFLUENZA | CLINICAL CHARACTERISTICS | MICROBIOLOGY | SERUM | IMMUNOLOGY | PNEUMONIA | EXPERIENCE | SARS Virus - immunology | Prospective Studies | Immunoglobulins - immunology | Humans | Plasma - immunology | Respiratory Tract Infections - immunology | Severe Acute Respiratory Syndrome - immunology | Risk | Immunoglobulins - administration & dosage | Influenza, Human - drug therapy | Severe Acute Respiratory Syndrome - drug therapy | Influenza, Human - immunology | Usage | Care and treatment | Immunoglobulins | Severe acute respiratory syndrome | Clinical trials | Research | Risk factors | Meta-analysis | Major and Brief Reports
meta-analysis | severe acute respiratory infection | MERS coronavirus | systematic review | convalescent plasma | INFECTIOUS DISEASES | AVIAN INFLUENZA | CLINICAL CHARACTERISTICS | MICROBIOLOGY | SERUM | IMMUNOLOGY | PNEUMONIA | EXPERIENCE | SARS Virus - immunology | Prospective Studies | Immunoglobulins - immunology | Humans | Plasma - immunology | Respiratory Tract Infections - immunology | Severe Acute Respiratory Syndrome - immunology | Risk | Immunoglobulins - administration & dosage | Influenza, Human - drug therapy | Severe Acute Respiratory Syndrome - drug therapy | Influenza, Human - immunology | Usage | Care and treatment | Immunoglobulins | Severe acute respiratory syndrome | Clinical trials | Research | Risk factors | Meta-analysis | Major and Brief Reports
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2014, Volume 111, Issue 13, pp. 4970 - 4975
In this era of continued emergence of zoonotic virus infections, the rapid development of rodent models represents a critical barrier to public health...
T lymphocytes | Coronavirus | Lungs | Genetic vectors | Antibodies | Viruses | P values | Infections | SARS virus | Cells | Sars | Emerging pathogen | Interferon | VIRUS-INFECTION | MULTIDISCIPLINARY SCIENCES | SARS | interferon | ADENOVIRUS VECTORS | INNATE IMMUNE-RESPONSES | IN-VIVO | DISEASE | C VIRUS | MICE | CYSTIC-FIBROSIS | emerging pathogen | SYNDROME CORONAVIRUS | SAUDI-ARABIA | Coronavirus Infections - prevention & control | Humans | Mice, Inbred C57BL | Respiratory Tract Infections - prevention & control | Severe Acute Respiratory Syndrome - immunology | Cross Reactions - immunology | Coronavirus Infections - immunology | Coronavirus - immunology | Middle East | Signal Transduction - immunology | Animals | Coronavirus Infections - virology | CD8-Positive T-Lymphocytes - virology | Respiratory Tract Infections - immunology | Interferon Type I - metabolism | Antibodies, Viral - immunology | Mice | Respiratory Tract Infections - virology | Coronavirus - physiology | Disease Models, Animal | Host-parasite relationships | Microbiological research | Research | Coronaviruses | Health aspects | Biological Sciences
T lymphocytes | Coronavirus | Lungs | Genetic vectors | Antibodies | Viruses | P values | Infections | SARS virus | Cells | Sars | Emerging pathogen | Interferon | VIRUS-INFECTION | MULTIDISCIPLINARY SCIENCES | SARS | interferon | ADENOVIRUS VECTORS | INNATE IMMUNE-RESPONSES | IN-VIVO | DISEASE | C VIRUS | MICE | CYSTIC-FIBROSIS | emerging pathogen | SYNDROME CORONAVIRUS | SAUDI-ARABIA | Coronavirus Infections - prevention & control | Humans | Mice, Inbred C57BL | Respiratory Tract Infections - prevention & control | Severe Acute Respiratory Syndrome - immunology | Cross Reactions - immunology | Coronavirus Infections - immunology | Coronavirus - immunology | Middle East | Signal Transduction - immunology | Animals | Coronavirus Infections - virology | CD8-Positive T-Lymphocytes - virology | Respiratory Tract Infections - immunology | Interferon Type I - metabolism | Antibodies, Viral - immunology | Mice | Respiratory Tract Infections - virology | Coronavirus - physiology | Disease Models, Animal | Host-parasite relationships | Microbiological research | Research | Coronaviruses | Health aspects | Biological Sciences
Journal Article
Nature Reviews Microbiology, ISSN 1740-1526, 08/2016, Volume 14, Issue 8, pp. 523 - 534
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the...
VIRAL LOAD | SYNERGISTICALLY INHIBIT | NEUTRALIZING ANTIBODIES | COV INFECTION | POSTEXPOSURE EFFICACY | RESPIRATORY SYNDROME-CORONAVIRUS | PAPAIN-LIKE PROTEASE | HUMAN MONOCLONAL-ANTIBODY | MICROBIOLOGY | CLINICAL-FEATURES | RECEPTOR-BINDING DOMAIN | Middle East Respiratory Syndrome Coronavirus - ultrastructure | Severe Acute Respiratory Syndrome - virology | Humans | Pandemics - prevention & control | Severe Acute Respiratory Syndrome - transmission | Severe Acute Respiratory Syndrome - immunology | Cross Infection | Coronavirus Infections - immunology | SARS Virus - pathogenicity | Coronavirus Infections - transmission | SARS Virus - ultrastructure | Camelus - virology | Travel | Middle East Respiratory Syndrome Coronavirus - pathogenicity | Animals | Immune Evasion | Communicable Diseases, Emerging - prevention & control | Coronavirus Infections - virology | Virus Replication | Coronavirus Infections - therapy | Disease Outbreaks - prevention & control | SARS Virus - physiology | Communicable Diseases, Emerging - virology | Middle East Respiratory Syndrome Coronavirus - physiology | Evaluation | Medical research | Care and treatment | Severe acute respiratory syndrome | Medicine, Experimental | Development and progression | Infection control
VIRAL LOAD | SYNERGISTICALLY INHIBIT | NEUTRALIZING ANTIBODIES | COV INFECTION | POSTEXPOSURE EFFICACY | RESPIRATORY SYNDROME-CORONAVIRUS | PAPAIN-LIKE PROTEASE | HUMAN MONOCLONAL-ANTIBODY | MICROBIOLOGY | CLINICAL-FEATURES | RECEPTOR-BINDING DOMAIN | Middle East Respiratory Syndrome Coronavirus - ultrastructure | Severe Acute Respiratory Syndrome - virology | Humans | Pandemics - prevention & control | Severe Acute Respiratory Syndrome - transmission | Severe Acute Respiratory Syndrome - immunology | Cross Infection | Coronavirus Infections - immunology | SARS Virus - pathogenicity | Coronavirus Infections - transmission | SARS Virus - ultrastructure | Camelus - virology | Travel | Middle East Respiratory Syndrome Coronavirus - pathogenicity | Animals | Immune Evasion | Communicable Diseases, Emerging - prevention & control | Coronavirus Infections - virology | Virus Replication | Coronavirus Infections - therapy | Disease Outbreaks - prevention & control | SARS Virus - physiology | Communicable Diseases, Emerging - virology | Middle East Respiratory Syndrome Coronavirus - physiology | Evaluation | Medical research | Care and treatment | Severe acute respiratory syndrome | Medicine, Experimental | Development and progression | Infection control
Journal Article
Journal of Virology, ISSN 0022-538X, 05/2013, Volume 87, Issue 9, pp. 5300 - 5304
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INTERFERON INDUCTION | RESPONSES | DOUBLE-STRANDED-RNA | ACTIVATION | REPLICATION | VIROLOGY | HUMAN AIRWAY EPITHELIUM | VALLEY FEVER VIRUS | INFECTION | DIFFERENTIATION | SARS-CORONAVIRUS | SARS Virus - immunology | Cell Line | Severe Acute Respiratory Syndrome - virology | Humans | Severe Acute Respiratory Syndrome - immunology | Immunity, Innate | Interferon Type I - immunology | Coronavirus Infections - immunology | Coronavirus - immunology | Animals | Coronavirus Infections - virology | Virus Replication | Primates | SARS Virus - physiology | Viral Tropism | Coronavirus - physiology | Interferon Regulatory Factor-3 - immunology | Virus-Cell Interactions
INTERFERON INDUCTION | RESPONSES | DOUBLE-STRANDED-RNA | ACTIVATION | REPLICATION | VIROLOGY | HUMAN AIRWAY EPITHELIUM | VALLEY FEVER VIRUS | INFECTION | DIFFERENTIATION | SARS-CORONAVIRUS | SARS Virus - immunology | Cell Line | Severe Acute Respiratory Syndrome - virology | Humans | Severe Acute Respiratory Syndrome - immunology | Immunity, Innate | Interferon Type I - immunology | Coronavirus Infections - immunology | Coronavirus - immunology | Animals | Coronavirus Infections - virology | Virus Replication | Primates | SARS Virus - physiology | Viral Tropism | Coronavirus - physiology | Interferon Regulatory Factor-3 - immunology | Virus-Cell Interactions
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 02/2016, Volume 19, Issue 2, pp. 181 - 193
Highly pathogenic human respiratory coronaviruses cause acute lethal disease characterized by exuberant inflammatory responses and lung damage. However, the...
VIRUS-INFECTION | DENDRITIC CELLS | LUNG PATHOLOGY | INFLUENZA | INNATE | MICROBIOLOGY | ACUTE RESPIRATORY SYNDROME | PATHOGENESIS | T-CELL RESPONSES | VIROLOGY | IMMUNE-RESPONSES | SYNDROME CORONAVIRUS | PARASITOLOGY | SARS Virus - immunology | Pneumonia - etiology | Severe Acute Respiratory Syndrome - virology | Humans | Severe Acute Respiratory Syndrome - complications | Severe Acute Respiratory Syndrome - immunology | Monocytes - immunology | Interferon Type I - immunology | Animals | Pneumonia - mortality | SARS Virus - genetics | Interferon Type I - genetics | Pneumonia - immunology | Severe Acute Respiratory Syndrome - genetics | Female | Mice | Mice, Inbred BALB C | SARS Virus - physiology | Macrophages - immunology | Pneumonia - genetics | Medical colleges | Pneumonia | Microbiology | Severe acute respiratory syndrome | Bacterial pneumonia | Interferon | Biological response modifiers | T cells | Macrophages | Health aspects
VIRUS-INFECTION | DENDRITIC CELLS | LUNG PATHOLOGY | INFLUENZA | INNATE | MICROBIOLOGY | ACUTE RESPIRATORY SYNDROME | PATHOGENESIS | T-CELL RESPONSES | VIROLOGY | IMMUNE-RESPONSES | SYNDROME CORONAVIRUS | PARASITOLOGY | SARS Virus - immunology | Pneumonia - etiology | Severe Acute Respiratory Syndrome - virology | Humans | Severe Acute Respiratory Syndrome - complications | Severe Acute Respiratory Syndrome - immunology | Monocytes - immunology | Interferon Type I - immunology | Animals | Pneumonia - mortality | SARS Virus - genetics | Interferon Type I - genetics | Pneumonia - immunology | Severe Acute Respiratory Syndrome - genetics | Female | Mice | Mice, Inbred BALB C | SARS Virus - physiology | Macrophages - immunology | Pneumonia - genetics | Medical colleges | Pneumonia | Microbiology | Severe acute respiratory syndrome | Bacterial pneumonia | Interferon | Biological response modifiers | T cells | Macrophages | Health aspects
Journal Article
Journal of Virology, ISSN 0022-538X, 01/2014, Volume 88, Issue 2, pp. 913 - 924
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ENVELOPE PROTEIN-E | REPLICATION | VIROLOGY | PATHWAY | IN-VIVO | ION-CHANNEL | NUCLEOCAPSID PROTEIN | SYNCYTIAL VIRUS | VIRUS ACTIVATES INFLAMMASOMES | EXPRESSION | SARS-CORONAVIRUS | Viral Envelope Proteins - genetics | Severe Acute Respiratory Syndrome - virology | Down-Regulation | Humans | NF-kappa B - immunology | Severe Acute Respiratory Syndrome - immunology | Severe Acute Respiratory Syndrome - mortality | Animals | SARS Virus - genetics | NF-kappa B - genetics | Viral Envelope Proteins - metabolism | Severe Acute Respiratory Syndrome - genetics | Female | Mice | Mice, Inbred BALB C | SARS Virus - physiology | Cytokines - genetics | Cytokines - immunology | Pathogenesis and Immunity
ENVELOPE PROTEIN-E | REPLICATION | VIROLOGY | PATHWAY | IN-VIVO | ION-CHANNEL | NUCLEOCAPSID PROTEIN | SYNCYTIAL VIRUS | VIRUS ACTIVATES INFLAMMASOMES | EXPRESSION | SARS-CORONAVIRUS | Viral Envelope Proteins - genetics | Severe Acute Respiratory Syndrome - virology | Down-Regulation | Humans | NF-kappa B - immunology | Severe Acute Respiratory Syndrome - immunology | Severe Acute Respiratory Syndrome - mortality | Animals | SARS Virus - genetics | NF-kappa B - genetics | Viral Envelope Proteins - metabolism | Severe Acute Respiratory Syndrome - genetics | Female | Mice | Mice, Inbred BALB C | SARS Virus - physiology | Cytokines - genetics | Cytokines - immunology | Pathogenesis and Immunity
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2007, Volume 282, Issue 44, pp. 32208 - 32221
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a novel coronavirus that causes a highly contagious respiratory disease, SARS, with significant...
TOLL-LIKE RECEPTOR-3 | INTERFERON INDUCTION | DEUBIQUITINATING ENZYME | DOUBLE-STRANDED-RNA | ANTIVIRAL RESPONSES | HEPATITIS-C VIRUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIG-I | NF-KAPPA-B | ADAPTER PROTEIN | INFLUENZA-VIRUSES | Protein Structure, Tertiary | SARS Virus - immunology | Cell Line | Bronchi - virology | Severe Acute Respiratory Syndrome - virology | Viral Proteins - chemistry | Humans | Severe Acute Respiratory Syndrome - immunology | Viral Proteins - immunology | Bronchi - immunology | Immunity, Innate | Interferon Type I - immunology | Peptide Hydrolases - chemistry | Peptide Hydrolases - immunology | Animals | Bronchi - cytology | SARS Virus - enzymology | Interferon Regulatory Factor-3 - immunology
TOLL-LIKE RECEPTOR-3 | INTERFERON INDUCTION | DEUBIQUITINATING ENZYME | DOUBLE-STRANDED-RNA | ANTIVIRAL RESPONSES | HEPATITIS-C VIRUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RIG-I | NF-KAPPA-B | ADAPTER PROTEIN | INFLUENZA-VIRUSES | Protein Structure, Tertiary | SARS Virus - immunology | Cell Line | Bronchi - virology | Severe Acute Respiratory Syndrome - virology | Viral Proteins - chemistry | Humans | Severe Acute Respiratory Syndrome - immunology | Viral Proteins - immunology | Bronchi - immunology | Immunity, Innate | Interferon Type I - immunology | Peptide Hydrolases - chemistry | Peptide Hydrolases - immunology | Animals | Bronchi - cytology | SARS Virus - enzymology | Interferon Regulatory Factor-3 - immunology
Journal Article
Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 6, pp. 2995 - 3007
Although the severe acute respiratory syndrome-associated coronavirus (SARS-CoV) epidemic was controlled by nonvaccine measures, coronaviruses remain a major...
MEMORY B-CELLS | VIROLOGY | NEUTRALIZING ANTIBODY | IMMUNE-RESPONSES | SARS CORONAVIRUS | RECEPTOR | INFECTION | INFLUENZA VACCINE | AGED MICE | CD8(+) T-CELLS | POLYSACCHARIDE ADJUVANT | SARS Virus - immunology | Adjuvants, Immunologic - administration & dosage | Severe Acute Respiratory Syndrome - virology | Humans | Viral Vaccines - genetics | Severe Acute Respiratory Syndrome - immunology | Th1 Cells - immunology | Eosinophils - immunology | SARS Virus - genetics | Inulin - administration & dosage | Female | Spike Glycoprotein, Coronavirus - immunology | Immunization | Lung - pathology | Spike Glycoprotein, Coronavirus - genetics | Viral Vaccines - administration & dosage | Interleukin-4 - immunology | Inulin - analogs & derivatives | Severe Acute Respiratory Syndrome - prevention & control | Spike Glycoprotein, Coronavirus - administration & dosage | Animals | Interferon-gamma - immunology | Mice | Mice, Inbred BALB C | Severe Acute Respiratory Syndrome - pathology | Viral Vaccines - immunology | Lung - immunology
MEMORY B-CELLS | VIROLOGY | NEUTRALIZING ANTIBODY | IMMUNE-RESPONSES | SARS CORONAVIRUS | RECEPTOR | INFECTION | INFLUENZA VACCINE | AGED MICE | CD8(+) T-CELLS | POLYSACCHARIDE ADJUVANT | SARS Virus - immunology | Adjuvants, Immunologic - administration & dosage | Severe Acute Respiratory Syndrome - virology | Humans | Viral Vaccines - genetics | Severe Acute Respiratory Syndrome - immunology | Th1 Cells - immunology | Eosinophils - immunology | SARS Virus - genetics | Inulin - administration & dosage | Female | Spike Glycoprotein, Coronavirus - immunology | Immunization | Lung - pathology | Spike Glycoprotein, Coronavirus - genetics | Viral Vaccines - administration & dosage | Interleukin-4 - immunology | Inulin - analogs & derivatives | Severe Acute Respiratory Syndrome - prevention & control | Spike Glycoprotein, Coronavirus - administration & dosage | Animals | Interferon-gamma - immunology | Mice | Mice, Inbred BALB C | Severe Acute Respiratory Syndrome - pathology | Viral Vaccines - immunology | Lung - immunology
Journal Article
Nature Reviews Microbiology, ISSN 1740-1526, 06/2009, Volume 7, Issue 6, pp. 439 - 450
Although coronaviruses were first identified nearly 60 years ago, they only received notoriety in 2003 when one of their members was identified as the...
ANGIOTENSIN-CONVERTING ENZYME-2 | FELINE INFECTIOUS PERITONITIS | ACUTE-RESPIRATORY-SYNDROME | MAGNETIC-RESONANCE STRUCTURE | OPEN READING FRAME | MOUSE HEPATITIS-VIRUS | PAPAIN-LIKE PROTEASE | MICROBIOLOGY | CENTRAL-NERVOUS-SYSTEM | ADAPTIVE IMMUNE-RESPONSES | HOST GENE-EXPRESSION | Animals | Coronavirus - pathogenicity | Coronavirus Infections - virology | Severe Acute Respiratory Syndrome - virology | Models, Biological | Humans | Severe Acute Respiratory Syndrome - immunology | Coronavirus Infections - immunology | Virus Replication - physiology | Coronavirus - immunology | Complications and side effects | Immune response | Severe acute respiratory syndrome | Physiological aspects | Causes of | Development and progression | Research | Coronaviruses | Properties
ANGIOTENSIN-CONVERTING ENZYME-2 | FELINE INFECTIOUS PERITONITIS | ACUTE-RESPIRATORY-SYNDROME | MAGNETIC-RESONANCE STRUCTURE | OPEN READING FRAME | MOUSE HEPATITIS-VIRUS | PAPAIN-LIKE PROTEASE | MICROBIOLOGY | CENTRAL-NERVOUS-SYSTEM | ADAPTIVE IMMUNE-RESPONSES | HOST GENE-EXPRESSION | Animals | Coronavirus - pathogenicity | Coronavirus Infections - virology | Severe Acute Respiratory Syndrome - virology | Models, Biological | Humans | Severe Acute Respiratory Syndrome - immunology | Coronavirus Infections - immunology | Virus Replication - physiology | Coronavirus - immunology | Complications and side effects | Immune response | Severe acute respiratory syndrome | Physiological aspects | Causes of | Development and progression | Research | Coronaviruses | Properties
Journal Article
Journal of Virology, ISSN 0022-538X, 11/2013, Volume 87, Issue 22, pp. 12489 - 12495
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LOCALIZATION | DOUBLE-STRANDED-RNA | VIROLOGY | SIGNALING PATHWAY | NSS PROTEIN | PHOSPHOPROTEIN-P | RIG-I | MEMBRANE-PROTEIN | SARS | SENSOR MDA5 | IDENTIFICATION | Amino Acid Sequence | Coronavirus - pathogenicity | Severe Acute Respiratory Syndrome - virology | Humans | Severe Acute Respiratory Syndrome - immunology | Molecular Sequence Data | Coronavirus Infections - immunology | Viral Regulatory and Accessory Proteins - metabolism | Middle East | Sequence Homology, Amino Acid | Immunity, Innate - immunology | Coronavirus Infections - metabolism | Coronavirus Infections - virology | Severe Acute Respiratory Syndrome - metabolism | RNA, Double-Stranded - metabolism | Coronavirus - growth & development | Interferon Type I - antagonists & inhibitors | Pathogenesis and Immunity
LOCALIZATION | DOUBLE-STRANDED-RNA | VIROLOGY | SIGNALING PATHWAY | NSS PROTEIN | PHOSPHOPROTEIN-P | RIG-I | MEMBRANE-PROTEIN | SARS | SENSOR MDA5 | IDENTIFICATION | Amino Acid Sequence | Coronavirus - pathogenicity | Severe Acute Respiratory Syndrome - virology | Humans | Severe Acute Respiratory Syndrome - immunology | Molecular Sequence Data | Coronavirus Infections - immunology | Viral Regulatory and Accessory Proteins - metabolism | Middle East | Sequence Homology, Amino Acid | Immunity, Innate - immunology | Coronavirus Infections - metabolism | Coronavirus Infections - virology | Severe Acute Respiratory Syndrome - metabolism | RNA, Double-Stranded - metabolism | Coronavirus - growth & development | Interferon Type I - antagonists & inhibitors | Pathogenesis and Immunity
Journal Article