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Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1019 - 1031
Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major... 
C-REACTIVE PROTEIN | INFLAMMATORY-RESPONSE | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis | of STAT3 and production of the neutrophil attractant CXCL1 in pancreatic acinar cells. Examination of human samples revealed expression of IL-6 in combination with soluble IL-6 receptor was a reliable predictor of ALI in SAP. These results demonstrate that IL-6 trans-signaling is an essential mediator of ALI in SAP across | INTERLEUKIN-6 | RESPIRATORY-DISTRESS-SYNDROME | PREDICTION | species and suggest that therapeutic inhibition of IL-6 may prevent SAP-associated ALI | ACUTE-PHASE RESPONSE | ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorly understood, but elevated serum levels of IL-6 is a reliable marker for disease severity. Here, we used a mouse model of acute pancreatitis-associated (AP-associated) ALI to determine the role of IL-6 in ALI lethality. Il6-deficient mice had a lower death rate compared with wild-type mice with AP, while mice injected with IL-6 were more likely to develop lethal ALI. We found that inflammation-associated NF-kappa B induced myeloid cell secretion of IL-6, and the effects of secreted IL-6 were mediated by complexation with soluble IL-6 receptor, a process known as trans-signaling. IL-6 trans-signaling stimulated phosphorylation | BLOCKADE | INHIBITOR | SEVERITY | Phosphorylation | Humans | NF-kappa B - metabolism | Pancreatitis - complications | Receptors, Interleukin-8B - antagonists & inhibitors | Benzenesulfonates - pharmacology | Interleukin-6 - physiology | Pancreatitis - immunology | Acute Lung Injury - metabolism | Chemokine CXCL1 - metabolism | STAT3 Transcription Factor - metabolism | Acinar Cells - metabolism | Aminosalicylic Acids - pharmacology | Signal Transduction | Mice, Inbred C57BL | Pancreas - pathology | Mice, Transgenic | Acute Lung Injury - pathology | Interleukin-6 - secretion | Animals | Myeloid Cells - secretion | Receptors, Interleukin-8B - metabolism | Myeloid Cells - metabolism | Acute Lung Injury - immunology | Pancreatitis - pathology | Mice | Phenylurea Compounds - pharmacology | Protein Processing, Post-Translational | Pancreatitis - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Acute Lung Injury - etiology | Receptors, Interleukin-6 - metabolism | Lung diseases | Pancreatitis | Genetic aspects | Research | Health aspects | Risk factors | Interleukin-6 | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Surgery | Kirurgi
Journal Article
Clinical Nutrition Supplements, ISSN 1744-1161, 2004, Volume 1, Issue 1, pp. 43 - 47
: To investigate the effect of total parenteral nutrition (TPN) and glutamine-supplemented TPN in patients with serious acute pancreatitis (SAP). : Sixty-four... 
Infectious complications | Severe acute pancreatitis | Total parenteral nutrition (TPN) | Mortality | Glutamine dipeptides | mortality | NUTRITION & DIETETICS | glutamine dipeptides | severe acute pancreatitis | total parenteral nutrition (TPN) | infectious complications
Journal Article
FRESENIUS ENVIRONMENTAL BULLETIN, ISSN 1018-4619, 2019, Volume 28, Issue 10, pp. 7069 - 7075
Severe acute pancreatitis (SAP) is a common acute inflammation in pancreas with a high mortality rate. Recently HMGB1 is reported to be involved in the... 
CELLS | ENVIRONMENTAL SCIENCES | Severe acute pancreatitis (SAP) | liver injury | ACTIVATION | MEDIATOR | HMGB1 A-BOX treatment | DEATH | inflammation cytokine | RELEASE | HMG-1
Journal Article
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, ISSN 1000-6834, 06/2017, Volume 33, Issue 6, pp. 550 - 554
Journal Article
Pancreas, ISSN 0885-3177, 08/2015, Volume 44, Issue 6, pp. 868 - 875
Objectives To evaluate alterations of the intestinal bacteria and its associations with the inflammation in acute pancreatitis (AP). Methods A multihospital... 
PCR - polymerase chain reaction | MAP - mild acute pancreatitis | BMI - body mass index | SIRS - systemic inflammatory syndrome | SAP - severe acute pancreatitis | AP - acute pancreatitis | LAL - Limulus amebocyte lysate | DGGE - denaturing gradient gel electrophoresis | interleukin-6 | intestinal microbiota | APACHE-II - Acute Physiology And Chronic Health Evaluation II | ELISA - enzyme-linked immunosorbent assay | IL-1 - interleukin 1 | qPCR - quantitative PCR | acute pancreatitis | MOF - multiple organ failure | polymerase chain reaction-denaturing gradient gel electrophoresis | Abbreviations | TNF-α - tumor necrosis factor α | MORTALITY | IL-1-interleukin 1 | TNF- - tumor necrosis factor | ORGAN FAILURE | BACTERIAL OVERGROWTH | DIVERSITY | BARRIER DYSFUNCTION | FECAL MICROBIOTA | GUT | PROBIOTICS | COMMUNITIES | DISEASE | GASTROENTEROLOGY & HEPATOLOGY | Endotoxins - blood | Predictive Value of Tests | Prospective Studies | Humans | Middle Aged | Male | Dysbiosis | Case-Control Studies | Feces - microbiology | Bacteria - immunology | Microbiota | China | Multiple Organ Failure - microbiology | Bacteria - classification | Pancreatitis - immunology | Adult | Female | Real-Time Polymerase Chain Reaction | Cytokines - blood | Severity of Illness Index | Acute Disease | Risk Factors | Inflammation Mediators - blood | Biomarkers - blood | Bacteria - genetics | Disease Progression | Denaturing Gradient Gel Electrophoresis | Pancreatitis - diagnosis | Host-Pathogen Interactions | DNA, Bacterial - genetics | Intestines - microbiology | Pancreatitis - blood | Pancreatitis - microbiology
Journal Article
Journal Article
Chinese Journal of Evidence-Based Medicine, ISSN 1672-2531, 2013, Volume 13, Issue 9, pp. 1123 - 1128
Journal Article
Pancreas, ISSN 0885-3177, 10/2009, Volume 38, Issue 7, pp. 752 - 757
Objectives: To investigate the influence of ghrelin on the development of severe acute pancreatitis (SAP) and the expression of nuclear factor kappa B... 
NF - nuclear factor | SAP - severe acute pancreatitis | GH - growth hormone | cytokine | CELLS | expression | RAT | FOOD-INTAKE | INSULIN-SECRETION | RELEASE | amylase | PEPTIDE | ghrelin | NF-kappa B | pancreatitis | HORMONE SECRETAGOGUE RECEPTOR | GASTROENTEROLOGY & HEPATOLOGY | FUNCTIONAL RECEPTOR | STOMACH
Journal Article