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index medicus (359) 359
animals (327) 327
shal potassium channels - metabolism (154) 154
rats (149) 149
patch-clamp techniques (133) 133
potassium channels (132) 132
humans (122) 122
shal potassium channels (122) 122
neurosciences (113) 113
male (105) 105
shal potassium channels - genetics (94) 94
cells, cultured (89) 89
potassium channels, voltage-gated (88) 88
mice (84) 84
physiology (74) 74
cardiac & cardiovascular systems (71) 71
membrane potentials - drug effects (71) 71
potassium channels - metabolism (67) 67
female (66) 66
transient outward current (64) 64
potassium channels - genetics (63) 63
membrane potentials - physiology (62) 62
potassium channel blockers - pharmacology (62) 62
rats, sprague-dawley (61) 61
dose-response relationship, drug (55) 55
shal potassium channels - physiology (52) 52
electrophysiology (50) 50
expression (50) 50
potassium - metabolism (50) 50
action potentials - drug effects (49) 49
cardiovascular system (48) 48
cho cells (47) 47
kinetics (46) 46
potassium channel (46) 46
kv4.2 (45) 45
kv4.3 (45) 45
shal potassium channels - antagonists & inhibitors (45) 45
k+ channel (44) 44
myocytes, cardiac - metabolism (44) 44
pharmacology & pharmacy (44) 44
ion channel gating - drug effects (43) 43
potassium channels - physiology (43) 43
cricetinae (42) 42
article (41) 41
neurons - drug effects (41) 41
transfection (41) 41
heart (40) 40
proteins (40) 40
kv channel-interacting proteins - metabolism (39) 39
4-aminopyridine - pharmacology (37) 37
potassium channels - drug effects (36) 36
cell biology (35) 35
currents (35) 35
modulation (35) 35
myocardium - metabolism (35) 35
neurons (35) 35
neurons - physiology (35) 35
peripheral vascular disease (35) 35
shal potassium channels - drug effects (35) 35
ion channel gating - physiology (34) 34
ion channels (34) 34
k+ channels (34) 34
potassium (34) 34
rats, wistar (34) 34
rna, messenger - metabolism (34) 34
action potentials - physiology (33) 33
rodents (33) 33
in vitro techniques (32) 32
long-term potentiation (32) 32
biochemistry & molecular biology (31) 31
kv channel-interacting proteins - genetics (31) 31
neurons - metabolism (31) 31
time factors (31) 31
action potentials (30) 30
cricetulus (29) 29
cell line (28) 28
gene expression (28) 28
molecular sequence data (28) 28
brain (27) 27
calcium - metabolism (27) 27
cells (27) 27
myocytes, cardiac - drug effects (27) 27
disease models, animal (26) 26
down-regulation (26) 26
mice, inbred c57bl (26) 26
myocytes (26) 26
ventricular myocytes (26) 26
amino acid sequence (25) 25
i-to (25) 25
phosphorylation (25) 25
pyramidal neurons (25) 25
xenopus laevis (25) 25
channels (24) 24
electric stimulation (24) 24
inactivation (24) 24
potassium channels, voltage-gated - genetics (24) 24
animals, newborn (23) 23
channel (23) 23
heart ventricles - metabolism (23) 23
heart-failure (23) 23
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Science, ISSN 0036-8075, 7/2004, Volume 305, Issue 5683, pp. 532 - 535
Inherited channelopathies are at the origin of many neurological disorders. Here we report a form of channelopathy that is acquired in experimental temporal... 
Phosphorylation | Neuroscience | Channelopathies | Neurons | Pyramidal cells | Epilepsy | Temporal lobe epilepsy | Reports | Dendrites | Membrane potential | Seizures | FIRING MODE | ACTIVATED PROTEIN-KINASE | GABAERGIC INHIBITION | POTASSIUM CHANNELS | MULTIDISCIPLINARY SCIENCES | STATUS EPILEPTICUS | H-CHANNELS | HIPPOCAMPAL-NEURONS | UP-REGULATION | K+ CHANNELS | CA1 PYRAMIDAL NEURONS | Shal Potassium Channels | Potassium Channels, Voltage-Gated | Nitriles - pharmacology | Potassium Channels - physiology | Epilepsy, Temporal Lobe - physiopathology | Male | Potassium Channels - metabolism | Protein Kinase C - metabolism | Dendrites - physiology | Pyramidal Cells - physiology | Pilocarpine - administration & dosage | 4-Aminopyridine - pharmacology | Action Potentials - drug effects | Potassium Channel Blockers - pharmacology | Butadienes - pharmacology | Enzyme Inhibitors - pharmacology | Rats | Protein Kinase C - antagonists & inhibitors | Hippocampus - cytology | Potassium Channels - drug effects | Rats, Sprague-Dawley | Animals | Membrane Potentials | Mitogen-Activated Protein Kinases - antagonists & inhibitors | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacology | Hippocampus - physiopathology | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Research | Drug therapy | Neurology | Nervous system | Potassium | Index Medicus
Journal Article
Circulation research, ISSN 0009-7330, 2013, Volume 112, Issue 10, pp. 1310 - 1322
A chromosomal haplotype producing cardiac overexpression of dipeptidyl peptidase-like protein-6 (DPP6) causes familial idiopathic ventricular fibrillation. The... 
Molecular electrophysiology | Ventricular tachycardia arrhythmia | Genetic arrhythmia syndromes | Sudden death | ECG | Cardiac arrhythmia mechanisms | Potassium channels | CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | molecular electrophysiology | K+-CURRENTS | CURRENT I | sudden death | BRUGADA-SYNDROME | potassium channels | genetic arrhythmia syndromes | PERIPHERAL VASCULAR DISEASE | cardiac arrhythmia mechanisms | LONG QT SYNDROME | IONIC MECHANISMS | GENE KNOCKDOWN | CONGESTIVE-HEART-FAILURE | HEMATOLOGY | EXPRESSION | CANINE | ventricular tachycardia arrhythmia | Tetraethylammonium - pharmacology | Cricetulus | Humans | Middle Aged | Potassium Channels - physiology | Male | Kv Channel-Interacting Proteins - genetics | Gene Knockdown Techniques | Shal Potassium Channels - drug effects | Shal Potassium Channels - genetics | Transfection | Ventricular Fibrillation - physiopathology | Adult | Female | Kv Channel-Interacting Proteins - physiology | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - genetics | Heart Ventricles - pathology | Potassium Channel Blockers - pharmacology | CHO Cells | Disease Models, Animal | Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - physiology | Models, Theoretical | Shal Potassium Channels - physiology | Cricetinae | Nerve Tissue Proteins - physiology | Kv Channel-Interacting Proteins - drug effects | Cells, Cultured | Potassium Channels - drug effects | Nerve Tissue Proteins - genetics | Potassium Channels - genetics | Purkinje Fibers - pathology | Patch-Clamp Techniques | Animals | Heart Ventricles - physiopathology | Dogs | In Vitro Techniques | Purkinje Fibers - physiology | Index Medicus
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 06/2007, Volume 292, Issue 6, pp. 2898 - 2905
Atrial fibrillation (AF) is the most frequent arrhythmia found in clinical practice. In recent studies, a decrease in the development or recurrence of AF was... 
Ion channels | Atrial fibrillation | Mechanical stretch | Hypertrophy | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | MYOCARDIAL-INFARCTION | hypertrophy | DOWN-REGULATION | CHANNEL SUBUNITS | RANDOMIZED-TRIAL | mechanical stretch | VENTRICULAR MYOCYTES | K+ CURRENTS | ion channels | HYPERTENSIVE PATIENTS | atrial fibrillation | RAT CARDIAC MYOCYTES | RENIN-ANGIOTENSIN SYSTEM | PERIPHERAL VASCULAR DISEASE | MOLECULAR-MECHANISMS | Potassium - metabolism | Antihypertensive Agents - pharmacology | Gene Expression - drug effects | Heart Atria - drug effects | Mechanotransduction, Cellular - drug effects | Angiotensin II Type 1 Receptor Blockers - therapeutic use | Hypertension - drug therapy | RNA, Messenger - metabolism | Angiotensin II Type 1 Receptor Blockers - pharmacology | Shal Potassium Channels - drug effects | Cell Enlargement - drug effects | Potassium Channels, Voltage-Gated - metabolism | Atrial Natriuretic Factor - genetics | Potassium Channels, Voltage-Gated - drug effects | Action Potentials - drug effects | Potassium Channels, Voltage-Gated - genetics | Animals, Newborn | Kv1.5 Potassium Channel - drug effects | Atrial Natriuretic Factor - metabolism | Heart Atria - cytology | Potassium Channels, Inwardly Rectifying - drug effects | Cell Size - drug effects | Cells, Cultured | Losartan - pharmacology | Rats | Antihypertensive Agents - therapeutic use | Heart Atria - metabolism | Cell Shape - drug effects | Shal Potassium Channels - metabolism | Animals | Myocytes, Cardiac - drug effects | Kv1.5 Potassium Channel - metabolism | Losartan - therapeutic use | Atrial Fibrillation - etiology | Hypertension - complications | Myocytes, Cardiac - metabolism | Kinetics | Potassium Channels, Inwardly Rectifying - metabolism | Atrial Fibrillation - prevention & control | Cardiac arrhythmia | Cell culture | Coronary vessels | Rodents | Cardiology | Drug therapy | ACE inhibitors | Clinical outcomes | Index Medicus
Journal Article
Psychopharmacology, ISSN 0033-3158, 6/2015, Volume 232, Issue 11, pp. 1995 - 2006
Chronic alcohol-induced cognitive impairments and maladaptive plasticity of glutamatergic synapses are well-documented. However, it is unknown if prolonged... 
Neurosciences | CA1 pyramidal neurons | Chronic alcohol | Biomedicine | Back-propagating action potentials | Kv4.2 channels | KChIP3 | Dendritic calcium transients | Pharmacology/Toxicology | Psychiatry | CHRONIC INTERMITTENT ETHANOL | EMERGENCY ROOM | BLOOD-ALCOHOL | PSYCHIATRY | D-ASPARTATE RECEPTORS | SYNAPTIC PLASTICITY | NEUROSCIENCES | NUCLEUS-ACCUMBENS | NMDA-RECEPTOR | PHARMACOLOGY & PHARMACY | LONG-TERM POTENTIATION | K+ CHANNELS | Dendrites - drug effects | Pyramidal Cells - metabolism | Shal Potassium Channels - physiology | Kv Channel-Interacting Proteins - drug effects | Calcium - metabolism | Calcium Signaling - physiology | Neuronal Plasticity - drug effects | Rats | Hippocampus - drug effects | Rats, Sprague-Dawley | Action Potentials - physiology | Shal Potassium Channels - drug effects | Animals | Neuronal Plasticity - physiology | Synapses - metabolism | Calcium Signaling - drug effects | Dendrites - physiology | Female | Kv Channel-Interacting Proteins - physiology | Alcoholism - physiopathology | Hippocampus - physiopathology | Action Potentials - drug effects | Neuroplasticity | Alcoholics | Physiological aspects | Genetic aspects | Research | Potassium channels | Brain | Alcohol | Psychopharmacology | Index Medicus | back-propagating action potentials | dendritic calcium transients | chronic alcohol
Journal Article
Journal Article
Neuron, ISSN 0896-6273, 11/2008, Volume 60, Issue 4, pp. 657 - 671
The transient, A-type K current (I ) controls the excitability of CA1 pyramidal neuron dendrites by regulating the back-propagation of action potentials and by... 
CELLBIO | MOLNEURO | SIGNALING | DENDRITIC SPINES | AMPA RECEPTORS | POTASSIUM CHANNELS | POSTNATAL-DEVELOPMENT | LONG-TERM POTENTIATION | RAT-BRAIN | D-ASPARTATE RECEPTOR | HOMEOSTATIC PLASTICITY | MOLECULAR-BASIS | NEUROSCIENCES | PROTEIN-KINASE-II | Protein Subunits - drug effects | Pyramidal Cells - metabolism | Membrane Potentials - genetics | Synaptic Transmission - physiology | Calcium - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Protein Subunits - metabolism | Receptors, N-Methyl-D-Aspartate - genetics | Shal Potassium Channels - drug effects | Shal Potassium Channels - genetics | Synapses - metabolism | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Organ Culture Techniques | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Synapses - drug effects | Receptors, N-Methyl-D-Aspartate - drug effects | Rats | Long-Term Potentiation - genetics | Hippocampus - cytology | Mutation - genetics | Rats, Sprague-Dawley | Mice, Knockout | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Hippocampus - metabolism | Shal Potassium Channels - metabolism | Animals | Mice | Calcium Signaling - genetics | Back propagation | Propagation | Kinases | Neurons | Rodents | Index Medicus | LTP | Kv4.2 | CaMKII | hippocampus | NMDA receptors | voltage-gated potassium channel
Journal Article
Journal Article
Journal Article
Gut, ISSN 0017-5749, 10/2013, Volume 62, Issue 10, pp. 1466 - 1474
Objective Increased faecal butyrate levels have been reported in irritable bowel syndrome. Rectal instillation of sodium butyrate (NaB) increases visceral... 
pain | irritable bowel syndrome | PHOSPHORYLATION | Kv4 | HORN NEURONS | K+ CURRENTS | 2 potassium channel | visceral hypersensitivity | VISCERAL PAIN | IN-VITRO | ERK INTEGRATES PKA | CHAIN FATTY-ACIDS | Sensory neurons | GENE-EXPRESSION | PRIMARY SENSORY NEURONS | GASTROENTEROLOGY & HEPATOLOGY | IRRITABLE-BOWEL-SYNDROME | Visceral Pain - chemically induced | MAP Kinase Signaling System - physiology | Nitriles - pharmacology | Irritable Bowel Syndrome - enzymology | Colon - drug effects | Colon - innervation | Male | Shal Potassium Channels - drug effects | Ganglia, Spinal - enzymology | Dilatation | Phosphorylation - drug effects | Irritable Bowel Syndrome - chemically induced | Butadienes - pharmacology | Cells, Cultured | Rats | Enzyme Activation - drug effects | Rats, Sprague-Dawley | Enema | Patch-Clamp Techniques | Shal Potassium Channels - metabolism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Butyrates - toxicity | Protein Kinase Inhibitors - pharmacology | Ganglia, Spinal - drug effects | Visceral Pain - enzymology | Mitogen-Activated Protein Kinases - metabolism | Care and treatment | Usage | Dorsal root ganglia | Western immunoblotting | Irritable bowel syndrome | Research | Risk factors | Proteins | Studies | Spinal cord | Phosphorylation | Hypotheses | Pain | Neurons | Rodents | Kinases | Catheters | Index Medicus | Abridged Index Medicus
Journal Article
Cardiovascular Research, ISSN 0008-6363, 11/2003, Volume 60, Issue 2, pp. 298 - 306
Journal Article
Circulation Research, ISSN 0009-7330, 12/2005, Volume 97, Issue 12, pp. 1280 - 1287
Journal Article
STEM CELLS, ISSN 1066-5099, 03/2005, Volume 23, Issue 3, pp. 371 - 382
This study characterized functional ion channels in cultured undifferentiated human mesenchymal stem cells (hMSCs) from bone marrow with whole‐cell patch clamp... 
current | Transient outward K | TTX‐sensitive Na | Heag K | Human mesenchymal stem cells | Ion channels | activated K | TTX-sensitive Na | ACTIVATION | K+ CURRENT-DENSITY | RAT | ionchannels | DROSOPHILA | CELL BIOLOGY | IN-VITRO | ONCOLOGY | human mesenchymal stem cells | ETHER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GO-GO CHANNELS | HEART FUNCTION | TTX sensitive Na+ current | transient outward K+ current | heag K(+)current | HEMATOLOGY | EXPRESSION | Ca2+-activated K+ current | POTASSIUM CHANNEL | Large-Conductance Calcium-Activated Potassium Channels | Shal Potassium Channels | Potassium Channels, Voltage-Gated - physiology | Gene Expression - genetics | Humans | NAV1.7 Voltage-Gated Sodium Channel | Bone Marrow Cells - physiology | Ion Channels - genetics | Ion Channels - physiology | Sodium Channels - physiology | RNA, Messenger - metabolism | Potassium Channels, Calcium-Activated - genetics | Mesenchymal Stromal Cells - cytology | Potassium Channels, Voltage-Gated - drug effects | Bone Marrow Cells - drug effects | Cell Differentiation | Tetrodotoxin - pharmacology | 4-Aminopyridine - pharmacology | Mesenchymal Stromal Cells - physiology | Potassium Channels, Voltage-Gated - genetics | Membrane Potentials - drug effects | Mesenchymal Stromal Cells - drug effects | Nifedipine - pharmacology | Potassium Channels, Calcium-Activated - physiology | Bone Marrow Cells - cytology | RNA, Messenger - genetics | Cells, Cultured | Ether-A-Go-Go Potassium Channels | Calcium Channels, L-Type - physiology | Sodium Channels - drug effects | Nerve Tissue Proteins - genetics | Peptides - pharmacology | Potassium Channels - genetics | Patch-Clamp Techniques | Calcium Channels, L-Type - genetics | Large-Conductance Calcium-Activated Potassium Channel alpha Subunits | Calcium Channels, L-Type - drug effects | Potassium Channels, Calcium-Activated - drug effects | Kv1.4 Potassium Channel | Sodium Channels - genetics | Index Medicus
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 07/2008, Volume 106, Issue 1, pp. 182 - 192
Somatodendritic voltage‐dependent K + currents (Kv4.2) channels mediate transient A‐type K + currents and play critical roles in controlling neuronal... 
epilepsy | A‐type potassium currents | excitability | extrasynaptic | NMDA receptors | long‐term potentiation | Excitability | A-type potassium currents | Extrasynaptic | Epilepsy | Long-term potentiation | NERVOUS-SYSTEM | DIFFERENTIAL EXPRESSION | POTASSIUM CHANNELS | DENDRITIC K+ CHANNELS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | NEUROSCIENCES | CA1 PYRAMIDAL NEURONS | IN-VITRO | MAMMALIAN BRAIN | long-term potentiation | Synaptic Transmission - physiology | Rats, Wistar | Calcium Signaling - physiology | Receptors, N-Methyl-D-Aspartate - metabolism | Neuronal Plasticity - drug effects | Neurons - cytology | Dendrites - ultrastructure | Shal Potassium Channels - drug effects | Neuronal Plasticity - physiology | Synapses - metabolism | Synaptic Transmission - drug effects | Cell Membrane - metabolism | Neurons - metabolism | Neurons - drug effects | Cell Membrane - drug effects | Membrane Potentials - drug effects | Dendrites - drug effects | Dendrites - metabolism | Synapses - drug effects | Glutamic Acid - pharmacology | Cells, Cultured | Rats | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Hippocampus - cytology | Membrane Potentials - physiology | Hippocampus - metabolism | Patch-Clamp Techniques | Shal Potassium Channels - metabolism | Animals | Calcium Signaling - drug effects | Receptors, N-Methyl-D-Aspartate - agonists | Glutamic Acid - metabolism | Glutamate | Methyl aspartate | Neurons | Neurology | Signal transduction | Brain | Cell culture | Biochemistry | Potassium | Index Medicus
Journal Article