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shal potassium channels - metabolism (320) 320
rats (266) 266
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shal potassium channels (226) 226
potassium channels (217) 217
shal potassium channels - genetics (202) 202
neurosciences (185) 185
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potassium channels, voltage-gated (168) 168
mice (160) 160
potassium channels - metabolism (152) 152
potassium channels - genetics (131) 131
cells, cultured (121) 121
physiology (117) 117
cardiac & cardiovascular systems (115) 115
female (115) 115
rats, sprague-dawley (114) 114
expression (107) 107
biochemistry & molecular biology (100) 100
cardiovascular system (94) 94
kv channel-interacting proteins - metabolism (93) 93
potassium - metabolism (92) 92
transient outward current (92) 92
potassium channel (88) 88
k+ channel (84) 84
proteins (84) 84
electrophysiology (83) 83
membrane potentials - physiology (83) 83
myocardium - metabolism (83) 83
kinetics (81) 81
article (79) 79
neurons (79) 79
neurons - metabolism (78) 78
cell biology (73) 73
k+ channels (73) 73
myocytes, cardiac - metabolism (73) 73
rna, messenger - metabolism (72) 72
kv4.2 (71) 71
molecular sequence data (71) 71
kv channel-interacting proteins - genetics (69) 69
modulation (67) 67
gene expression (65) 65
potassium (65) 65
amino acid sequence (64) 64
transfection (64) 64
ion channels (62) 62
action potentials - physiology (61) 61
cell line (61) 61
action potentials (59) 59
membrane potentials - drug effects (58) 58
calcium - metabolism (57) 57
i-to (57) 57
ion channel gating - physiology (57) 57
heart (55) 55
neurons - physiology (55) 55
peripheral vascular disease (55) 55
down-regulation (53) 53
shal potassium channels - physiology (53) 53
kv channel-interacting proteins (51) 51
potassium channel blockers - pharmacology (51) 51
xenopus laevis (51) 51
currents (50) 50
immunohistochemistry (50) 50
kv4.3 (50) 50
mice, inbred c57bl (50) 50
potassium channels - physiology (50) 50
rats, wistar (50) 50
long-term potentiation (49) 49
cho cells (48) 48
rodents (48) 48
cricetinae (47) 47
heart ventricles - metabolism (47) 47
potassium channels, voltage-gated - metabolism (47) 47
pyramidal neurons (47) 47
time factors (47) 47
brain (46) 46
biophysics (45) 45
differential expression (45) 45
ion channel gating (45) 45
phosphorylation (45) 45
dose-response relationship, drug (43) 43
hippocampus - metabolism (43) 43
reverse transcriptase polymerase chain reaction (43) 43
blotting, western (42) 42
cells (42) 42
gene-expression (42) 42
inactivation (42) 42
calcium-binding proteins - metabolism (41) 41
mice, knockout (41) 41
physiological aspects (41) 41
protein binding (41) 41
shal potassium channels - chemistry (41) 41
ventricular myocytes (41) 41
action potentials - drug effects (40) 40
channels (40) 40
heart-failure (40) 40
in vitro techniques (40) 40
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Heart Rhythm, ISSN 1547-5271, 2011, Volume 8, Issue 7, pp. 1024 - 1032
Journal Article
Molecular Cell, ISSN 1097-2765, 01/2017, Volume 65, Issue 1, pp. 52 - 65
Tetrameric assembly of channel subunits in the endoplasmic reticulum (ER) is essential for surface expression and function of K channels, but the molecular... 
J-protein | hERG | protein trafficking | long QT syndrome | chaperone protein | C. elegans | protein oligomerization | potassium channel | protein biogenesis | subunit assembly | PAS DOMAIN | CAENORHABDITIS-ELEGANS | HERG | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC-ARRHYTHMIA | LONG QT SYNDROME | SHAKER POTASSIUM CHANNEL | I-KR | CONFORMATIONAL DEFECT | MEMBRANE-PROTEINS | MOLECULAR-BASIS | CELL BIOLOGY | HSP47 Heat-Shock Proteins - chemistry | Caenorhabditis elegans Proteins - chemistry | Humans | Protein Multimerization | Caenorhabditis elegans Proteins - metabolism | Endoplasmic Reticulum - metabolism | Potassium Channels - metabolism | Shal Potassium Channels - genetics | Transfection | RNA Interference | Time Factors | HEK293 Cells | Protein Structure, Quaternary | ERG1 Potassium Channel - genetics | Protein Stability | HSP40 Heat-Shock Proteins - chemistry | Induced Pluripotent Stem Cells - metabolism | HSP40 Heat-Shock Proteins - metabolism | Caenorhabditis elegans - metabolism | ERG1 Potassium Channel - chemistry | HSP40 Heat-Shock Proteins - genetics | Animals, Genetically Modified | Caenorhabditis elegans - genetics | ERG1 Potassium Channel - metabolism | HSP47 Heat-Shock Proteins - genetics | HSP70 Heat-Shock Proteins - metabolism | Potassium Channels - genetics | Long QT Syndrome - metabolism | Shal Potassium Channels - metabolism | Animals | Membrane Potentials | Cell Line, Tumor | Long QT Syndrome - genetics | Myocytes, Cardiac - metabolism | HSP47 Heat-Shock Proteins - metabolism | Potassium Channels - chemistry | Mutation | Caenorhabditis elegans Proteins - genetics | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 11/2012, Volume 15, Issue 11, pp. 1488 - 1497
FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.... 
NEURODEGENERATIVE DISEASE | GENE | AMYOTROPHIC-LATERAL-SCLEROSIS | FAMILY PROTEINS | FUS PATHOLOGY | MUTATIONS | FRONTOTEMPORAL LOBAR DEGENERATION | BINDING | NEUROSCIENCES | BRAIN | NASCENT TRANSCRIPTION | RNA, Small Interfering - genetics | Protein Binding - genetics | Oligonucleotide Array Sequence Analysis | Humans | tau Proteins - metabolism | Gene Expression Profiling | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - metabolism | Brain - metabolism | Frontotemporal Dementia - metabolism | RNA Splicing - genetics | Frontotemporal Dementia - genetics | RNA-Binding Protein FUS - deficiency | Amyotrophic Lateral Sclerosis - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | RNA-Binding Protein FUS - genetics | Mice, Knockout | Motor Neurons - metabolism | Amyotrophic Lateral Sclerosis - pathology | Shal Potassium Channels - metabolism | Brain - pathology | Mice | Neurofilament Proteins - metabolism | RNA, Small Interfering - metabolism | Immunoprecipitation | Spinal Cord - metabolism | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | tau Proteins - genetics | Cell Cycle Proteins - genetics | Female | RNA Precursors - metabolism | Excitatory Amino Acid Transporter 2 - genetics | Membrane Proteins - metabolism | Frontotemporal Dementia - pathology | Gene Expression Regulation - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA Precursors - genetics | Protein Structure, Tertiary - genetics | RNA-Binding Protein FUS - metabolism | DNA-Binding Proteins - genetics | Excitatory Amino Acid Transporter 2 - metabolism | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Neural Cell Adhesion Molecules - metabolism | Neural Stem Cells - metabolism | Cell Line, Transformed | Amyotrophic lateral sclerosis | Development and progression | Genetic aspects | Messenger RNA | Health aspects | Index Medicus
Journal Article
Circulation, ISSN 0009-7322, 03/2009, Volume 119, Issue 9, pp. 1220 - 1230
Background-Cardiac resynchronization therapy (CRT) is widely applied in patients with heart failure and dyssynchronous contraction (DHF), but the... 
Heart failure | Ion channels | Resynchronization, electrophysiology | Remodeling | heart failure | remodeling | CARDIAC & CARDIOVASCULAR SYSTEMS | SUDDEN-DEATH | resynchronization | IONIC MECHANISM | VENTRICULAR MYOCYTES | QT INTERVAL | ion channels | OUTWARD POTASSIUM CURRENT | BUNDLE-BRANCH-BLOCK | electrophysiology | CARDIAC-RESYNCHRONIZATION | CALCIUM-CHANNELS | FAILING HEART | TRANSMURAL DISPERSION | PERIPHERAL VASCULAR DISEASE | Calcium Channels - metabolism | Calcium - metabolism | Heart Failure - physiopathology | Bundle-Branch Block - physiopathology | Male | Bundle-Branch Block - diagnosis | RNA, Messenger - metabolism | Kv Channel-Interacting Proteins - genetics | Kv Channel-Interacting Proteins - metabolism | Pacemaker, Artificial | Bundle-Branch Block - therapy | Heart Failure - therapy | Shal Potassium Channels - genetics | Electrocardiography | Heart Failure - diagnostic imaging | Calcium Channels - genetics | Coronary Circulation | Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism | Echocardiography | Potassium Channels, Inwardly Rectifying - genetics | Action Potentials - physiology | Patch-Clamp Techniques | Shal Potassium Channels - metabolism | Animals | Myocytes, Cardiac - physiology | Homeostasis - physiology | Dogs | Sarcoplasmic Reticulum Calcium-Transporting ATPases - genetics | Potassium Channels, Inwardly Rectifying - metabolism | Care and treatment | Usage | Animal models in research | Cardiac pacing | Electrophysiology | Physiological aspects | Research | Index Medicus | Abridged Index Medicus
Journal Article
eLife, ISSN 2050-084X, 2014, Volume 3, pp. e03255 - e03255
Temperature-sensitive transient receptor potential (TRP) ion channels are members of the large tetrameric cation channels superfamily but are considered to be... 
gating | TRP channel | allosteric coupling | potassium channel | conformational changes | temperature sensing | Potassium - metabolism | Large-Conductance Calcium-Activated Potassium Channels - metabolism | Allosteric Regulation | Humans | Shaker Superfamily of Potassium Channels - metabolism | Large-Conductance Calcium-Activated Potassium Channels - chemistry | TRPV Cation Channels - metabolism | Shal Potassium Channels - genetics | Shaker Superfamily of Potassium Channels - chemistry | HEK293 Cells | Large-Conductance Calcium-Activated Potassium Channels - genetics | Shal Potassium Channels - chemistry | Ion Transport | Transgenes | Protein Structure, Tertiary | Shab Potassium Channels - genetics | Gene Expression | Shaker Superfamily of Potassium Channels - genetics | Shab Potassium Channels - chemistry | TRPV Cation Channels - chemistry | Hot Temperature | Membrane Potentials - physiology | TRPV Cation Channels - genetics | Patch-Clamp Techniques | Shab Potassium Channels - metabolism | Shal Potassium Channels - metabolism | Animals | Mice | Ion Channel Gating | GATING CHARGE | DEPENDENT POTASSIUM | ACTIVATION | TRP channels | CAPSAICIN RECEPTOR | TRPV1 ION-CHANNEL | potassium channels | BIOLOGY | CLOSED-STATE INACTIVATION | SHAKER | K+ CHANNEL | PORE DOMAIN | KV4.2 CHANNELS | Data analysis | Pain perception | Channel gating | Capsaicin receptors | Equilibrium | Thermal energy | Transient receptor potential proteins | Heat | Allosteric properties | Temperature effects | Nociceptors | Physiology | Potassium channels (voltage-gated) | Ion channels | Sensors | Potassium | Index Medicus
Journal Article
Toxicological Sciences, ISSN 1096-6080, 03/2017, Volume 156, Issue 1, pp. 25 - 38
Drug-induced proarrhythmia is a major safety issue in drug development. Developing sensitive in vitro assays that can predict drug-induced cardiotoxicity in... 
Drug-induced proarrhythmia | iPSC-CMs | Batch variations | ACTION-POTENTIALS | TORSADES-DE-POINTES | DOFETILIDE | CONTRACTILITY | drug-induced proarrhythmia | PROLONGATION | LONG-QT SYNDROME | VENTRICULAR MYOCYTES | MATURATION | IMPEDANCE | TOXICOLOGY | batch variations | RISK-ASSESSMENT | Arrhythmias, Cardiac - chemically induced | Drug Evaluation, Preclinical - economics | Calcium Channel Blockers - adverse effects | Anti-Arrhythmia Agents - pharmacology | Humans | Potassium Channel Blockers - antagonists & inhibitors | Toxicity Tests, Acute - methods | Potassium Channel Blockers - adverse effects | Arrhythmias, Cardiac - pathology | Shal Potassium Channels - genetics | Kv1.5 Potassium Channel - genetics | Toxicity Tests, Acute - economics | Induced Pluripotent Stem Cells - cytology | Voltage-Gated Sodium Channel Blockers - adverse effects | Potassium Channel Blockers - pharmacology | Induced Pluripotent Stem Cells - metabolism | Arrhythmias, Cardiac - metabolism | Induced Pluripotent Stem Cells - pathology | Cell Line | Drug Evaluation, Preclinical - methods | Reproducibility of Results | Induced Pluripotent Stem Cells - drug effects | Myocytes, Cardiac - cytology | Antioxidants - pharmacology | Calcium Channel Blockers - pharmacology | Gene Expression Regulation - drug effects | Myocytes, Cardiac - pathology | Shal Potassium Channels - metabolism | Calcium Channels, L-Type - genetics | Myocytes, Cardiac - drug effects | Cell Differentiation - drug effects | Kv1.5 Potassium Channel - metabolism | Calcium Channel Blockers - chemistry | Myocytes, Cardiac - metabolism | Voltage-Gated Sodium Channel Blockers - pharmacology | Calcium Channels, L-Type - metabolism | Kinetics | Electrophysiological Phenomena - drug effects | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 7/2004, Volume 305, Issue 5683, pp. 532 - 535