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animals (658) 658
src homology 2 domain-containing, transforming protein 1 (635) 635
humans (569) 569
shc signaling adaptor proteins (489) 489
mice (425) 425
phosphorylation (382) 382
adaptor proteins, signal transducing (351) 351
index medicus (338) 338
biochemistry & molecular biology (321) 321
signal transduction (313) 313
cell biology (299) 299
adaptor proteins, vesicular transport (286) 286
proteins - metabolism (270) 270
shc signaling adaptor proteins - metabolism (233) 233
oxidative stress (221) 221
shc signaling adaptor proteins - genetics (192) 192
shc (184) 184
cell line (162) 162
apoptosis (152) 152
oncology (146) 146
activation (144) 144
male (142) 142
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female (133) 133
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grb2 adaptor protein (111) 111
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amino acid sequence (105) 105
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expression (95) 95
proteins - genetics (93) 93
reactive oxygen species - metabolism (92) 92
adapter protein (90) 90
mice, knockout (90) 90
enzyme activation (88) 88
genetics & heredity (88) 88
proto-oncogene proteins - metabolism (83) 83
p66shc (82) 82
src homology domains (82) 82
p66 (81) 81
research (81) 81
cell line, tumor (78) 78
mitogen-activated protein kinases - metabolism (77) 77
phosphoproteins - metabolism (76) 76
receptor protein-tyrosine kinases - metabolism (74) 74
adaptor proteins, signal transducing - genetics (73) 73
signaling pathway (73) 73
phosphatidylinositol 3-kinase (72) 72
binding sites (71) 71
phosphatidylinositol 3-kinases - metabolism (71) 71
3t3 cells (70) 70
protein (70) 70
tyrosine phosphorylation (70) 70
cells (68) 68
protein-tyrosine kinases - metabolism (67) 67
physiological aspects (66) 66
tyrosine kinase (65) 65
cell proliferation (62) 62
tumor cells, cultured (62) 62
endocrinology & metabolism (61) 61
blotting, western (59) 59
phosphotyrosine - metabolism (59) 59
protein structure, tertiary (59) 59
gene expression (58) 58
mice, inbred c57bl (57) 57
pathway (57) 57
ras (56) 56
receptor (56) 56
recombinant fusion proteins - metabolism (56) 56
signal transduction - drug effects (56) 56
genetic aspects (54) 54
multidisciplinary sciences (53) 53
kinases (52) 52
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phosphorylation - drug effects (50) 50
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calcium-calmodulin-dependent protein kinases - metabolism (47) 47
growth-factor receptor (47) 47
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reactive oxygen species (46) 46
shc protein (46) 46
shc signaling adaptor proteins - physiology (46) 46
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Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7457, pp. 166 - 171
Journal Article
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Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 52, pp. 44326 - 44335
Endogenous glucocorticoids (GCs) and inflammatory cytokines contribute to the age-associated loss of bone mass and strength, but the molecular mechanisms... 
TRANSCRIPTIONAL ACTIVITY | REACTIVE OXYGEN | BONE-MINERAL DENSITY | PROTEASOMAL DEGRADATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORKHEAD-BOX-O | GENE-EXPRESSION | EXTENDS LIFE-SPAN | T-CELL-FACTOR | BETA-CATENIN | NF-KAPPA-B | Tumor Necrosis Factor-alpha - metabolism | Shc Signaling Adaptor Proteins - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Oxidative Stress - physiology | Tumor Necrosis Factor-alpha - genetics | Wnt Signaling Pathway - physiology | Male | Wnt Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Dexamethasone - pharmacology | MAP Kinase Kinase 4 - metabolism | Wnt Proteins - genetics | Forkhead Transcription Factors - metabolism | Female | Osteoblasts - cytology | Proto-Oncogene Proteins c-akt - metabolism | Cell Differentiation - physiology | Forkhead Transcription Factors - genetics | Prednisolone - pharmacology | beta Catenin - metabolism | beta Catenin - genetics | Mice, Knockout | Animals | Shc Signaling Adaptor Proteins - genetics | Src Homology 2 Domain-Containing, Transforming Protein 1 | Wnt Signaling Pathway - drug effects | Cell Differentiation - drug effects | Glucocorticoids - pharmacology | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | Mice | Apoptosis - physiology | Oxidative Stress - drug effects | Osteoblasts - metabolism | Wnt Signaling | FoxO | Glucocorticoids | Oxidative Stress | Tumor Necrosis Factor (TNF) | Osteoblasts | Cell Biology
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5811
Epidermal growth factor receptor (EGFR) overexpression plays an important oncogenic role in cancer. Regular EGFR protein levels are increased in cancer cells... 
AUTOCRINE LOOP | RECEPTOR TYROSINE KINASES | MULTIDISCIPLINARY SCIENCES | EPIDERMAL-GROWTH-FACTOR | GENE-EXPRESSION | HUMAN GLIOMAS | CANCER-THERAPY | TRANSGENIC MICE | INNATE IMMUNITY | BRAIN-TUMORS | FACTOR-ALPHA | Receptor, Epidermal Growth Factor - genetics | Shc Signaling Adaptor Proteins - metabolism | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Interferon Regulatory Factor-3 - genetics | Brain Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Receptor, Epidermal Growth Factor - metabolism | Glioblastoma - genetics | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Brain Neoplasms - genetics | Signal Transduction - genetics | TNF-Related Apoptosis-Inducing Ligand - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Shc Signaling Adaptor Proteins - genetics | Glioblastoma - pathology | Cell Line, Tumor | Interferon Regulatory Factor-3 - metabolism | Epidermal Growth Factor - pharmacology | Primary Cell Culture | TNF-Related Apoptosis-Inducing Ligand - genetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2017, Volume 292, Issue 14, pp. 5748 - 5759
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 83, pp. 112 - 121
Abstract Ageing is associated with functional, structural and mechanical changes in arteries that closely resemble the vascular alterations in hypertension.... 
Cardiovascular | Vascular remodeling | Endothelial dysfunction | Oxidative stress | Mitochondria | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOPLASMIC-RETICULUM STRESS | AGE-RELATED DECLINE | HYDROGEN-SULFIDE | BLOOD-PRESSURE | CELL BIOLOGY | RENIN-ANGIOTENSIN SYSTEM | FREE-RADICAL THEORY | NITRIC-OXIDE | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | Shc Signaling Adaptor Proteins - metabolism | Oxidative Stress | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Transforming Growth Factor beta1 - metabolism | Forkhead Transcription Factors - metabolism | Myocardium - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Cell Cycle Proteins - genetics | Hypertension - genetics | Signal Transduction | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Myocardium - pathology | Transforming Growth Factor beta1 - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Hypertension - pathology | Aging - pathology | Hypertension - metabolism | Transcription Factors - metabolism | Animals | Shc Signaling Adaptor Proteins - genetics | Src Homology 2 Domain-Containing, Transforming Protein 1 | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Mitogen-Activated Protein Kinases - genetics | Aged | Aging - metabolism | Mitogen-Activated Protein Kinases - metabolism | Hypertension | Review
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2012, Volume 53, Issue 1, pp. 30 - 43
Epithelial–mesenchymal transition (EMT) plays a pivotal role in the pathogenesis of renal tubulointerstitial fibrosis. We previously demonstrated that... 
Oxidative stress | Epithelial–mesenchymal transition | Mitochondrial dysfunction | Free radicals | Aldosterone | Epithelial-mesenchymal transition | APOPTOSIS | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | P66SHC | MUSCLE | SIRT1 | DAMAGE | BIOGENESIS | DISEASE | ENDOCRINOLOGY & METABOLISM | RESISTANCE | RNA, Small Interfering - genetics | Shc Signaling Adaptor Proteins - metabolism | Epithelial Cells - metabolism | Cadherins - metabolism | Epithelial Cells - drug effects | Humans | Transcriptional Activation | Epithelial-Mesenchymal Transition - drug effects | Heat-Shock Proteins - antagonists & inhibitors | Mitochondrial Proteins - genetics | Membrane Potential, Mitochondrial - drug effects | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Shc Signaling Adaptor Proteins - antagonists & inhibitors | DNA, Mitochondrial - genetics | Mitochondrial Proteins - metabolism | Sirtuin 1 | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Phosphorylation - drug effects | Cadherins - genetics | Real-Time Polymerase Chain Reaction | DNA Damage - drug effects | Kidney Tubules, Proximal - cytology | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Cells, Cultured | Aldosterone - pharmacology | Epithelial Cells - pathology | Transcription Factors - antagonists & inhibitors | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Transcription Factors - metabolism | Shc Signaling Adaptor Proteins - genetics | Src Homology 2 Domain-Containing, Transforming Protein 1 | Kidney Tubules, Proximal - metabolism | Protein Processing, Post-Translational | Oxidative Stress - drug effects | Kidney Tubules, Proximal - drug effects | Yuan (China) | Corticosteroids | RNA | Genes | Mitochondrial DNA | Genetic transcription | Muscle proteins | Cells | Actin | DNA | Resveratrol | Physiological aspects
Journal Article
PLoS Genetics, ISSN 1553-7390, 08/2012, Volume 8, Issue 8, p. e1002836
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