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src homology 2 domain-containing, transforming protein 1 (961) 961
animals (936) 936
shc signaling adaptor proteins (806) 806
humans (795) 795
phosphorylation (657) 657
adaptor proteins, signal transducing (647) 647
proteins - metabolism (552) 552
adaptor proteins, vesicular transport (540) 540
mice (538) 538
signal transduction (501) 501
biochemistry & molecular biology (466) 466
index medicus (372) 372
cell biology (351) 351
shc signaling adaptor proteins - metabolism (306) 306
grb2 adaptor protein (266) 266
cell line (253) 253
rats (238) 238
oxidative stress (232) 232
tyrosine - metabolism (232) 232
shc (229) 229
cells, cultured (207) 207
activation (195) 195
protein binding (189) 189
shc signaling adaptor proteins - genetics (178) 178
male (176) 176
phosphoproteins - metabolism (173) 173
apoptosis (172) 172
signal-transduction (170) 170
enzyme activation (165) 165
signal transduction - physiology (163) 163
adaptor proteins, signal transducing - metabolism (161) 161
oncology (158) 158
protein-tyrosine kinases - metabolism (150) 150
female (146) 146
molecular sequence data (146) 146
amino acid sequence (142) 142
mitogen-activated protein kinases - metabolism (141) 141
src homology domains (140) 140
tyrosine phosphorylation (138) 138
proto-oncogene proteins - metabolism (135) 135
phosphatidylinositol 3-kinases - metabolism (129) 129
transfection (129) 129
proteins (125) 125
reactive oxygen species - metabolism (116) 116
signal transduction - drug effects (116) 116
phosphotyrosine - metabolism (115) 115
expression (114) 114
phosphatidylinositol 3-kinase (114) 114
calcium-calmodulin-dependent protein kinases - metabolism (111) 111
life-span (111) 111
tumor cells, cultured (108) 108
protein (107) 107
adapter protein (105) 105
endocrinology & metabolism (104) 104
binding sites (102) 102
p66shc (100) 100
3t3 cells (99) 99
cells (97) 97
mutation (96) 96
receptor protein-tyrosine kinases - metabolism (95) 95
phosphorylation - drug effects (93) 93
receptor (91) 91
research (91) 91
ras (89) 89
tyrosine kinase (89) 89
mice, knockout (87) 87
receptor, epidermal growth factor - metabolism (87) 87
blotting, western (86) 86
cell line, tumor (85) 85
signaling pathway (84) 84
p66 (82) 82
epidermal growth factor - pharmacology (80) 80
enzyme inhibitors - pharmacology (78) 78
grb2 (78) 78
recombinant fusion proteins - metabolism (78) 78
insulin receptor substrate proteins (77) 77
kinase (77) 77
protein structure, tertiary (77) 77
proteins - genetics (76) 76
map kinase (74) 74
association (73) 73
genetics & heredity (72) 72
ras proteins - metabolism (72) 72
research article (71) 71
intracellular signaling peptides and proteins (69) 69
precipitin tests (69) 69
binding (68) 68
cell proliferation (68) 68
models, biological (68) 68
physiological aspects (68) 68
adaptor proteins, signal transducing - genetics (67) 67
multidisciplinary sciences (65) 65
time factors (64) 64
immunology (63) 63
pathway (63) 63
ligands (61) 61
mice, inbred c57bl (61) 61
domain (60) 60
mitochondria - metabolism (60) 60
biophysics (59) 59
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Nature, ISSN 0028-0836, 2013, Volume 499, Issue 7457, pp. 166 - 171
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2013, Volume 8, Issue 8, p. e70536
Journal Article
Journal of Cell Science, ISSN 0021-9533, 09/2017, Volume 130, Issue 17, pp. 2808 - 2820
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 52, pp. 44326 - 44335
Endogenous glucocorticoids (GCs) and inflammatory cytokines contribute to the age-associated loss of bone mass and strength, but the molecular mechanisms... 
TRANSCRIPTIONAL ACTIVITY | REACTIVE OXYGEN | BONE-MINERAL DENSITY | PROTEASOMAL DEGRADATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORKHEAD-BOX-O | GENE-EXPRESSION | EXTENDS LIFE-SPAN | T-CELL-FACTOR | BETA-CATENIN | NF-KAPPA-B | Tumor Necrosis Factor-alpha - metabolism | Shc Signaling Adaptor Proteins - metabolism | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Oxidative Stress - physiology | Tumor Necrosis Factor-alpha - genetics | Wnt Signaling Pathway - physiology | Male | Wnt Proteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Dexamethasone - pharmacology | MAP Kinase Kinase 4 - metabolism | Wnt Proteins - genetics | Forkhead Transcription Factors - metabolism | Female | Osteoblasts - cytology | Proto-Oncogene Proteins c-akt - metabolism | Cell Differentiation - physiology | Forkhead Transcription Factors - genetics | Prednisolone - pharmacology | beta Catenin - metabolism | beta Catenin - genetics | Mice, Knockout | Animals | Shc Signaling Adaptor Proteins - genetics | Src Homology 2 Domain-Containing, Transforming Protein 1 | Wnt Signaling Pathway - drug effects | Cell Differentiation - drug effects | Glucocorticoids - pharmacology | MAP Kinase Kinase 4 - genetics | Cell Proliferation - drug effects | Mice | Apoptosis - physiology | Oxidative Stress - drug effects | Osteoblasts - metabolism | Wnt Signaling | FoxO | Glucocorticoids | Oxidative Stress | Tumor Necrosis Factor (TNF) | Osteoblasts | Cell Biology
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2015, Volume 83, pp. 112 - 121
Abstract Ageing is associated with functional, structural and mechanical changes in arteries that closely resemble the vascular alterations in hypertension.... 
Cardiovascular | Vascular remodeling | Endothelial dysfunction | Oxidative stress | Mitochondria | CARDIAC & CARDIOVASCULAR SYSTEMS | ENDOPLASMIC-RETICULUM STRESS | AGE-RELATED DECLINE | HYDROGEN-SULFIDE | BLOOD-PRESSURE | CELL BIOLOGY | RENIN-ANGIOTENSIN SYSTEM | FREE-RADICAL THEORY | NITRIC-OXIDE | SMOOTH-MUSCLE-CELLS | NF-KAPPA-B | Shc Signaling Adaptor Proteins - metabolism | Oxidative Stress | Blood Vessels - metabolism | Blood Vessels - pathology | Humans | Transforming Growth Factor beta1 - metabolism | Forkhead Transcription Factors - metabolism | Myocardium - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Cell Cycle Proteins - genetics | Hypertension - genetics | Signal Transduction | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Myocardium - pathology | Transforming Growth Factor beta1 - genetics | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Hypertension - pathology | Aging - pathology | Hypertension - metabolism | Transcription Factors - metabolism | Animals | Shc Signaling Adaptor Proteins - genetics | Src Homology 2 Domain-Containing, Transforming Protein 1 | Endothelium, Vascular - metabolism | Endothelium, Vascular - pathology | Mitogen-Activated Protein Kinases - genetics | Aged | Aging - metabolism | Mitogen-Activated Protein Kinases - metabolism | Hypertension | Review
Journal Article
Nature Communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 5811
Epidermal growth factor receptor (EGFR) overexpression plays an important oncogenic role in cancer. Regular EGFR protein levels are increased in cancer cells... 
AUTOCRINE LOOP | RECEPTOR TYROSINE KINASES | MULTIDISCIPLINARY SCIENCES | EPIDERMAL-GROWTH-FACTOR | GENE-EXPRESSION | HUMAN GLIOMAS | CANCER-THERAPY | TRANSGENIC MICE | INNATE IMMUNITY | BRAIN-TUMORS | FACTOR-ALPHA | Receptor, Epidermal Growth Factor - genetics | Shc Signaling Adaptor Proteins - metabolism | Apoptosis - drug effects | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Interferon Regulatory Factor-3 - genetics | Brain Neoplasms - metabolism | Proto-Oncogene Proteins c-akt - genetics | Receptor, Epidermal Growth Factor - metabolism | Glioblastoma - genetics | Glioblastoma - metabolism | Antineoplastic Agents - pharmacology | Membrane Proteins - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Membrane Proteins - genetics | Protein-Serine-Threonine Kinases - genetics | Brain Neoplasms - genetics | Signal Transduction - genetics | TNF-Related Apoptosis-Inducing Ligand - metabolism | Carrier Proteins - genetics | Carrier Proteins - metabolism | Shc Signaling Adaptor Proteins - genetics | Glioblastoma - pathology | Cell Line, Tumor | Interferon Regulatory Factor-3 - metabolism | Epidermal Growth Factor - pharmacology | Primary Cell Culture | TNF-Related Apoptosis-Inducing Ligand - genetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2017, Volume 292, Issue 14, pp. 5748 - 5759
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2012, Volume 53, Issue 1, pp. 30 - 43
Epithelial–mesenchymal transition (EMT) plays a pivotal role in the pathogenesis of renal tubulointerstitial fibrosis. We previously demonstrated that... 
Oxidative stress | Epithelial–mesenchymal transition | Mitochondrial dysfunction | Free radicals | Aldosterone | Epithelial-mesenchymal transition | APOPTOSIS | PGC-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | P66SHC | MUSCLE | SIRT1 | DAMAGE | BIOGENESIS | DISEASE | ENDOCRINOLOGY & METABOLISM | RESISTANCE | RNA, Small Interfering - genetics | Shc Signaling Adaptor Proteins - metabolism | Epithelial Cells - metabolism | Cadherins - metabolism | Epithelial Cells - drug effects | Humans | Transcriptional Activation | Epithelial-Mesenchymal Transition - drug effects | Heat-Shock Proteins - antagonists & inhibitors | Mitochondrial Proteins - genetics | Membrane Potential, Mitochondrial - drug effects | DNA-Binding Proteins - metabolism | Heat-Shock Proteins - genetics | Shc Signaling Adaptor Proteins - antagonists & inhibitors | DNA, Mitochondrial - genetics | Mitochondrial Proteins - metabolism | Sirtuin 1 | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Phosphorylation - drug effects | Cadherins - genetics | Real-Time Polymerase Chain Reaction | DNA Damage - drug effects | Kidney Tubules, Proximal - cytology | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Cells, Cultured | Aldosterone - pharmacology | Epithelial Cells - pathology | Transcription Factors - antagonists & inhibitors | Mitochondria - metabolism | Mitochondria - drug effects | Mitochondria - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Transcription Factors - metabolism | Shc Signaling Adaptor Proteins - genetics | Src Homology 2 Domain-Containing, Transforming Protein 1 | Kidney Tubules, Proximal - metabolism | Protein Processing, Post-Translational | Oxidative Stress - drug effects | Kidney Tubules, Proximal - drug effects | Yuan (China) | Corticosteroids | RNA | Genes | Mitochondrial DNA | Genetic transcription | Muscle proteins | Cells | Actin | DNA | Resveratrol | Physiological aspects
Journal Article
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