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1. Full Text Correction: Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1
by Zorman, Jernej and Sušjan, Petra and Hafner-Bratkovič, Iva
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 9, p. e0163887
[This corrects the article DOI: 10.1371/journal.pone.0159826.]. 
Caspase | Shikonin | Caspase-1
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2. Full Text Application of “macromolecular crowding” in vitro to investigate the naphthoquinones shikonin, naphthazarin and related analogues for the treatment of dermal scars
by Fan, Chen and Lim, Lay Keng Priscilla and Loh, See Qi and Ying Lim, Kimberley Ying and Upton, Zee and Leavesley, David
Chemico-Biological Interactions, ISSN 0009-2797, 09/2019, Volume 310, p. 108747
Pathological scarring is an intractable problem for both patients and clinicians. A major obstacle for the development of scar remediation therapies is the... 
Macromolecular crowding | Naphthazarin | Shikonin | Hypertrophic scars
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3. Full Text Shikonin inhibits cancer cell cycling by targeting Cdc25s 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology
by Zhang, Shoude and Gao, Qiang and Li, Wei and Zhu, Luwei and Shang, Qianhan and Feng, Shuo and Jia, Junmei and Jia, Qiangqiang and Shen, Shuo and Su, Zhanhai
BMC Cancer, 01/2019, Volume 19, Issue 1
Cell cycle progression | Anticancer | Shikonin | Cdc25s
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4. Full Text Biosynthesis of Novel Shikonin Glucosides by Enzymatic Glycosylation
by Bohan Lia and Meilin Zhua and Hui Maa and Tao Maa and Yiqun Daia and Hongmei Lia and Yu Lib and Cheng-Zhu Wua and Bengbu Medical College and bSchool of Pharmacy and aSchool of Pharmacy and Second Military Medical University
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2019, Volume 67, Issue 10, pp. 1072 - 1075
Shikonin, a natural naphthoquinone, has attracted much attention due to its various biological activities. Two shikonin glucosides,... 
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5. Full Text Shikonin protects against D-Galactosamine and lipopolysaccharideinduced acute hepatic injury by inhibiting TLR4 signaling pathway
by Lin, Meng-Xiang and Yi, Yong-Xiang and Fang, Pei-Pei and Huang, Shan-Shan and Pan, Chen-Wei and Jin, Ling-Xiang and Zhang, Tong and Zhou, Guang-Yao
Oncotarget, 2017, Volume 8, Issue 53, pp. 91542 - 91550
Hepatic injury | Shikonin | TLR4 | LPS
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6. Full Text Inhibition of STAT(3), FAK and Src mediated signaling reduces cancer stem cell load, tumorigenic potential and metastasis in breast cancer
by Thakur, R and Trivedi, R and Rastogi, N and Singh, M and Mishra, DP
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2015, Volume 5
Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin... 
EPITHELIAL-MESENCHYMAL TRANSITION | SHIKONIN | ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | DYNAMICS | INDUCTION | MODEL | EXPRESSION | PROGRESSION
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7. Effect of shikonin in pulmonary fibroblasts culture under conditions of oxidative stress
by Zakharevich, L.M and Sazonova, E.N and Basharov, A. Ya and Slobodenyuk, E.V and Lebed’ko, O.A and Bulgakov, V.P
Russian Journal of Biopharmaceuticals, ISSN 2073-8099, 2018, Volume 10, Issue 6, pp. 39 - 43
Oxidative stress | Shikonin | Fibroblast
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8. Full Text Pharmacological properties and derivatives of shikonin—A review in recent years
by Guo, Chuanjie and He, Junlin and Song, Xiaominting and Tan, Lu and Wang, Miao and Jiang, Peidu and Li, Yuzhi and Cao, Zhixing and Peng, Cheng
Pharmacological Research, ISSN 1043-6618, 11/2019, Volume 149, p. 104463
Shikonin is the major bioactive component extracted from the roots of which is also known as “Zicao” in Traditional Chinese Medicine (TCM). Recent studies have... 
Derivative | Anticancer | Shikonin | Anti-inflammatory | Wound-healing
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9. Full Text Broad blocking of MDR efflux pumps by acetylshikonin and acetoxyisovalerylshikonin to generate hypersensitive phenotype of malignant carcinoma cells
by Mirzaei, Seyed Abbas and Reiisi, Somayeh and Ghiasi Tabari, Parmida and Shekari, Abolfazl and Aliakbari, Fatemeh and Azadfallah, Elaheh and Elahian, Fatemeh
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3446 - 8
Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant... 
BREAST-CANCER | PROTEIN | INHIBITION | MESSENGER-RNA | ANALOGS | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CANCER DRUG-RESISTANCE | SHIKONIN DERIVATIVES | MULTIDRUG-RESISTANCE | EXPRESSION | Flow cytometry | MDR1 protein | Chemotherapy | Phenotypes | Daunorubicin | Transcription | Shikonin | Multidrug resistance | Cell lines | Cytotoxicity | P-Glycoprotein | Drug resistance
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10. Full Text Shikonin induced necroptosis via reactive oxygen species in the T-47D breast cancer cell line
by Shahsavari, Zahra and Karami-Tehrani, Fatemeh and Salami, Siamak
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2015, Volume 16, Issue 16, pp. 7261 - 7266
Breast cancer | Necroptosis | Shikonin | ROS | Apoptosis
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11. Full Text The Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension is Regulated through a MiR-124/PTBP1/PKM Axis
by Zhang, Hui and Wang, Daren and Li, Min and Plecitá-Hlavatá, Lydie and D’Alessandro, Angelo and Tauber, Jan and Riddle, Suzette and Kumar, Sushil and Flockton, Amanda and McKeon, B Alexandre and Frid, Maria G and Reisz, Julie A and Caruso, Paola and El Kasmi, Karim C and Ježek, Petr and Morrell, Nicholas W and Hu, Cheng-Jun and Stenmark, Kurt R
Circulation, ISSN 0009-7322, 10/2017, Volume 136, Issue 25, pp. 2468 - 2485
BACKGROUND—An emerging 'metabolic theory' of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology... 
splicing factors | hypoxia | Shikonin | mitochondria | pyruvate kinase | TEPP-46 | metabolism
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12. CALLUS INDUCTION AND REGENERATION OF ALKANNA ORIENTALIS VAR. ORIENTALIS AND A. SIEHEANA
by Yaman, C and Uranbey, S and Ahmed, HA and Ozcan, S and Tugay, O and Basalma, D
BANGLADESH JOURNAL OF BOTANY, ISSN 0253-5416, 09/2019, Volume 48, Issue 3, pp. 633 - 640
Callus induction and proliferation of Alkanna orientalis var. orientalis and Alkanna sieheana containing valuable alkannin/shikonin (A/S) derivates were... 
A. sieheana | Alkannin/Shikonin | Micropropagation | ARNEBIA-EUCHROMA | Alkanna orientalis | SHIKONIN BIOSYNTHESIS | CULTURES | PLANT SCIENCES
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13. Full Text Simultaneous Addition of Shikonin and Its Derivatives with Lipopolysaccharide Induces Rapid Macrophage Death
by Atsushi Koikea and Makio Shibanob and Hideya Moria and Kiyoko Kohamaa and Ko Fujimoria and Fumio Amanoa and Osaka University of Pharmaceutical Sciences and bLaboratory of Pharmacognosy and aLaboratory of Biodefense & Regulation
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 6, pp. 969 - 976
Macrophages play pivotal roles in inflammatory responses. Previous studies showed that various natural products exert antiinflammatory effects by regulating... 
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14. Türkiye’de yabani yetişen bazı echium türlerindeki şikonin türevlerinin basit izokratik HPLC yöntemiyle eşzamanlı olarak belirlenmesi
by Eruygur, Nuraniye
Turkish Journal of Pharmaceutical Sciences, ISSN 1304-530X, 04/2018, Volume 15, Issue 1, pp. 38 - 43
Shikonin derivatives | Echium sp | HPLC
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15. Full Text DMAKO-20 as a New Multitarget Anticancer Prodrug Activated by the Tumor Specific CYP1B1 Enzyme
by Cui, Jiahua and Zhang, Xu and Huang, Guang and Zhang, Qijing and Dong, Jinyun and Sun, Gege and Meng, Qingqing and Li, Shaoshun
Molecular Pharmaceutics, ISSN 1543-8384, 01/2019, Volume 16, Issue 1, pp. 409 - 421
To reduce the pervasive toxicity of natural shikonin, alkannin, and their synthetic analogues and to enhance the selectivity of these chemotherapeutics toward... 
anticancer prodrugs | CYP1B1 | shikonin derivatives | in vivo efficacy | DMAKO-20 | MEDICINE, RESEARCH & EXPERIMENTAL | SHIKONIN | DESIGN | ANTITUMOR-ACTIVITY | 1B1 INHIBITORS | 5-FLUOROURACIL | IN-VITRO | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | ALKANNIN | CYTOTOXICITY | DERIVATIVES | Index Medicus
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16. Effects of Shikonin on Th17 related cytokines in psoriasis-like mouse model
by Zhao, Sha and Pan, Min and Chen, Fei-Fei and Liu, Yan-Ru and Lin, Xiang-Fei and Zhu, Xiao-Fang
Journal of Clinical Dermatology, ISSN 1000-4963, 05/2016, Volume 45, Issue 5, pp. 323 - 327
MTX | Mouse | Psoriasis | Shikonin
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17. Full Text Shikonin attenuates sympathetic remodeling in chronic heart failure mice via regulating miR-124
by Liu, Qiang and Liu, Wen-Lin
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2019, Volume 520, Issue 2, pp. 359 - 365
Shikonin is a naphthoquinone compound extracted from the root of with various pharmacological activities. Sympathetic neural remodeling greatly contributes to... 
Heart failure | Shikonin | Sympathetic remodeling | miRNA-124 | Proteins | Immunohistochemistry | Health aspects | Astronautics | Accidents
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18. Shikonin reduces TGF-ß1-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts
by Fan, Chen and Dong, Ying and Xie, Yan and Su, Yonghua and Zhang, Xufang and Leavesley, David and Upton, Zee
International Journal of Molecular Medicine, ISSN 1107-3756, 10/2015, Volume 36, Issue 4, pp. 985 - 991
Fibroblasts | Hypetrophic scar | Transforming growth factor-ß1 | Shikonin | Collagen
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19. Full Text Sensitive and selective voltammetric determination of anti˗cancer agent shikonin on sepiolite clay/TiO2 nanoparticle/MWCNTs composite carbon paste sensor and investigation of its electro˗oxidation mechanism
by Bayraktepe, Dilek Eskiköy and Yazan, Zehra and Polat, Kamran
Journal of Electroanalytical Chemistry, ISSN 1572-6657, 11/2016, Volume 780, pp. 38 - 45
A simple and highly sensitive voltammetric method was developed to determine the Shikonin (SHI) content in synthetic and real samples. The method is based on a... 
Sepiolite clay | Multiwalled carbon nanotubes | Carbon paste electrode | Shikonin | TiO2 nanoparticles | Composite electrode | nanoparticles | TiO | HERBAL DRUG-SHIKONIN | ELECTROCHEMISTRY | CHEMISTRY, ANALYTICAL | BIOLOGICAL-FLUIDS | BEHAVIOR | PHARMACEUTICAL DOSAGE FORMS | CHROMATOGRAPHY | ELECTROCHEMICAL OXIDATION | MODIFIED ELECTRODE | ELECTROPHORESIS | ADSORPTIVE STRIPPING DETERMINATION | SAMPLES
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20. Full Text Highly Sensitive Electrochemical Sensor Based on PEDOT:PSS-beta-CD-SWCNT-COOH Modified Glassy Carbon Electrode Enables Trace Analysis Shikonin
by Chai, JD and Zhang, J and Wen, YP and Zou, L and Zhang, XX and Xin, X and Zhou, MH and Xu, JK and Zhang, G
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, ISSN 0013-4651, 03/2019, Volume 166, Issue 6, pp. B388 - B394
An electrochemical sensor based on PEDOT: PSS-beta-CD-SWCNT-COOH/GCE for highly sensitive analysis of shikonin (SHI) in PBS buffer solution was reported.... 
HERBAL DRUG-SHIKONIN | ELECTROCHEMISTRY | DOPAMINE | COMPOSITE FILM | PERFORMANCE | MATERIALS SCIENCE, COATINGS & FILMS
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