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PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 9, p. e0163887
[This corrects the article DOI: 10.1371/journal.pone.0159826.]. 
Caspase | Shikonin | Caspase-1
Journal Article
Chemico-Biological Interactions, ISSN 0009-2797, 09/2019, Volume 310, p. 108747
Pathological scarring is an intractable problem for both patients and clinicians. A major obstacle for the development of scar remediation therapies is the... 
Macromolecular crowding | Naphthazarin | Shikonin | Hypertrophic scars
Journal Article
Chemical and Pharmaceutical Bulletin, ISSN 0009-2363, 2019, Volume 67, Issue 10, pp. 1072 - 1075
Shikonin, a natural naphthoquinone, has attracted much attention due to its various biological activities. Two shikonin glucosides,... 
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2015, Volume 5
Cancer stem cells (CSCs) are responsible for aggressive tumor growth, metastasis and therapy resistance. In this study, we evaluated the effects of Shikonin... 
EPITHELIAL-MESENCHYMAL TRANSITION | SHIKONIN | ACTIVATION | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | DYNAMICS | INDUCTION | MODEL | EXPRESSION | PROGRESSION
Journal Article
Russian Journal of Biopharmaceuticals, ISSN 2073-8099, 2018, Volume 10, Issue 6, pp. 39 - 43
Journal Article
Pharmacological Research, ISSN 1043-6618, 11/2019, Volume 149, p. 104463
Shikonin is the major bioactive component extracted from the roots of which is also known as “Zicao” in Traditional Chinese Medicine (TCM). Recent studies have... 
Derivative | Anticancer | Shikonin | Anti-inflammatory | Wound-healing
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 3446 - 8
Cytotoxic activities of acetylshikonin and acetoxyisovalerylshikonin alone and in combination with chemotherapeutic agents against parental and drug resistant... 
BREAST-CANCER | PROTEIN | INHIBITION | MESSENGER-RNA | ANALOGS | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | CANCER DRUG-RESISTANCE | SHIKONIN DERIVATIVES | MULTIDRUG-RESISTANCE | EXPRESSION | Flow cytometry | MDR1 protein | Chemotherapy | Phenotypes | Daunorubicin | Transcription | Shikonin | Multidrug resistance | Cell lines | Cytotoxicity | P-Glycoprotein | Drug resistance
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2015, Volume 16, Issue 16, pp. 7261 - 7266
Journal Article
Circulation, ISSN 0009-7322, 10/2017, Volume 136, Issue 25, pp. 2468 - 2485
BACKGROUND—An emerging 'metabolic theory' of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology... 
splicing factors | hypoxia | Shikonin | mitochondria | pyruvate kinase | TEPP-46 | metabolism
Journal Article
BANGLADESH JOURNAL OF BOTANY, ISSN 0253-5416, 09/2019, Volume 48, Issue 3, pp. 633 - 640
Callus induction and proliferation of Alkanna orientalis var. orientalis and Alkanna sieheana containing valuable alkannin/shikonin (A/S) derivates were... 
A. sieheana | Alkannin/Shikonin | Micropropagation | ARNEBIA-EUCHROMA | Alkanna orientalis | SHIKONIN BIOSYNTHESIS | CULTURES | PLANT SCIENCES
Journal Article
Biological and Pharmaceutical Bulletin, ISSN 0918-6158, 2016, Volume 39, Issue 6, pp. 969 - 976
Macrophages play pivotal roles in inflammatory responses. Previous studies showed that various natural products exert antiinflammatory effects by regulating... 
Journal Article
Turkish Journal of Pharmaceutical Sciences, ISSN 1304-530X, 04/2018, Volume 15, Issue 1, pp. 38 - 43
Journal Article
Molecular Pharmaceutics, ISSN 1543-8384, 01/2019, Volume 16, Issue 1, pp. 409 - 421
To reduce the pervasive toxicity of natural shikonin, alkannin, and their synthetic analogues and to enhance the selectivity of these chemotherapeutics toward... 
anticancer prodrugs | CYP1B1 | shikonin derivatives | in vivo efficacy | DMAKO-20 | MEDICINE, RESEARCH & EXPERIMENTAL | SHIKONIN | DESIGN | ANTITUMOR-ACTIVITY | 1B1 INHIBITORS | 5-FLUOROURACIL | IN-VITRO | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | ALKANNIN | CYTOTOXICITY | DERIVATIVES | Index Medicus
Journal Article
Journal of Clinical Dermatology, ISSN 1000-4963, 05/2016, Volume 45, Issue 5, pp. 323 - 327
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2019, Volume 520, Issue 2, pp. 359 - 365
Shikonin is a naphthoquinone compound extracted from the root of with various pharmacological activities. Sympathetic neural remodeling greatly contributes to... 
Heart failure | Shikonin | Sympathetic remodeling | miRNA-124 | Proteins | Immunohistochemistry | Health aspects | Astronautics | Accidents
Journal Article
International Journal of Molecular Medicine, ISSN 1107-3756, 10/2015, Volume 36, Issue 4, pp. 985 - 991
Journal Article
by Chai, JD and Zhang, J and Wen, YP and Zou, L and Zhang, XX and Xin, X and Zhou, MH and Xu, JK and Zhang, G
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, ISSN 0013-4651, 03/2019, Volume 166, Issue 6, pp. B388 - B394
An electrochemical sensor based on PEDOT: PSS-beta-CD-SWCNT-COOH/GCE for highly sensitive analysis of shikonin (SHI) in PBS buffer solution was reported.... 
HERBAL DRUG-SHIKONIN | ELECTROCHEMISTRY | DOPAMINE | COMPOSITE FILM | PERFORMANCE | MATERIALS SCIENCE, COATINGS & FILMS
Journal Article
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