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Nature, ISSN 0028-0836, 07/2004, Volume 430, Issue 6996, pp. 213 - 218
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2007, Volume 179, Issue 5, pp. 2686 - 2689
TNF-alpha, a potent proinflammatory cytokine, is synthesized as a membrane-anchored precursor and proteolytically released from cells. Soluble TNF is the... 
ADAM17 Protein | Myeloid Cells - enzymology | Myxovirus Resistance Proteins | ADAM Proteins - antagonists & inhibitors | Animals | Mice, Mutant Strains | Shock, Septic - prevention & control | Mice | Shock, Septic - enzymology | ADAM Proteins - genetics | GTP-Binding Proteins - genetics | Integrases - genetics
Journal Article
Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5983, pp. 1290 - 1294
During sepsis, activation of phagocytes leads to the overproduction of proinflammatory cytokines, causing systemic inflammation. Despite substantial... 
Bacteriophages | Cytokines | Antibiotics | REPORTS | Neutrophils | Small interfering RNA | Sepsis | Septic shock | Inflammation | Macrophages | Vehicles | ACTIVATION | THERAPY | CECAL LIGATION | INFLAMMATORY RESPONSES | MULTIDISCIPLINARY SCIENCES | RECEPTOR | FC-GAMMA-RI | SPHINGOSINE KINASE | CA2+ SIGNALS | MODULATION | PUNCTURE | Up-Regulation | Humans | Middle Aged | Endotoxins | Male | NF-kappa B - metabolism | Shock, Septic - immunology | Lipopolysaccharides - immunology | Young Adult | Sepsis - drug therapy | RNA Interference | Aged, 80 and over | Adult | Female | Bacterial Proteins - immunology | Macrophages - immunology | Cytokines - blood | Sepsis - immunology | Cytokines - metabolism | Neutrophils - enzymology | Signal Transduction | Enzyme Inhibitors - pharmacology | Macrophages, Peritoneal - enzymology | Neutrophils - immunology | Macrophages, Peritoneal - immunology | Phosphotransferases (Alcohol Group Acceptor) - genetics | Peritonitis - immunology | Enzyme Inhibitors - therapeutic use | Macrophages - enzymology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Protein Kinase C-delta - metabolism | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Peritonitis - enzymology | Animals | Sepsis - enzymology | Adolescent | Aged | Mice | Shock, Septic - enzymology | Enzyme Activation | Lipoproteins - immunology | Phagocytes | Physiological aspects | Diagnosis | Research | Risk factors | Enzymes | Molecular biology | Immune system
Journal Article
Nature, ISSN 0028-0836, 04/2006, Volume 440, Issue 7087, pp. 1064 - 1068
Journal Article
Journal Article
Immunity, ISSN 1074-7613, 07/2018, Volume 49, Issue 1, pp. 42 - 55.e6
The execution of shock following high dose lipopolysaccharide (LPS) or bacterial sepsis in mice required pro-apoptotic caspase-8 in addition to pro-pyroptotic... 
ileum | pyroptosis | endotoxic shock | programmed necrosis | Caspase | RIP kinase | interferon | TNF | extrinsic apoptosis | KINASE-ACTIVITY | RIPK3 | I INTERFERONS | APOPTOTIC CELL-DEATH | SEPTIC SHOCK | MICE | INTRACELLULAR LPS | SEPSIS | IMMUNOLOGY | NONCANONICAL INFLAMMASOME ACTIVATION | MOUSE MODELS | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Intestine, Small - pathology | Escherichia coli Infections - enzymology | Tumor Necrosis Factor-alpha - blood | Caspase 8 - metabolism | Escherichia coli Infections - physiopathology | Male | Interferon Regulatory Factor-3 - genetics | Caspase 8 - genetics | Inflammation - metabolism | Caspases - metabolism | Female | Spleen - pathology | Lipopolysaccharides - toxicity | Signal Transduction | Caspases - genetics | Mice, Inbred C57BL | Cells, Cultured | Shock, Septic - physiopathology | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Interferon-beta - metabolism | Interferon-beta - blood | Shock, Septic - enzymology | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Apoptosis | Medical colleges | Cell death | Proteases | Escherichia coli | Resveratrol | Septic shock | Interferon | Biological response modifiers | Mitogens | Spleen | Shock | Cytokines | Caspase-11 | Inflammation | Kinases | Gene expression | Small intestine | Hemopoiesis | Thymus | Lipopolysaccharides | Caspase-8 | E coli | Rodents | MyD88 protein | Sepsis | Tumor necrosis factor-TNF | Software | Endotoxemia | Deoxyribonucleic acid--DNA
Journal Article
Journal Article