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Nature, ISSN 0028-0836, 07/2010, Volume 466, Issue 7303, pp. 243 - 247
Journal Article
Molecular Microbiology, ISSN 0950-382X, 10/2018, Volume 110, Issue 2, pp. 204 - 218
Summary 3‐Deoxy‐d‐manno‐oct‐2‐ulosonic acid (Kdo) is an essential component of lipopolysaccharides (LPS) in the Gram‐negative bacterial outer membrane.... 
K-12 | CATABOLISM | PATHWAY | BIOSYNTHESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | LIPOPOLYSACCHARIDE | OUTER-MEMBRANE PERMEABILITY | MICROBIOLOGY | HAEMOPHILUS-INFLUENZAE | IDENTIFICATION | HELICOBACTER-PYLORI | MOLECULAR-BASIS | Escherichia coli K12 - physiology | Sugar Acids - pharmacology | Lipopolysaccharides - metabolism | Neuraminic Acids - pharmacology | Cytoplasm - metabolism | Escherichia coli Proteins - metabolism | Pseudomonas aeruginosa - physiology | Pseudomonas aeruginosa - drug effects | Organic Anion Transporters - metabolism | Symporters - metabolism | Acinetobacter baumannii - physiology | Organic Anion Transporters - genetics | Escherichia coli K12 - drug effects | Pseudomonas aeruginosa - genetics | Membrane Transport Proteins - genetics | Symporters - genetics | Escherichia coli Proteins - genetics | Fluorescent Dyes - pharmacology | Membrane Transport Proteins - metabolism | Cell Membrane - metabolism | Azides - pharmacology | Acinetobacter baumannii - drug effects | Acinetobacter baumannii - genetics | Escherichia coli K12 - genetics | Physiological aspects | Escherichia coli | Organic acids | Incorporation | Labelling | Biosynthesis | Imports | Sialic acids | Optimization | Lipopolysaccharides | Acids | Restoration | E coli | Morphology | Pseudomonas aeruginosa | Bacteria | Transporter | Cytoplasm | Ulosonic acid
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2010, Volume 107, Issue Supplement 2, pp. 8939 - 8946
Journal Article
by Hollingworth, P and Harold, D and Sims, R and Gerrish, A and Lambert, J.C and Carrasquillo, M.M and Abraham, R and Hamshere, M.L and Pahwa, J.S and Moskvina, V and Dowzell, K and Jones, N and Stretton, A and Thomas, C and Richards, A and Ivanov, D and Widdowson, C and Chapman, J and Lovestone, S and Powell, J and Proitsi, P and Lupton, M.K and Brayne, C and Rubinsztein, D.C and Gill, M and Lawlor, B and Lynch, A and Brown, K.S and Passmore, P.A and Craig, D and McGuinness, B and Todd, S and Holmes, C and Mann, D and Smith, A.D and Beaumont, H and Warden, D and Wilcock, G and Love, S and Kehoe, P.G and Hooper, N.M and Vardy, E.R.L.C and Hardy, J and Mead, S and Fox, N.C and Rossor, M and Collinge, J and Maier, W and Jessen, F and Ruther, E and Schurmann, B and Heun, R and Kolsch, H and van den Bussche, H and Heuser, I and Kornhuber, J and Wiltfang, J and Dichgans, M and Frolich, L and Hampel, H and Gallacher, J and Hull, M and Rujescu, D and Giegling, I and Goate, A.M and Kauwe, J.S.K and Cruchaga, C and Nowotny, P and Morris, J.C and Mayo, K and Sleegers, K and Bettens, K and Engelborghs, S and de Deyn, P.P and Van Broeckhoven, C and Livingston, G and Bass, N.J and Gurling, H and McQuillin, A and Gwilliam, R and Deloukas, P and Al-Chalabi, A and Shaw, C.E and Tsolaki, M and Singleton, A.B and Guerreiro, R and Muhleisen, T. W and Nothen, M. M and Moebus, S and Jockel, K.H and Klopp, N and Wichmann, H. E and Pankratz, V.S and Sando, S.B and Aasly, J.O and Barcikowska, M and Wszolek, Z.K and Dickson, D.W and Graff-Radford, N.R. and others and Alzheimer's Dis Neuroimaging and EADI1 Consortium and CHARGE Consortium and the Alzheimer's Disease Neuroimaging Initiative and EADI1 consortium and CHARGE consortium
Nature Genetics, ISSN 1061-4036, 2011, Volume 43, Issue 5, pp. 429 - 435
We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by... 
IDENTIFIES VARIANTS | GENETICS & HEREDITY | GENE-EXPRESSION | RISK | LOCI | APOE | CR-1 | CLU | RECEPTOR TYROSINE KINASE | GENOME-WIDE ASSOCIATION | PICALM | Usage | Genetic aspects | Disease susceptibility | Research | Single nucleotide polymorphisms | Drug therapy | Alzheimer's disease | Health aspects | Risk factors | Genomes | Medical imaging | Biomedical research | Alzheimers disease | Genes
Journal Article
Journal Article
British Journal of Haematology, ISSN 0007-1048, 08/2015, Volume 170, Issue 3, pp. 305 - 322
Summary The acute myeloid leukaemia (AML) genome contains more than 20 driver recurrent mutations. Here, we review the potential for therapeutic targeting of... 
normal cytogenetics | NPM1 | epigenetic gene mutations | acute myeloid leukaemia | FLT3 | Acute myeloid leukaemia | Epigenetic gene mutations | Normal cytogenetics | ISOCITRATE DEHYDROGENASE 1 | INTERNAL TANDEM DUPLICATION | ACUTE MYELOGENOUS LEUKEMIA | NUCLEOPHOSMIN NPMC(+) AML | TRANS-RETINOIC ACID | DNMT3A MUTATIONS | TET2 MUTATIONS | HEMATOPOIETIC STEM-CELLS | KINASE DOMAIN MUTANTS | HEMATOLOGY | MINIMAL RESIDUAL DISEASE | fms-Like Tyrosine Kinase 3 - antagonists & inhibitors | Transcription, Genetic - drug effects | Interleukin-3 Receptor alpha Subunit - biosynthesis | Humans | Leukemia, Myeloid, Acute - metabolism | Antineoplastic Agents - therapeutic use | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Isocitrate Dehydrogenase - antagonists & inhibitors | Gene Expression Regulation, Leukemic - genetics | DNA (Cytosine-5-)-Methyltransferases - metabolism | DNA-Binding Proteins - metabolism | fms-Like Tyrosine Kinase 3 - genetics | Leukemia, Myeloid, Acute - drug therapy | Epigenesis, Genetic - drug effects | Nuclear Proteins - genetics | Proto-Oncogene Proteins - metabolism | Sialic Acid Binding Ig-like Lectin 3 - genetics | Proto-Oncogene Proteins - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Gene Expression Regulation, Leukemic - drug effects | Isocitrate Dehydrogenase - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | DNA-Binding Proteins - genetics | fms-Like Tyrosine Kinase 3 - metabolism | Sialic Acid Binding Ig-like Lectin 3 - biosynthesis | DNA (Cytosine-5-)-Methyltransferases - genetics | Animals | Epigenesis, Genetic - genetics | Interleukin-3 Receptor alpha Subunit - genetics | Nuclear Proteins - antagonists & inhibitors | Isocitrate Dehydrogenase - metabolism | Mutation | Transcription, Genetic - genetics | Drug Delivery Systems - methods | Leukemia, Myeloid, Acute - genetics | Cytogenetics | Genetic aspects | Gene mutations | Health aspects | Genes
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 06/2016, Volume 41, Issue 6, pp. 519 - 531
Sialic acid sugars are vital regulators of the immune system through binding to immunosuppressive sialic acid-binding immunoglobulin-like lectin (Siglec)... 
sialic acid mimetics | Siglecs | sialic acids | glycans | glycoengineering | sialome | Glycans | Sialic acids | Sialic acid mimetics | Sialome | Glycoengineering | HIGH-AFFINITY LIGAND | COMMON VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | INHIBITORY RECEPTOR | PAIRED RECEPTORS | MAG ANTAGONISTS | BINDING | MODIFIED SIALOSIDES | CD22 | B-CELL TOLERANCE | Immune System Diseases - genetics | Humans | Sialyltransferases - immunology | Killer Cells, Natural - pathology | Molecular Targeted Therapy | Sialic Acids - chemistry | Drug Carriers | Sialic Acid Binding Immunoglobulin-like Lectins - immunology | Aging - immunology | Myeloid Cells - immunology | Nanoparticles - therapeutic use | T-Lymphocytes - drug effects | Sialyltransferases - antagonists & inhibitors | Killer Cells, Natural - immunology | Myeloid Cells - drug effects | B-Lymphocytes - pathology | T-Lymphocytes - pathology | Sialic Acids - immunology | Immune System Diseases - pathology | Biomimetic Materials - chemistry | Sialic Acids - antagonists & inhibitors | Carbohydrate Sequence | Biomimetic Materials - therapeutic use | Gene Expression | Immunologic Factors - chemistry | Immune System Diseases - immunology | Sialyltransferases - genetics | Immune System Diseases - drug therapy | Sialic Acid Binding Immunoglobulin-like Lectins - genetics | B-Lymphocytes - drug effects | B-Lymphocytes - immunology | Sialic Acid Binding Immunoglobulin-like Lectins - antagonists & inhibitors | Protein Binding | T-Lymphocytes - immunology | Killer Cells, Natural - drug effects | Myeloid Cells - pathology | Immunologic Factors - therapeutic use | Autoimmunity | Lectins | Organic acids
Journal Article