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British Journal of Pharmacology, ISSN 0007-1188, 08/2012, Volume 166, Issue 8, pp. 2289 - 2306
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2019, Volume 144, pp. 244 - 255
The histamine H receptor is a G protein-coupled receptor (GPCR) drug target that is highly expressed in the CNS, where it acts as both an auto- and... 
receptor | Kinetics | S 38093-2 | Histamine H | Receptor occupancy | Sigma-1 receptor | MECHANISM | EFFICACY | ALZHEIMERS-DISEASE | RELEASE | NEUROSCIENCES | S 38093 | POTENT | INHIBITION | PHARMACOLOGY & PHARMACY | Histamine H-3 receptor | H3 RECEPTORS | BRAIN | PHARMACOLOGICAL-PROPERTIES
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 03/2013, Volume 168, Issue 6, pp. 1445 - 1455
Background and Purpose The Sigma-1 receptor (Sig1R) impacts on calcium ion signalling and has a plethora of ligands. This study investigated Sig1R and its... 
cationic channels | endothelial cells | TRP | histamine | channels | calcium channels | vascular endothelial growth factor | hydrogen peroxide | igma‐1 receptor | Sigma-1 receptor | TRP channels | ACTIVATION | ANGIOGENESIS | DEPENDENCE | INTRACELLULAR CA2 | CALCIUM | PHARMACOLOGY & PHARMACY | Endothelium, Vascular - cytology | Humans | Endothelium, Vascular - drug effects | Protein Transport - drug effects | Receptors, sigma - antagonists & inhibitors | Vascular Endothelial Growth Factor A - metabolism | Histamine - metabolism | RNA Interference | Membrane Transport Modulators - pharmacology | HEK293 Cells | Receptors, sigma - metabolism | TRPC Cation Channels - genetics | Membrane Potentials - drug effects | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Cells, Cultured | Receptors, sigma - agonists | Receptors, sigma - genetics | TRPC Cation Channels - antagonists & inhibitors | Patch-Clamp Techniques | TRPM Cation Channels - antagonists & inhibitors | Calcium Signaling - drug effects | Endothelium, Vascular - metabolism | TRPC Cation Channels - metabolism | TRPM Cation Channels - genetics | Ligands | RNA, Small Interfering | TRPM Cation Channels - metabolism | Kinetics | Fluorescence | Histamine | Calcium channels | Hydrogen peroxide | Vascular endothelial growth factor | Endothelium | Index Medicus | Research Papers
Journal Article
Journal Article
Journal Article
Neuropharmacology, ISSN 0028-3908, 01/2019, Volume 144, pp. 244 - 255
The histamine H receptor is a G protein-coupled receptor (GPCR) drug target that is highly expressed in the CNS, where it acts as both an auto- and... 
Kinetics | S 38093-2 | Sigma-1 receptor | Receptor occupancy | Histamine H3 receptor | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 04/2015, Volume 35, Issue 17, pp. 6639 - 6653
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 10/2017, Volume 143, Issue 2, pp. 171 - 182
Sigma‐1 receptors are intracellular chaperone proteins that can translocate to the plasma membrane to modulate various ion channels and cellular functions. We... 
adrenal chromaffin cell | catecholamine | serotonin transporter | calcium channels | sigma‐1 receptor | sigma-1 receptor | ACTIVATION | TRANSPORTER | EXOCYTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROSCIENCES | SEROTONIN REUPTAKE INHIBITORS | ANTIDEPRESSANTS | PHEOCHROMOCYTOMA PC12 CELLS | CALCIUM-CHANNELS | ANIMAL-MODELS | SUBSTANCE-P | MODULATION | Adrenal Medulla - metabolism | Catecholamines - metabolism | Anisoles - pharmacology | Mice, Inbred C57BL | Cells, Cultured | Male | Receptors, sigma - physiology | Nicotinic Antagonists - pharmacology | Receptors, sigma - agonists | Adrenal Medulla - cytology | Dose-Response Relationship, Drug | Catecholamines - antagonists & inhibitors | Chromaffin Cells - metabolism | Animals | Receptors, Nicotinic - physiology | Cattle | Ligands | Adrenal Medulla - drug effects | Mice | Propylamines - pharmacology | Chromaffin Cells - drug effects | Physiological aspects | Catecholamines | Serotonin uptake inhibitors | Calcium channels | Stress (physiology) | Drugs | Adrenal glands | Neuropeptides | Exocytosis | Serotonin S1 receptors | Calcium influx | Citalopram | Depolarization | Chromaffin cells | Proteins | Receptors | Antidepressants | Nerves | Ion channels | Membrane potential | Stimulus-secretion coupling | Calcium (intracellular) | Serotonin | Secretion | Calcium channels (voltage-gated) | Blocking | Sympathetic nervous system | Catecholamine | Serotonin transporter | Carbachol | Acetylcholine receptors (nicotinic) | Acetylcholine | Receptor mechanisms | Fluvoxamine | Transporter | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 04/2017, Volume 116, pp. 387 - 398
Sigma-1 receptor knockout (σ R ) in male mice causes depressive-like phenotype. We observed the expression of σ R in principal neurons of basolateral amygdala... 
Sigma-1 receptor (σ1R) | N-methyl-d-aspartate receptor (NMDAr) | GABAA receptor (GABAAR) | Basolateral amygdala (BLA) | Synaptic plasticity | neuronal nitric oxide synthase (nNOS) | receptor (GABA | Sigma-1 receptor (σ | GABA | N-methyl-D-aspartate receptor (NMDAr) | FEAR MEMORY | NMDA RECEPTORS | SYNAPTIC-TRANSMISSION | CONDITIONED FEAR | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | GABA(A) receptor (GABA(A)R) | LATERAL AMYGDALA | NITRIC-OXIDE | PREGNENOLONE SULFATE | PHARMACOLOGY & PHARMACY | RAT HIPPOCAMPUS | LONG-TERM POTENTIATION | Sigma-1 receptor (sigma R-1) | Long-Term Synaptic Depression - physiology | Receptors, sigma - deficiency | Tissue Culture Techniques | gamma-Aminobutyric Acid - metabolism | Disks Large Homolog 4 Protein - metabolism | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Receptors, sigma - genetics | Long-Term Synaptic Depression - drug effects | Basolateral Nuclear Complex - metabolism | Excitatory Postsynaptic Potentials - drug effects | Mice, Knockout | Excitatory Postsynaptic Potentials - physiology | Depression - metabolism | Animals | Neurotransmitter Agents - pharmacology | Nitric Oxide Synthase Type I - antagonists & inhibitors | Nitric Oxide Synthase Type I - metabolism | Neurons - metabolism | Receptors, GABA-A - metabolism | Neurons - drug effects | Nitric Oxide - metabolism | Basolateral Nuclear Complex - drug effects | Physiological aspects | Nitric oxide | Methyl aspartate | Glutamate | Neurons | Index Medicus
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 08/2014, Volume 34, Issue 34, pp. 11325 - 11338
Sigma-1 receptors (sigma-1Rs) are endoplasmic reticulum resident chaperone proteins implicated in many physiological and pathological processes in the CNS. A... 
Western blot | NMDA receptor | Protein synthesis | Sigma-1 receptor | Trafficking | Surface biotinylation | INDUCED NEURITE OUTGROWTH | INDUCED NEURONAL ACTIVATION | POTASSIUM CHANNELS | protein synthesis | sigma-1 receptor | PROTEIN-SYNTHESIS | NEUROSCIENCES | surface biotinylation | GLUTAMATE-RECEPTOR | PYRAMIDAL NEURONS | DORSAL HIPPOCAMPUS | CALCIUM-CHANNELS | BINDING-SITES | trafficking | METHYL-D-ASPARTATE | Disks Large Homolog 4 Protein | Receptors, N-Methyl-D-Aspartate - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Protein Transport - drug effects | Receptors, sigma - antagonists & inhibitors | Hippocampus - drug effects | Receptors, N-Methyl-D-Aspartate - genetics | Time Factors | Up-Regulation - physiology | Cell Membrane - metabolism | Membrane Proteins - metabolism | Receptors, sigma - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Cell Membrane - drug effects | Subcellular Fractions - drug effects | Membrane Proteins - genetics | Morpholines - pharmacology | Pentazocine - pharmacology | Rats | Receptors, sigma - agonists | Receptors, sigma - genetics | Piperazines - pharmacology | Rats, Sprague-Dawley | Subcellular Fractions - metabolism | Ethylenediamines - pharmacology | Protein Transport - genetics | Mice, Knockout | Up-Regulation - drug effects | Hippocampus - metabolism | Phenazocine - analogs & derivatives | Animals | Phenazocine - pharmacology | Mice | Index Medicus
Journal Article
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 3, p. 702
Journal Article